| Standard Type | Standard Relation | Standard Value | Standard Units |
|---|---|---|---|
| Inhibition | = | 0 | % |
| Inhibition | = | 95 | % |
| Inhibition | = | 29.1 | % |
| Inhibition | = | 13.6 | % |
| Inhibition | = | 18.3 | % |
| Inhibition | = | 0 | % |
| Inhibition | = | 6.4 | % |
| Inhibition | = | 27.7 | % |
| Inhibition | = | 0 | % |
| Inhibition | = | 46.7 | % |
| Inhibition | = | 7.5 | % |
| Inhibition | = | 29.6 | % |
| Inhibition | = | 0 | % |
| Inhibition | = | 17.4 | % |
| Inhibition | = | 19.8 | % |
| Inhibition | = | 13.6 | % |
| Inhibition | = | 30.7 | % |
| Inhibition | = | 16.1 | % |
| Inhibition | = | 34.9 | % |
| Inhibition | = | 47.9 | % |
| Species | Strain | IsPseudotypeVirus | AssayMeth | Target | Mutations | IC50Mod | IC50 | IC50Unit | ICOtherPct | ICOtherPctUnit | ICOtherConc | ICOtherConcUnit | KiMod | Ki | KiUnit | Km | KmUnit | HostAnalog | HostAnalogSpecies | RelResFoldChgMod | RelResFoldChg | Comments | Reference | Citation | Other Information |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3' PROCESSING | Integrase | > | 100 | uM | 18662877 | EFFICIENT SYNTHESIS AND UTILIZATION OF PHENYL-SUBSTITUTED HETEROAROMATIC CARBOXYLIC ACIDS AS ARYL DIKETO ACID ISOSTERES IN THE DESIGN OF NOVEL HIV-1 INTEGRASE INHIBITORS. Bioorganic & Medical Chemistry Letters 2008, 18(16), 4521-4. | |||||||||||||||||||
| 3' PROCESSING | Integrase | > | 100 | uM | 18662877 | EFFICIENT SYNTHESIS AND UTILIZATION OF PHENYL-SUBSTITUTED HETEROAROMATIC CARBOXYLIC ACIDS AS ARYL DIKETO ACID ISOSTERES IN THE DESIGN OF NOVEL HIV-1 INTEGRASE INHIBITORS. Bioorganic & Medical Chemistry Letters 2008, 18(16), 4521-4. | |||||||||||||||||||
| 3' PROCESSING | Integrase | > | 100 | uM | 18662877 | EFFICIENT SYNTHESIS AND UTILIZATION OF PHENYL-SUBSTITUTED HETEROAROMATIC CARBOXYLIC ACIDS AS ARYL DIKETO ACID ISOSTERES IN THE DESIGN OF NOVEL HIV-1 INTEGRASE INHIBITORS. Bioorganic & Medical Chemistry Letters 2008, 18(16), 4521-4. | |||||||||||||||||||
| STRAND TRANSFER | Integrase | > | 100 | uM | 18662877 | EFFICIENT SYNTHESIS AND UTILIZATION OF PHENYL-SUBSTITUTED HETEROAROMATIC CARBOXYLIC ACIDS AS ARYL DIKETO ACID ISOSTERES IN THE DESIGN OF NOVEL HIV-1 INTEGRASE INHIBITORS. Bioorganic & Medical Chemistry Letters 2008, 18(16), 4521-4. | |||||||||||||||||||
| HIV-1 | dTTP incorporation assay by liquid scintillation | Reverse transcriptase | 6.2 | uM | 19442130 | CHARACTERIZATION OF HIV-1 ENZYME REVERSE TRANSCRIPTASE INHIBITION BY THE COMPOUND 6-CHLORO-1,4-DIHYDRO-4-OXO-1-(BETA-D-RIBOFURANOSYL) QUINOLINE-3-CARBOXYLIC ACID THROUGH KINETIC AND IN SILICO STUDIES. Current HIV Research 2009, 7(3), 327-335. | |||||||||||||||||||
| HIV-1 | dTTP incorporation assay by liquid scintillation | Reverse transcriptase | 5.3 | uM | 19442130 | CHARACTERIZATION OF HIV-1 ENZYME REVERSE TRANSCRIPTASE INHIBITION BY THE COMPOUND 6-CHLORO-1,4-DIHYDRO-4-OXO-1-(BETA-D-RIBOFURANOSYL) QUINOLINE-3-CARBOXYLIC ACID THROUGH KINETIC AND IN SILICO STUDIES. Current HIV Research 2009, 7(3), 327-335. | |||||||||||||||||||
| HIV-1 | dTTP incorporation assay by liquid scintillation | Reverse transcriptase | 5 | uM | 19442130 | CHARACTERIZATION OF HIV-1 ENZYME REVERSE TRANSCRIPTASE INHIBITION BY THE COMPOUND 6-CHLORO-1,4-DIHYDRO-4-OXO-1-(BETA-D-RIBOFURANOSYL) QUINOLINE-3-CARBOXYLIC ACID THROUGH KINETIC AND IN SILICO STUDIES. Current HIV Research 2009, 7(3), 327-335. | |||||||||||||||||||
| HIV-1 | N | standard reverse transcriptase assay | Reverse transcriptase | 50 | ug/mL | SYNTHESIS AND HIV-1 REVERSE TRANSCRIPTASE INHIBITION ACTIVITY OF 1,4-NAPHTHOQUINONE DERIVATIVES. Chemistry of Natural Compounds 2012, 47(6), 883-887. | |||||||||||||||||||
| STRAND TRANSFER | Integrase | > | 100 | uM | 18805696 | DISCOVERY OF 3-ACETYL-4-HYDROXY-2-PYRANONE DERIVATIVES AND THEIR DIFLUORIDOBORATE COMPLEXES AS A NOVEL CLASS OF HIV-1 INTEGRASE INHIBITORS. Bioorganic & Medical Chemistry 2008, 16(19), 8988-98. | |||||||||||||||||||
| STRAND TRANSFER | Integrase | > | 100 | uM | 18805696 | DISCOVERY OF 3-ACETYL-4-HYDROXY-2-PYRANONE DERIVATIVES AND THEIR DIFLUORIDOBORATE COMPLEXES AS A NOVEL CLASS OF HIV-1 INTEGRASE INHIBITORS. Bioorganic & Medical Chemistry 2008, 16(19), 8988-98. | |||||||||||||||||||
| 3'-PROCESSING | Integrase | > | 100 | uM | 18805696 | DISCOVERY OF 3-ACETYL-4-HYDROXY-2-PYRANONE DERIVATIVES AND THEIR DIFLUORIDOBORATE COMPLEXES AS A NOVEL CLASS OF HIV-1 INTEGRASE INHIBITORS. Bioorganic & Medical Chemistry 2008, 16(19), 8988-98. | |||||||||||||||||||
| HIV-1 | STRAND TRANSFER | Integrase | 0.015 | uM | 19523819 | N-(4-FLUOROBENZYL)-3-HYDROXY-9;9-DIMETHYL-4-OXO-6;7;8;9-TETRAHYDRO-4H-PYRAZINO[1;2-A]PYRIMIDINE-2-CARBOXAMIDES A NOVEL CLASS OF POTENT HIV-1 INTEGRASE INHIBITORS. Bioorganic & Medical Chemistry Letters 2009, 19, 4245-9. | |||||||||||||||||||
| HIV-1 | HPLC | Protease | 5.8 | uM | 18543149 | INHIBITION OF HIV-1 PROTEASE AND RNASE H OF HIV-1 REVERSE TRANSCRIPTASE ACTIVITIES BY LONG CHAIN PHENOLS FROM THE SARCOTESTAS OF GINKGO BILOBA. Planta Medica 2008, 74(5), 532-534. | |||||||||||||||||||
| HIV-1 | RNASE H OF HIV-1 REVERSE TRANSCRIPTASE ASSAY | Reverse transcriptase | 170.3 | uM | 18543149 | INHIBITION OF HIV-1 PROTEASE AND RNASE H OF HIV-1 REVERSE TRANSCRIPTASE ACTIVITIES BY LONG CHAIN PHENOLS FROM THE SARCOTESTAS OF GINKGO BILOBA. Planta Medica 2008, 74(5), 532-534. | |||||||||||||||||||
| HIV-1 | HPLC | Protease | 10.2 | uM | 18543149 | INHIBITION OF HIV-1 PROTEASE AND RNASE H OF HIV-1 REVERSE TRANSCRIPTASE ACTIVITIES BY LONG CHAIN PHENOLS FROM THE SARCOTESTAS OF GINKGO BILOBA. Planta Medica 2008, 74(5), 532-534. | |||||||||||||||||||
| HIV-1 | RNASE H OF HIV-1 REVERSE TRANSCRIPTASE ASSAY | Reverse transcriptase | 33.7 | uM | 18543149 | INHIBITION OF HIV-1 PROTEASE AND RNASE H OF HIV-1 REVERSE TRANSCRIPTASE ACTIVITIES BY LONG CHAIN PHENOLS FROM THE SARCOTESTAS OF GINKGO BILOBA. Planta Medica 2008, 74(5), 532-534. | |||||||||||||||||||
| HIV-1 | HPLC | Protease | 24.9 | uM | 18543149 | INHIBITION OF HIV-1 PROTEASE AND RNASE H OF HIV-1 REVERSE TRANSCRIPTASE ACTIVITIES BY LONG CHAIN PHENOLS FROM THE SARCOTESTAS OF GINKGO BILOBA. Planta Medica 2008, 74(5), 532-534. | |||||||||||||||||||
| HIV-1 | 3'-processing | Integrase | > | 100 | uM | COMPOUNDS WITH HIV-1 INTEGRASE INHIBITORY ACTIVITY AND USE THEREOF AS ANTI-HIV/AIDS THERAPEUTICS. . Patent 2009, , . | |||||||||||||||||||
| HIV-1 | Strand Transfer | Integrase | > | 100 | uM | COMPOUNDS WITH HIV-1 INTEGRASE INHIBITORY ACTIVITY AND USE THEREOF AS ANTI-HIV/AIDS THERAPEUTICS. . Patent 2009, , . | |||||||||||||||||||
| HIV-1 | 3'-processing | Integrase | > | 100 | uM | COMPOUNDS WITH HIV-1 INTEGRASE INHIBITORY ACTIVITY AND USE THEREOF AS ANTI-HIV/AIDS THERAPEUTICS. . Patent 2009, , . |
| PubChem Standard Value | Standard Type | Standard Relation | Standard Value | Standard Units |
|---|---|---|---|---|
| 100 | IC50 | > | 100000 | nM |
| 100 | IC50 | > | 100000 | nM |
| 28 | IC50 | = | 28000 | nM |
| 100 | IC50 | > | 100000 | nM |
| 100 | IC50 | > | 100000 | nM |
| 44 | IC50 | = | 44000 | nM |
| 100 | IC50 | > | 100000 | nM |
| 16 | IC50 | = | 16000 | nM |
| 23 | IC50 | = | 23000 | nM |
| 0.07 | IC50 | = | 70 | nM |
| 48 | IC50 | = | 48000 | nM |
| 100 | IC50 | > | 100000 | nM |
| 85 | IC50 | = | 85000 | nM |
| 72 | IC50 | = | 72000 | nM |
| 25 | IC50 | = | 25000 | nM |
| 100 | IC50 | > | 100000 | nM |
| 35 | IC50 | = | 35000 | nM |
| 32 | IC50 | = | 32000 | nM |
| 20 | IC50 | = | 20000 | nM |
| 100 | IC50 | > | 100000 | nM |
| Standard Type | Standard Relation | Standard Value |
|---|---|---|
| FC | = | 0.9 |
| FC | = | 1.8 |
| FC | = | 4.1 |
| FC | = | 2.4 |
| FC | = | 2 |
| FC | = | 4.6 |
| FC | = | 2.8 |
| FC | = | 0.6 |
| FC | = | 1.4 |
| FC | = | 1.7 |
| FC | = | 1.3 |
| FC | = | 2.2 |
| FC | = | 1.5 |
| FC | = | 1.5 |
| FC | = | 1.7 |
| FC | = | 1.1 |
| FC | = | 2.7 |
| FC | = | 1.4 |
| FC | = | 1.2 |
| FC | = | 1.1 |
| PubChem Standard Value | Standard Type | Standard Relation | Standard Value | Standard Units |
|---|---|---|---|---|
| 100 | IC50 | > | 100000 | nM |
| 100 | IC50 | > | 100000 | nM |
| 20 | IC50 | = | 20000 | nM |
| 100 | IC50 | > | 100000 | nM |
| 100 | IC50 | > | 100000 | nM |
| 45 | IC50 | = | 45000 | nM |
| 100 | IC50 | > | 100000 | nM |
| 5.8 | IC50 | = | 5800 | nM |
| 7.3 | IC50 | = | 7300 | nM |
| 0.09 | IC50 | = | 90 | nM |
| 43 | IC50 | = | 43000 | nM |
| 100 | IC50 | > | 100000 | nM |
| 74 | IC50 | = | 74000 | nM |
| 48 | IC50 | = | 48000 | nM |
| 21 | IC50 | = | 21000 | nM |
| 100 | IC50 | > | 100000 | nM |
| 32 | IC50 | = | 32000 | nM |
| 28 | IC50 | = | 28000 | nM |
| 13 | IC50 | = | 13000 | nM |
| 100 | IC50 | > | 100000 | nM |
| Standard Type | Standard Relation | Standard Value | Standard Units |
|---|---|---|---|
| Inhibition | = | 4.1 | % |
| Inhibition | = | 82.1 | % |
| Inhibition | = | 14.2 | % |
| Inhibition | = | 14.5 | % |
| Inhibition | = | 17.2 | % |
| Inhibition | = | 9.9 | % |
| Inhibition | = | 1.3 | % |
| Inhibition | = | 22.8 | % |
| Inhibition | = | 21 | % |
| Inhibition | = | 16 | % |
| Inhibition | = | 9.8 | % |
| Inhibition | = | 57.6 | % |
| Inhibition | = | 9.5 | % |
| Inhibition | = | 10.1 | % |
| Inhibition | = | 3.6 | % |
| Inhibition | = | 65.1 | % |
| Inhibition | = | 7.1 | % |
| Inhibition | = | 14.6 | % |
| Inhibition | = | 80.3 | % |
| Inhibition | = | 42 | % |
| Standard Type | Standard Relation | Standard Value | Standard Units |
|---|---|---|---|
| Inhibition | = | 2.2 | % |
| Inhibition | = | 15.3 | % |
| Inhibition | = | 10.6 | % |
| Inhibition | = | 22.6 | % |
| Inhibition | = | 4.3 | % |
| Inhibition | = | 12.5 | % |
| Inhibition | = | 41.7 | % |
| Inhibition | = | 11 | % |
| Inhibition | = | 18.4 | % |
| Inhibition | = | 4.6 | % |
| Inhibition | = | 28.7 | % |
| Inhibition | = | 2.4 | % |
| Inhibition | = | 2.9 | % |
| Inhibition | = | 99.7 | % |
| Inhibition | = | 2.3 | % |
| Inhibition | = | 76.6 | % |
| Inhibition | = | 2.2 | % |
| Inhibition | = | 0 | % |
| Inhibition | = | 0 | % |
| Inhibition | = | 4.4 | % |
| PubChem Standard Value | Standard Type | Standard Relation | Standard Value | Standard Units |
|---|---|---|---|---|
| 100 | IC50 | > | 100000 | nM |
| 100 | IC50 | > | 100000 | nM |
| 36 | IC50 | = | 36000 | nM |
| 100 | IC50 | > | 100000 | nM |
| 100 | IC50 | > | 100000 | nM |
| 50 | IC50 | = | 50000 | nM |
| 100 | IC50 | > | 100000 | nM |
| 42 | IC50 | = | 42000 | nM |
| 30 | IC50 | = | 30000 | nM |
| 3.6 | IC50 | = | 3600 | nM |
| 49 | IC50 | = | 49000 | nM |
| 73 | IC50 | = | 73000 | nM |
| 68 | IC50 | = | 68000 | nM |
| 100 | IC50 | > | 100000 | nM |
| 46 | IC50 | = | 46000 | nM |
| 100 | IC50 | > | 100000 | nM |
| 28 | IC50 | = | 28000 | nM |
| 35 | IC50 | = | 35000 | nM |
| 26 | IC50 | = | 26000 | nM |
| 100 | IC50 | > | 100000 | nM |
| Standard Type | Standard Relation | Standard Value | Standard Units |
|---|---|---|---|
| Inhibition | = | 0.3 | % |
| Inhibition | = | 91.8 | % |
| Inhibition | = | 8.3 | % |
| Inhibition | = | 17.8 | % |
| Inhibition | = | 6.4 | % |
| Inhibition | = | 15.4 | % |
| Inhibition | = | 6.5 | % |
| Inhibition | = | 14.4 | % |
| Inhibition | = | 0 | % |
| Inhibition | = | 3.5 | % |
| Inhibition | = | 0 | % |
| Inhibition | = | 4.3 | % |
| Inhibition | = | 34.7 | % |
| Inhibition | = | 0 | % |
| Inhibition | = | 12.7 | % |
| Inhibition | = | 3.2 | % |
| Inhibition | = | 0 | % |
| Inhibition | = | 35.9 | % |
| Inhibition | = | 47.6 | % |
| Inhibition | = | 34.3 | % |
| Standard Type | Standard Relation | Standard Value | Standard Units |
|---|---|---|---|
| Inhibition | = | 16.8 | % |
| Inhibition | = | 93.6 | % |
| Inhibition | = | 65.6 | % |
| Inhibition | = | 55.9 | % |
| Inhibition | = | 35.4 | % |
| Inhibition | = | 51.8 | % |
| Inhibition | = | 9.7 | % |
| Inhibition | = | 15.1 | % |
| Inhibition | = | 13.6 | % |
| Inhibition | = | 15.6 | % |
| Inhibition | = | 7.7 | % |
| Inhibition | = | 12.7 | % |
| Inhibition | = | 6.8 | % |
| Inhibition | = | 13.8 | % |
| Inhibition | = | 8.8 | % |
| Inhibition | = | 48 | % |
| Inhibition | = | 17.6 | % |
| Inhibition | = | 5.3 | % |
| Inhibition | = | 21.9 | % |
| Inhibition | = | 38.3 | % |
| Standard Type | Standard Relation | Standard Value | Standard Units |
|---|---|---|---|
| Inhibition | = | 34.5 | % |
| Inhibition | = | 98.9 | % |
| Inhibition | = | 6.5 | % |
| Inhibition | = | 57.9 | % |
| Inhibition | = | 33.9 | % |
| Inhibition | = | 8.2 | % |
| Inhibition | = | 0 | % |
| Inhibition | = | 15.6 | % |
| Inhibition | = | 23.7 | % |
| Inhibition | = | 27.3 | % |
| Inhibition | = | 7 | % |
| Inhibition | = | 12.7 | % |
| Inhibition | = | 0 | % |
| Inhibition | = | 33.9 | % |
| Inhibition | = | 12.1 | % |
| Inhibition | = | 51.3 | % |
| Inhibition | = | 25.9 | % |
| Inhibition | = | 54.2 | % |
| Inhibition | = | 26.7 | % |
| Inhibition | = | 45.9 | % |
| Standard Type | Standard Relation | Standard Value | Standard Units |
|---|---|---|---|
| Inhibition | = | 0 | % |
| Inhibition | = | 79.2 | % |
| Inhibition | = | 17.1 | % |
| Inhibition | = | 57.2 | % |
| Inhibition | = | 69 | % |
| Inhibition | = | 0 | % |
| Inhibition | = | 32.2 | % |
| Inhibition | = | 75.8 | % |
| Inhibition | = | 30.8 | % |
| Inhibition | = | 13.2 | % |
| Inhibition | = | 0 | % |
| Inhibition | = | 0 | % |
| Inhibition | = | 2.1 | % |
| Inhibition | = | 23.1 | % |
| Inhibition | = | 0 | % |
| Inhibition | = | 28.2 | % |
| Inhibition | = | 41.7 | % |
| Inhibition | = | 4.1 | % |
| Inhibition | = | 13.3 | % |
| Inhibition | = | 0 | % |
| Standard Type | Standard Relation | Standard Value | Standard Units |
|---|---|---|---|
| MIC | = | 15.62 | ug.mL-1 |
| MIC | = | 7.81 | ug.mL-1 |
| Standard Type | Standard Relation | Standard Value | Standard Units |
|---|---|---|---|
| MIC | = | 15.62 | ug.mL-1 |
| MIC | = | 7.81 | ug.mL-1 |
| Standard Type | Standard Relation | Standard Value | Standard Units |
|---|---|---|---|
| Inhibition | = | 0 | % |
| Inhibition | = | 21 | % |
| Inhibition | = | 14.2 | % |
| Inhibition | = | 31.6 | % |
| Inhibition | = | 0 | % |
| Inhibition | = | 48.9 | % |
| Inhibition | = | 21.6 | % |
| Inhibition | = | 0 | % |
| Inhibition | = | 7.5 | % |
| Inhibition | = | 2.8 | % |
| Inhibition | = | 5.6 | % |
| Inhibition | = | 2.6 | % |
| Inhibition | = | 0 | % |
| Inhibition | = | 19.8 | % |
| Inhibition | = | 14.7 | % |
| Inhibition | = | 57.5 | % |
| Inhibition | = | 8.5 | % |
| Inhibition | = | 4 | % |
| Inhibition | = | 10.5 | % |
| Inhibition | = | 0 | % |
| Standard Type | Standard Relation | Standard Value | Standard Units |
|---|---|---|---|
| MIC | = | 15.62 | ug.mL-1 |
| MIC | = | 7.81 | ug.mL-1 |
| Standard Type | Standard Relation | Standard Value | Standard Units |
|---|---|---|---|
| MIC | = | 15.62 | ug.mL-1 |
| MIC | = | 7.81 | ug.mL-1 |