HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Deoxyuridine 5'-triphosphate nucleotidohydrolase

External ID: CHEMBL869761

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2006
Volume: 49
Issue: 14
First Page: 4183
Last Page: 4195
DOI: 10.1021/jm060126s

Target ChEMBL ID: CHEMBL4222
ChEMBL Target Name: dUTP pyrophosphatase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
2.8	Ki	=	2800	nM
5	Ki	=	5000	nM
17	Ki	=	17000	nM
44	Ki	=	44000	nM
2.2	Ki	=	2200	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial

External ID: CHEMBL869762

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2006
Volume: 49
Issue: 14
First Page: 4183
Last Page: 4195
DOI: 10.1021/jm060126s

Target ChEMBL ID: CHEMBL5203
ChEMBL Target Name: dUTP pyrophosphatase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
909	Ki	=	909000	nM	Outside typical range
457	Ki	=	457000	nM	Outside typical range
1000	Ki	>	1000000	nM	Outside typical range
63	Ki	=	63000	nM
260	Ki	=	260000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NIH3T3

External ID: CHEMBL748632

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2004
Volume: 14
Issue: 2
First Page: 347
Last Page: 350
DOI: 10.1016/j.bmcl.2003.11.004

Target ChEMBL ID: CHEMBL614822
ChEMBL Target Name: NIH3T3
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
3.9	IC50	=	3900	nM
0.3	IC50	=	300	nM
0.8	IC50	=	800	nM
3.3	IC50	=	3300	nM
0.5	IC50	=	500	nM
3.1	IC50	=	3100	nM
0.8	IC50	=	800	nM
3.8	IC50	=	3800	nM
0.4	IC50	=	400	nM
9.5	IC50	=	9500	nM
1.2	IC50	=	1200	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL870927

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2006
Volume: 49
Issue: 14
First Page: 4183
Last Page: 4195
DOI: 10.1021/jm060126s

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
6	IC50	=	6000	nM
1.1	IC50	=	1100	nM
2	IC50	=	2000	nM
15	IC50	=	15000	nM
62	IC50	=	62000	nM
1.2	IC50	=	1200	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Kinesin-like protein KIF11

External ID: CHEMBL934296

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2008
Volume: 51
Issue: 5
First Page: 1115
Last Page: 1125
DOI: 10.1021/jm070606z

Target ChEMBL ID: CHEMBL4581
ChEMBL Target Name: Kinesin-like protein 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
0.12	Ki	=	120	nM
0.2	Ki	=	200	nM
	Activity				Not Active
0.9	Ki	=	900	nM
	Activity				Not Active
1	Ki	=	1000	nM
2	Ki	=	2000	nM
0.6	Ki	=	600	nM
23	Ki	=	23000	nM
	Activity				Not Active
	Activity				Not Active
	Activity				Not Active
0.25	Ki	=	250	nM
0.2	Ki	=	200	nM
0.175	Ki	=	175	nM
0.15	Ki	=	150	nM
1.5	Ki	=	1500	nM
	Activity				Not Active
1.5	Ki	=	1500	nM
0.6	Ki	=	600	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NIH3T3

External ID: CHEMBL749693

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2004
Volume: 14
Issue: 2
First Page: 347
Last Page: 350
DOI: 10.1016/j.bmcl.2003.11.004

Target ChEMBL ID: CHEMBL614822
ChEMBL Target Name: NIH3T3
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	93	%
Inhibition	=	99	%
Inhibition	=	31	%
Inhibition	=	91.8	%
Inhibition	=	99	%
Inhibition	=	98	%
Inhibition	=	99	%
Inhibition	=	99	%
Inhibition	=	98	%
Inhibition	=	94	%
Inhibition	=	95.8	%
Inhibition	=	99	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：L6

External ID: CHEMBL870928

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2006
Volume: 49
Issue: 14
First Page: 4183
Last Page: 4195
DOI: 10.1021/jm060126s

Target ChEMBL ID: CHEMBL614793
ChEMBL Target Name: L6
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
192	IC50	=	192000	nM		Outside typical range
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined
299	IC50	>	299000	nM		Outside typical range
33	IC50	=	33000	nM

76-84-6 靶点实验数据