HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Nitric oxide synthase, inducible

External ID: CHEMBL700508

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1998
Volume: 41
Issue: 19
First Page: 3675
Last Page: 3683
DOI: 10.1021/jm970840x

Target ChEMBL ID: CHEMBL4481
ChEMBL Target Name: Nitric oxide synthase, inducible
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
26	IC50	=	26000	nM
0.36	IC50	=	360	nM
4.5	IC50	=	4500	nM
7.5	IC50	=	7500	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Indolethylamine N-methyltransferase

External ID: CHEMBL3231054

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1979
Volume: 22
Issue: 3
First Page: 237
Last Page: 247
DOI: 10.1021/jm00189a004

Target ChEMBL ID: CHEMBL2131
ChEMBL Target Name: Indolethylamine N-methyltransferase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
852	IC50	=	852000	nM	Outside typical range
3.3	IC50	=	3300	nM
46.8	IC50	=	46800	nM
6.7	IC50	=	6700	nM
19.2	IC50	=	19200	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Indolethylamine N-methyltransferase

External ID: CHEMBL3231053

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1979
Volume: 22
Issue: 3
First Page: 237
Last Page: 247
DOI: 10.1021/jm00189a004

Target ChEMBL ID: CHEMBL3227915
ChEMBL Target Name: Indolethylamine N-methyltransferase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
74.8	IC50	=	74800	nM
0.7	IC50	=	700	nM
7.7	IC50	=	7700	nM
13.8	IC50	=	13800	nM
5.2	IC50	=	5200	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Nitric oxide sythases; iNOS & nNOS

External ID: CHEMBL847293

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1998
Volume: 41
Issue: 19
First Page: 3675
Last Page: 3683
DOI: 10.1021/jm970840x

Target ChEMBL ID: CHEMBL2096621
ChEMBL Target Name: Nitric oxide sythases; iNOS & nNOS
ChEMBL Target Type: SELECTIVITY GROUP - Target is a pair of proteins for which the selectivity has been assessed
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Standard Type	Standard Relation	Standard Value
Ratio	=	0.066
Ratio	=	0.7
Ratio	=	0.78
Ratio	=	0.96
Ratio	=	4

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Nitric oxide synthase (inducible and endothelial)

External ID: CHEMBL847292

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1998
Volume: 41
Issue: 19
First Page: 3675
Last Page: 3683
DOI: 10.1021/jm970840x

Target ChEMBL ID: CHEMBL2111350
ChEMBL Target Name: Nitric oxide synthase (inducible and endothelial)
ChEMBL Target Type: SELECTIVITY GROUP - Target is a pair of proteins for which the selectivity has been assessed
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Standard Type	Standard Relation	Standard Value
Ratio	=	0.066
Ratio	=	0.4
Ratio	=	3.65
Ratio	=	2.44
Ratio	=	11

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Nitric oxide synthase, endothelial

External ID: CHEMBL678360

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1998
Volume: 41
Issue: 19
First Page: 3675
Last Page: 3683
DOI: 10.1021/jm970840x

Target ChEMBL ID: CHEMBL4803
ChEMBL Target Name: Nitric-oxide synthase, endothelial
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
93	IC50	=	93000	nM
243	IC50	=	243000	nM	Outside typical range
578	IC50	=	578000	nM	Outside typical range
1680	IC50	=	1680000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Nitric oxide synthase, brain

External ID: CHEMBL750653

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1998
Volume: 41
Issue: 19
First Page: 3675
Last Page: 3683
DOI: 10.1021/jm970840x

Target ChEMBL ID: CHEMBL3568
ChEMBL Target Name: Nitric-oxide synthase, brain
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
20	IC50	=	20000	nM
5.37	IC50	=	5370	nM
1.31	IC50	=	1310	nM
5.44	IC50	=	5440	nM

7544-75-4 靶点实验数据