HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1798344

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2008
Volume: 43
Issue: 3
First Page: 478
Last Page: 485
DOI: 10.1016/j.ejmech.2007.04.002

Standard Type	Standard Relation	Standard Value
logK(blood)	=	2.92
logK(blood)	=	2.36
logK(blood)	=	3.06
logK(blood)	=	3.41
logK(blood)	=	3.27
logK(blood)	=	0.21
logK(blood)	=	0.17
logK(blood)	=	0.63
logK(blood)	=	2.24
logK(blood)	=	1.14
logK(blood)	=	1.05
logK(blood)	=	-0.29
logK(blood)	=	1.14
logK(blood)	=	3.02
logK(blood)	=	1.11
logK(blood)	=	-0.39
logK(blood)	=	-0.07
logK(blood)	=	1.42
logK(blood)	=	1.12
logK(blood)	=	1.15

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1798343

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2008
Volume: 43
Issue: 3
First Page: 478
Last Page: 485
DOI: 10.1016/j.ejmech.2007.04.002

Standard Type	Standard Relation	Standard Value
logK(lung)	=	2.6
logK(lung)	=	2.2
logK(lung)	=	2.91
logK(lung)	=	3.24
logK(lung)	=	3.07
logK(lung)	=	0
logK(lung)	=	0.43
logK(lung)	=	0.67
logK(lung)	=	2.01
logK(lung)	=	1.32
logK(lung)	=	1.08
logK(lung)	=	-0.3
logK(lung)	=	1.15
logK(lung)	=	2.77
logK(lung)	=	1.14
logK(lung)	=	-0.1
logK(lung)	=	0.23
logK(lung)	=	1.94
logK(lung)	=	0.76
logK(lung)	=	1.12

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1798345

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2008
Volume: 43
Issue: 3
First Page: 478
Last Page: 485
DOI: 10.1016/j.ejmech.2007.04.002

Standard Type	Standard Relation	Standard Value
logP(lung)	=	-0.32
logP(lung)	=	-0.16
logP(lung)	=	-0.15
logP(lung)	=	-0.17
logP(lung)	=	-0.2
logP(lung)	=	-0.21
logP(lung)	=	0.26
logP(lung)	=	0.04
logP(lung)	=	-0.23
logP(lung)	=	0.18
logP(lung)	=	0.03
logP(lung)	=	-0.01
logP(lung)	=	0.01
logP(lung)	=	-0.25
logP(lung)	=	0.03
logP(lung)	=	0.29
logP(lung)	=	0.3
logP(lung)	=	0.52
logP(lung)	=	-0.36
logP(lung)	=	-0.03

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：25294 靶标：N/A

External ID: cpdb

Protocol: N/A

Comment: N/A

CAS#	Chemical Code	TD50	Species	Strain	Sex	Route	Tissue	Tumor	Opinion	Historic	Xpo Time	Xpr Time	Notes	Lifetable	P-value	Lower Confidence	Upper Confidence	Plotted Symbol	Ndoses	Curve	Ndsig	Control Total	Tumors Count	Data Number	ID	Paper Number	Source	PubMed ID	Citation
78-79-5	isr	25800	Mouse	B6C3F1	Male	Inhalation	spleen	hemangiosarcoma	0	0	80	96	e	s	0.566	3460	1.0E31	$	1	0	1	49	1	8	43667	2258n	Literature	8901906	M E :Placke;Toxicology,113,253-262;1996
78-79-5	isr	247	Mouse	B6C3F1	Female	Inhalation	pituitary gland	pars distalis adenoma	+	0	80	105	e	s	0.022	97.1	1.0E31	%	2	*	2	49	1	8	43641	2258o	Literature	8901906	M E :Placke;Toxicology,113,253-262;1996
78-79-5	isr	319	Mouse	B6C3F1	Female	Inhalation	Harderian gland	adenoma	+	0	80	105	e	s	0.026	122	1.0E31	$	2	*	2	49	2	8	43642	2258o	Literature	8901906	M E :Placke;Toxicology,113,253-262;1996
78-79-5	isr	682	Mouse	B6C3F1	Female	Inhalation	spleen	hemangiosarcoma	+	h	80	105	e	s	0.096	201	1.0E31	$	2	*	2	50	1	8	43643	2258o	Literature	8901906	M E :Placke;Toxicology,113,253-262;1996
78-79-5	isr	1.0E31	Mouse	B6C3F1	Female	Inhalation	liver	hepatocellular carcinoma	0	0	80	105	e	s	1	322	1.0E31	$	2	0	2	50	2	8	43644	2258o	Literature	8901906	M E :Placke;Toxicology,113,253-262;1996
78-79-5	isr	1.0E31	Mouse	B6C3F1	Female	Inhalation	liver	hepatocellular adenoma	0	0	80	105	e	s	1	310	1.0E31	$	2	0	2	50	4	8	43645	2258o	Literature	8901906	M E :Placke;Toxicology,113,253-262;1996
78-79-5	isr	1.0E31	Mouse	B6C3F1	Female	Inhalation	lung	alveolar/bronchiolar adenoma	0	0	80	105	e	s	1	227	1.0E31	$	2	0	2	50	5	8	43646	2258o	Literature	8901906	M E :Placke;Toxicology,113,253-262;1996
78-79-5	isr	881	Mouse	B6C3F1	Male	Inhalation	Harderian gland	adenoma	+	0	80	105	e	s	0	601	1430	%	5	*	5	47	4	8	43668	2258o	Literature	8901906	M E :Placke;Toxicology,113,253-262;1996
78-79-5	isr	1570	Mouse	B6C3F1	Male	Inhalation	liver	hepatocellular adenoma	+	0	80	105	e	s	0	891	4070	$	5	*	5	50	11	8	43669	2258o	Literature	8901906	M E :Placke;Toxicology,113,253-262;1996
78-79-5	isr	1660	Mouse	B6C3F1	Male	Inhalation	lung	alveolar/bronchiolar adenoma	+	0	80	105	e	s	0	997	3620	$	5	*	5	50	11	8	43670	2258o	Literature	8901906	M E :Placke;Toxicology,113,253-262;1996
78-79-5	isr	6680	Mouse	B6C3F1	Male	Inhalation	lung	alveolar/bronchiolar carcinoma	+	0	80	105	e	s	0	4020	28800	$	5	*	5	50	0	8	43671	2258o	Literature	8901906	M E :Placke;Toxicology,113,253-262;1996
78-79-5	isr	22200	Mouse	B6C3F1	Male	Inhalation	forestomach	squamous-cell carcinoma	+	0	80	105	e	s	0.007	7680	740000	$	5	*	5	50	0	8	43672	2258o	Literature	8901906	M E :Placke;Toxicology,113,253-262;1996
78-79-5	isr	4850	Mouse	B6C3F1	Male	Inhalation	liver	hepatocellular carcinoma	+	0	80	105	e	s	0.021	2000	1.0E31	$	5	*	5	50	9	8	43673	2258o	Literature	8901906	M E :Placke;Toxicology,113,253-262;1996
78-79-5	isr	15000	Mouse	B6C3F1	Male	Inhalation	Harderian gland	carcinoma	+	0	80	105	e	s	0.016	6100	1.0E31	$	5	*	5	47	0	8	43674	2258o	Literature	8901906	M E :Placke;Toxicology,113,253-262;1996
78-79-5	isr	45000	Mouse	B6C3F1	Male	Inhalation	forestomach	squamous-cell papilloma	0	0	80	105	e	s	0.068	11100	1.0E31	$	5	*	5	50	0	8	43675	2258o	Literature	8901906	M E :Placke;Toxicology,113,253-262;1996
78-79-5	isr	39000	Mouse	B6C3F1	Male	Inhalation	heart	hemangiosarcoma	+	h	80	105	e	s	0.308	8070	1.0E31	$	5	*	5	49	0	8	43676	2258o	Literature	8901906	M E :Placke;Toxicology,113,253-262;1996
78-79-5	isr	150000	Mouse	B6C3F1	Male	Inhalation	lymphoreticular system	histiocytic sarcoma	0	0	80	105	e	s	0.821	8450	1.0E31	$	5	*	5	50	0	8	43677	2258o	Literature	8901906	M E :Placke;Toxicology,113,253-262;1996
78-79-5	isr	1.0E31	Mouse	B6C3F1	Male	Inhalation	spleen	hemangiosarcoma	0	0	80	105	e	s	1	13500	1.0E31	$	5	0	5	49	1	8	43678	2258o	Literature	8901906	M E :Placke;Toxicology,113,253-262;1996
26675-46-7	isu	30000	Mouse	Swiss Webster	Female	Inhalation	lung	alveolar-cell adenoma	-	0	78	81	0	s	0.235	8670	1.0E31	%	2	*	2	92	15	5	40370	1879	Literature	3189921	J M :Baden;Anesthesiology,69,750-753;1988
26675-46-7	isu	1.0E31	Mouse	Swiss Webster	Female	Inhalation	liver	basophil adenoma	-	0	78	81	0	s	1	36000	1.0E31	$	2	0	2	92	1	5	40371	1879	Literature	3189921	J M :Baden;Anesthesiology,69,750-753;1988

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL636006

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1996
Volume: 39
Issue: 24
First Page: 4750
Last Page: 4755
DOI: 10.1021/jm960163r

Standard Type	Standard Relation	Standard Value
Log BB	=	-0.17
Log BB	=	-0.15
Log BB	=	-0.16
Log BB	=	-0.16
Log BB	=	0
Log BB	=	0.8
Log BB	=	0.4
Log BB	=	-0.08
Log BB	=	0.37
Log BB	=	0.37
Log BB	=	0.76
Log BB	=	0.34
Log BB	=	-0.15
Log BB	=	0
Log BB	=	0.9
Log BB	=	0.97
Log BB	=	0.93
Log BB	=	0.04
Log BB	=	0.35
Log BB	=	-0.3

75-88-7 靶点实验数据