HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Isocitrate lyase

External ID: CHEMBL1273722

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 22
First Page: 6644
Last Page: 6648
DOI: 10.1016/j.bmcl.2010.09.015

Target ChEMBL ID: CHEMBL5359
ChEMBL Target Name: Isocitrate lyase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
28.06	IC50	=	28060	nM
46.15	IC50	=	46150	nM
30.88	IC50	=	30880	nM
21.21	IC50	=	21210	nM
100	IC50	>	100000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Staphylococcus aureus

External ID: CHEMBL1273723

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 22
First Page: 6644
Last Page: 6648
DOI: 10.1016/j.bmcl.2010.09.015

Target ChEMBL ID: CHEMBL352
ChEMBL Target Name: Staphylococcus aureus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	1.56	ug.mL-1
MIC	=	25	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bacillus subtilis

External ID: CHEMBL1273724

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 22
First Page: 6644
Last Page: 6648
DOI: 10.1016/j.bmcl.2010.09.015

Target ChEMBL ID: CHEMBL359
ChEMBL Target Name: Bacillus subtilis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	1.56	ug.mL-1
MIC	=	25	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Micrococcus luteus

External ID: CHEMBL1273725

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 22
First Page: 6644
Last Page: 6648
DOI: 10.1016/j.bmcl.2010.09.015

Target ChEMBL ID: CHEMBL614421
ChEMBL Target Name: Micrococcus luteus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	1.56	ug.mL-1
MIC	=	25	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Proteus vulgaris

External ID: CHEMBL1273726

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 22
First Page: 6644
Last Page: 6648
DOI: 10.1016/j.bmcl.2010.09.015

Target ChEMBL ID: CHEMBL614450
ChEMBL Target Name: Proteus vulgaris
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	3.12	ug.mL-1
MIC	=	50	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Salmonella enterica subsp. enterica serovar Typhimurium

External ID: CHEMBL1273727

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 22
First Page: 6644
Last Page: 6648
DOI: 10.1016/j.bmcl.2010.09.015

Target ChEMBL ID: CHEMBL351
ChEMBL Target Name: Salmonella typhimurium
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	3.12	ug.mL-1
MIC	=	50	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Candida albicans

External ID: CHEMBL1273728

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 22
First Page: 6644
Last Page: 6648
DOI: 10.1016/j.bmcl.2010.09.015

Target ChEMBL ID: CHEMBL366
ChEMBL Target Name: Candida albicans
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	6.25	ug.mL-1
MIC	=	1.56	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Aspergillus fumigatus

External ID: CHEMBL1273729

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 22
First Page: 6644
Last Page: 6648
DOI: 10.1016/j.bmcl.2010.09.015

Target ChEMBL ID: CHEMBL363
ChEMBL Target Name: Aspergillus fumigatus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	3.12	ug.mL-1
MIC	=	0.78	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Trichophyton rubrum

External ID: CHEMBL1273730

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 22
First Page: 6644
Last Page: 6648
DOI: 10.1016/j.bmcl.2010.09.015

Target ChEMBL ID: CHEMBL612649
ChEMBL Target Name: Trichophyton rubrum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	3.12	ug.mL-1
MIC	=	1.56	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Trichophyton mentagrophytes

External ID: CHEMBL1273731

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 22
First Page: 6644
Last Page: 6648
DOI: 10.1016/j.bmcl.2010.09.015

Target ChEMBL ID: CHEMBL613162
ChEMBL Target Name: Trichophyton mentagrophytes
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	3.12	ug.mL-1
MIC	=	1.56	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1

74849-07-3 靶点实验数据