HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3285489

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1976
Volume: 19
Issue: 4
First Page: 499
Last Page: 503
DOI: 10.1021/jm00226a010

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
126	IC50	=	126000	nM	Outside typical range
100	IC50	>	100000	nM
100	IC50	>	100000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Adenosine receptor A2a

External ID: CHEMBL641991

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1986
Volume: 29
Issue: 7
First Page: 1305
Last Page: 1308
DOI: 10.1021/jm00157a035

Target ChEMBL ID: CHEMBL2605
ChEMBL Target Name: Adenosine A2a receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
11	Ki	=	11000	nM
4	Ki	=	4000	nM
68	Ki	=	68000	nM
0.7	Ki	=	700	nM
1.4	Ki	=	1400	nM
2.8	Ki	=	2800	nM
3.3	Ki	=	3300	nM
50	Ki	=	50000	nM
5	Ki	=	5000	nM
80	Ki	=	80000	nM
6	Ki	=	6000	nM
4.1	Ki	=	4100	nM
1.5	Ki	=	1500	nM
135	Ki	=	135000	nM	Outside typical range
9	Ki	=	9000	nM
5	Ki	=	5000	nM
11	Ki	=	11000	nM
10	Ki	=	10000	nM
4.5	Ki	=	4500	nM
7	Ki	=	7000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Adenosine receptor A1

External ID: CHEMBL649108

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1986
Volume: 29
Issue: 7
First Page: 1305
Last Page: 1308
DOI: 10.1021/jm00157a035

Target ChEMBL ID: CHEMBL318
ChEMBL Target Name: Adenosine A1 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
13	Ki	=	13000	nM
18	Ki	=	18000	nM
40	Ki	=	40000	nM
1.9	Ki	=	1900	nM
2.6	Ki	=	2600	nM
3.1	Ki	=	3100	nM
3.3	Ki	=	3300	nM
85	Ki	=	85000	nM
10	Ki	=	10000	nM
60	Ki	=	60000	nM
12	Ki	=	12000	nM
12	Ki	=	12000	nM
1	Ki	=	1000	nM
105	Ki	=	105000	nM	Outside typical range
24	Ki	=	24000	nM
38	Ki	=	38000	nM
21	Ki	=	21000	nM
33	Ki	=	33000	nM
8	Ki	=	8000	nM
19	Ki	=	19000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL840467

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1986
Volume: 29
Issue: 7
First Page: 1305
Last Page: 1308
DOI: 10.1021/jm00157a035

Standard Type	Standard Relation	Standard Value
Selectivity ratio	=	0.9
Selectivity ratio	=	1.1
Selectivity ratio	=	5.8
Selectivity ratio	=	4.5
Selectivity ratio	=	0.6
Selectivity ratio	=	1.5
Selectivity ratio	=	0.4
Selectivity ratio	=	0.14
Selectivity ratio	=	0.3
Selectivity ratio	=	1.1
Selectivity ratio	=	2
Selectivity ratio	=	0.8
Selectivity ratio	=	2
Selectivity ratio	=	2.9
Selectivity ratio	=	0.8
Selectivity ratio	=	0.7
Selectivity ratio	=	0.8
Selectivity ratio	=	2.7
Selectivity ratio	=	9.5
Selectivity ratio	=	3.3

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3285488

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1976
Volume: 19
Issue: 4
First Page: 499
Last Page: 503
DOI: 10.1021/jm00226a010

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
55	IC50	=	55000	nM
19	IC50	=	19000	nM
17	IC50	=	17000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3285250

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1976
Volume: 19
Issue: 4
First Page: 499
Last Page: 503
DOI: 10.1021/jm00226a010

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
65	IC50	=	65000	nM
16	IC50	=	16000	nM
28	IC50	=	28000	nM

7464-84-8 靶点实验数据