HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Sigma non-opioid intracellular receptor 1

External ID: CHEMBL802050

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2004
Volume: 47
Issue: 9
First Page: 2308
Last Page: 2317
DOI: 10.1021/jm031026e

Target ChEMBL ID: CHEMBL287
ChEMBL Target Name: Sigma opioid receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.00216	Ki	=	2.16	nM
6.9E-4	Ki	=	0.69	nM
3.6E-5	Ki	=	0.036	nM
0.00157	Ki	=	1.57	nM
0.00157	Ki	=	1.57	nM
6.1E-4	Ki	=	0.61	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL807586

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2004
Volume: 47
Issue: 9
First Page: 2308
Last Page: 2317
DOI: 10.1021/jm031026e

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.00358	Ki	=	3.58	nM
0.0146	Ki	=	14.6	nM
0.0211	Ki	=	21.1	nM
0.00924	Ki	=	9.24	nM
6.8E-4	Ki	=	0.68	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Alpha-1A adrenergic receptor

External ID: CHEMBL644955

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2004
Volume: 47
Issue: 9
First Page: 2308
Last Page: 2317
DOI: 10.1021/jm031026e

Target ChEMBL ID: CHEMBL1907610
ChEMBL Target Name: Adrenergic receptor alpha-1
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: H - Homologous protein target assigned
Confidence: Multiple homologous protein targets may be assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
7.5	Ki	>	7500	nM
7.5	Ki	>	7500	nM
7.5	Ki	>	7500	nM
7.5	Ki	>	7500	nM
7.5	Ki	>	7500	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 3B

External ID: CHEMBL619788

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2004
Volume: 47
Issue: 9
First Page: 2308
Last Page: 2317
DOI: 10.1021/jm031026e

Target ChEMBL ID: CHEMBL2094116
ChEMBL Target Name: Serotonin 3 (5-HT3) receptor
ChEMBL Target Type: PROTEIN COMPLEX - Target is a defined protein complex, consisting of multiple subunits
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous protein complex subunits assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.7	Ki	>	700	nM
0.7	Ki	>	700	nM
0.7	Ki	>	700	nM
0.7	Ki	>	700	nM
0.7	Ki	>	700	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cavia porcellus

External ID: CHEMBL684565

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2004
Volume: 47
Issue: 9
First Page: 2308
Last Page: 2317
DOI: 10.1021/jm031026e

Target ChEMBL ID: CHEMBL369
ChEMBL Target Name: Cavia porcellus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1.82	EC50	=	1820	nM
9.94	EC50	=	9940	nM
1.5	EC50	=	1500	nM
11.5	EC50	=	11500	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Sigma non-opioid intracellular receptor 1

External ID: CHEMBL1676914

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2011
Volume: 54
Issue: 4
First Page: 1022
Last Page: 1032
DOI: 10.1021/jm1013133

Target ChEMBL ID: CHEMBL4153
ChEMBL Target Name: Sigma-1 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
6.3E-4	Ki	=	0.63	nM
0.00217	Ki	=	2.17	nM
0.0204	Ki	=	20.4	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1676916

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2011
Volume: 54
Issue: 4
First Page: 1022
Last Page: 1032
DOI: 10.1021/jm1013133

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
4.9E-4	Ki	=	0.49	nM
0.0111	Ki	=	11.1	nM
0.0101	Ki	=	10.1	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Sigma non-opioid intracellular receptor 1

External ID: CHEMBL881475

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2004
Volume: 47
Issue: 9
First Page: 2308
Last Page: 2317
DOI: 10.1021/jm031026e

Target ChEMBL ID: CHEMBL287
ChEMBL Target Name: Sigma opioid receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value
Ratio	=	3.5

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1676917

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2011
Volume: 54
Issue: 4
First Page: 1022
Last Page: 1032
DOI: 10.1021/jm1013133

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
5.3	EC50	=	5300	nM
6.6	EC50	=	6600	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：SK-N-SH

External ID: CHEMBL1676918

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2011
Volume: 54
Issue: 4
First Page: 1022
Last Page: 1032
DOI: 10.1021/jm1013133

Target ChEMBL ID: CHEMBL614924
ChEMBL Target Name: SK-N-SH
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
44	EC50	=	44000	nM
41.6	EC50	=	41600	nM

736134-79-5 靶点实验数据