HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL634599

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1984
Volume: 27
Issue: 8
First Page: 967
Last Page: 978
DOI: 10.1021/jm00374a006

Standard Type	Standard Relation	Standard Value
Solubility ratio	=	1.234
Solubility ratio	=	1.32
Solubility ratio	=	1.398
Solubility ratio	=	1.302
Solubility ratio	=	1.198
Solubility ratio	=	1.178
Solubility ratio	=	1.296
Solubility ratio	=	1.149
Solubility ratio	=	1.36
Solubility ratio	=	1.317
Solubility ratio	=	1.351
Solubility ratio	=	1.144
Solubility ratio	=	1.313
Solubility ratio	=	1.176
Solubility ratio	=	1.284
Solubility ratio	=	1.246
Solubility ratio	=	1.223
Solubility ratio	=	1.092
Solubility ratio	=	1.135
Solubility ratio	=	1.39

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL634600

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1984
Volume: 27
Issue: 8
First Page: 967
Last Page: 978
DOI: 10.1021/jm00374a006

Standard Type	Standard Relation	Standard Value	Activity Comment
Solubility ratio	=	1.04
Solubility ratio	=	1.083
Solubility ratio	=	1.059
Solubility ratio		1.018	Not Active
Solubility ratio	=	0.954
Solubility ratio	=	1.036
Solubility ratio	=	1.026
Solubility ratio	=	0.996
Solubility ratio	=	1.057
Solubility ratio	=	1.049
Solubility ratio	=	1.035
Solubility ratio	=	1.017
Solubility ratio	=	1.049
Solubility ratio	=	1.04
Solubility ratio	=	1.077
Solubility ratio	=	1.079
Solubility ratio	=	1.035
Solubility ratio	=	0.996
Solubility ratio	=	1.025
Solubility ratio	=	1.057

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL638278

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1984
Volume: 27
Issue: 8
First Page: 967
Last Page: 978
DOI: 10.1021/jm00374a006

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
Solubility	=	172200	ug.mL-1	Outside typical range
Solubility	=	183900	ug.mL-1	Outside typical range
Solubility	=	171400	ug.mL-1	Outside typical range
Solubility	=	175100	ug.mL-1	Outside typical range
Solubility	=	182400	ug.mL-1	Outside typical range
Solubility	=	173200	ug.mL-1	Outside typical range
Solubility	=	170700	ug.mL-1	Outside typical range
Solubility	=	177300	ug.mL-1	Outside typical range
Solubility	=	176200	ug.mL-1	Outside typical range
Solubility	=	166300	ug.mL-1	Outside typical range
Solubility	=	167000	ug.mL-1	Outside typical range
Solubility	=	170700	ug.mL-1	Outside typical range
Solubility	=	173600	ug.mL-1	Outside typical range
Solubility	=	166300	ug.mL-1	Outside typical range
Solubility	=	170700	ug.mL-1	Outside typical range
Solubility	=	172500	ug.mL-1	Outside typical range
Solubility	=	190500	ug.mL-1	Outside typical range
Solubility	=	175100	ug.mL-1	Outside typical range
Solubility	=	179500	ug.mL-1	Outside typical range
Solubility	=	167000	ug.mL-1	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：DTP/NCI 靶标：N/A

External ID: MCF7_OneDose

Protocol: NCI-60 Human Tumor Cell Lines Screen was performed using the standard one-dose NCI protocol, which is described in more detail at https://dtp.cancer.gov/discovery_development/nci-60/default.htm.

Compounds with GIPRCNT values below 10 were considered active. Activity score was based on GIPRCNT using the following formula:
max(-GIPRCNT/2 + 50, 0)
Score is 0 for GIPRCNT values of 100 or above, 50 for GIPRCNT values of 0, and 100 for GIPRCNT values of -100.

Comment: These data are a subset of the data from the NCI human tumor cell line screen. Compounds are identified by the NCI National Service Center (NSC) number, which is contained in the
PUBCHEM_EXT_DATASOURCE_REGID field. In the NCI cell line identification system, MCF7 is panel number 5, cell number 1. PANELCODE or PANELNAME identify the NCI-60 cell panel. PANELNBR does NOT identify the NCI-60 panel.

EXPID is the NCI internal tracking number for the experiment identifier, and PREFIX = 'S' for the NSCs submitted through the NCI Chemical Agents repository.

Substance concentration unit is indicated in the data table, using the following abbreviations: M = molar (M), u = micrograms/milliliter (microg/mL), V = volumetric fraction.

M_GIPRCNT represents the mean growth percent for that experiment, and N_GIPRCNT indicates the number of values for that NSC within an experiment, while STDEV_GIPRCNT is the standard deviation. Most NSCs are tested once per experiment, resulting in EXP_COUNT = 1.

EXPID	PREFIX	CONCENTRATION_UNIT	CONCENTRATION	PANELNBR	CELLNBR	PANELNAME	CELLNAME	PANELCODE	M_GIPRCNT	N_GIPRCNT	EXP_COUNT
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	88.231	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	87.1119	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	14.4371	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	89.7113	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	97.2463	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	90.0129	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	85.7031	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	30.8539	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	14.2896	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	85.8526	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	83.1036	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	84.2194	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	89.3237	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	85.6034	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	89.6643	1	1
2106OS52	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	91.2503	1	1
2106OS52	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	94.8714	1	1
2106OS52	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	93.7372	1	1
2106OS52	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	112.6132	1	1
2106OS52	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	73.375	1	1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL638280

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1984
Volume: 27
Issue: 8
First Page: 967
Last Page: 978
DOI: 10.1021/jm00374a006

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
Solubility	=	249900	ug.mL-1	Outside typical range
Solubility	=	242400	ug.mL-1	Outside typical range
Solubility	=	249900	ug.mL-1	Outside typical range
Solubility	=	253600	ug.mL-1	Outside typical range
Solubility	=	248100	ug.mL-1	Outside typical range
Solubility	=	245000	ug.mL-1	Outside typical range
Solubility	=	230700	ug.mL-1	Outside typical range
Solubility	=	238700	ug.mL-1	Outside typical range
Solubility	=	246300	ug.mL-1	Outside typical range
Solubility	=	230700	ug.mL-1	Outside typical range
Solubility	=	234100	ug.mL-1	Outside typical range
Solubility	=	241500	ug.mL-1	Outside typical range
Solubility	=	238800	ug.mL-1	Outside typical range
Solubility	=	230700	ug.mL-1	Outside typical range
Solubility	=	230700	ug.mL-1	Outside typical range
Solubility	=	238700	ug.mL-1	Outside typical range
Solubility	=	242400	ug.mL-1	Outside typical range
Solubility	=	238700	ug.mL-1	Outside typical range
Solubility	=	242400	ug.mL-1	Outside typical range
Solubility	=	242900	ug.mL-1	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：DTP/NCI 靶标：N/A

External ID: IGROV1_OneDose

Protocol: NCI-60 Human Tumor Cell Lines Screen was performed using the standard one-dose NCI protocol, which is described in more detail at https://dtp.cancer.gov/discovery_development/nci-60/default.htm.

Compounds with GIPRCNT values below 10 were considered active. Activity score was based on GIPRCNT using the following formula:
max(-GIPRCNT/2 + 50, 0)
Score is 0 for GIPRCNT values of 100 or above, 50 for GIPRCNT values of 0, and 100 for GIPRCNT values of -100.

Comment: These data are a subset of the data from the NCI human tumor cell line screen. Compounds are identified by the NCI National Service Center (NSC) number, which is contained in the
PUBCHEM_EXT_DATASOURCE_REGID field. In the NCI cell line identification system, IGROV1 is panel number 6, cell number 10. PANELCODE or PANELNAME identify the NCI-60 cell panel. PANELNBR does NOT identify the NCI-60 panel.

EXPID is the NCI internal tracking number for the experiment identifier, and PREFIX = 'S' for the NSCs submitted through the NCI Chemical Agents repository.

Substance concentration unit is indicated in the data table, using the following abbreviations: M = molar (M), u = micrograms/milliliter (microg/mL), V = volumetric fraction.

M_GIPRCNT represents the mean growth percent for that experiment, and N_GIPRCNT indicates the number of values for that NSC within an experiment, while STDEV_GIPRCNT is the standard deviation. Most NSCs are tested once per experiment, resulting in EXP_COUNT = 1.

EXPID	PREFIX	CONCENTRATION_UNIT	CONCENTRATION	PANELNBR	CELLNBR	PANELNAME	CELLNAME	PANELCODE	M_GIPRCNT	N_GIPRCNT	EXP_COUNT
0809OS51	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	89.6274	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	94.0185	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	77.1805	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	76.1686	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	82.5618	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	88.7561	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	83.5845	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	92.7497	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	70.9555	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	58.7306	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	72.6041	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	90.3839	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	110.2345	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	97.6538	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	93.7697	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	56.4618	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	80.8893	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	79.078	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	-20.3008	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	72.0949	1	1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL633104

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1984
Volume: 27
Issue: 8
First Page: 967
Last Page: 978
DOI: 10.1021/jm00374a006

Standard Type	Standard Relation	Standard Value
Solubility ratio	=	1.073
Solubility ratio	=	1.162
Solubility ratio	=	1.118
Solubility ratio	=	1.064
Solubility ratio	=	0.932
Solubility ratio	=	1.048
Solubility ratio	=	1.069
Solubility ratio	=	1.012
Solubility ratio	=	1.134
Solubility ratio	=	1.093
Solubility ratio	=	1.086
Solubility ratio	=	1.036
Solubility ratio	=	1.083
Solubility ratio	=	1.046
Solubility ratio	=	1.043
Solubility ratio	=	1.13
Solubility ratio	=	1.027
Solubility ratio	=	1.004
Solubility ratio	=	1.057
Solubility ratio	=	1.123

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL633105

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1984
Volume: 27
Issue: 8
First Page: 967
Last Page: 978
DOI: 10.1021/jm00374a006

Standard Type	Standard Relation	Standard Value
Solubility ratio	=	1.117
Solubility ratio	=	1.309
Solubility ratio	=	1.233
Solubility ratio	=	1.155
Solubility ratio	=	0.981
Solubility ratio	=	1.093
Solubility ratio	=	1.168
Solubility ratio	=	1.054
Solubility ratio	=	1.323
Solubility ratio	=	1.18
Solubility ratio	=	1.18
Solubility ratio	=	1.064
Solubility ratio	=	1.151
Solubility ratio	=	1.09
Solubility ratio	=	1.139
Solubility ratio	=	1.295
Solubility ratio	=	1.16
Solubility ratio	=	1.063
Solubility ratio	=	1.09
Solubility ratio	=	1.228

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Guanylate cyclase soluble subunit alpha-1

External ID: CHEMBL4829795

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2021
Volume: 224
First Page: 113729
Last Page: 113729
DOI: 10.1016/j.ejmech.2021.113729

Target ChEMBL ID: CHEMBL3137281
ChEMBL Target Name: Soluble guanylate cyclase alpha1/beta1 complex
ChEMBL Target Type: PROTEIN COMPLEX - Target is a defined protein complex, consisting of multiple subunits
Relationship Type: D - Direct protein target assigned
Confidence: Direct protein complex subunits assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
	Activity				Not Active
	Activity				Not Active
	Activity				Not Active
	Activity				Not Active
128	EC50	=	128000	nM		Outside typical range

7356-41-4 靶点实验数据