HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bifunctional dihydrofolate reductase-thymidylate synthase

External ID: CHEMBL667612

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2002
Volume: 45
Issue: 6
First Page: 1244
Last Page: 1252
DOI: 10.1021/jm010131q

Target ChEMBL ID: CHEMBL1939
ChEMBL Target Name: Dihydrofolate reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value
Relative activity	=	0.5
Relative activity	=	3.8
Relative activity	=	1.5

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bifunctional dihydrofolate reductase-thymidylate synthase

External ID: CHEMBL667613

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2002
Volume: 45
Issue: 6
First Page: 1244
Last Page: 1252
DOI: 10.1021/jm010131q

Target ChEMBL ID: CHEMBL1939
ChEMBL Target Name: Dihydrofolate reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value
Relative activity	=	1.1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL766289

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2002
Volume: 45
Issue: 6
First Page: 1244
Last Page: 1252
DOI: 10.1021/jm010131q

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Relative activity	=	0.6
Relative activity	=	8.7
Relative activity	=	3.8

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bifunctional dihydrofolate reductase-thymidylate synthase

External ID: CHEMBL849932

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2002
Volume: 45
Issue: 6
First Page: 1244
Last Page: 1252
DOI: 10.1021/jm010131q

Target ChEMBL ID: CHEMBL1939
ChEMBL Target Name: Dihydrofolate reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value
Ratio	=	89.8
Ratio	=	147.7
Ratio	=	35.4
Ratio	=	3.8
Ratio	=	95.6
Ratio	=	10.8
Ratio		12.6
Ratio	=	71
Ratio	=	2.3
Ratio	=	3.4
Ratio	=	231.6
Ratio	=	1.8
Ratio	=	1.6
Ratio	=	5
Ratio	=	31.5

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bifunctional dihydrofolate reductase-thymidylate synthase

External ID: CHEMBL848232

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2002
Volume: 45
Issue: 6
First Page: 1244
Last Page: 1252
DOI: 10.1021/jm010131q

Target ChEMBL ID: CHEMBL1939
ChEMBL Target Name: Dihydrofolate reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value
Ratio	=	47.7
Ratio	=	105
Ratio	=	8.5
Ratio	=	2
Ratio	=	43.3
Ratio	=	7.9
Ratio	=	9
Ratio	=	51.8
Ratio	=	4
Ratio	=	2.3
Ratio	=	153.6
Ratio	=	1.9
Ratio	=	1.7
Ratio	=	4.2
Ratio	=	15.6

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bifunctional dihydrofolate reductase-thymidylate synthase

External ID: CHEMBL828776

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2004
Volume: 47
Issue: 17
First Page: 4258
Last Page: 4267
DOI: 10.1021/jm040769c

Target ChEMBL ID: CHEMBL1939
ChEMBL Target Name: Dihydrofolate reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.14	Ki	=	140	nM
0.09	Ki	=	90	nM
8.7E-4	Ki	=	0.87	nM
7.7E-4	Ki	=	0.77	nM
0.0011	Ki	=	1.1	nM
8.4E-4	Ki	=	0.84	nM
0.0013	Ki	=	1.3	nM
0.09	Ki	=	90	nM
0.013	Ki	=	13	nM
0.01	Ki	=	10	nM
0.11	Ki	=	110	nM
7.4E-4	Ki	=	0.74	nM
0.037	Ki	=	37	nM
0.1	Ki	=	100	nM
0.083	Ki	=	83	nM
0.072	Ki	=	72	nM
0.0011	Ki	=	1.1	nM
0.085	Ki	=	85	nM
0.088	Ki	=	88	nM
1.4	Ki	=	1400	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bifunctional dihydrofolate reductase-thymidylate synthase

External ID: CHEMBL668409

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2002
Volume: 45
Issue: 6
First Page: 1244
Last Page: 1252
DOI: 10.1021/jm010131q

Target ChEMBL ID: CHEMBL1939
ChEMBL Target Name: Dihydrofolate reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0147	Ki	=	14.7	nM
0.0443	Ki	=	44.3	nM
0.0035	Ki	=	3.5	nM
0.0052	Ki	=	5.2	nM
0.7301	Ki	=	730.1	nM
0.0097	Ki	=	9.7	nM
0.0126	Ki	=	12.6	nM
7.0E-4	Ki	=	0.7	nM
0.0367	Ki	=	36.7	nM
0.5558	Ki	=	555.8	nM
0.0028	Ki	=	2.8	nM
0.5345	Ki	=	534.5	nM
0.0031	Ki	=	3.1	nM
0.0391	Ki	=	39.1	nM
0.0423	Ki	=	42.3	nM
0.0346	Ki	=	34.6	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bifunctional dihydrofolate reductase-thymidylate synthase

External ID: CHEMBL668410

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2002
Volume: 45
Issue: 6
First Page: 1244
Last Page: 1252
DOI: 10.1021/jm010131q

Target ChEMBL ID: CHEMBL1939
ChEMBL Target Name: Dihydrofolate reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0106	Ki	=	10.6	nM
0.0315	Ki	=	31.5	nM
0.0016	Ki	=	1.6	nM
0.0033	Ki	=	3.3	nM
0.4213	Ki	=	421.3	nM
0.0071	Ki	=	7.1	nM
0.009	Ki	=	9	nM
0.0012	Ki	=	1.2	nM
0.0256	Ki	=	25.6	nM
0.3687	Ki	=	368.7	nM
0.0017	Ki	=	1.7	nM
0.4152	Ki	=	415.2	nM
0.0032	Ki	=	3.2	nM
0.0235	Ki	=	23.5	nM
0.0209	Ki	=	20.9	nM
0.0172	Ki	=	17.2	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bifunctional dihydrofolate reductase-thymidylate synthase

External ID: CHEMBL668411

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2002
Volume: 45
Issue: 6
First Page: 1244
Last Page: 1252
DOI: 10.1021/jm010131q

Target ChEMBL ID: CHEMBL1939
ChEMBL Target Name: Dihydrofolate reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
4.0E-4	Ki	=	0.4	nM
3.0E-4	Ki	=	0.3	nM
4.0E-4	Ki	=	0.4	nM
0.0013	Ki	=	1.3	nM
0.188	Ki	=	188	nM
9.0E-4	Ki	=	0.9	nM
0.001	Ki	=	1	nM
3.0E-4	Ki	=	0.3	nM
0.0109	Ki	=	10.9	nM
0.0024	Ki	=	2.4	nM
5.0E-4	Ki	=	0.5	nM
0.007	Ki	=	7	nM
0.0019	Ki	=	1.9	nM
9.0E-4	Ki	=	0.9	nM
0.001	Ki	=	1	nM
0.0011	Ki	=	1.1	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL849104

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2002
Volume: 45
Issue: 6
First Page: 1244
Last Page: 1252
DOI: 10.1021/jm010131q

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Ratio	=	20.4
Ratio	=	386.3
Ratio	=	500
Ratio	=	4.7
Ratio	=	4.7
Ratio	>	84
Ratio	=	33.2
Ratio	=	290
Ratio	=	120.2
Ratio	=	21.7
Ratio	=	4.2
Ratio	=	11.4
Ratio	=	0.9
Ratio	=	2
Ratio	=	1.5
Ratio	=	7.1
Ratio	=	53.8

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL767132

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2002
Volume: 45
Issue: 6
First Page: 1244
Last Page: 1252
DOI: 10.1021/jm010131q

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.1	IC50	=	100	nM
0.05	IC50	=	50	nM
0.15	IC50	=	150	nM
0.7	IC50	=	700	nM
13.1	IC50	=	13100	nM
0.5	IC50	=	500	nM
0.06	IC50	=	60	nM
0.06	IC50	=	60	nM
7.4	IC50	=	7400	nM
2.3	IC50	=	2300	nM
0.8	IC50	=	800	nM
3.7	IC50	=	3700	nM
2.4	IC50	=	2400	nM
3	IC50	=	3000	nM
3.7	IC50	=	3700	nM
0.4	IC50	=	400	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bifunctional dihydrofolate reductase-thymidylate synthase

External ID: CHEMBL668418

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2002
Volume: 45
Issue: 6
First Page: 1244
Last Page: 1252
DOI: 10.1021/jm010131q

Target ChEMBL ID: CHEMBL1939
ChEMBL Target Name: Dihydrofolate reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value
Relative activity	=	1
Relative activity	=	0.8
Relative activity	=	1.6

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_2268_1

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	PubChem Standard Value	Ki	IC50 Qualifier	IC50	Target Accession(s)	Ligand	Target
Ki	0.00342	3.42		1520	O02604	BDBM18774	Bifunctional dihydrofolate reductase-thymidylate synthase
Ki	1.07593	1075.93	>	50000	O02604	BDBM18774	Bifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N]
Ki	7.8E-4	0.78		1950	O02604	BDBM18775	Bifunctional dihydrofolate reductase-thymidylate synthase
Ki	0.0634	63.4	>	50000	O02604	BDBM18775	Bifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N]
Ki	0.0014	1.4		220	O02604	BDBM18776	Bifunctional dihydrofolate reductase-thymidylate synthase
Ki	0.02807	28.07		18220	O02604	BDBM18776	Bifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N]
Ki	7.8E-4	0.78		90	O02604	BDBM18781	Bifunctional dihydrofolate reductase-thymidylate synthase
Ki	0.00659	6.59		30050	O02604	BDBM18781	Bifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N]
Ki	0.00114	1.14		1760	O02604	BDBM18782	Bifunctional dihydrofolate reductase-thymidylate synthase
Ki	0.04749	47.49	>	50000	O02604	BDBM18782	Bifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N]
Ki	3.1E-4	0.31		360	O02604	BDBM18784	Bifunctional dihydrofolate reductase-thymidylate synthase
Ki	5.4E-4	0.54		300	O02604	BDBM18784	Bifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N]
Ki	7.7E-4	0.77		2380	O02604	BDBM18786	Bifunctional dihydrofolate reductase-thymidylate synthase
Ki	0.00132	1.32		13890	O02604	BDBM18786	Bifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N]
Ki	0.00418	4.18		11330	O02604	BDBM18789	Bifunctional dihydrofolate reductase-thymidylate synthase
Ki	0.02247	22.47		12850	O02604	BDBM18789	Bifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N]
IC50	0.23			230	O02604	BDBM18790	Bifunctional dihydrofolate reductase-thymidylate synthase
Ki	9.0E-4	0.9		3020	O02604	BDBM18790	Bifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N]
Ki	5.3E-4	0.53		800	O02604	BDBM18791	Bifunctional dihydrofolate reductase-thymidylate synthase
Ki	8.1E-4	0.81		2760	O02604	BDBM18791	Bifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N]

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL766285

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2002
Volume: 45
Issue: 6
First Page: 1244
Last Page: 1252
DOI: 10.1021/jm010131q

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Relative activity	=	0.8
Relative activity	=	0.1
Relative activity	>	0.8

7331-26-2 靶点实验数据