HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Staphylococcus aureus

External ID: CHEMBL4002872

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2016
Volume: 79
Issue: 11
First Page: 2814
Last Page: 2823
DOI: 10.1021/acs.jnatprod.6b00581

Target ChEMBL ID: CHEMBL352
ChEMBL Target Name: Staphylococcus aureus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Ratio	=	7
Ratio	=	16

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：RAW264.7

External ID: CHEMBL5244463

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Nat Prod
Year: 2018
Volume: 81
Issue: 3.0
First Page: 661
Last Page: 678
DOI: 10.1021/acs.jnatprod.7b00619

Target ChEMBL ID: CHEMBL612557
ChEMBL Target Name: RAW264.7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
15.6	IC50	=	15600	nM
12.7	IC50	=	12700	nM
10.5	IC50	=	10500	nM
16	IC50	=	16000	nM
14.4	IC50	=	14400	nM
20.8	IC50	=	20800	nM
7.4	IC50	=	7400	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL1942014

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2011
Volume: 21
Issue: 23
First Page: 7064
Last Page: 7067
DOI: 10.1016/j.bmcl.2011.09.094

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	62	ug.mL-1
MIC	=	20	ug.mL-1
MIC	=	200	ug.mL-1
MIC	=	133	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Solute carrier family 22 member 6

External ID: CHEMBL4482185

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2019
Volume: 82
Issue: 4
First Page: 832
Last Page: 839
DOI: 10.1021/acs.jnatprod.8b00888

Target ChEMBL ID: CHEMBL1641347
ChEMBL Target Name: Solute carrier family 22 member 6
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	<	50	%
Inhibition	>	50	%
Inhibition	>	50	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Solute carrier family 22 member 6

External ID: CHEMBL4482187

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Nat Prod
Year: 2019
Volume: 82
Issue: 4
First Page: 832
Last Page: 839
DOI: 10.1021/acs.jnatprod.8b00888

Target ChEMBL ID: CHEMBL1641347
ChEMBL Target Name: Solute carrier family 22 member 6
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
3.5	IC50	=	3500	nM
4.4	IC50	=	4400	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Staphylococcus aureus

External ID: CHEMBL4002873

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2016
Volume: 79
Issue: 11
First Page: 2814
Last Page: 2823
DOI: 10.1021/acs.jnatprod.6b00581

Target ChEMBL ID: CHEMBL352
ChEMBL Target Name: Staphylococcus aureus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Ratio	=	16

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Solute carrier family 22 member 8

External ID: CHEMBL4482186

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2019
Volume: 82
Issue: 4
First Page: 832
Last Page: 839
DOI: 10.1021/acs.jnatprod.8b00888

Target ChEMBL ID: CHEMBL1641348
ChEMBL Target Name: Solute carrier family 22 member 8
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	>	50	%
Inhibition	>	50	%
Inhibition	>	50	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Solute carrier family 22 member 8

External ID: CHEMBL4482188

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Nat Prod
Year: 2019
Volume: 82
Issue: 4
First Page: 832
Last Page: 839
DOI: 10.1021/acs.jnatprod.8b00888

Target ChEMBL ID: CHEMBL1641348
ChEMBL Target Name: Solute carrier family 22 member 8
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
1.1	IC50	=	1100	nM
	Inhibition			%	Dose-dependent effect
8.3	IC50	=	8300	nM
	Inhibition			%	Dose-dependent effect
1.1	IC50	=	1100	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Estrogen receptor

External ID: CHEMBL865582

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2006
Volume: 16
Issue: 6
First Page: 1468
Last Page: 1472
DOI: 10.1016/j.bmcl.2005.12.057

Target ChEMBL ID: CHEMBL206
ChEMBL Target Name: Estrogen receptor alpha
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10	IC50	>	10000	nM
10	IC50	>	10000	nM
10	IC50	>	10000	nM
1	IC50	=	1000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Estrogen receptor beta

External ID: CHEMBL865583

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2006
Volume: 16
Issue: 6
First Page: 1468
Last Page: 1472
DOI: 10.1016/j.bmcl.2005.12.057

Target ChEMBL ID: CHEMBL242
ChEMBL Target Name: Estrogen receptor beta
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.308	IC50	=	308	nM
0.128	IC50	=	128	nM
0.326	IC50	=	326	nM
0.117	IC50	=	117	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Estrogen receptor beta

External ID: CHEMBL865584

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2006
Volume: 16
Issue: 6
First Page: 1468
Last Page: 1472
DOI: 10.1016/j.bmcl.2005.12.057

Target ChEMBL ID: CHEMBL2093866
ChEMBL Target Name: Estrogen receptor
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Standard Type	Standard Relation	Standard Value
Ratio IC50	=	1.1
Ratio IC50	=	7
Ratio IC50	=	32
Ratio IC50	=	20

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL5244505

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2018
Volume: 81
Issue: 3.0
First Page: 661
Last Page: 678
DOI: 10.1021/acs.jnatprod.7b00619

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
TIME	=	0.03108	hr
TIME	=	0.01633	hr
TIME	=	0.02097	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL5244506

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2018
Volume: 81
Issue: 3.0
First Page: 661
Last Page: 678
DOI: 10.1021/acs.jnatprod.7b00619

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Activity	=	13.6
Activity	=	6.6
Activity	=	7.8

73166-28-6 靶点实验数据