| Standard Type | Activity Comment |
|---|---|
| Activity | Non-toxic |
| Standard Type | Standard Relation | Standard Value | Activity Comment |
|---|---|---|---|
| Ratio CC50/EC50 | > | 5 | |
| Ratio CC50/EC50 | > | 58 | |
| Ratio CC50/EC50 | Not Determined |
| Standard Type | Activity Comment |
|---|---|
| Activity | Non-toxic |
| Activity | Non-toxic |
| Activity | Non-toxic |
| PubChem Standard Value | Standard Type | Standard Relation | Standard Value | Standard Units | Activity Comment |
|---|---|---|---|---|---|
| EC50 | Not Determined |
| PubChem Standard Value | Standard Type | Standard Relation | Standard Value | Standard Units |
|---|---|---|---|---|
| 0.57 | EC50 | = | 570 | nM |
| PubChem Standard Value | Standard Type | Standard Relation | Standard Value | Standard Units | Activity Comment |
|---|---|---|---|---|---|
| 50 | CC50 | > | 50000 | nM |
| PubChem Standard Value | Standard Type | Standard Relation | Standard Value | Standard Units | Activity Comment |
|---|---|---|---|---|---|
| 0.23 | EC50 | = | 230 | nM |
| Standard Type | Standard Relation | Standard Value | Standard Units |
|---|---|---|---|
| Tmax | = | 0.08 | hr |
| Tmax | = | 0.08 | hr |
| Standard Type | Standard Relation | Standard Value | Standard Units |
|---|---|---|---|
| Tmax | = | 2.6 | hr |
| Tmax | = | 2.6 | hr |
| Standard Type | Standard Relation | Standard Value | Standard Units |
|---|---|---|---|
| T1/2 | = | 4.4 | hr |
| PubChem Standard Value | Standard Type | Standard Relation | Standard Value | Standard Units |
|---|---|---|---|---|
| 0.4 | EC50 | = | 400 | nM |
| Standard Type | Standard Relation | Standard Value | Standard Units |
|---|---|---|---|
| T1/2 | = | 3.7 | hr |
| T1/2 | = | 5 | hr |
| Standard Type | Standard Relation | Standard Value | Standard Units | Data Validity Comment |
|---|---|---|---|---|
| Inhibition | = | 13.77 | % | |
| Inhibition | = | 2.35 | % | |
| Inhibition | = | 21.17 | % | |
| Inhibition | = | 18.36 | % | |
| Inhibition | = | 5.381 | % | |
| Inhibition | = | 18.17 | % | |
| Inhibition | = | 10.15 | % | |
| Inhibition | = | 29.56 | % | |
| Inhibition | = | 18.27 | % | |
| Inhibition | = | 11.42 | % | |
| Inhibition | = | 15.4 | % | |
| Inhibition | = | 7.437 | % | |
| Inhibition | = | -3.216 | % | |
| Inhibition | = | 18 | % | |
| Inhibition | = | 1.021 | % | |
| Inhibition | = | 16.4 | % | |
| Inhibition | = | 2.544 | % | |
| Inhibition | = | 19.11 | % | |
| Inhibition | = | 26.15 | % | |
| Inhibition | = | 5.133 | % |
| Standard Type | Standard Relation | Standard Value | Standard Units |
|---|---|---|---|
| Tmax | = | 1.5 | hr |
| Standard Type | Standard Relation | Standard Value | Standard Units |
|---|---|---|---|
| Vdss | = | 2.7 | L.kg-1 |
| Standard Type | Standard Relation | Standard Value | Standard Units |
|---|---|---|---|
| Vdss | = | 2.5 | L.kg-1 |
| Vdss | = | 2.2 | L.kg-1 |
| Standard Type | Standard Relation | Standard Value | Standard Units | Activity Comment |
|---|---|---|---|---|
| Vdss | = | 7.5 | L.kg-1 | |
| Vdss | = | 4.2 | L.kg-1 |
| Standard Type | Standard Relation | Standard Value | Standard Units |
|---|---|---|---|
| F | = | 76 | % |
| F | = | 77 | % |
| Standard Type | Standard Relation | Standard Value | Standard Units | Activity Comment |
|---|---|---|---|---|
| T1/2 | = | 8.1 | hr | |
| T1/2 | = | 5.9 | hr |
| Standard Type | Standard Relation | Standard Value | Standard Text Value | Standard Units | Data Validity Comment |
|---|---|---|---|---|---|
| Inhibition | = | -13.63 | % | Outside typical range | |
| Inhibition | = | -37.85 | % | Outside typical range | |
| Inhibition | = | -31.68 | % | Outside typical range | |
| Inhibition | = | -40.84 | % | Outside typical range | |
| Inhibition | = | -33.51 | % | Outside typical range | |
| Inhibition | = | -11.71 | % | Outside typical range | |
| Inhibition | = | -12.48 | % | Outside typical range | |
| Inhibition | = | 8.75 | % | ||
| Inhibition | = | -57.22 | % | Outside typical range | |
| Inhibition | = | -43.91 | % | Outside typical range | |
| Inhibition | = | -42.06 | % | Outside typical range | |
| Inhibition | = | 25.26 | % | ||
| Inhibition | = | 31.78 | % | ||
| Inhibition | = | -63.83 | % | Outside typical range | |
| Inhibition | = | 1.14 | % | ||
| Inhibition | = | -17.63 | % | Outside typical range | |
| Inhibition | = | 14.49 | % | ||
| Inhibition | = | 3.28 | % | ||
| Inhibition | = | 10.08 | % | ||
| Inhibition | = | 13.93 | % |
| Standard Type | Standard Relation | Standard Value | Activity Comment |
|---|---|---|---|
| FC | > | 12.3 | |
| FC | = | 50.7 | |
| FC | = | 0.85 |
| Standard Type | Standard Relation | Standard Value | Standard Units |
|---|---|---|---|
| CL/F | = | 7.3 | mL.min-1.kg-1 |
| Standard Type | Standard Relation | Standard Value | Standard Text Value | Standard Units | Data Validity Comment |
|---|---|---|---|---|---|
| Inhibition | = | -7.39 | % | ||
| Inhibition | = | -3.08 | % | ||
| Inhibition | = | 97.8 | % | ||
| Inhibition | = | -9.09 | % | ||
| Inhibition | = | 47.05 | % | ||
| Inhibition | = | -5.94 | % | ||
| Inhibition | = | -0.48 | % | ||
| Inhibition | = | -2.98 | % | ||
| Inhibition | = | 1.42 | % | ||
| Inhibition | = | 12.25 | % | ||
| Inhibition | = | -2.13 | % | ||
| Inhibition | = | -4.43 | % | ||
| Inhibition | = | 4.53 | % | ||
| Inhibition | = | -5.82 | % | ||
| Inhibition | = | 10.36 | % | ||
| Inhibition | = | -1.3 | % | ||
| Inhibition | = | 12.9 | % | ||
| Inhibition | = | -3.37 | % | ||
| Inhibition | = | 3.17 | % | ||
| Inhibition | = | -0.97 | % |
| PubChem Standard Value | Standard Type | Standard Relation | Standard Value | Standard Units | Activity Comment |
|---|---|---|---|---|---|
| EC50 | Not Determined |
| Standard Type | Standard Relation | Standard Value | Standard Units |
|---|---|---|---|
| CL | = | 7.8 | mL.min-1.kg-1 |
| CL | = | 5.3 | mL.min-1.kg-1 |
| Standard Type | Standard Relation | Standard Value | Standard Units | Activity Comment |
|---|---|---|---|---|
| CL/F | = | 9.5 | mL.min-1.kg-1 | |
| CL/F | = | 4.9 | mL.min-1.kg-1 |
| PubChem Standard Value | Standard Type | Standard Relation | Standard Value | Standard Units | Activity Comment |
|---|---|---|---|---|---|
| 1.3 | EC50 | = | 1300 | nM |
| Standard Type | Standard Relation | Standard Value | Activity Comment |
|---|---|---|---|
| FC | = | 3.1 | |
| FC | = | 3.9 | |
| FC | Not Determined |
| Standard Type | Standard Relation | Standard Value | Standard Units |
|---|---|---|---|
| Inhibition | = | 0.24 | % |
| Inhibition | = | 4.58 | % |
| Inhibition | = | -0.3 | % |
| Inhibition | = | -0.3 | % |
| Inhibition | = | -0.04 | % |
| Inhibition | = | -0.04 | % |
| Inhibition | = | -0.08 | % |
| Inhibition | = | -0.08 | % |
| Inhibition | = | -0.08 | % |
| Inhibition | = | -0.08 | % |
| Inhibition | = | 0.03 | % |
| Inhibition | = | 0 | % |
| Inhibition | = | 0.03 | % |
| Inhibition | = | 0 | % |
| Inhibition | = | -0.27 | % |
| Inhibition | = | -0.27 | % |
| Inhibition | = | -0.08 | % |
| Inhibition | = | -0.08 | % |
| Inhibition | = | 14.41 | % |
| Inhibition | = | 0.39 | % |
| Standard Type | Standard Relation | Standard Value | Standard Units | Data Validity Comment |
|---|---|---|---|---|
| Inhibition | = | -11.52 | % | Outside typical range |
| Inhibition | = | 5.09 | % | |
| Inhibition | = | -1.71 | % | |
| Inhibition | = | 3.69 | % | |
| Inhibition | = | 22.47 | % | |
| Inhibition | = | 8.51 | % | |
| Inhibition | = | -6.86 | % | |
| Inhibition | = | -6.18 | % | |
| Inhibition | = | -2.07 | % | |
| Inhibition | = | 3.91 | % | |
| Inhibition | = | -5.9 | % | |
| Inhibition | = | -2.45 | % | |
| Inhibition | = | -5.55 | % | |
| Inhibition | = | 6.31 | % | |
| Inhibition | = | -1.08 | % | |
| Inhibition | = | 12.7 | % | |
| Inhibition | = | 0.37 | % | |
| Inhibition | = | 8.88 | % | |
| Inhibition | = | 11.63 | % | |
| Inhibition | = | -1.96 | % |
| PubChem Standard Value | Standard Type | Standard Relation | Standard Value | Standard Units |
|---|---|---|---|---|
| 0.55 | IC50 | = | 550 | nM |
| 10 | IC50 | > | 10000 | nM |
| PubChem Standard Value | Standard Type | Standard Relation | Standard Value | Standard Units |
|---|---|---|---|---|
| 0.58 | IC50 | = | 580 | nM |
| 10 | IC50 | > | 10000 | nM |
| PubChem Standard Value | Standard Type | Standard Relation | Standard Value | Standard Units |
|---|---|---|---|---|
| 0.9 | EC50 | = | 900 | nM |
| PubChem Standard Value | Standard Type | Standard Relation | Standard Value | Standard Units |
|---|---|---|---|---|
| 0.8 | EC50 | = | 800 | nM |
| PubChem Standard Value | Standard Type | Standard Relation | Standard Value | Standard Units |
|---|---|---|---|---|
| 0.5 | EC50 | = | 500 | nM |