HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Receptor-type tyrosine-protein kinase FLT3

External ID: CHEMBL1958984

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2012
Volume: 55
Issue: 2
First Page: 725
Last Page: 734
DOI: 10.1021/jm201198w

Target ChEMBL ID: CHEMBL1974
ChEMBL Target Name: Tyrosine-protein kinase receptor FLT3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.01	IC50	=	10	nM
0.003	IC50	=	3	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1840414

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2011
Volume: 54
Issue: 20
First Page: 7184
Last Page: 7192
DOI: 10.1021/jm200712h

Standard Type	Standard Relation	Standard Value
Ratio Ki	=	113
Ratio Ki	=	92
Ratio Ki	=	80
Ratio Ki	=	147
Ratio Ki	=	366

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1840413

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2011
Volume: 54
Issue: 20
First Page: 7184
Last Page: 7192
DOI: 10.1021/jm200712h

Standard Type	Standard Relation	Standard Value
Ratio Ki	=	113
Ratio Ki	=	92
Ratio Ki	=	80
Ratio Ki	=	147
Ratio Ki	=	366

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1839830

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2011
Volume: 54
Issue: 20
First Page: 7184
Last Page: 7192
DOI: 10.1021/jm200712h

Standard Type	Standard Relation	Standard Value
Ratio Ki	=	113
Ratio Ki	=	92
Ratio Ki	=	80
Ratio Ki	=	147
Ratio Ki	=	366

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1839829

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2011
Volume: 54
Issue: 20
First Page: 7184
Last Page: 7192
DOI: 10.1021/jm200712h

Standard Type	Standard Relation	Standard Value
Ratio Ki	=	113
Ratio Ki	=	92
Ratio Ki	=	80
Ratio Ki	=	147
Ratio Ki	=	366

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1839832

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2011
Volume: 54
Issue: 20
First Page: 7184
Last Page: 7192
DOI: 10.1021/jm200712h

Standard Type	Standard Relation	Standard Value
Ratio Ki	=	113
Ratio Ki	=	92
Ratio Ki	=	80
Ratio Ki	=	147
Ratio Ki	=	366

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1839831

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2011
Volume: 54
Issue: 20
First Page: 7184
Last Page: 7192
DOI: 10.1021/jm200712h

Standard Type	Standard Relation	Standard Value
Ratio Ki	=	113
Ratio Ki	=	92
Ratio Ki	=	80
Ratio Ki	=	147
Ratio Ki	=	366

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL1959553

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2012
Volume: 55
Issue: 2
First Page: 725
Last Page: 734
DOI: 10.1021/jm201198w

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.016	IC50	=	16	nM
0.02	IC50	=	20	nM
0.092	IC50	=	92	nM
0.1	IC50	=	100	nM
0.011	IC50	=	11	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1959552

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2012
Volume: 55
Issue: 2
First Page: 725
Last Page: 734
DOI: 10.1021/jm201198w

Standard Type	Standard Relation	Standard Value
Ratio IC50	=	1.2
Ratio IC50	=	1.8
Ratio IC50	=	1.1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Receptor-type tyrosine-protein kinase FLT3

External ID: CHEMBL1840408

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2011
Volume: 54
Issue: 20
First Page: 7184
Last Page: 7192
DOI: 10.1021/jm200712h

Target ChEMBL ID: CHEMBL1974
ChEMBL Target Name: Tyrosine-protein kinase receptor FLT3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.005	Ki	=	5	nM
0.011	Ki	=	11	nM
0.012	Ki	=	12	nM
0.005	Ki	=	5	nM
0.001	Ki	=	1	nM
0.005	Ki	=	5	nM
0.042	Ki	=	42	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL1959555

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2012
Volume: 55
Issue: 2
First Page: 725
Last Page: 734
DOI: 10.1021/jm201198w

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.03	IC50	=	30	nM
0.012	IC50	=	12	nM
0.09	IC50	=	90	nM
0.03	IC50	=	30	nM
0.004	IC50	=	4	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL1959554

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2012
Volume: 55
Issue: 2
First Page: 725
Last Page: 734
DOI: 10.1021/jm201198w

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.24	IC50	=	240	nM
0.22	IC50	=	220	nM
8.9	IC50	=	8900	nM
0.31	IC50	=	310	nM
0.3	IC50	=	300	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mast/stem cell growth factor receptor Kit

External ID: CHEMBL1840409

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2011
Volume: 54
Issue: 20
First Page: 7184
Last Page: 7192
DOI: 10.1021/jm200712h

Target ChEMBL ID: CHEMBL1936
ChEMBL Target Name: Stem cell growth factor receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
0.05	Ki	<	50	nM
0.05	Ki	<	50	nM
0.001	Ki	<	1	nM
0.018	Ki	=	18	nM
	Ki				Not Determined
0.037	Ki	=	37	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL1839842

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2011
Volume: 54
Issue: 20
First Page: 7184
Last Page: 7192
DOI: 10.1021/jm200712h

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
T1/2	=	1.615	hr
T1/2	=	1.33	hr
T1/2	=	2.81	hr
T1/2	=	2.84	hr
T1/2	=	2.446	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL1839841

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2011
Volume: 54
Issue: 20
First Page: 7184
Last Page: 7192
DOI: 10.1021/jm200712h

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
CL	=	63.9	mL.min-1.kg-1
CL	=	42.1	mL.min-1.kg-1
CL	=	44.6	mL.min-1.kg-1
CL	=	31.1	mL.min-1.kg-1
CL	=	77.1	mL.min-1.kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1839834

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2011
Volume: 54
Issue: 20
First Page: 7184
Last Page: 7192
DOI: 10.1021/jm200712h

Standard Type	Standard Relation	Standard Value
Ratio Ki	=	113
Ratio Ki	=	92
Ratio Ki	=	80
Ratio Ki	=	147
Ratio Ki	=	366

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1839833

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2011
Volume: 54
Issue: 20
First Page: 7184
Last Page: 7192
DOI: 10.1021/jm200712h

Standard Type	Standard Relation	Standard Value
Ratio Ki	=	113
Ratio Ki	=	92
Ratio Ki	=	80
Ratio Ki	=	147
Ratio Ki	=	366

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1839836

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2011
Volume: 54
Issue: 20
First Page: 7184
Last Page: 7192
DOI: 10.1021/jm200712h

Standard Type	Standard Relation	Standard Value
Ratio Ki	=	113
Ratio Ki	=	92
Ratio Ki	=	80
Ratio Ki	=	147
Ratio Ki	=	366

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：TF-1

External ID: CHEMBL1959114

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2012
Volume: 55
Issue: 2
First Page: 725
Last Page: 734
DOI: 10.1021/jm201198w

Target ChEMBL ID: CHEMBL612552
ChEMBL Target Name: TF-1
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.007	IC50	=	7	nM
0.005	IC50	=	5	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1839835

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2011
Volume: 54
Issue: 20
First Page: 7184
Last Page: 7192
DOI: 10.1021/jm200712h

Standard Type	Standard Relation	Standard Value
Ratio Ki	=	113
Ratio Ki	=	92
Ratio Ki	=	80
Ratio Ki	=	147
Ratio Ki	=	366

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：TF-1

External ID: CHEMBL1959113

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2012
Volume: 55
Issue: 2
First Page: 725
Last Page: 734
DOI: 10.1021/jm201198w

Target ChEMBL ID: CHEMBL612552
ChEMBL Target Name: TF-1
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.01	IC50	=	10	nM
0.0035	IC50	=	3.5	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1839838

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2011
Volume: 54
Issue: 20
First Page: 7184
Last Page: 7192
DOI: 10.1021/jm200712h

Standard Type	Standard Relation	Standard Value
Ratio Ki	=	113
Ratio Ki	=	92
Ratio Ki	=	80
Ratio Ki	=	147
Ratio Ki	=	366

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：TF-1

External ID: CHEMBL1959116

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2012
Volume: 55
Issue: 2
First Page: 725
Last Page: 734
DOI: 10.1021/jm201198w

Target ChEMBL ID: CHEMBL612552
ChEMBL Target Name: TF-1
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.018	IC50	=	18	nM
0.004	IC50	=	4	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1839837

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2011
Volume: 54
Issue: 20
First Page: 7184
Last Page: 7192
DOI: 10.1021/jm200712h

Standard Type	Standard Relation	Standard Value
Ratio Ki	=	113
Ratio Ki	=	92
Ratio Ki	=	80
Ratio Ki	=	147
Ratio Ki	=	366

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：TF-1

External ID: CHEMBL1959115

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2012
Volume: 55
Issue: 2
First Page: 725
Last Page: 734
DOI: 10.1021/jm201198w

Target ChEMBL ID: CHEMBL612552
ChEMBL Target Name: TF-1
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
0.11	IC50	=	110	nM
0.003	IC50	=	3	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MV4-11

External ID: CHEMBL1839840

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2011
Volume: 54
Issue: 20
First Page: 7184
Last Page: 7192
DOI: 10.1021/jm200712h

Target ChEMBL ID: CHEMBL613835
ChEMBL Target Name: MV4-11
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
2.0E-4	IC50	<	0.2	nM
0.002	IC50	=	2	nM
0.002	IC50	=	2	nM
3.0E-4	IC50	=	0.3	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1839839

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2011
Volume: 54
Issue: 20
First Page: 7184
Last Page: 7192
DOI: 10.1021/jm200712h

Standard Type	Standard Relation	Standard Value
Ratio Ki	=	113
Ratio Ki	=	92
Ratio Ki	=	80
Ratio Ki	=	147
Ratio Ki	=	366

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mast/stem cell growth factor receptor Kit

External ID: CHEMBL1958983

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2012
Volume: 55
Issue: 2
First Page: 725
Last Page: 734
DOI: 10.1021/jm201198w

Target ChEMBL ID: CHEMBL1936
ChEMBL Target Name: Stem cell growth factor receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.001	Ki	<	1	nM
1.16	IC50	=	1160	nM
0.018	IC50	=	18	nM
0.004	IC50	=	4	nM

700809-17-2 靶点实验数据