HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Glucose transporter

External ID: CHEMBL3436044

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL3431938
ChEMBL Target Name: Glucose transporter
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: St. Jude Childrenâ€™s Research Hospital Leishmania Screening

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	6.02	%
Inhibition	=	1.08	%
Inhibition	=	3.62	%
Inhibition	=	-0.55	%
Inhibition	=	-2.13	%
Inhibition	=	-1.54	%
Inhibition	=	0.73	%
Inhibition	=	0.63	%
Inhibition	=	-1.34	%
Inhibition	=	2.77	%
Inhibition	=	-5.87	%
Inhibition	=	8.94	%
Inhibition	=	2.88	%
Inhibition	=	0.77	%
Inhibition	=	-0.15	%
Inhibition	=	4.63	%
Inhibition	=	2.43	%
Inhibition	=	-1.72	%
Inhibition	=	-0.85	%
Inhibition	=	2.22	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：1187 靶标：Calcium-Dependent Protein Kinase 1 (CDPK1)

External ID: PfalCDPK1

Protocol: The kinase's catalytic activity was measured with an ATP depletion assay. A luciferase-based reagent, Kinase-Glo, was used to measure the [ATP] remaining after each incubation period.

Comment:

CDPK1_IC50_uM
0.103
0.235
0.402
0.798

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Trypanosoma brucei brucei

External ID: CHEMBL3110905

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2013
Volume: 56
Issue: 24
First Page: 9861
Last Page: 9873
DOI: 10.1021/jm401530a

Target ChEMBL ID: CHEMBL612851
ChEMBL Target Name: Trypanosoma brucei brucei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.02	IC50	=	20	nM
100	IC50	>	100000	nM
1.15	IC50	=	1150	nM
100	IC50	>	100000	nM
0.17	IC50	=	170	nM
50	IC50	>	50000	nM
8.79	IC50	=	8790	nM
50	IC50	>	50000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Solute carrier family 2, facilitated glucose transporter member 1

External ID: CHEMBL3436042

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL2535
ChEMBL Target Name: Glucose transporter
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: St. Jude Childrenâ€™s Research Hospital Leishmania Screening

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	10.68	%
Inhibition	=	3.27	%
Inhibition	=	2.26	%
Inhibition	=	17.48	%
Inhibition	=	1.41	%
Inhibition	=	8.17	%
Inhibition	=	5.47	%
Inhibition	=	2.31	%
Inhibition	=	3.05	%
Inhibition	=	3.73	%
Inhibition	=	5.67	%
Inhibition	=	0.14	%
Inhibition	=	1.93	%
Inhibition	=	16.24	%
Inhibition	=	1.51	%
Inhibition	=	7.91	%
Inhibition	=	6.9	%
Inhibition	=	1.69	%
Inhibition	=	75.77	%
Inhibition	=	96.79	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：1187 靶标：Protein Kinase 7 (PK7)

External ID: PfalPK7

Protocol: The kinase's catalytic activity was measured with an ATP depletion assay. A luciferase-based reagent, Kinase-Glo, was used to measure the [ATP] remaining after each incubation period.

Comment:

PK7_IC50_uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Hexose transporter 1

External ID: CHEMBL3436043

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL4697
ChEMBL Target Name: Hexose transporter 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: St. Jude Childrenâ€™s Research Hospital Leishmania Screening

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	-1.2	%
Inhibition	=	6.76	%
Inhibition	=	14.6	%
Inhibition	=	0.38	%
Inhibition	=	5.62	%
Inhibition	=	10.22	%
Inhibition	=	1.73	%
Inhibition	=	1.53	%
Inhibition	=	2.85	%
Inhibition	=	0.24	%
Inhibition	=	2.22	%
Inhibition	=	3.5	%
Inhibition	=	4.54	%
Inhibition	=	0.98	%
Inhibition	=	5.18	%
Inhibition	=	-2.18	%
Inhibition	=	1.23	%
Inhibition	=	0.63	%
Inhibition	=	8.47	%
Inhibition	=	1.71	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：1187 靶标：Protein Kinase 6 (PK6)

External ID: PfalPK6

Protocol: The kinase's catalytic activity was measured with an ATP depletion assay. A luciferase-based reagent, Kinase-Glo, was used to measure the [ATP] remaining after each incubation period.

Comment:

PK6_IC50_uM
0.151
0.181
0.229
0.375

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：1187 靶标：mitogen-activated protein kinase 2 (MAP2 or MAPK2)

External ID: PfalMAPK2

Protocol: The kinase's catalytic activity was measured with an ATP depletion assay. A luciferase-based reagent, Kinase-Glo, was used to measure the [ATP] remaining after each incubation period.

Comment:

ACTIVITY_COMMENT

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：1187 靶标：Calcium-Dependent Protein Kinase 4 (CDPK4)

External ID: PfalCDPK4

Protocol: The kinase's catalytic activity was measured with an ATP depletion assay. A luciferase-based reagent, Kinase-Glo, was used to measure the [ATP] remaining after each incubation period.

Comment:

CDPK4_IC50_uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4020051

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2017
Volume: 60
Issue: 19
First Page: 8170
Last Page: 8182
DOI: 10.1021/acs.jmedchem.7b01066

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
218	IC50	=	218000	nM		Outside typical range
	IC50				Not Active
164.2	IC50	=	164200	nM		Outside typical range
95.4	IC50	=	95400	nM
156	IC50	=	156000	nM		Outside typical range
7.3	IC50	=	7300	nM
28060	IC50	=	28060000	nM		Outside typical range
1199	IC50	=	1199000	nM		Outside typical range
	IC50				Not Active
837	IC50	=	837000	nM		Outside typical range
445	IC50	=	445000	nM		Outside typical range
1207	IC50	=	1207000	nM		Outside typical range
118	IC50	=	118000	nM		Outside typical range
2623	IC50	=	2623000	nM		Outside typical range
1363	IC50	=	1363000	nM		Outside typical range
1786	IC50	=	1786000	nM		Outside typical range
	IC50				Not Active
131	IC50	=	131000	nM		Outside typical range
1283	IC50	=	1283000	nM		Outside typical range
145	IC50	=	145000	nM		Outside typical range

700-49-2 靶点实验数据