HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：DNA-dependent protein kinase catalytic subunit

External ID: CHEMBL827974

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2005
Volume: 48
Issue: 2
First Page: 569
Last Page: 585
DOI: 10.1021/jm049526a

Target ChEMBL ID: CHEMBL3142
ChEMBL Target Name: DNA-dependent protein kinase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1.5	IC50	=	1500	nM
1.2	IC50	=	1200	nM
0.23	IC50	=	230	nM
1.26	IC50	=	1260	nM
5.71	IC50	=	5710	nM
10	IC50	>	10000	nM
5.15	IC50	=	5150	nM
6.66	IC50	=	6660	nM
2.24	IC50	=	2240	nM
10	IC50	>	10000	nM
10	IC50	>	10000	nM
10	IC50	>	10000	nM
10	IC50	>	10000	nM
5.35	IC50	=	5350	nM
10	IC50	>	10000	nM
0.28	IC50	=	280	nM
8.05	IC50	=	8050	nM
1.38	IC50	=	1380	nM
1.65	IC50	=	1650	nM
6.17	IC50	=	6170	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：DNA-dependent protein kinase catalytic subunit

External ID: CHEMBL858719

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2005
Volume: 48
Issue: 24
First Page: 7829
Last Page: 7846
DOI: 10.1021/jm050444b

Target ChEMBL ID: CHEMBL3142
ChEMBL Target Name: DNA-dependent protein kinase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.23	IC50	=	230	nM
3.81	IC50	=	3810	nM
0.9	IC50	=	900	nM
0.6	IC50	=	600	nM
0.8	IC50	=	800	nM
0.8	IC50	=	800	nM
0.04	IC50	=	40	nM
0.7	IC50	=	700	nM
0.3	IC50	=	300	nM
0.02	IC50	=	20	nM
6.5E-4	Ki	=	0.65	nM
8.15	IC50	=	8150	nM
0.47	IC50	=	470	nM
9.32	IC50	=	9320	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：DNA-dependent protein kinase catalytic subunit

External ID: CHEMBL916755

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2007
Volume: 50
Issue: 8
First Page: 1958
Last Page: 1972
DOI: 10.1021/jm061121y

Target ChEMBL ID: CHEMBL3142
ChEMBL Target Name: DNA-dependent protein kinase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.7	IC50	=	700	nM
0.84	IC50	=	840	nM
0.54	IC50	=	540	nM
100	IC50	>	100000	nM
1.06	IC50	=	1060	nM
1	IC50	=	1000	nM

69540-97-2 靶点实验数据