HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HepG2

External ID: CHEMBL5331375

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2022
Volume: 242
First Page: 114641
Last Page: 114641
DOI: 10.1016/j.ejmech.2022.114641

Target ChEMBL ID: CHEMBL395
ChEMBL Target Name: HepG2
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Non-Toxic
Activity	Non-Toxic
Activity	Non-Toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：LS174T

External ID: CHEMBL5331376

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2022
Volume: 242
First Page: 114641
Last Page: 114641
DOI: 10.1016/j.ejmech.2022.114641

Target ChEMBL ID: CHEMBL614097
ChEMBL Target Name: LS174T
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Non-Toxic
Activity	Non-Toxic
Activity	Non-Toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Fatty-acid amide hydrolase 1

External ID: CHEMBL1046621

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2009
Volume: 52
Issue: 22
First Page: 7310
Last Page: 7314
DOI: 10.1021/jm901323s

Target ChEMBL ID: CHEMBL2243
ChEMBL Target Name: Anandamide amidohydrolase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
3.311E-4	IC50	=	0.3311	nM
44.6684	IC50	=	44668.36	nM
1000	IC50	>	1000000	nM	Outside typical range
79.4328	IC50	=	79432.82	nM
1000	IC50	>	1000000	nM	Outside typical range
0.03802	IC50	=	38.02	nM
1000	IC50	>	1000000	nM	Outside typical range
1000	IC50	>	1000000	nM	Outside typical range
1000	IC50	>	1000000	nM	Outside typical range
1000	IC50	>	1000000	nM	Outside typical range
1000	IC50	>	1000000	nM	Outside typical range
1000	IC50	>	1000000	nM	Outside typical range
1000	IC50	>	1000000	nM	Outside typical range
1000	IC50	>	1000000	nM	Outside typical range
2.18776	IC50	=	2187.76	nM
1000	IC50	>	1000000	nM	Outside typical range
134.896	IC50	=	134896.29	nM	Outside typical range
169.824	IC50	=	169824.37	nM	Outside typical range
33.8844	IC50	=	33884.42	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Monoglyceride lipase

External ID: CHEMBL1046619

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2009
Volume: 52
Issue: 22
First Page: 7310
Last Page: 7314
DOI: 10.1021/jm901323s

Target ChEMBL ID: CHEMBL4191
ChEMBL Target Name: Monoglyceride lipase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	>	50	%
Inhibition	>	50	%
Inhibition	>	50	%
Inhibition	>	50	%
Inhibition	>	50	%
Inhibition	>	50	%
Inhibition	>	50	%
Inhibition	>	50	%
Inhibition	>	50	%
Inhibition	>	50	%
Inhibition	>	50	%
Inhibition	>	50	%
Inhibition	>	50	%
Inhibition	>	50	%
Inhibition	>	50	%
Inhibition	>	50	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Monoglyceride lipase

External ID: CHEMBL1046620

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2009
Volume: 52
Issue: 22
First Page: 7310
Last Page: 7314
DOI: 10.1021/jm901323s

Target ChEMBL ID: CHEMBL4191
ChEMBL Target Name: Monoglyceride lipase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
0.0263	IC50	=	26.3	nM
0.97724	IC50	=	977.24	nM
9.54993	IC50	=	9549.93	nM
0.21878	IC50	=	218.78	nM
0.31623	IC50	=	316.23	nM
0.05495	IC50	=	54.95	nM
0.91201	IC50	=	912.01	nM
0.74131	IC50	=	741.31	nM
102.329	IC50	=	102329.3	nM	Outside typical range
95.4993	IC50	=	95499.26	nM
0.47863	IC50	=	478.63	nM
0.43652	IC50	=	436.52	nM
11.2202	IC50	=	11220.18	nM
9.54993	IC50	=	9549.93	nM
1.12202	IC50	=	1122.02	nM
0.16596	IC50	=	165.96	nM
0.48978	IC50	=	489.78	nM
5.01187	IC50	=	5011.87	nM
0.74131	IC50	=	741.31	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Schistosoma mansoni

External ID: CHEMBL5331377

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2022
Volume: 242
First Page: 114641
Last Page: 114641
DOI: 10.1016/j.ejmech.2022.114641

Target ChEMBL ID: CHEMBL612893
ChEMBL Target Name: Schistosoma mansoni
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active

686-07-7 靶点实验数据