HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Orexin receptor type 2

External ID: CHEMBL1006173

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2008
Volume: 18
Issue: 21
First Page: 5729
Last Page: 5729
DOI: 10.1016/j.bmcl.2008.09.079

Target ChEMBL ID: CHEMBL4792
ChEMBL Target Name: Orexin receptor 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.048	IC50	=	48	nM
0.142	IC50	=	142	nM
0.06	IC50	=	60	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Orexin/Hypocretin receptor type 1

External ID: CHEMBL1006172

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2008
Volume: 18
Issue: 21
First Page: 5729
Last Page: 5729
DOI: 10.1016/j.bmcl.2008.09.079

Target ChEMBL ID: CHEMBL5113
ChEMBL Target Name: Orexin receptor 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
2.486	IC50	=	2486	nM
10	IC50	>	10000	nM
10	IC50	>	10000	nM

680588-91-4 靶点实验数据