HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789871

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	25	ug
Activity	=	25	ug
Activity	=	22	ug
Activity	=	2.5	ug
Activity	=	25	ug
Activity	=	6	ug
Activity	=	2.5	ug
Activity	=	5	ug

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789869

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789868

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value	Activity Comment
FC	=	1.5
FC	=	1.5
FC	=	1.5
FC			Not Active
FC	=	1.5
FC	=	1.5
FC			Not Active
FC	=	1.5

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789872

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	3.5	ug
Activity	=	3.5	ug
Activity	=	3.5	ug
Activity	=	2.5	ug
Activity	=	3.5	ug
Activity	=	3.5	ug
Activity	=	2.5	ug
Activity	=	3.5	ug

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：NIAID 靶标：N/A

External ID: HIV Enzyme Data

Protocol: N/A

Comment: N/A

Species	Strain	IsPseudotypeVirus	AssayMeth	Target	IC50Mod	IC50	IC50Unit	Ki	KiUnit	Reference	Citation
			3' PROCESSING	Integrase	>	100	uM			18662877	EFFICIENT SYNTHESIS AND UTILIZATION OF PHENYL-SUBSTITUTED HETEROAROMATIC CARBOXYLIC ACIDS AS ARYL DIKETO ACID ISOSTERES IN THE DESIGN OF NOVEL HIV-1 INTEGRASE INHIBITORS. Bioorganic & Medical Chemistry Letters 2008, 18(16), 4521-4.
			3' PROCESSING	Integrase	>	100	uM			18662877	EFFICIENT SYNTHESIS AND UTILIZATION OF PHENYL-SUBSTITUTED HETEROAROMATIC CARBOXYLIC ACIDS AS ARYL DIKETO ACID ISOSTERES IN THE DESIGN OF NOVEL HIV-1 INTEGRASE INHIBITORS. Bioorganic & Medical Chemistry Letters 2008, 18(16), 4521-4.
			3' PROCESSING	Integrase	>	100	uM			18662877	EFFICIENT SYNTHESIS AND UTILIZATION OF PHENYL-SUBSTITUTED HETEROAROMATIC CARBOXYLIC ACIDS AS ARYL DIKETO ACID ISOSTERES IN THE DESIGN OF NOVEL HIV-1 INTEGRASE INHIBITORS. Bioorganic & Medical Chemistry Letters 2008, 18(16), 4521-4.
			STRAND TRANSFER	Integrase	>	100	uM			18662877	EFFICIENT SYNTHESIS AND UTILIZATION OF PHENYL-SUBSTITUTED HETEROAROMATIC CARBOXYLIC ACIDS AS ARYL DIKETO ACID ISOSTERES IN THE DESIGN OF NOVEL HIV-1 INTEGRASE INHIBITORS. Bioorganic & Medical Chemistry Letters 2008, 18(16), 4521-4.
	HIV-1		dTTP incorporation assay by liquid scintillation	Reverse transcriptase				6.2	uM	19442130	CHARACTERIZATION OF HIV-1 ENZYME REVERSE TRANSCRIPTASE INHIBITION BY THE COMPOUND 6-CHLORO-1,4-DIHYDRO-4-OXO-1-(BETA-D-RIBOFURANOSYL) QUINOLINE-3-CARBOXYLIC ACID THROUGH KINETIC AND IN SILICO STUDIES. Current HIV Research 2009, 7(3), 327-335.
	HIV-1		dTTP incorporation assay by liquid scintillation	Reverse transcriptase				5.3	uM	19442130	CHARACTERIZATION OF HIV-1 ENZYME REVERSE TRANSCRIPTASE INHIBITION BY THE COMPOUND 6-CHLORO-1,4-DIHYDRO-4-OXO-1-(BETA-D-RIBOFURANOSYL) QUINOLINE-3-CARBOXYLIC ACID THROUGH KINETIC AND IN SILICO STUDIES. Current HIV Research 2009, 7(3), 327-335.
	HIV-1		dTTP incorporation assay by liquid scintillation	Reverse transcriptase				5	uM	19442130	CHARACTERIZATION OF HIV-1 ENZYME REVERSE TRANSCRIPTASE INHIBITION BY THE COMPOUND 6-CHLORO-1,4-DIHYDRO-4-OXO-1-(BETA-D-RIBOFURANOSYL) QUINOLINE-3-CARBOXYLIC ACID THROUGH KINETIC AND IN SILICO STUDIES. Current HIV Research 2009, 7(3), 327-335.
HIV-1		N	standard reverse transcriptase assay	Reverse transcriptase		50	ug/mL				SYNTHESIS AND HIV-1 REVERSE TRANSCRIPTASE INHIBITION ACTIVITY OF 1,4-NAPHTHOQUINONE DERIVATIVES. Chemistry of Natural Compounds 2012, 47(6), 883-887.
			STRAND TRANSFER	Integrase	>	100	uM			18805696	DISCOVERY OF 3-ACETYL-4-HYDROXY-2-PYRANONE DERIVATIVES AND THEIR DIFLUORIDOBORATE COMPLEXES AS A NOVEL CLASS OF HIV-1 INTEGRASE INHIBITORS. Bioorganic & Medical Chemistry 2008, 16(19), 8988-98.
			STRAND TRANSFER	Integrase	>	100	uM			18805696	DISCOVERY OF 3-ACETYL-4-HYDROXY-2-PYRANONE DERIVATIVES AND THEIR DIFLUORIDOBORATE COMPLEXES AS A NOVEL CLASS OF HIV-1 INTEGRASE INHIBITORS. Bioorganic & Medical Chemistry 2008, 16(19), 8988-98.
			3'-PROCESSING	Integrase	>	100	uM			18805696	DISCOVERY OF 3-ACETYL-4-HYDROXY-2-PYRANONE DERIVATIVES AND THEIR DIFLUORIDOBORATE COMPLEXES AS A NOVEL CLASS OF HIV-1 INTEGRASE INHIBITORS. Bioorganic & Medical Chemistry 2008, 16(19), 8988-98.
	HIV-1		STRAND TRANSFER	Integrase		0.015	uM			19523819	N-(4-FLUOROBENZYL)-3-HYDROXY-9;9-DIMETHYL-4-OXO-6;7;8;9-TETRAHYDRO-4H-PYRAZINO[1;2-A]PYRIMIDINE-2-CARBOXAMIDES A NOVEL CLASS OF POTENT HIV-1 INTEGRASE INHIBITORS. Bioorganic & Medical Chemistry Letters 2009, 19, 4245-9.
	HIV-1		HPLC	Protease		5.8	uM			18543149	INHIBITION OF HIV-1 PROTEASE AND RNASE H OF HIV-1 REVERSE TRANSCRIPTASE ACTIVITIES BY LONG CHAIN PHENOLS FROM THE SARCOTESTAS OF GINKGO BILOBA. Planta Medica 2008, 74(5), 532-534.
	HIV-1		RNASE H OF HIV-1 REVERSE TRANSCRIPTASE ASSAY	Reverse transcriptase		170.3	uM			18543149	INHIBITION OF HIV-1 PROTEASE AND RNASE H OF HIV-1 REVERSE TRANSCRIPTASE ACTIVITIES BY LONG CHAIN PHENOLS FROM THE SARCOTESTAS OF GINKGO BILOBA. Planta Medica 2008, 74(5), 532-534.
	HIV-1		HPLC	Protease		10.2	uM			18543149	INHIBITION OF HIV-1 PROTEASE AND RNASE H OF HIV-1 REVERSE TRANSCRIPTASE ACTIVITIES BY LONG CHAIN PHENOLS FROM THE SARCOTESTAS OF GINKGO BILOBA. Planta Medica 2008, 74(5), 532-534.
	HIV-1		RNASE H OF HIV-1 REVERSE TRANSCRIPTASE ASSAY	Reverse transcriptase		33.7	uM			18543149	INHIBITION OF HIV-1 PROTEASE AND RNASE H OF HIV-1 REVERSE TRANSCRIPTASE ACTIVITIES BY LONG CHAIN PHENOLS FROM THE SARCOTESTAS OF GINKGO BILOBA. Planta Medica 2008, 74(5), 532-534.
	HIV-1		HPLC	Protease		24.9	uM			18543149	INHIBITION OF HIV-1 PROTEASE AND RNASE H OF HIV-1 REVERSE TRANSCRIPTASE ACTIVITIES BY LONG CHAIN PHENOLS FROM THE SARCOTESTAS OF GINKGO BILOBA. Planta Medica 2008, 74(5), 532-534.
	HIV-1		3'-processing	Integrase	>	100	uM				COMPOUNDS WITH HIV-1 INTEGRASE INHIBITORY ACTIVITY AND USE THEREOF AS ANTI-HIV/AIDS THERAPEUTICS. . Patent 2009, , .
	HIV-1		Strand Transfer	Integrase	>	100	uM				COMPOUNDS WITH HIV-1 INTEGRASE INHIBITORY ACTIVITY AND USE THEREOF AS ANTI-HIV/AIDS THERAPEUTICS. . Patent 2009, , .
	HIV-1		3'-processing	Integrase	>	100	uM				COMPOUNDS WITH HIV-1 INTEGRASE INHIBITORY ACTIVITY AND USE THEREOF AS ANTI-HIV/AIDS THERAPEUTICS. . Patent 2009, , .

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：NIAID 靶标：N/A

External ID: HIV Cellular Data

Protocol: N/A

Comment: N/A

Species	Strain	AssayMeth	CellType	CellType2	Target	Mutations	EC50Mod	EC50	EC50Unit	ECOtherPct	ECOtherPctUnit	ECOtherConc	ECOtherConcUnit	ToxAssayMeth	CC50Mod	CC50	CC50Unit	TIMod	TI	Comments	Reference	Citation	Other Information
HIV-1	LAI	RT	HuT TK+	HuT 78	Reverse transcriptase		<	1	uM	100	%	1	uM	MTT	>	10	uM	>	10	HuT TK+=HuT 78 CELLS EXPRESSING HSV-1 THYMIDINE KINASE; MEASUREMENT WAS MADE ON DAY10 POSTINFECTION AT 10 TCID50	9281520	USE OF HERPES SIMPLEX VIRUS THYMIDINE KINASE TO IMPROVE THE ANTIVIRAL ACTIVITY OF ZIDOVUDINE. Virology 1997, 235, 398-405.
HIV-1	MN	RT	HuT TK+	HuT 78	Reverse transcriptase		<	0.3	uM	76.74	%	0.3	uM	MTT	>	10	uM	>	33.3	HuT TK+=HuT 78 CELLS EXPRESSING HSV-1 THYMIDINE KINASE; MEASUREMENT WAS MADE ON DAY14 POSTINFECTION AT 10 TCID50	9281520	USE OF HERPES SIMPLEX VIRUS THYMIDINE KINASE TO IMPROVE THE ANTIVIRAL ACTIVITY OF ZIDOVUDINE. Virology 1997, 235, 398-405.
HIV-1	MN	RT	HuT TK+	HuT 78	Reverse transcriptase		<	0.3	uM	69	%	0.3	uM	MTT	>	10	uM	>	33.3	HuT TK+=HuT 78 CELLS EXPRESSING HSV-1 THYMIDINE KINASE; MEASUREMENT WAS MADE ON DAY14 POSTINFECTION AT 100 TCID50	9281520	USE OF HERPES SIMPLEX VIRUS THYMIDINE KINASE TO IMPROVE THE ANTIVIRAL ACTIVITY OF ZIDOVUDINE. Virology 1997, 235, 398-405.
R5; CLINICAL ISOLATE	1(JSL)	P24	PBMC		Reverse transcriptase	MDR		0.07	uM	90	%	1	uM	MTT	>	100	uM	>	1428	HIV-1(JSL) WAS ISOLATED FROM PATIENTS WHO RECEIVED ANTIRETROVIRAL THERAPY FOR A LONG PERIOD AND WHOSE VIRUS ACQUIRED A NUMBER OF MUTATIONS IN THE RT- AND PR-ENCODING GENES; DETAILS OF MUTATIONS NOT GIVEN	15280474	SPIRODIKETOPIPERAZINE-BASED CCR5 INHIBITOR WHICH PRESERVES CC-CHEMOKINE/CCR5 INTERACTIONS AND EXERTS POTENT ACTIVITY AGAINST R5 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 IN VITRO. Journal of Virology 2004, 78(16), 8654-8662.	ECOtherConcMod:>
HIV-1	NL4-3	LUCIFERASE	1G5 T		Reverse transcriptase		<	1	uM	99	%	1	uM	TRYPAN BLUE	>	1	uM	>	1	ASSAY WAS CONDUCTED ON DAY 3 POST-INFECTION	16725040	INHIBITION OF HIGHLY PRODUCTIVE HIV-1 INFECTION IN T CELLS, PRIMARY HUMAN MACROPHAGES, MICROGLIA, AND ASTROCYTES BY SARGASSUM FUSIFORME. AIDS Research and Therapy 2006, 3(1), 15 PP.	CCOtherPct:6 \| CCOtherPctUnit:% \| CCOtherConc:1 \| CCOtherConcUnit:uM
HIV-1	NL4-3	LUCIFERASE	1G5 T		Reverse transcriptase		<	1	uM	99	%	1	uM	TRYPAN BLUE	>	1	uM	>	1	ASSAY WAS CONDUCTED ON DAY 5 POST-INFECTION	16725040	INHIBITION OF HIGHLY PRODUCTIVE HIV-1 INFECTION IN T CELLS, PRIMARY HUMAN MACROPHAGES, MICROGLIA, AND ASTROCYTES BY SARGASSUM FUSIFORME. AIDS Research and Therapy 2006, 3(1), 15 PP.	CCOtherPct:7 \| CCOtherPctUnit:% \| CCOtherConc:1 \| CCOtherConcUnit:uM
HIV-1	NL4-3	LUCIFERASE	1G5 T		Reverse transcriptase		<	1	uM	99	%	1	uM	TRYPAN BLUE	>	1	uM	>	1	ASSAY WAS CONDUCTED ON DAY 7 POST-INFECTION	16725040	INHIBITION OF HIGHLY PRODUCTIVE HIV-1 INFECTION IN T CELLS, PRIMARY HUMAN MACROPHAGES, MICROGLIA, AND ASTROCYTES BY SARGASSUM FUSIFORME. AIDS Research and Therapy 2006, 3(1), 15 PP.	CCOtherPct:3 \| CCOtherPctUnit:% \| CCOtherConc:1 \| CCOtherConcUnit:uM
HIV-1	LAV	RT	U1(THF-.alpha. STIM)	U1	Tumor necrosis factor alpha		~	30	ug/mL	70	%	50	ug/mL		>	50	ug/mL	>	1.66	CHRONICALLY HIV-1 INFECTED PROMONOCYTE CELL LINE	8327469	THALIDOMIDE INHIBITS THE REPLICATION OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1. Proceedings of the National Academy of Sciences of the United States of America 1993, 90, 5974-5978.	CCOtherPct:0 \| CCOtherPctUnit:% \| CCOtherConc:50 \| CCOtherConcUnit:ug/mL
HIV-1	BaL	P24 (DAY 18)	MACROPHAGES(GM-CSF)	Macrophage	Ribonucleotide reductase		<	10	uM	75	%	10	uM		>	1000	uM	>	10	MAXIMAL P24 EXPRESSION AT DAY 18	7973634	HYDROXYUREA AS AN INHIBITOR OF HUMAN IMMUNODEFICIENCY VIRUS-TYPE 1 REPLICATION. Science 1994, 266(5186), 801-805.	CCOtherPct:0 \| CCOtherPctUnit:% \| CCOtherConc:1000 \| CCOtherConcUnit:uM
HIV-1	BaL	P24 (DAY 18)	MACROPHAGES(GM-CSF)	Macrophage	Ribonucleotide reductase		<	10	uM	38	%	2	uM		>	1000	uM	>	10	MAXIMAL P24 EXPRESSION AT DAY 18	7973634	HYDROXYUREA AS AN INHIBITOR OF HUMAN IMMUNODEFICIENCY VIRUS-TYPE 1 REPLICATION. Science 1994, 266(5186), 801-805.	CCOtherPct:0 \| CCOtherPctUnit:% \| CCOtherConc:1000 \| CCOtherConcUnit:uM
HIV-1	BaL	P24 (DAY 18)	MACROPHAGES(GM-CSF)	Macrophage	Ribonucleotide reductase		<	10	uM	99	%	50	uM		>	1000	uM	>	10	MAXIMAL P24 EXPRESSION AT DAY 18	7973634	HYDROXYUREA AS AN INHIBITOR OF HUMAN IMMUNODEFICIENCY VIRUS-TYPE 1 REPLICATION. Science 1994, 266(5186), 801-805.	ECOtherPctMod:> \| CCOtherPct:0 \| CCOtherPctUnit:% \| CCOtherConc:1000 \| CCOtherConcUnit:uM
HIV-1	IIIB	RT	HT4(R116; AZT RESISTANT CELLS)	HT4	Reverse transcriptase		~	0.01	uM	70	%	0.01	uM		~`	1	uM	~	100	FLOXURIDINE APPEARS TO POTENTIATE AZT ACTIVITY AND ALSO HAVE SOME ANTI-HIV ACTIVITY IN AZT RESISTANT CELL LINES	8827211	USE OF FLOXURIDINE TO MODULATE THE ANTIVIRAL ACTIVITY OF ZIDOVUDINE. AIDS Research and Human Retroviruses 1996, 12(11), 965-968.	ECOtherPctMod:~ \| CCOtherPct:35 \| CCOtherPctUnit:% \| CCOtherConc:.1 \| CCOtherConcUnit:uM
HIV-1	1	.beta.GAL AS A MEASURE OF TAT-MEDIATED TRANSACTIVATION	HeLa H12(HIV-1 LTR-Laz, TAT)	HeLa	Tat:TAR/LTR		<	0.1	uM	52	%	0.1	uM	TRYPAN BLUE	>	100	uM	>	1000	DRUG AND RECOMBINANT TAT WERE INTRODUCED INTO CELLS THROUGH ELECTROPORATION	9561563	CURCUMIN AND CURCUMIN DERIVATIVES INHIBIT TAT-MEDIATED TRANSACTIVATION OF TYPE 1 HUMAN IMMUNODEFICIENCY VIRUS LONG TERMINAL REPEAT. Research in Virology 1998, 149(1), 43-52.
HIV-1	1	.beta.GAL AS A MEASURE OF TAT-MEDIATED TRANSACTIVATION	HeLa H12(HIV-1 LTR-Laz, TAT)	HeLa	Tat:TAR/LTR		<	0.01	uM	78	%	0.01	uM	TRYPAN BLUE	>	100	uM	>	10000	DRUG AND RECOMBINANT TAT WERE INTRODUCED INTO CELLS THROUGH ELECTROPORATION	9561563	CURCUMIN AND CURCUMIN DERIVATIVES INHIBIT TAT-MEDIATED TRANSACTIVATION OF TYPE 1 HUMAN IMMUNODEFICIENCY VIRUS LONG TERMINAL REPEAT. Research in Virology 1998, 149(1), 43-52.
HIV-1	IIIB	SYNCYT FORM	MOLT-4/H9(HIV-1(IIIB))	MOLT-4	gp120		<	1	uM	95	%	10	uM		-100	10	uM	>	10	CHRONICALLY INFECTED H9 CELLS	9343823	TRIAZINE DYES INHIBIT HIV-1 ENTRY BY BINDING TO ENVELOPE GLYCOPROTEINS. Microbiology and Immunology 1997, 41(9), 717-724.	CCOtherPct:30 \| CCOtherPctUnit:% \| CCOtherConc:10 \| CCOtherConcUnit:uM
HIV-1	1	.beta.GAL AS A MEASURE OF TAT-MEDIATED TRANSACTIVATION	HeLa H12(HIV-1 LTR-Laz, TAT)	HeLa	Tat:TAR/LTR		<	0.01	uM	75	%	0.01	uM	TRYPAN BLUE	>	100	uM	>	10000	DRUG AND RECOMBINANT TAT WERE INTRODUCED INTO CELLS THROUGH ELECTROPORATION	9561563	CURCUMIN AND CURCUMIN DERIVATIVES INHIBIT TAT-MEDIATED TRANSACTIVATION OF TYPE 1 HUMAN IMMUNODEFICIENCY VIRUS LONG TERMINAL REPEAT. Research in Virology 1998, 149(1), 43-52.
HIV-1	1	P24	MT-4		Integrase		<	0.25	uM	95	%	0.25	uM	MICROSCOPIC EXAMINATION	>	20	uM	>	80	IN THE PRESENCE OF 50% NHS	16554152	A SERIES OF 5-AMINOSUBSTITUTED 4-FLUOROBENZYL-8-HYDROXY-[1,6]NAPHTHYRIDINE-7-CARBOXAMIDE HIV-1 INTEGRASE INHIBITORS. Bioorganic & Medical Chemistry Letters 2006, 16(11), 2900-2904.	ECOtherPctMod:>
HIV-1	1	P24	MT-4		Integrase		<	0.103	uM	95	%	0.103	uM	MICROSCOPIC EXAMINATION	>	20	uM	>	194	IN THE PRESENCE OF 10% FBS	16554152	A SERIES OF 5-AMINOSUBSTITUTED 4-FLUOROBENZYL-8-HYDROXY-[1,6]NAPHTHYRIDINE-7-CARBOXAMIDE HIV-1 INTEGRASE INHIBITORS. Bioorganic & Medical Chemistry Letters 2006, 16(11), 2900-2904.	ECOtherPctMod:>
HIV-1	NL4-3	RT	MT-4		Reverse transcriptase		<	1	uM	100	%	1	uM	WST-8	>	1	uM	>	1	MEASUREMENTS WERE MADE ON DAY 4, 6 AND 8 POST INFECTION	15371436	POLYARGININE INHIBITS GP160 PROCESSING BY FURIN AND SUPPRESSES PRODUCTIVE HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 INFECTION. The Journal of Biological Chemistry 2004, 279(47), 49055-49063.
HIV-1	LAI	RT	HuT 78		Reverse transcriptase		<	1	uM	57.14	%	1	uM	MTT	>	10	uM	>	10	MEASUREMENT WAS MADE ON DAY10 POSTINFECTION AT 10 TCID50	9281520	USE OF HERPES SIMPLEX VIRUS THYMIDINE KINASE TO IMPROVE THE ANTIVIRAL ACTIVITY OF ZIDOVUDINE. Virology 1997, 235, 398-405.

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789855

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value
FC	=	2
FC	=	10
FC	=	3
FC	=	4
FC	=	4
FC	=	2
FC	=	2
FC	=	3
FC	=	2
FC	=	5
FC	=	6
FC	=	10
FC	=	3
FC	=	12
FC	=	6
FC	=	10
FC	=	2
FC	=	7
FC	=	5
FC	=	8

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789854

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
MHC	=	10	ug
MHC	=	50	ug
MHC	=	15	ug
MHC	=	20	ug
MHC	=	20	ug
MHC	=	10	ug
MHC				Not Active
MHC	=	10	ug
MHC	=	15	ug
MHC	=	10	ug
MHC	=	25	ug
MHC	=	30	ug
MHC				Not Active
MHC	=	50	ug
MHC	=	15	ug
MHC				Not Active
MHC	=	60	ug
MHC	=	30	ug
MHC	=	50	ug
MHC	=	10	ug

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789853

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value
FC	=	3.2
FC	=	1
FC	=	3.2
FC	=	3.2
FC	=	3.2
FC	=	3.2
FC	=	1
FC	=	1
FC	=	1
FC	=	2.1
FC	=	1
FC	=	3.2
FC	=	1
FC	=	1
FC	=	2.1
FC	=	3.2
FC	=	2.1
FC	=	1
FC	=	2.1
FC	=	3.2

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789852

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
LD50				Not Active
LD50	=	9	ug
LD50	=	3	ug
LD50				Not Active
LD50	=	9	ug
LD50				Not Active
LD50				Not Active
LD50				Not Active
LD50	=	9	ug
LD50				Not Active
LD50				Not Active
LD50	=	9	ug
LD50				Not Active
LD50	=	9	ug
LD50				Not Active
LD50				Not Active
LD50	=	3	ug
LD50	=	3	ug
LD50	=	3	ug
LD50	=	6	ug

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789859

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
LD50				Not Active
LD50	=	10	ug
LD50				Not Active
LD50				Not Active
LD50	=	10	ug
LD50				Not Active
LD50				Not Active
LD50				Not Active
LD50				Not Active
LD50				Not Active
LD50				Not Active
LD50	=	10	ug
LD50				Not Active
LD50	=	10	ug
LD50				Not Active
LD50				Not Active
LD50				Not Active
LD50				Not Active
LD50	=	8	ug
LD50				Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789858

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value
FC	=	3.75
FC	=	1.25
FC	=	3.75
FC	=	2.5
FC	=	3.75
FC	=	1.25
FC	=	3.75
FC	=	1.25
FC	=	1.25
FC	=	2.5
FC	=	2.5
FC	=	1.25
FC	=	2.5
FC	=	2.5
FC	=	2.5
FC	=	3.75
FC	=	3.75
FC	=	1.25
FC	=	2.5
FC	=	3.75

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789857

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
LD50				Not Active
LD50	=	150	ug
LD50	=	50	ug
LD50				Not Active
LD50	=	150	ug
LD50				Not Active
LD50				Not Active
LD50				Not Active
LD50	=	100	ug
LD50				Not Active
LD50				Not Active
LD50	=	150	ug
LD50	=	50	ug
LD50	=	150	ug
LD50				Not Active
LD50				Not Active
LD50	=	50	ug
LD50	=	50	ug
LD50	=	100	ug
LD50	=	100	ug

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789856

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value
LogP	=	1.24
LogP	=	0.97
LogP	=	2.39
LogP	=	1.15
LogP	=	1.48
LogP	=	1.87
LogP	=	1.76
LogP	=	1.47
LogP	=	1.44
LogP	=	1.15
LogP	=	1.48
LogP	=	1.48
LogP	=	1.47
LogP	=	3.19
LogP	=	1.19
LogP	=	1.47
LogP	=	2
LogP	=	1.15
LogP	=	1.19
LogP	=	1.15

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789863

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789862

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value
FC	=	2
FC	=	2
FC	=	2
FC	=	2
FC	=	1
FC	=	1
FC	=	1
FC	=	1
FC	=	2
FC	=	3
FC	=	1
FC	=	2
FC	=	2
FC	=	1
FC	=	4
FC	=	3
FC	=	1
FC	=	1
FC	=	3
FC	=	2

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789861

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
MHC	=	10	ug
MHC	=	10	ug
MHC	=	10	ug
MHC	=	10	ug
MHC	=	5	ug
MHC	=	5	ug
MHC				Not Active
MHC	=	5	ug
MHC	=	5	ug
MHC	=	10	ug
MHC	=	15	ug
MHC	=	5	ug
MHC	=	10	ug
MHC	=	10	ug
MHC	=	5	ug
MHC				Not Active
MHC	=	20	ug
MHC	=	15	ug
MHC	=	5	ug
MHC	=	5	ug

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789860

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value
FC	=	2
FC	=	2
FC	=	2
FC	=	2
FC	=	1.6
FC	=	1.6
FC	=	2
FC	=	1.6
FC	=	2
FC	=	2
FC	=	2
FC	=	2

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789867

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value	Activity Comment
FC	=	10
FC	=	10
FC	=	8.8
FC			Not Active
FC	=	10
FC	=	2.4
FC			Not Active
FC	=	2

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789866

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789865

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	10	%
Activity	=	10	%
Activity	=	10	%
Activity	=	10	%
Activity	=	10	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789864

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	40	%
Activity	=	40	%
Activity	=	40	%
Activity	=	40	%
Activity	=	40	%
Activity	=	40	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：E3 ubiquitin-protein ligase TRIM33

External ID: CHEMBL4418855

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL2176772
ChEMBL Target Name: E3 ubiquitin-protein ligase TRIM33
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SureChEMBL Patent Bioactivity Data

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.2994	IC50	=	299.4	nM
0.3006	IC50	=	300.6	nM
0.2834	IC50	=	283.4	nM
0.3054	IC50	=	305.4	nM
6.323	IC50	=	6323	nM
50.87	IC50	=	50870	nM
4.69	IC50	=	4690	nM
13.79	IC50	=	13790	nM
16.3	IC50	=	16300	nM
95.59	IC50	=	95590	nM
1.934	IC50	=	1934	nM
20.43	IC50	=	20430	nM
7.172	IC50	=	7172	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Transcription intermediary factor 1-alpha

External ID: CHEMBL4418856

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL3108638
ChEMBL Target Name: Transcription intermediary factor 1-alpha
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SureChEMBL Patent Bioactivity Data

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
0.2213	IC50	=	221.3	nM
0.2197	IC50	=	219.7	nM
0.2252	IC50	=	225.2	nM
0.1802	IC50	=	180.2	nM
0.01107	IC50	=	11.07	nM
45.31	IC50	=	45310	nM
1.96	IC50	=	1960	nM
249	IC50	=	249000	nM	Outside typical range
35.4	IC50	=	35400	nM
1039	IC50	=	1039000	nM	Outside typical range
81.73	IC50	=	81730	nM
283.5	IC50	=	283500	nM	Outside typical range
622.4	IC50	=	622400	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL891104

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 5
First Page: 2006
Last Page: 2015
DOI: 10.1016/j.bmc.2006.12.038

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
39810700	IC50	=	3.981071705535E10	nM	Outside typical range
5750	IC50	=	5750000	nM	Outside typical range
173780000	IC50	=	1.7378008287494E11	nM	Outside typical range
3120	IC50	=	3120000	nM	Outside typical range
323594000	IC50	=	3.2359365692963E11	nM	Outside typical range
50500	IC50	=	50500000	nM	Outside typical range
19952600	IC50	=	1.995262314969E10	nM	Outside typical range
14200	IC50	=	14200000	nM	Outside typical range
70794600	IC50	=	7.079457843841E10	nM	Outside typical range
16250	IC50	=	16250000	nM	Outside typical range
61659500	IC50	=	6.165950018615E10	nM	Outside typical range
5900	IC50	=	5900000	nM	Outside typical range
169824000	IC50	=	1.6982436524617E11	nM	Outside typical range
5550	IC50	=	5550000	nM	Outside typical range
181970000	IC50	=	181970085861	nM	Outside typical range
42880	IC50	=	42880000	nM	Outside typical range
23442300	IC50	=	2.34422881532E10	nM	Outside typical range
13300	IC50	=	13300000	nM	Outside typical range
75857800	IC50	=	7.585775750292E10	nM	Outside typical range
29500	IC50	=	29500000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789851

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value
FC	=	11.2
FC	=	2.6
FC	=	9.8
FC	=	11.2
FC	=	9.8
FC	=	9.8
FC	=	2.6
FC	=	2.6
FC	=	2.6
FC	=	8
FC	=	2.1
FC	=	9.8
FC	=	2.1
FC	=	4.9
FC	=	4.9
FC	=	11.2
FC	=	8
FC	=	2.6
FC	=	8
FC	=	9.8

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789850

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
LD50				Not Active
LD50	=	25	ug
LD50	=	6	ug
LD50				Not Active
LD50	=	22	ug
LD50				Not Active
LD50				Not Active
LD50				Not Active
LD50	=	25	ug
LD50				Not Active
LD50				Not Active
LD50	=	22	ug
LD50				Not Active
LD50	=	22	ug
LD50				Not Active
LD50				Not Active
LD50	=	6	ug
LD50	=	6	ug
LD50	=	6	ug
LD50	=	18	ug

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL905146

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 15
First Page: 5300
Last Page: 5315
DOI: 10.1016/j.bmc.2007.05.011

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
161	IC50	=	161000	nM	Outside typical range
12	IC50	=	12000	nM
35	IC50	>	35000	nM
23	IC50	=	23000	nM
12.5	IC50	>	12500	nM
151	IC50	=	151000	nM	Outside typical range
26	IC50	>	26000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL905147

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 15
First Page: 5300
Last Page: 5315
DOI: 10.1016/j.bmc.2007.05.011

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
3	MIC	=	3000	nM
2	MIC	=	2000	nM
71	MIC	=	71000	nM
33	MIC	=	33000	nM
12.5	MIC	>	12500	nM
52	MIC	=	52000	nM
26	MIC	>	26000	nM

Standard Type	Standard Relation	Standard Value
FC	=	2
FC	=	10
FC	=	3
FC	=	4
FC	=	4
FC	=	2
FC	=	2
FC	=	3
FC	=	2
FC	=	5
FC	=	6
FC	=	10
FC	=	3
FC	=	12
FC	=	6
FC	=	10
FC	=	2
FC	=	7
FC	=	5
FC	=	8

Standard Type	Standard Relation	Standard Value
FC	=	3.2
FC	=	1
FC	=	3.2
FC	=	3.2
FC	=	3.2
FC	=	3.2
FC	=	1
FC	=	1
FC	=	1
FC	=	2.1
FC	=	1
FC	=	3.2
FC	=	1
FC	=	1
FC	=	2.1
FC	=	3.2
FC	=	2.1
FC	=	1
FC	=	2.1
FC	=	3.2

Standard Type	Standard Relation	Standard Value
FC	=	2
FC	=	2
FC	=	2
FC	=	2
FC	=	1
FC	=	1
FC	=	1
FC	=	1
FC	=	2
FC	=	3
FC	=	1
FC	=	2
FC	=	2
FC	=	1
FC	=	4
FC	=	3
FC	=	1
FC	=	1
FC	=	3
FC	=	2

Standard Type	Standard Relation	Standard Value
FC	=	2
FC	=	10
FC	=	3
FC	=	4
FC	=	4
FC	=	2
FC	=	2
FC	=	3
FC	=	2
FC	=	5
FC	=	6
FC	=	10
FC	=	3
FC	=	12
FC	=	6
FC	=	10
FC	=	2
FC	=	7
FC	=	5
FC	=	8

Standard Type	Standard Relation	Standard Value
FC	=	3.2
FC	=	1
FC	=	3.2
FC	=	3.2
FC	=	3.2
FC	=	3.2
FC	=	1
FC	=	1
FC	=	1
FC	=	2.1
FC	=	1
FC	=	3.2
FC	=	1
FC	=	1
FC	=	2.1
FC	=	3.2
FC	=	2.1
FC	=	1
FC	=	2.1
FC	=	3.2

Standard Type	Standard Relation	Standard Value
FC	=	2
FC	=	2
FC	=	2
FC	=	2
FC	=	1
FC	=	1
FC	=	1
FC	=	1
FC	=	2
FC	=	3
FC	=	1
FC	=	2
FC	=	2
FC	=	1
FC	=	4
FC	=	3
FC	=	1
FC	=	1
FC	=	3
FC	=	2

673-22-3 靶点实验数据

Standard Type	Standard Relation	Standard Value
FC	=	2
FC	=	10
FC	=	3
FC	=	4
FC	=	4
FC	=	2
FC	=	2
FC	=	3
FC	=	2
FC	=	5
FC	=	6
FC	=	10
FC	=	3
FC	=	12
FC	=	6
FC	=	10
FC	=	2
FC	=	7
FC	=	5
FC	=	8

Standard Type	Standard Relation	Standard Value
FC	=	3.2
FC	=	1
FC	=	3.2
FC	=	3.2
FC	=	3.2
FC	=	3.2
FC	=	1
FC	=	1
FC	=	1
FC	=	2.1
FC	=	1
FC	=	3.2
FC	=	1
FC	=	1
FC	=	2.1
FC	=	3.2
FC	=	2.1
FC	=	1
FC	=	2.1
FC	=	3.2

Standard Type	Standard Relation	Standard Value
FC	=	2
FC	=	2
FC	=	2
FC	=	2
FC	=	1
FC	=	1
FC	=	1
FC	=	1
FC	=	2
FC	=	3
FC	=	1
FC	=	2
FC	=	2
FC	=	1
FC	=	4
FC	=	3
FC	=	1
FC	=	1
FC	=	3
FC	=	2