前往化源商城

672-13-9 靶点实验数据

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源：ChEMBL 靶标：N/A
External ID: CHEMBL3789851
Protocol: N/A
Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008
Standard TypeStandard RelationStandard Value
FC=11.2
FC=2.6
FC=9.8
FC=11.2
FC=9.8
FC=9.8
FC=2.6
FC=2.6
FC=2.6
FC=8
FC=2.1
FC=9.8
FC=2.1
FC=4.9
FC=4.9
FC=11.2
FC=8
FC=2.6
FC=8
FC=9.8
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源：ChEMBL 靶标：N/A
External ID: CHEMBL3789850
Protocol: N/A
Comment: Journal: Eur J Med Chem
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008
Standard TypeStandard RelationStandard ValueStandard UnitsActivity Comment
LD50Not Active
LD50=25ug
LD50=6ug
LD50Not Active
LD50=22ug
LD50Not Active
LD50Not Active
LD50Not Active
LD50=25ug
LD50Not Active
LD50Not Active
LD50=22ug
LD50Not Active
LD50=22ug
LD50Not Active
LD50Not Active
LD50=6ug
LD50=6ug
LD50=6ug
LD50=18ug
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源：ChEMBL 靶标：N/A
External ID: CHEMBL3789855
Protocol: N/A
Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008
Standard TypeStandard RelationStandard Value
FC=2
FC=10
FC=3
FC=4
FC=4
FC=2
FC=2
FC=3
FC=2
FC=5
FC=6
FC=10
FC=3
FC=12
FC=6
FC=10
FC=2
FC=7
FC=5
FC=8
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源：ChEMBL 靶标：N/A
External ID: CHEMBL3789854
Protocol: N/A
Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008
Standard TypeStandard RelationStandard ValueStandard UnitsActivity Comment
MHC=10ug
MHC=50ug
MHC=15ug
MHC=20ug
MHC=20ug
MHC=10ug
MHCNot Active
MHC=10ug
MHC=15ug
MHC=10ug
MHC=25ug
MHC=30ug
MHCNot Active
MHC=50ug
MHC=15ug
MHCNot Active
MHC=60ug
MHC=30ug
MHC=50ug
MHC=10ug
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源：ChEMBL 靶标：N/A
External ID: CHEMBL3789853
Protocol: N/A
Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008
Standard TypeStandard RelationStandard Value
FC=3.2
FC=1
FC=3.2
FC=3.2
FC=3.2
FC=3.2
FC=1
FC=1
FC=1
FC=2.1
FC=1
FC=3.2
FC=1
FC=1
FC=2.1
FC=3.2
FC=2.1
FC=1
FC=2.1
FC=3.2
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源：ChEMBL 靶标：N/A
External ID: CHEMBL3789852
Protocol: N/A
Comment: Journal: Eur J Med Chem
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008
Standard TypeStandard RelationStandard ValueStandard UnitsActivity Comment
LD50Not Active
LD50=9ug
LD50=3ug
LD50Not Active
LD50=9ug
LD50Not Active
LD50Not Active
LD50Not Active
LD50=9ug
LD50Not Active
LD50Not Active
LD50=9ug
LD50Not Active
LD50=9ug
LD50Not Active
LD50Not Active
LD50=3ug
LD50=3ug
LD50=3ug
LD50=6ug
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源：ChEMBL 靶标：N/A
External ID: CHEMBL3789859
Protocol: N/A
Comment: Journal: Eur J Med Chem
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008
Standard TypeStandard RelationStandard ValueStandard UnitsActivity Comment
LD50Not Active
LD50=10ug
LD50Not Active
LD50Not Active
LD50=10ug
LD50Not Active
LD50Not Active
LD50Not Active
LD50Not Active
LD50Not Active
LD50Not Active
LD50=10ug
LD50Not Active
LD50=10ug
LD50Not Active
LD50Not Active
LD50Not Active
LD50Not Active
LD50=8ug
LD50Not Active
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源：BindingDB 靶标：N/A
External ID: BindingDB_3284_1
Protocol: N/A
Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.
Standard TypePubChem Standard ValueIC50Target Accession(s)LigandTarget
IC500.0440O75460BDBM110972Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.0880O75460BDBM110974Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.1100O75460BDBM110975Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.11110O75460BDBM110976Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.17170O75460BDBM110978Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.24240O75460BDBM110980Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.24240O75460BDBM110981Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.25250O75460BDBM110982Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.27270O75460BDBM110983Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.3300O75460BDBM110985Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.35350O75460BDBM110986Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.38380O75460BDBM110987Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.38380O75460BDBM110988Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.39390O75460BDBM110989Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.4400O75460BDBM110990Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.4400O75460BDBM110991Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.4400O75460BDBM110992Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.41410O75460BDBM110993Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.44440O75460BDBM110994Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.51510O75460BDBM110995Serine/threonine-protein kinase/endoribonuclease IRE1
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源：ChEMBL 靶标：N/A
External ID: CHEMBL3789858
Protocol: N/A
Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008
Standard TypeStandard RelationStandard Value
FC=3.75
FC=1.25
FC=3.75
FC=2.5
FC=3.75
FC=1.25
FC=3.75
FC=1.25
FC=1.25
FC=2.5
FC=2.5
FC=1.25
FC=2.5
FC=2.5
FC=2.5
FC=3.75
FC=3.75
FC=1.25
FC=2.5
FC=3.75
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源：BindingDB 靶标：N/A
External ID: BindingDB_6134_1
Protocol: N/A
Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.
Standard TypeStandard RelationPubChem Standard ValueIC50 QualifierIC50Target Accession(s)LigandTarget
IC500.03434O75460BDBM110972Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.07979O75460BDBM110973Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.0880O75460BDBM110974Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.1100O75460BDBM110975Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.0880O75460BDBM110975Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.11110O75460BDBM110976Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.12120O75460BDBM110977Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.17170O75460BDBM110978Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.102102O75460BDBM110979Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.102102O75460BDBM110979Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.24240O75460BDBM110980Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.24240O75460BDBM110981Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.25250O75460BDBM110982Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.27270O75460BDBM110983Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.02222O75460BDBM110983Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.28280O75460BDBM110984Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.3300O75460BDBM110985Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.772772O75460BDBM110985Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.35350O75460BDBM110986Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.38380O75460BDBM110987Serine/threonine-protein kinase/endoribonuclease IRE1
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源：ChEMBL 靶标：N/A
External ID: CHEMBL3789857
Protocol: N/A
Comment: Journal: Eur J Med Chem
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008
Standard TypeStandard RelationStandard ValueStandard UnitsActivity Comment
LD50Not Active
LD50=150ug
LD50=50ug
LD50Not Active
LD50=150ug
LD50Not Active
LD50Not Active
LD50Not Active
LD50=100ug
LD50Not Active
LD50Not Active
LD50=150ug
LD50=50ug
LD50=150ug
LD50Not Active
LD50Not Active
LD50=50ug
LD50=50ug
LD50=100ug
LD50=100ug
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源：ChEMBL 靶标：N/A
External ID: CHEMBL3789856
Protocol: N/A
Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008
Standard TypeStandard RelationStandard Value
LogP=1.24
LogP=0.97
LogP=2.39
LogP=1.15
LogP=1.48
LogP=1.87
LogP=1.76
LogP=1.47
LogP=1.44
LogP=1.15
LogP=1.48
LogP=1.48
LogP=1.47
LogP=3.19
LogP=1.19
LogP=1.47
LogP=2
LogP=1.15
LogP=1.19
LogP=1.15
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源：ChEMBL 靶标：N/A
External ID: CHEMBL3789862
Protocol: N/A
Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008
Standard TypeStandard RelationStandard Value
FC=2
FC=2
FC=2
FC=2
FC=1
FC=1
FC=1
FC=1
FC=2
FC=3
FC=1
FC=2
FC=2
FC=1
FC=4
FC=3
FC=1
FC=1
FC=3
FC=2
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源：ChEMBL 靶标：N/A
External ID: CHEMBL3789861
Protocol: N/A
Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008
Standard TypeStandard RelationStandard ValueStandard UnitsActivity Comment
MHC=10ug
MHC=10ug
MHC=10ug
MHC=10ug
MHC=5ug
MHC=5ug
MHCNot Active
MHC=5ug
MHC=5ug
MHC=10ug
MHC=15ug
MHC=5ug
MHC=10ug
MHC=10ug
MHC=5ug
MHCNot Active
MHC=20ug
MHC=15ug
MHC=5ug
MHC=5ug
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源：ChEMBL 靶标：N/A
External ID: CHEMBL3789860
Protocol: N/A
Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008
Standard TypeStandard RelationStandard Value
FC=2
FC=2
FC=2
FC=2
FC=1.6
FC=1.6
FC=2
FC=1.6
FC=2
FC=2
FC=2
FC=2
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源：BindingDB 靶标：N/A
External ID: BindingDB_7561_1
Protocol: N/A
Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.
Standard TypeStandard RelationPubChem Standard ValueIC50 QualifierIC50Target Accession(s)LigandTarget
IC500.03434O75460BDBM110972Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.07979O75460BDBM110973Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.0880O75460BDBM110974Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.1100O75460BDBM110975Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.0880O75460BDBM110975Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.11110O75460BDBM110976Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.17170O75460BDBM110978Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.17170O75460BDBM110979Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.102102O75460BDBM110979Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.24240O75460BDBM110980Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.24240O75460BDBM110981Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.25250O75460BDBM110982Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.27270O75460BDBM110983Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.02222O75460BDBM110983Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.28280O75460BDBM110984Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.3300O75460BDBM110985Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.772772O75460BDBM110985Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.35350O75460BDBM110986Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.38380O75460BDBM110987Serine/threonine-protein kinase/endoribonuclease IRE1
IC500.38380O75460BDBM110988Serine/threonine-protein kinase/endoribonuclease IRE1

首页 |  期刊大全 |  MSDS查询 |  化工产品分类 |  生物活性化合物 |  关于我们 |  免责声明:知识产权问题请联系 service1@chemsrc.com
Copyright © 2026 ChemSrc All Rights Reserved