HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL838353

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2000
Volume: 43
Issue: 15
First Page: 2814
Last Page: 2823
DOI: 10.1021/jm990321p

Standard Type	Standard Relation	Standard Value
Selectivity	=	0.07
Selectivity	=	19
Selectivity	>	59
Selectivity	=	21
Selectivity	=	0.13
Selectivity	=	0.07
Selectivity	=	6.7
Selectivity	=	3.1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL838352

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2000
Volume: 43
Issue: 15
First Page: 2814
Last Page: 2823
DOI: 10.1021/jm990321p

Standard Type	Standard Relation	Standard Value
Selectivity	=	87
Selectivity	=	1660
Selectivity	>	10
Selectivity	>	2440
Selectivity	=	14000
Selectivity	=	20
Selectivity	=	88
Selectivity	=	323
Selectivity	=	3.5

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL838351

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2000
Volume: 43
Issue: 15
First Page: 2814
Last Page: 2823
DOI: 10.1021/jm990321p

Standard Type	Standard Relation	Standard Value
Selectivity	=	1300
Selectivity	=	87
Selectivity	>	10
Selectivity	=	41
Selectivity	=	670
Selectivity	=	150
Selectivity	=	1250
Selectivity	=	48
Selectivity	=	1.1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Adenosine receptor A3

External ID: CHEMBL642211

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2000
Volume: 43
Issue: 15
First Page: 2814
Last Page: 2823
DOI: 10.1021/jm990321p

Target ChEMBL ID: CHEMBL3360
ChEMBL Target Name: Adenosine A3 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10	Ki	>	10000	nM
10	Ki	>	10000	nM
10	Ki	>	10000	nM
4.6	Ki	=	4600	nM
10	Ki	>	10000	nM
0.049	Ki	=	49	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Adenosine receptor A1

External ID: CHEMBL638717

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2000
Volume: 43
Issue: 15
First Page: 2814
Last Page: 2823
DOI: 10.1021/jm990321p

Target ChEMBL ID: CHEMBL4975
ChEMBL Target Name: Adenosine A1 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.017	Ki	=	17	nM
1.2	Ki	=	1200	nM
0.011	Ki	=	11	nM
0.0099	Ki	=	9.9	nM
0.014	Ki	=	14	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL849972

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2004
Volume: 47
Issue: 12
First Page: 3019
Last Page: 3031
DOI: 10.1021/jm030977p

Standard Type	Standard Relation	Standard Value
Ratio	=	0.0056
Ratio	=	87
Ratio	>	10
Ratio	=	41
Ratio	=	670
Ratio	=	19
Ratio	=
Ratio	>	1.4
Ratio	=	800

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Adenosine receptor A1

External ID: CHEMBL643493

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2004
Volume: 47
Issue: 12
First Page: 3019
Last Page: 3031
DOI: 10.1021/jm030977p

Target ChEMBL ID: CHEMBL226
ChEMBL Target Name: Adenosine A1 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
2	Ki	=	2000	nM
0.56	Ki	=	560	nM
10	Ki	>	10000	nM
0.49	Ki	=	490	nM
3.1	Ki	=	3100	nM
10	Ki	>	10000	nM
10	Ki	>	10000	nM
4	Ki	=	4000	nM
7.5	Ki	=	7500	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Adenosine receptor A2a

External ID: CHEMBL642332

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2004
Volume: 47
Issue: 12
First Page: 3019
Last Page: 3031
DOI: 10.1021/jm030977p

Target ChEMBL ID: CHEMBL251
ChEMBL Target Name: Adenosine A2a receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.21	Ki	=	210	nM
0.49	Ki	=	490	nM
4.8	Ki	=	4800	nM
0.04	Ki	=	40	nM
0.64	Ki	=	640	nM
10	Ki	>	10000	nM
1.8	Ki	=	1800	nM
1.3	Ki	=	1300	nM
10	Ki	>	10000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Adenosine receptor A1

External ID: CHEMBL920042

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2005
Volume: 48
Issue: 23
First Page: 7172
Last Page: 7185
DOI: 10.1021/jm050407k

Target ChEMBL ID: CHEMBL226
ChEMBL Target Name: Adenosine A1 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.01	Ki	=	10	nM
1	Ki	=	1000	nM
0.03162	Ki	=	31.62	nM
0.02512	Ki	=	25.12	nM
0.005012	Ki	=	5.012	nM
7.94328	Ki	=	7943.28	nM
1.99526	Ki	=	1995.26	nM
6.31E-4	Ki	=	0.631	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Adenosine receptors; A1 & A2

External ID: CHEMBL849976

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2004
Volume: 47
Issue: 12
First Page: 3019
Last Page: 3031
DOI: 10.1021/jm030977p

Target ChEMBL ID: CHEMBL2096679
ChEMBL Target Name: Adenosine receptors; A1 & A2
ChEMBL Target Type: SELECTIVITY GROUP - Target is a pair of proteins for which the selectivity has been assessed
Relationship Type: H - Homologous protein target assigned
Confidence: Multiple homologous protein targets may be assigned

Standard Type	Standard Relation	Standard Value
Ratio	=	0.007
Ratio	=	1.3
Ratio	=	1.9
Ratio	=	1.5
Ratio	=	0.66
Ratio	<	0.75
Ratio	<	0.18
Ratio	=	21.5

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Adenosine receptor A1

External ID: CHEMBL638724

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2004
Volume: 47
Issue: 12
First Page: 3019
Last Page: 3031
DOI: 10.1021/jm030977p

Target ChEMBL ID: CHEMBL4975
ChEMBL Target Name: Adenosine A1 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.017	Ki	=	17	nM
0.028	Ki	=	28	nM
0.026	Ki	=	26	nM
0.011	Ki	=	11	nM
0.0099	Ki	=	9.9	nM
10	Ki	>	10000	nM
7	Ki	=	7000	nM
0.023	Ki	=	23	nM
0.0072	Ki	=	7.2	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Adenosine receptor A2a

External ID: CHEMBL639492

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2004
Volume: 47
Issue: 12
First Page: 3019
Last Page: 3031
DOI: 10.1021/jm030977p

Target ChEMBL ID: CHEMBL251
ChEMBL Target Name: Adenosine A2a receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.42	Ki	=	420	nM
0.83	Ki	=	830	nM
1.9	Ki	=	1900	nM
0.47	Ki	=	470	nM
0.46	Ki	=	460	nM
10	Ki	>	10000	nM
0.23	Ki	=	230	nM
10	Ki	>	10000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Adenosine receptor A2a

External ID: CHEMBL642117

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2000
Volume: 43
Issue: 15
First Page: 2814
Last Page: 2823
DOI: 10.1021/jm990321p

Target ChEMBL ID: CHEMBL251
ChEMBL Target Name: Adenosine A2a receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.42	Ki	=	420	nM
10	Ki	>	10000	nM
1.9	Ki	=	1900	nM
0.47	Ki	=	470	nM
0.46	Ki	=	460	nM
0.016	Ki	=	16	nM

67159-08-4 靶点实验数据