HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Saccharomyces cerevisiae

External ID: CHEMBL4156747

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2018
Volume: 156
First Page: 711
Last Page: 721
DOI: 10.1016/j.ejmech.2018.07.037

Target ChEMBL ID: CHEMBL361
ChEMBL Target Name: Saccharomyces cerevisiae
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
GI	Non-Toxic
GI	Non-Toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Saccharomyces cerevisiae

External ID: CHEMBL4156748

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2018
Volume: 156
First Page: 711
Last Page: 721
DOI: 10.1016/j.ejmech.2018.07.037

Target ChEMBL ID: CHEMBL361
ChEMBL Target Name: Saccharomyces cerevisiae
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
GI	Non-Toxic
GI	Non-Toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Saccharomyces cerevisiae

External ID: CHEMBL4156749

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2018
Volume: 156
First Page: 711
Last Page: 721
DOI: 10.1016/j.ejmech.2018.07.037

Target ChEMBL ID: CHEMBL361
ChEMBL Target Name: Saccharomyces cerevisiae
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
GI	Non-Toxic
GI	Non-Toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Polyphenol oxidase 2

External ID: CHEMBL3396786

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2015
Volume: 25
Issue: 4
First Page: 799
Last Page: 802
DOI: 10.1016/j.bmcl.2014.12.082

Target ChEMBL ID: CHEMBL3318
ChEMBL Target Name: Tyrosinase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
	IC50				Not Active
	IC50				Not Active
	IC50				Not Active
	IC50				Not Active
	IC50				Not Active
	IC50				Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HCT-116

External ID: CHEMBL4156727

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2018
Volume: 156
First Page: 711
Last Page: 721
DOI: 10.1016/j.ejmech.2018.07.037

Target ChEMBL ID: CHEMBL394
ChEMBL Target Name: HCT-116
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
4.4	IC50	=	4400	nM
3.5	IC50	=	3500	nM
14	IC50	=	14000	nM
3.2	IC50	=	3200	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL3396787

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2015
Volume: 25
Issue: 4
First Page: 799
Last Page: 802
DOI: 10.1016/j.bmcl.2014.12.082

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
	IC50				Not Determined
31.6	IC50	=	31600	nM
6.9	IC50	=	6900	nM
	Inhibition			%	Dose-dependent effect
3.8	IC50	=	3800	nM
3	IC50	=	3000	nM
9.9	IC50	=	9900	nM
2.7	IC50	=	2700	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cellular tumor antigen p53

External ID: CHEMBL4156745

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2018
Volume: 156
First Page: 711
Last Page: 721
DOI: 10.1016/j.ejmech.2018.07.037

Target ChEMBL ID: CHEMBL1907611
ChEMBL Target Name: Tumour suppressor p53/oncoprotein Mdm2
ChEMBL Target Type: PROTEIN-PROTEIN INTERACTION - Target is the disruption of a protein-protein interaction
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Standard Type	Standard Units	Activity Comment
Inhibition	%	Active
Inhibition	%	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：RAW264.7

External ID: CHEMBL4768636

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2020
Volume: 193
First Page: 112216
Last Page: 112216
DOI: 10.1016/j.ejmech.2020.112216

Target ChEMBL ID: CHEMBL612557
ChEMBL Target Name: RAW264.7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	54.6	%
Inhibition	=	80.6	%
Inhibition	=	70	%
Inhibition	=	79.5	%
Inhibition	=	78.7	%
Inhibition	=	66.8	%
Inhibition	=	82.5	%
Inhibition	=	70.6	%
Inhibition	=	77.4	%
Inhibition	=	67.6	%
Inhibition	=	73.7	%
Inhibition	=	78	%
Inhibition	=	84	%
Inhibition	=	78.4	%

64200-22-2 靶点实验数据