HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL3370017

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2014
Volume: 24
Issue: 15
First Page: 3596
Last Page: 3599
DOI: 10.1016/j.bmcl.2014.05.032

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
42.6	IC50	=	42600	nM
38.8	IC50	=	38800	nM
44.6	IC50	=	44600	nM
47.7	IC50	=	47700	nM
39.3	IC50	=	39300	nM
28.6	IC50	=	28600	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：RAW264.7

External ID: CHEMBL3370016

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2014
Volume: 24
Issue: 15
First Page: 3596
Last Page: 3599
DOI: 10.1016/j.bmcl.2014.05.032

Target ChEMBL ID: CHEMBL612557
ChEMBL Target Name: RAW264.7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
39.2	IC50	=	39200	nM
38.5	IC50	=	38500	nM
46	IC50	=	46000	nM
48.7	IC50	=	48700	nM
39.2	IC50	=	39200	nM
27.8	IC50	=	27800	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3367633

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 15
First Page: 3596
Last Page: 3599
DOI: 10.1016/j.bmcl.2014.05.032

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	88.27	%
Activity	=	87.72	%
Activity	=	83.51	%
Activity	=	92.08	%
Activity	=	90.13	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：RAW264.7

External ID: CHEMBL3367632

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 15
First Page: 3596
Last Page: 3599
DOI: 10.1016/j.bmcl.2014.05.032

Target ChEMBL ID: CHEMBL612557
ChEMBL Target Name: RAW264.7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	87.3	%
Activity	=	89.6	%
Activity	=	80.35	%
Activity	=	95.2	%
Activity	=	91.29	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：L6

External ID: CHEMBL3294655

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 12
First Page: 2674
Last Page: 2679
DOI: 10.1016/j.bmcl.2014.04.059

Target ChEMBL ID: CHEMBL614793
ChEMBL Target Name: L6
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
5.2	IC50	=	5200	nM
	Activity				Dose-dependent effect
6.2	IC50	=	6200	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：L6

External ID: CHEMBL3294654

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 12
First Page: 2674
Last Page: 2679
DOI: 10.1016/j.bmcl.2014.04.059

Target ChEMBL ID: CHEMBL614793
ChEMBL Target Name: L6
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	26.8	%
Activity	=	112.4	%
Activity	=	173.1	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Solute carrier family 2, facilitated glucose transporter member 4

External ID: CHEMBL3294657

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 12
First Page: 2674
Last Page: 2679
DOI: 10.1016/j.bmcl.2014.04.059

Target ChEMBL ID: CHEMBL3286066
ChEMBL Target Name: Solute carrier family 2, facilitated glucose transporter member 4
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：L6

External ID: CHEMBL3294656

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 12
First Page: 2674
Last Page: 2679
DOI: 10.1016/j.bmcl.2014.04.059

Target ChEMBL ID: CHEMBL614793
ChEMBL Target Name: L6
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Insulin receptor substrate 1

External ID: CHEMBL3294659

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 12
First Page: 2674
Last Page: 2679
DOI: 10.1016/j.bmcl.2014.04.059

Target ChEMBL ID: CHEMBL1163110
ChEMBL Target Name: Insulin receptor substrate 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2044717

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2012
Volume: 75
Issue: 4
First Page: 669
Last Page: 676
DOI: 10.1021/np200910u

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Inhibition	=	17	%
Inhibition				Not Active
Inhibition				Not Active
Inhibition	=	31	%
Inhibition				Not Active
Inhibition				Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Insulin receptor substrate 1

External ID: CHEMBL3294658

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 12
First Page: 2674
Last Page: 2679
DOI: 10.1016/j.bmcl.2014.04.059

Target ChEMBL ID: CHEMBL1163110
ChEMBL Target Name: Insulin receptor substrate 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5'-AMP-activated protein kinase catalytic subunit alpha-1

External ID: CHEMBL3294661

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 12
First Page: 2674
Last Page: 2679
DOI: 10.1016/j.bmcl.2014.04.059

Target ChEMBL ID: CHEMBL4533
ChEMBL Target Name: AMP-activated protein kinase, alpha-1 subunit
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Insulin receptor

External ID: CHEMBL3294660

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 12
First Page: 2674
Last Page: 2679
DOI: 10.1016/j.bmcl.2014.04.059

Target ChEMBL ID: CHEMBL5486
ChEMBL Target Name: Insulin receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HepG2

External ID: CHEMBL3294663

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 12
First Page: 2674
Last Page: 2679
DOI: 10.1016/j.bmcl.2014.04.059

Target ChEMBL ID: CHEMBL395
ChEMBL Target Name: HepG2
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：3T3-L1

External ID: CHEMBL3294662

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 12
First Page: 2674
Last Page: 2679
DOI: 10.1016/j.bmcl.2014.04.059

Target ChEMBL ID: CHEMBL614510
ChEMBL Target Name: 3T3-L1
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2044718

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2012
Volume: 75
Issue: 4
First Page: 669
Last Page: 676
DOI: 10.1021/np200910u

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Inhibition	=	34	%
Inhibition				Not Active
Inhibition				Not Active
Inhibition	=	15	%
Inhibition				Not Active
Inhibition				Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：L6

External ID: CHEMBL3294883

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 12
First Page: 2674
Last Page: 2679
DOI: 10.1016/j.bmcl.2014.04.059

Target ChEMBL ID: CHEMBL614793
ChEMBL Target Name: L6
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active

64181-07-3 靶点实验数据