HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HepG2

External ID: CHEMBL4393571

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2019
Volume: 82
Issue: 6
First Page: 1694
Last Page: 1703
DOI: 10.1021/acs.jnatprod.9b00290

Target ChEMBL ID: CHEMBL395
ChEMBL Target Name: HepG2
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：24642 靶标：ubiquitin specific peptidase 8

External ID: USP8 FAST DUB HTS Primary

Protocol: Deubiquitinases were purified from E. Coli. Ub-Rho substrate was purchased from Boston BioChem (Cat #: U-555). Assay buffer consisted of 50 mM Tris pH 8, 50 mM NaCl, 0.002% Tween20, 5 mM DTT in MilliQ water. Stop buffer consisted of assay buffer + 0.2% trifluoroacetic acid.

Protocol for Inhibitors of USP8: Primary Screen
1.#Compound, 20 nL of screening compounds (final concentration of 20 uM) to columns 1-46 of a Greiner 1536 well Black, flat bottom, polystyrene microplate (Griener 782076) (columns 45-46: DMSO control)
2.#Reagent, 2.5 uL of assay buffer to columns 47-48 on all plates (No enzyme control)
3.#Reagent, 2.5 uL of USP8 in assay buffer (final concentration of 1 nM) to columns 1-46
4.#Reagent, 2.5 uL of Ub-Rho in assay buffer (final concentration of 50 nM) to all wells
5.#Time, Incubate at room temperature for 30 minutes
6.#Detection, Fluorescence, PheraStar, FITC Module

Comment: Normalization of raw data to positive and negative control wells were applied to the data using Helios, a high-throughput screening data analysis program developed at Novartis.(Gubler et al., 2018)

Compounds demonstrating greater than or equal to 30% inhibition of USP8 (USP8_EFFICACY >/= 30) were called as active, compounds demonstrating activity below this threshold were called as inactive.

USP8-Efficacy
46.639
-12.507
31.998
5.438
-6.685
15.21
-15.155
14.048
-4.808
14.043
13.854
55.661
-5.386
27.936
7.845
12.88
0.228
3.333
-3.366
0.283

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：24642 靶标：ubiquitin specific peptidase 17 like family member 5

External ID: USP17 FAST DUB HTS Primary

Protocol: Deubiquitinases were purified from E. Coli. Ub-Rho substrate was purchased from Boston BioChem (Cat #: U-555). Assay buffer consisted of 50 mM Tris pH 8, 50 mM NaCl, 0.002% Tween20, 5 mM DTT in MilliQ water. Stop buffer consisted of assay buffer + 0.2% trifluoroacetic acid.

Protocol for Inhibitors of USP17: Primary Screen
1. Compound, 50 nL of screening compounds (final concentration of 50 uM) to columns 1-46 of a Greiner 1536 well Black, flat bottom, polystyrene microplate (Griener 782076) (columns 45-46: DMSO control)
2. Reagent, 2.5 uL of assay buffer to columns 47-48 on all plates (No enzyme control)
3. Reagent, 2.5 uL of USP17 in assay buffer (final concentration of 1 nM) to columns 1-46
4. Reagent, 2.5 uL of Ub-Rho in assay buffer (final concentration of 40 nM) to all wells
5. Time, Incubate at room temperature for 3 hours
6. Reagent, 2.5 uL of stop buffer to all wells
7. Centrifuge plates (5s, 350 rpm)
8. Detection, Fluorescence, PheraStar, FITC Module

Comment: Normalization of raw data to positive and negative control wells were applied to the data using Helios, a high-throughput screening data analysis program developed at Novartis.(Gubler et al., 2018)

Compounds demonstrating greater than or equal to 30% inhibition of USP17 (USP17_EFFICACY >/= 30) were called as active, compounds demonstrating activity below this threshold were called as inactive.

USP17-Efficacy
-11.703
-22.774
-17.896
1.991
13.524
0.0347
-9.782
55.109
-7.352
14.263
28.858
-17.021
12.515
47.032
7.524
3.661
-9.31
-4.13
17.206
2.868

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：24642 靶标：ubiquitin specific peptidase 7

External ID: USP7 FAST DUB HTS Primary

Protocol: Deubiquitinases were purified from E. Coli. Ub-Rho substrate was purchased from Boston BioChem (Cat #: U-555). Assay buffer consisted of 50 mM Tris pH 8, 50 mM NaCl, 0.002% Tween20, 5 mM DTT in MilliQ water. Stop buffer consisted of assay buffer + 0.2% trifluoroacetic acid.

Protocol for Inhibitors of USP7: Primary Screen
1. Reagent, 2.5 uL of USP7 in assay buffer (final concentration of 4 nM) to columns 1-46 of a Greiner 1536 well Black, flat bottom, polystyrene microplate (Griener 782076)
2. Compound, 20 nL of screening compounds (final concentration of 20 uM) to columns 1-46 (columns 45-46: DMSO control)
3. Reagent, 2.5 uL of assay buffer to columns 47-48 on all plates (No enzyme control)
4. Time, Incubate at room temperature for 60 minutes
5. Reagent, 2.5 uL of Ub-Rho in assay buffer (final concentration of 40 nM) to all wells
6. Time, Incubate at room temperature for 10 minutes
7. Detection, Fluorescence, PheraStar, FITC Module

Comment: Normalization of raw data to positive and negative control wells were applied to the data using Helios, a high-throughput screening data analysis program developed at Novartis.(Gubler et al., 2018)

Compounds demonstrating greater than or equal to 30% inhibition of USP7 (USP7_EFFICACY >/= 30) were called as active, compounds demonstrating activity below this threshold were called as inactive.

USP7_EFFICACY
-0.801
-6.934
-7.543
2.861
2.363
-17.749
-0.834
-2.389
0.879
0.233
2.8
-8.773
-0.815
-0.271
7.414
-5.634
0.496
3.06
-13.572
5.477

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL3866812

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2016
Volume: 79
Issue: 8
First Page: 2022
Last Page: 2031
DOI: 10.1021/acs.jnatprod.6b00327

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type
Activity

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HepG2

External ID: CHEMBL4393568

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2019
Volume: 82
Issue: 6
First Page: 1694
Last Page: 1703
DOI: 10.1021/acs.jnatprod.9b00290

Target ChEMBL ID: CHEMBL395
ChEMBL Target Name: HepG2
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
%max	=	72	%
%max	=	64.9	%
%max	=	15.2	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Vascular endothelial growth factor receptor 2

External ID: CHEMBL962872

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 6
First Page: 972
Last Page: 980
DOI: 10.1021/np070447m

Target ChEMBL ID: CHEMBL279
ChEMBL Target Name: Vascular endothelial growth factor receptor 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	=	5.1	ug.mL-1
IC50	=	0.92	ug.mL-1
IC50	=	1.1	ug.mL-1
IC50	=	0.64	ug.mL-1
IC50	=	5	ug.mL-1
IC50	>	10	ug.mL-1
IC50	=	1.4	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：RAC-alpha serine/threonine-protein kinase

External ID: CHEMBL966174

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 6
First Page: 972
Last Page: 980
DOI: 10.1021/np070447m

Target ChEMBL ID: CHEMBL4282
ChEMBL Target Name: Serine/threonine-protein kinase AKT
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	>	10	ug.mL-1
IC50	>	10	ug.mL-1
IC50	=	7.9	ug.mL-1
IC50	=	5.3	ug.mL-1
IC50	>	10	ug.mL-1
IC50	>	10	ug.mL-1
IC50	>	10	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Xanthomonas euvesicatoria

External ID: CHEMBL3866788

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2016
Volume: 79
Issue: 8
First Page: 2022
Last Page: 2031
DOI: 10.1021/acs.jnatprod.6b00327

Target ChEMBL ID: CHEMBL613184
ChEMBL Target Name: Xanthomonas euvesicatoria
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
MIC	=	25	ug.mL-1
IC50	=	4.9	ug.mL-1
MIC	=	10	ug.mL-1
IC50	=	2.6	ug.mL-1
MIC	>	200	ug.mL-1
IC50				Not Determined
MIC	>	200	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NUAK family SNF1-like kinase 1

External ID: CHEMBL966175

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 6
First Page: 972
Last Page: 980
DOI: 10.1021/np070447m

Target ChEMBL ID: CHEMBL5784
ChEMBL Target Name: NUAK family SNF1-like kinase 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	=	4	ug.mL-1
IC50	=	0.95	ug.mL-1
IC50	=	4	ug.mL-1
IC50	=	0.35	ug.mL-1
IC50	=	6.6	ug.mL-1
IC50	>	10	ug.mL-1
IC50	=	2.2	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Vascular endothelial growth factor receptor 3

External ID: CHEMBL962873

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 6
First Page: 972
Last Page: 980
DOI: 10.1021/np070447m

Target ChEMBL ID: CHEMBL1955
ChEMBL Target Name: Vascular endothelial growth factor receptor 3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	=	3.7	ug.mL-1
IC50	=	1.3	ug.mL-1
IC50	=	0.96	ug.mL-1
IC50	=	0.39	ug.mL-1
IC50	>	10	ug.mL-1
IC50	>	10	ug.mL-1
IC50	=	2.8	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Insulin-like growth factor 1 receptor

External ID: CHEMBL962870

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 6
First Page: 972
Last Page: 980
DOI: 10.1021/np070447m

Target ChEMBL ID: CHEMBL1957
ChEMBL Target Name: Insulin-like growth factor I receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	=	3.6	ug.mL-1
IC50	=	3.4	ug.mL-1
IC50	=	1.7	ug.mL-1
IC50	=	0.91	ug.mL-1
IC50	=	4.9	ug.mL-1
IC50	>	10	ug.mL-1
IC50	=	1.7	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：L5178Y

External ID: CHEMBL966172

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 6
First Page: 972
Last Page: 980
DOI: 10.1021/np070447m

Target ChEMBL ID: CHEMBL614720
ChEMBL Target Name: L5178Y
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
EC50	=	1.7	ug.mL-1
EC50	=	7.8	ug.mL-1
EC50	=	6.8	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Proto-oncogene tyrosine-protein kinase Src

External ID: CHEMBL962871

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 6
First Page: 972
Last Page: 980
DOI: 10.1021/np070447m

Target ChEMBL ID: CHEMBL267
ChEMBL Target Name: Tyrosine-protein kinase SRC
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	=	4.6	ug.mL-1
IC50	=	4.4	ug.mL-1
IC50	=	1.2	ug.mL-1
IC50	=	1.4	ug.mL-1
IC50	=	8.3	ug.mL-1
IC50	>	10	ug.mL-1
IC50	=	2.1	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：L5178Y

External ID: CHEMBL966173

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 6
First Page: 972
Last Page: 980
DOI: 10.1021/np070447m

Target ChEMBL ID: CHEMBL614720
ChEMBL Target Name: L5178Y
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	101.2	%
Activity	=	95	%
Activity	=	3.7	%
Activity	=	1.8	%
Activity	=	89	%
Activity	=	47.1	%
Activity	=	1.2	%
Activity	=	11.8	%
Activity	=	77.3	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Receptor tyrosine-protein kinase erbB-2

External ID: CHEMBL962868

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 6
First Page: 972
Last Page: 980
DOI: 10.1021/np070447m

Target ChEMBL ID: CHEMBL1824
ChEMBL Target Name: Receptor protein-tyrosine kinase erbB-2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	>	10	ug.mL-1
IC50	=	9.4	ug.mL-1
IC50	=	4.5	ug.mL-1
IC50	=	2.7	ug.mL-1
IC50	>	10	ug.mL-1
IC50	>	10	ug.mL-1
IC50	>	10	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bacillus subtilis

External ID: CHEMBL3866784

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2016
Volume: 79
Issue: 8
First Page: 2022
Last Page: 2031
DOI: 10.1021/acs.jnatprod.6b00327

Target ChEMBL ID: CHEMBL359
ChEMBL Target Name: Bacillus subtilis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	=	7	ug.mL-1
MIC	=	50	ug.mL-1
IC50	=	1.4	ug.mL-1
MIC	=	5	ug.mL-1
MIC	>	200	ug.mL-1
IC50	=	21.6	ug.mL-1
MIC	=	50	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Focal adhesion kinase 1

External ID: CHEMBL962869

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 6
First Page: 972
Last Page: 980
DOI: 10.1021/np070447m

Target ChEMBL ID: CHEMBL2695
ChEMBL Target Name: Focal adhesion kinase 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	>	10	ug.mL-1
IC50	=	2.4	ug.mL-1
IC50	=	8.9	ug.mL-1
IC50	=	4.9	ug.mL-1
IC50	>	10	ug.mL-1
IC50	>	10	ug.mL-1
IC50	=	7.3	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Pseudomonas amygdali pv. lachrymans

External ID: CHEMBL3866785

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2016
Volume: 79
Issue: 8
First Page: 2022
Last Page: 2031
DOI: 10.1021/acs.jnatprod.6b00327

Target ChEMBL ID: CHEMBL2366843
ChEMBL Target Name: Pseudomonas amygdali pv. lachrymans
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
MIC	=	25	ug.mL-1
IC50	=	3.5	ug.mL-1
MIC	=	7.5	ug.mL-1
IC50	=	2.3	ug.mL-1
MIC	>	200	ug.mL-1
IC50				Not Determined
MIC	>	200	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Epidermal growth factor receptor

External ID: CHEMBL962866

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 6
First Page: 972
Last Page: 980
DOI: 10.1021/np070447m

Target ChEMBL ID: CHEMBL203
ChEMBL Target Name: Epidermal growth factor receptor erbB1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	=	6.5	ug.mL-1
IC50	=	5.5	ug.mL-1
IC50	=	1.7	ug.mL-1
IC50	=	1.1	ug.mL-1
IC50	=	9.8	ug.mL-1
IC50	>	10	ug.mL-1
IC50	=	3.5	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL3866786

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2016
Volume: 79
Issue: 8
First Page: 2022
Last Page: 2031
DOI: 10.1021/acs.jnatprod.6b00327

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
MIC	=	25	ug.mL-1
IC50	=	5.5	ug.mL-1
MIC	=	5	ug.mL-1
IC50	=	1.2	ug.mL-1
MIC	>	200	ug.mL-1
IC50				Not Determined
MIC	>	200	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Ephrin type-B receptor 4

External ID: CHEMBL962867

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 6
First Page: 972
Last Page: 980
DOI: 10.1021/np070447m

Target ChEMBL ID: CHEMBL5147
ChEMBL Target Name: Ephrin type-B receptor 4
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	>	10	ug.mL-1
IC50	>	10	ug.mL-1
IC50	=	1.4	ug.mL-1
IC50	=	2.1	ug.mL-1
IC50	=	9.4	ug.mL-1
IC50	>	10	ug.mL-1
IC50	=	8.9	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Staphylococcus haemolyticus

External ID: CHEMBL3866787

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2016
Volume: 79
Issue: 8
First Page: 2022
Last Page: 2031
DOI: 10.1021/acs.jnatprod.6b00327

Target ChEMBL ID: CHEMBL612507
ChEMBL Target Name: Staphylococcus haemolyticus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
MIC	=	50	ug.mL-1
IC50	=	7.9	ug.mL-1
MIC	=	5	ug.mL-1
IC50	=	1.4	ug.mL-1
MIC	>	200	ug.mL-1
IC50				Not Determined
MIC	>	200	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HT-29

External ID: CHEMBL4119185

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Nat Prod
Year: 2017
Volume: 80
Issue: 5
First Page: 1397
Last Page: 1403
DOI: 10.1021/acs.jnatprod.6b01069

Target ChEMBL ID: CHEMBL384
ChEMBL Target Name: HT-29
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
6.4	IC50	=	6400	nM
14.1	IC50	=	14100	nM
20	IC50	>	20000	nM
0.0014	IC50	=	1.4	nM
20	IC50	>	20000	nM
20	IC50	>	20000	nM
20	IC50	>	20000	nM
20	IC50	>	20000	nM
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined
20	IC50	>	20000	nM
	IC50				Not Determined
20	IC50	>	20000	nM
	IC50				Not Determined
	IC50				Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Serine/threonine-protein kinase PLK4

External ID: CHEMBL966209

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 6
First Page: 972
Last Page: 980
DOI: 10.1021/np070447m

Target ChEMBL ID: CHEMBL3788
ChEMBL Target Name: Serine/threonine-protein kinase PLK4
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	=	2.5	ug.mL-1
IC50	=	0.96	ug.mL-1
IC50	=	2.5	ug.mL-1
IC50	=	0.83	ug.mL-1
IC50	=	3.2	ug.mL-1
IC50	>	10	ug.mL-1
IC50	=	1.7	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL3866796

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Nat Prod
Year: 2016
Volume: 79
Issue: 8
First Page: 2022
Last Page: 2031
DOI: 10.1021/acs.jnatprod.6b00327

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10	IC50	>	10000	nM
10	IC50	>	10000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Angiopoietin-1 receptor

External ID: CHEMBL965366

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 6
First Page: 972
Last Page: 980
DOI: 10.1021/np070447m

Target ChEMBL ID: CHEMBL4128
ChEMBL Target Name: Tyrosine-protein kinase TIE-2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	>	10	ug.mL-1
IC50	=	7	ug.mL-1
IC50	=	3.5	ug.mL-1
IC50	=	1.4	ug.mL-1
IC50	=	9.8	ug.mL-1
IC50	>	10	ug.mL-1
IC50	=	8.8	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL3866797

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Nat Prod
Year: 2016
Volume: 79
Issue: 8
First Page: 2022
Last Page: 2031
DOI: 10.1021/acs.jnatprod.6b00327

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10	IC50	>	10000	nM
10	IC50	>	10000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Serine/threonine-protein kinase PLK1

External ID: CHEMBL962878

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 6
First Page: 972
Last Page: 980
DOI: 10.1021/np070447m

Target ChEMBL ID: CHEMBL3024
ChEMBL Target Name: Serine/threonine-protein kinase PLK1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	>	10	ug.mL-1
IC50	=	6.9	ug.mL-1
IC50	=	8.2	ug.mL-1
IC50	=	5.7	ug.mL-1
IC50	=	7.1	ug.mL-1
IC50	>	10	ug.mL-1
IC50	>	10	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 4

External ID: CHEMBL966180

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 6
First Page: 972
Last Page: 980
DOI: 10.1021/np070447m

Target ChEMBL ID: CHEMBL1907601
ChEMBL Target Name: Cyclin-dependent kinase 4/cyclin D1
ChEMBL Target Type: PROTEIN COMPLEX - Target is a defined protein complex, consisting of multiple subunits
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous protein complex subunits assigned

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	>	10	ug.mL-1
IC50	=	2.4	ug.mL-1
IC50	=	2.1	ug.mL-1
IC50	=	1.7	ug.mL-1
IC50	=	4.5	ug.mL-1
IC50	>	10	ug.mL-1
IC50	=	6.4	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL3866798

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Nat Prod
Year: 2016
Volume: 79
Issue: 8
First Page: 2022
Last Page: 2031
DOI: 10.1021/acs.jnatprod.6b00327

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10	IC50	>	10000	nM
10	IC50	>	10000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MCF7

External ID: CHEMBL4119184

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Nat Prod
Year: 2017
Volume: 80
Issue: 5
First Page: 1397
Last Page: 1403
DOI: 10.1021/acs.jnatprod.6b01069

Target ChEMBL ID: CHEMBL387
ChEMBL Target Name: MCF7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
17.1	IC50	=	17100	nM
5.7	IC50	=	5700	nM
20	IC50	>	20000	nM
	IC50				Not Determined
20	IC50	>	20000	nM
20	IC50	>	20000	nM
20	IC50	>	20000	nM
20	IC50	>	20000	nM
	IC50				Not Determined
9.7	IC50	=	9700	nM
	IC50				Not Determined
20	IC50	>	20000	nM
14.9	IC50	=	14900	nM
20	IC50	>	20000	nM
20	IC50	>	20000	nM
20	IC50	>	20000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Casein kinase II subunit alpha

External ID: CHEMBL962879

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 6
First Page: 972
Last Page: 980
DOI: 10.1021/np070447m

Target ChEMBL ID: CHEMBL3629
ChEMBL Target Name: Casein kinase II alpha
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	>	10	ug.mL-1
IC50	=	2	ug.mL-1
IC50	>	10	ug.mL-1
IC50	>	10	ug.mL-1
IC50	>	10	ug.mL-1
IC50	>	10	ug.mL-1
IC50	>	10	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mitogen-activated protein kinase kinase kinase 8

External ID: CHEMBL966181

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 6
First Page: 972
Last Page: 980
DOI: 10.1021/np070447m

Target ChEMBL ID: CHEMBL4899
ChEMBL Target Name: Mitogen-activated protein kinase kinase kinase 8
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	>	10	ug.mL-1
IC50	=	8	ug.mL-1
IC50	=	2.6	ug.mL-1
IC50	=	2.3	ug.mL-1
IC50	=	8.8	ug.mL-1
IC50	>	10	ug.mL-1
IC50	=	5.5	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL3866799

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Nat Prod
Year: 2016
Volume: 79
Issue: 8
First Page: 2022
Last Page: 2031
DOI: 10.1021/acs.jnatprod.6b00327

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10	IC50	>	10000	nM
10	IC50	>	10000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Serine/threonine-protein kinase B-raf

External ID: CHEMBL966178

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2008
Volume: 71
Issue: 6
First Page: 972
Last Page: 980
DOI: 10.1021/np070447m

Target ChEMBL ID: CHEMBL5145
ChEMBL Target Name: Serine/threonine-protein kinase B-raf
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	=	9	ug.mL-1
IC50	=	1.6	ug.mL-1
IC50	=	4.8	ug.mL-1
IC50	=	1.5	ug.mL-1
IC50	=	3.3	ug.mL-1
IC50	>	10	ug.mL-1
IC50	=	6.7	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Hepatocyte growth factor receptor

External ID: CHEMBL962876

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 6
First Page: 972
Last Page: 980
DOI: 10.1021/np070447m

Target ChEMBL ID: CHEMBL3717
ChEMBL Target Name: Hepatocyte growth factor receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	=	9.4	ug.mL-1
IC50	=	5.4	ug.mL-1
IC50	>	10	ug.mL-1
IC50	=	1.7	ug.mL-1
IC50	=	4.3	ug.mL-1
IC50	>	10	ug.mL-1
IC50	=	7	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 2

External ID: CHEMBL966179

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 6
First Page: 972
Last Page: 980
DOI: 10.1021/np070447m

Target ChEMBL ID: CHEMBL301
ChEMBL Target Name: Cyclin-dependent kinase 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	>	10	ug.mL-1
IC50	=	3.3	ug.mL-1
IC50	=	3.6	ug.mL-1
IC50	=	2.4	ug.mL-1
IC50	>	10	ug.mL-1
IC50	>	10	ug.mL-1
IC50	>	10	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Platelet-derived growth factor receptor beta

External ID: CHEMBL962877

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 6
First Page: 972
Last Page: 980
DOI: 10.1021/np070447m

Target ChEMBL ID: CHEMBL1913
ChEMBL Target Name: Platelet-derived growth factor receptor beta
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	>	10	ug.mL-1
IC50	=	0.89	ug.mL-1
IC50	=	1.8	ug.mL-1
IC50	=	1.8	ug.mL-1
IC50	=	5.9	ug.mL-1
IC50	>	10	ug.mL-1
IC50	=	7.6	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Pyricularia oryzae

External ID: CHEMBL3866793

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2016
Volume: 79
Issue: 8
First Page: 2022
Last Page: 2031
DOI: 10.1021/acs.jnatprod.6b00327

Target ChEMBL ID: CHEMBL612925
ChEMBL Target Name: Pyricularia oryzae
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
IC50	=	6.9	ug.mL-1
IC50	>	200	ug.mL-1	Outside typical range
IC50	>	200	ug.mL-1	Outside typical range
IC50	=	12	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Aurora kinase A

External ID: CHEMBL966176

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 6
First Page: 972
Last Page: 980
DOI: 10.1021/np070447m

Target ChEMBL ID: CHEMBL4722
ChEMBL Target Name: Serine/threonine-protein kinase Aurora-A
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	=	4.4	ug.mL-1
IC50	=	0.73	ug.mL-1
IC50	=	5	ug.mL-1
IC50	=	1.5	ug.mL-1
IC50	=	1.8	ug.mL-1
IC50	>	10	ug.mL-1
IC50	=	1.7	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Receptor-type tyrosine-protein kinase FLT3

External ID: CHEMBL962874

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 6
First Page: 972
Last Page: 980
DOI: 10.1021/np070447m

Target ChEMBL ID: CHEMBL1974
ChEMBL Target Name: Tyrosine-protein kinase receptor FLT3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	=	6.6	ug.mL-1
IC50	=	0.43	ug.mL-1
IC50	=	1	ug.mL-1
IC50	=	0.53	ug.mL-1
IC50	=	1.6	ug.mL-1
IC50	>	10	ug.mL-1
IC50	=	0.66	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Aurora kinase B

External ID: CHEMBL966177

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 6
First Page: 972
Last Page: 980
DOI: 10.1021/np070447m

Target ChEMBL ID: CHEMBL2185
ChEMBL Target Name: Serine/threonine-protein kinase Aurora-B
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	=	3	ug.mL-1
IC50	=	0.42	ug.mL-1
IC50	=	1.3	ug.mL-1
IC50	=	1.1	ug.mL-1
IC50	=	1.1	ug.mL-1
IC50	>	10	ug.mL-1
IC50	=	0.98	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Insulin receptor

External ID: CHEMBL962875

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 6
First Page: 972
Last Page: 980
DOI: 10.1021/np070447m

Target ChEMBL ID: CHEMBL1981
ChEMBL Target Name: Insulin receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	=	8.1	ug.mL-1
IC50	=	2.1	ug.mL-1
IC50	=	7.9	ug.mL-1
IC50	=	1.3	ug.mL-1
IC50	=	5.6	ug.mL-1
IC50	>	10	ug.mL-1
IC50	=	9.4	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL3866795

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Nat Prod
Year: 2016
Volume: 79
Issue: 8
First Page: 2022
Last Page: 2031
DOI: 10.1021/acs.jnatprod.6b00327

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
50	IC50	>	50000	nM
37.3	IC50	=	37300	nM
50	IC50	>	50000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：RAW264.7

External ID: CHEMBL5048029

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Nat Prod
Year: 2022
Volume: 85
Issue: 1.0
First Page: 162
Last Page: 168
DOI: 10.1021/acs.jnatprod.1c00900

Target ChEMBL ID: CHEMBL612557
ChEMBL Target Name: RAW264.7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
39.1	IC50	=	39100	nM
22.2	IC50	=	22200	nM
46.1	IC50	=	46100	nM
35.1	IC50	=	35100	nM
43.3	IC50	=	43300	nM
22.4	IC50	=	22400	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Vascular endothelial growth factor receptor 2

External ID: CHEMBL965369

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 6
First Page: 972
Last Page: 980
DOI: 10.1021/np070447m

Target ChEMBL ID: CHEMBL279
ChEMBL Target Name: Vascular endothelial growth factor receptor 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	=	1	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Receptor-type tyrosine-protein kinase FLT3

External ID: CHEMBL965370

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 6
First Page: 972
Last Page: 980
DOI: 10.1021/np070447m

Target ChEMBL ID: CHEMBL1974
ChEMBL Target Name: Tyrosine-protein kinase receptor FLT3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	=	1	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Aurora kinase B

External ID: CHEMBL965367

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 6
First Page: 972
Last Page: 980
DOI: 10.1021/np070447m

Target ChEMBL ID: CHEMBL2185
ChEMBL Target Name: Serine/threonine-protein kinase Aurora-B
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	=	1	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Insulin-like growth factor 1 receptor

External ID: CHEMBL965368

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 6
First Page: 972
Last Page: 980
DOI: 10.1021/np070447m

Target ChEMBL ID: CHEMBL1957
ChEMBL Target Name: Insulin-like growth factor I receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	=	1	ug.mL-1

641-38-3 靶点实验数据