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64090-98-8 靶点实验数据

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Large neutral amino acids transporter small subunit 1
External ID: CHEMBL4234829
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2018
Volume: 61
Issue: 16
First Page: 7358
Last Page: 7373
DOI: 10.1021/acs.jmedchem.8b01007

Target ChEMBL ID: CHEMBL4459
ChEMBL Target Name: L-type amino acid transporter 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
68IC50=68000nM
69IC50=69000nM
85IC50=85000nM
160IC50=160000nMOutside typical range
6.6IC50=6600nM
380IC50=380000nMOutside typical range
460IC50=460000nMOutside typical range
200IC50=200000nMOutside typical range
260IC50=260000nMOutside typical range
46IC50=46000nM
380IC50=380000nMOutside typical range
220IC50=220000nMOutside typical range
50000IC50>50000000nMOutside typical range
130IC50=130000nMOutside typical range
190IC50=190000nMOutside typical range
140IC50=140000nMOutside typical range
120IC50=120000nMOutside typical range
7.3IC50=7300nM
36IC50=36000nM
130IC50=130000nMOutside typical range
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Large neutral amino acids transporter small subunit 1
External ID: CHEMBL4386799
Protocol: N/A
Comment: Journal: Bioorg Med Chem Lett
Year: 2019
Volume: 29
Issue: 16
First Page: 2254
Last Page: 2258
DOI: 10.1016/j.bmcl.2019.06.033

Target ChEMBL ID: CHEMBL4459
ChEMBL Target Name: L-type amino acid transporter 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
Standard TypeStandard RelationStandard ValueStandard Units
Activity=140%
Activity=59%
Activity=28%
Activity=85%
Activity=81%
Activity=89%
Activity=130%
Activity=140%
Activity=82%
Activity=100%
Activity=63%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Large neutral amino acids transporter small subunit 1
External ID: CHEMBL4386800
Protocol: N/A
Comment: Journal: Bioorg Med Chem Lett
Year: 2019
Volume: 29
Issue: 16
First Page: 2254
Last Page: 2258
DOI: 10.1016/j.bmcl.2019.06.033

Target ChEMBL ID: CHEMBL4459
ChEMBL Target Name: L-type amino acid transporter 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
Standard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
Inhibition=92%
Inhibition=85%
Inhibition=79%
Inhibition=49%
Inhibition=70%
Inhibition=74%
Inhibition=99%
Inhibition=98%
Inhibition=84%
Inhibition=58%
Inhibition=59%
Inhibition=20%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Large neutral amino acids transporter small subunit 1
External ID: CHEMBL4386801
Protocol: N/A
Comment: Journal: Bioorg Med Chem Lett
Year: 2019
Volume: 29
Issue: 16
First Page: 2254
Last Page: 2258
DOI: 10.1016/j.bmcl.2019.06.033

Target ChEMBL ID: CHEMBL4459
ChEMBL Target Name: L-type amino acid transporter 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsActivity CommentData Validity Comment
190IC50=190000nMOutside typical range
170IC50=170000nMOutside typical range
100IC50=100000nM
69IC50=69000nM
160IC50=160000nMOutside typical range
1000IC50>1000000nMOutside typical range
IC50Not Determined
160IC50=160000nMOutside typical range
IC50Not Determined
1000IC50>1000000nMOutside typical range
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Large neutral amino acids transporter small subunit 1
External ID: CHEMBL4234831
Protocol: N/A
Comment: Journal: J Med Chem
Year: 2018
Volume: 61
Issue: 16
First Page: 7358
Last Page: 7373
DOI: 10.1021/acs.jmedchem.8b01007

Target ChEMBL ID: CHEMBL4459
ChEMBL Target Name: L-type amino acid transporter 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
Standard TypeStandard RelationStandard ValueStandard Units
Activity=33%
Activity=27%
Activity=140%
Activity=29%
Activity=89%
Activity=100%
Activity=96%
Activity=100%
Activity=120%
Activity=59%
Activity=29%
Activity=81%
Activity=78%
Activity=120%
Activity=130%
Activity=96%
Activity=28%
Activity=27%
Activity=85%
Activity=70%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Large neutral amino acids transporter small subunit 1
External ID: CHEMBL4234830
Protocol: N/A
Comment: Journal: J Med Chem
Year: 2018
Volume: 61
Issue: 16
First Page: 7358
Last Page: 7373
DOI: 10.1021/acs.jmedchem.8b01007

Target ChEMBL ID: CHEMBL4459
ChEMBL Target Name: L-type amino acid transporter 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
Standard TypeStandard RelationStandard ValueStandard Units
Inhibition=-2.1%
Inhibition=4.2%
Inhibition=92%
Inhibition=33%
Inhibition=43%
Inhibition=68%
Inhibition=85%
Inhibition=73%
Inhibition=79%
Inhibition=98%
Inhibition=29%
Inhibition=33%
Inhibition=32%
Inhibition=42%
Inhibition=74%
Inhibition=49%
Inhibition=-2.4%
Inhibition=35%
Inhibition=67%
Inhibition=86%