HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cannabinoid receptor 1

External ID: CHEMBL959186

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2009
Volume: 17
Issue: 7
First Page: 2842
Last Page: 2851
DOI: 10.1016/j.bmc.2009.02.027

Target ChEMBL ID: CHEMBL3571
ChEMBL Target Name: Cannabinoid CB1 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
4.19	Ki	=	4190	nM
10	Ki	>	10000	nM
10	Ki	>	10000	nM
10	Ki	>	10000	nM
10	Ki	>=	10000	nM
3.46	Ki	=	3460	nM
9.14	Ki	=	9140	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cannabinoid receptor 1

External ID: CHEMBL959187

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2009
Volume: 17
Issue: 7
First Page: 2842
Last Page: 2851
DOI: 10.1016/j.bmc.2009.02.027

Target ChEMBL ID: CHEMBL3571
ChEMBL Target Name: Cannabinoid CB1 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	18	%
Activity	=	10	%
Activity	=	15	%
Activity	=	1	%
Activity	=	6	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：G-protein coupled receptor 55

External ID: CHEMBL2388878

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2013
Volume: 56
Issue: 11
First Page: 4798
Last Page: 4810
DOI: 10.1021/jm4005175

Target ChEMBL ID: CHEMBL1075322
ChEMBL Target Name: G-protein coupled receptor 55
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10	IC50	>	10000	nM
10	IC50	>	10000	nM
10	IC50	>	10000	nM
10	IC50	>	10000	nM
6.74	IC50	=	6740	nM
5.33	IC50	=	5330	nM
10	IC50	>	10000	nM
10	IC50	>	10000	nM
0.854	IC50	=	854	nM
10	IC50	>	10000	nM
1.77	IC50	=	1770	nM
10	IC50	>	10000	nM
3.76	IC50	=	3760	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：G-protein coupled receptor 55

External ID: CHEMBL2388877

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2013
Volume: 56
Issue: 11
First Page: 4798
Last Page: 4810
DOI: 10.1021/jm4005175

Target ChEMBL ID: CHEMBL1075322
ChEMBL Target Name: G-protein coupled receptor 55
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	28	%
Activity	=	28	%
Activity	=	13	%
Activity	=	25	%
Activity	=	7	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cannabinoid receptor 2

External ID: CHEMBL959188

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2009
Volume: 17
Issue: 7
First Page: 2842
Last Page: 2851
DOI: 10.1016/j.bmc.2009.02.027

Target ChEMBL ID: CHEMBL253
ChEMBL Target Name: Cannabinoid CB2 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10	Ki	>=	10000	nM
2.06	Ki	=	2060	nM
10	Ki	>=	10000	nM
10	Ki	>=	10000	nM
10	Ki	>=	10000	nM
10	Ki	>=	10000	nM
4.76	Ki	=	4760	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：G-protein coupled receptor 55

External ID: CHEMBL2388865

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2013
Volume: 56
Issue: 11
First Page: 4798
Last Page: 4810
DOI: 10.1021/jm4005175

Target ChEMBL ID: CHEMBL1075322
ChEMBL Target Name: G-protein coupled receptor 55
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cannabinoid receptor 2

External ID: CHEMBL959189

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2009
Volume: 17
Issue: 7
First Page: 2842
Last Page: 2851
DOI: 10.1016/j.bmc.2009.02.027

Target ChEMBL ID: CHEMBL253
ChEMBL Target Name: Cannabinoid CB2 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	28	%
Activity	=	2	%
Activity	=	7	%
Activity	=	2	%
Activity	=	4	%

62399-35-3 靶点实验数据