HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL738554

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1990
Volume: 33
Issue: 1
First Page: 360
Last Page: 370
DOI: 10.1021/jm00163a058

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	20	%
Inhibition	=	58	%
Inhibition	=	25	%
Inhibition	=	50	%
Inhibition	=	82	%
Inhibition	=	66	%
Inhibition	=	79	%
Inhibition	=	21	%
Inhibition	=	16	%
Inhibition	=	59	%
Inhibition	=	30	%
Inhibition	=	67	%
Inhibition	=	73	%
Inhibition	=	59	%
Inhibition	=	45	%
Inhibition	=	32	%
Inhibition	=	0	%
Inhibition	=	69	%
Inhibition	=	44	%
Inhibition	=	84	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Polyunsaturated fatty acid 5-lipoxygenase

External ID: CHEMBL3074514

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Med Chem Res
Year: 2013
Volume: 22
Issue: 11
First Page: 5390
Last Page: 5407
DOI: 10.1007/s00044-013-0499-2

Target ChEMBL ID: CHEMBL312
ChEMBL Target Name: Arachidonate 5-lipoxygenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.068	IC50	=	68	nM
0.011	IC50	=	11	nM
0.057	IC50	=	57	nM
0.12	IC50	=	120	nM
0.07	IC50	=	70	nM
0.056	IC50	=	56	nM
0.14	IC50	=	140	nM
48	IC50	=	48000	nM
40	IC50	=	40000	nM
0.14	IC50	=	140	nM
0.18	IC50	=	180	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Polyunsaturated fatty acid 5-lipoxygenase

External ID: CHEMBL619406

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1990
Volume: 33
Issue: 1
First Page: 360
Last Page: 370
DOI: 10.1021/jm00163a058

Target ChEMBL ID: CHEMBL312
ChEMBL Target Name: Arachidonate 5-lipoxygenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.019	IC50	=	19	nM
0.13	IC50	=	130	nM
0.088	IC50	=	88	nM
0.068	IC50	=	68	nM
0.011	IC50	=	11	nM
0.57	IC50	=	570	nM
1.7	IC50	=	1700	nM
3.5	IC50	=	3500	nM
0.23	IC50	=	230	nM
3.6	IC50	=	3600	nM
0.12	IC50	=	120	nM
0.07	IC50	=	70	nM
0.16	IC50	=	160	nM
0.056	IC50	=	56	nM
0.14	IC50	=	140	nM
0.82	IC50	=	820	nM
0.077	IC50	=	77	nM
48	IC50	=	48000	nM
40	IC50	=	40000	nM
0.14	IC50	=	140	nM

62085-40-9 靶点实验数据