HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Solute carrier family 22 member 8

External ID: CHEMBL2077561

Protocol: N/A

Comment: Journal: Biochem. Biophys. Res. Commun.
Year: 1999
Volume: 255
Issue: 1
First Page: 508
Last Page: 514
DOI: 10.1006/bbrc.1998.9978

Target ChEMBL ID: CHEMBL1641348
ChEMBL Target Name: Solute carrier family 22 member 8
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Activity Comment
Activity	is not a substrate [-]
Activity	is not a substrate [-]
Activity	is not a substrate [-]

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 9

External ID: CHEMBL838821

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2005
Volume: 15
Issue: 3
First Page: 573
Last Page: 578
DOI: 10.1016/j.bmcl.2004.11.057

Target ChEMBL ID: CHEMBL3594
ChEMBL Target Name: Carbonic anhydrase IX
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
150000	Ki	>	150000000	nM	Outside typical range
7420	Ki	=	7420000	nM	Outside typical range
4930	Ki	=	4930000	nM	Outside typical range
3280	Ki	=	3280000	nM	Outside typical range
150000	Ki	>	150000000	nM	Outside typical range
1270	Ki	=	1270000	nM	Outside typical range
1120	Ki	=	1120000	nM	Outside typical range
150000	Ki	>	150000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 4

External ID: CHEMBL838820

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2005
Volume: 15
Issue: 3
First Page: 573
Last Page: 578
DOI: 10.1016/j.bmcl.2004.11.057

Target ChEMBL ID: CHEMBL3729
ChEMBL Target Name: Carbonic anhydrase IV
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
550	Ki	=	550000	nM	Outside typical range
53.7	Ki	=	53700	nM
0.099	Ki	=	99	nM
0.099	Ki	=	99	nM
74.7	Ki	=	74700	nM
2.8	Ki	=	2800	nM
14.5	Ki	=	14500	nM
1530	Ki	=	1530000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL838819

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2005
Volume: 15
Issue: 3
First Page: 573
Last Page: 578
DOI: 10.1016/j.bmcl.2004.11.057

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
130	Ki	=	130000	nM	Outside typical range
1870	Ki	=	1870000	nM	Outside typical range
2160	Ki	=	2160000	nM	Outside typical range
990	Ki	=	990000	nM	Outside typical range
30	Ki	=	30000	nM
1620	Ki	=	1620000	nM	Outside typical range
2110	Ki	=	2110000	nM	Outside typical range
3220	Ki	=	3220000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1011826

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2009
Volume: 17
Issue: 7
First Page: 2654
Last Page: 2657
DOI: 10.1016/j.bmc.2009.02.058

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
7.3	Ki	=	7300	nM
88.6	Ki	=	88600	nM
67.7	Ki	=	67700	nM
1267	Ki	=	1267000	nM	Outside typical range
793	Ki	=	793000	nM	Outside typical range
787	Ki	=	787000	nM	Outside typical range
404	Ki	=	404000	nM	Outside typical range
42.8	Ki	=	42800	nM
8.7	Ki	=	8700	nM
899	Ki	=	899000	nM	Outside typical range
953	Ki	=	953000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase

External ID: CHEMBL1011827

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2009
Volume: 17
Issue: 7
First Page: 2654
Last Page: 2657
DOI: 10.1016/j.bmc.2009.02.058

Target ChEMBL ID: CHEMBL5337
ChEMBL Target Name: Carbonic anhydrase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
36	Ki	=	36000	nM
39.1	Ki	=	39100	nM
37.7	Ki	=	37700	nM
24.4	Ki	=	24400	nM
26.3	Ki	=	26300	nM
105.7	Ki	=	105700	nM	Outside typical range
51.5	Ki	=	51500	nM
94	Ki	=	94000	nM
8.6	Ki	=	8600	nM
87.7	Ki	=	87700	nM
46.8	Ki	=	46800	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Free fatty acid receptor 3

External ID: CHEMBL3881355

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL3886125
ChEMBL Target Name: Free fatty acid receptor 3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SureChEMBL Patent Bioactivity Data

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
	EC50					Potential missing data
	EC50					Potential missing data
	EC50					Potential missing data
	EC50					Potential missing data
	EC50					Potential missing data
	EC50					Potential missing data
500	EC50	=	500000	nM		Outside typical range
30	EC50	=	30000	nM
	EC50					Potential missing data
1000	EC50	=	1000000	nM		Outside typical range
3000	EC50	=	3000000	nM		Outside typical range
	EC50				Nd(Toxic)
	EC50					Potential missing data
	EC50				Active
5	EC50	=	5000	nM
	EC50					Potential missing data
	EC50					Potential missing data
	EC50					Potential missing data
	EC50				Active
	EC50					Potential missing data

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 1

External ID: CHEMBL830202

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2005
Volume: 15
Issue: 3
First Page: 573
Last Page: 578
DOI: 10.1016/j.bmcl.2004.11.057

Target ChEMBL ID: CHEMBL261
ChEMBL Target Name: Carbonic anhydrase I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Units	Activity Comment
Ki	nM	Activator
Ki	nM	Activator
Ki	nM	Activator
Ki	nM	Activator
Ki	nM	Activator
Ki	nM	Activator
Ki	nM	Activator
Ki	nM	Activator
Ki	nM	Activator
Ki	nM	Activator

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL1011825

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2009
Volume: 17
Issue: 7
First Page: 2654
Last Page: 2657
DOI: 10.1016/j.bmc.2009.02.058

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
130	Ki	=	130000	nM	Outside typical range
2160	Ki	=	2160000	nM	Outside typical range
990	Ki	=	990000	nM	Outside typical range
30	Ki	=	30000	nM
1620	Ki	=	1620000	nM	Outside typical range
2110	Ki	=	2110000	nM	Outside typical range
960	Ki	=	960000	nM	Outside typical range
257	Ki	=	257000	nM	Outside typical range
989	Ki	=	989000	nM	Outside typical range
1870	Ki	=	1870000	nM	Outside typical range
3220	Ki	=	3220000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 5A, mitochondrial

External ID: CHEMBL838571

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2005
Volume: 15
Issue: 3
First Page: 573
Last Page: 578
DOI: 10.1016/j.bmcl.2004.11.057

Target ChEMBL ID: CHEMBL4789
ChEMBL Target Name: Carbonic anhydrase VA
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
25900	Ki	=	25900000	nM	Outside typical range
2490	Ki	=	2490000	nM	Outside typical range
1670	Ki	=	1670000	nM	Outside typical range
2230	Ki	=	2230000	nM	Outside typical range
7010	Ki	=	7010000	nM	Outside typical range
6000	Ki	=	6000000	nM	Outside typical range
5500	Ki	=	5500000	nM	Outside typical range
3370	Ki	=	3370000	nM	Outside typical range

62-76-0 靶点实验数据