HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tyrosine-protein phosphatase non-receptor type 1

External ID: CHEMBL905766

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 20
First Page: 6535
Last Page: 6548
DOI: 10.1016/j.bmc.2007.07.010

Target ChEMBL ID: CHEMBL335
ChEMBL Target Name: Protein-tyrosine phosphatase 1B
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
859	IC50	=	859000	nM	Outside typical range
1180	IC50	=	1180000	nM	Outside typical range
403	IC50	=	403000	nM	Outside typical range
148	IC50	=	148000	nM	Outside typical range
153	IC50	=	153000	nM	Outside typical range
57	IC50	=	57000	nM
1000	IC50	>	1000000	nM	Outside typical range
850	IC50	=	850000	nM	Outside typical range
1000	IC50	>	1000000	nM	Outside typical range
215	IC50	=	215000	nM	Outside typical range
6.5	Ki	=	6500	nM
19	IC50	=	19000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Major histocompatibility complex class I-related gene protein

External ID: CHEMBL5324831

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2023
Volume: 66
Issue: 17
First Page: 12520
Last Page: 12535
DOI: 10.1021/acs.jmedchem.3c01122

Target ChEMBL ID: CHEMBL5465401
ChEMBL Target Name: B2M-MR1
ChEMBL Target Type: PROTEIN COMPLEX - Target is a defined protein complex, consisting of multiple subunits
Relationship Type: D - Direct protein target assigned
Confidence: Direct protein complex subunits assigned

Standard Type	Activity Comment
Activity	Dose-Dependent Effect
Activity	Dose-Dependent Effect
Activity	Dose-Dependent Effect
Activity	Dose-Dependent Effect
Activity	Dose-Dependent Effect
Activity	Dose-Dependent Effect
Activity	Dose-Dependent Effect
Activity	Dose-Dependent Effect

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5324832

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2023
Volume: 66
Issue: 17
First Page: 12520
Last Page: 12535
DOI: 10.1021/acs.jmedchem.3c01122

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active

616-76-2 靶点实验数据