HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL743061

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1982
Volume: 25
Issue: 10
First Page: 1133
Last Page: 1140
DOI: 10.1021/jm00352a007

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Protection	=	5	%
Protection	=	50	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL775310

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1980
Volume: 23
Issue: 8
First Page: 878
Last Page: 884
DOI: 10.1021/jm00182a013

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Activity	=	4

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：D(2) dopamine receptor

External ID: CHEMBL672127

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1982
Volume: 25
Issue: 10
First Page: 1133
Last Page: 1140
DOI: 10.1021/jm00352a007

Target ChEMBL ID: CHEMBL2093868
ChEMBL Target Name: Dopamine receptor
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.18	IC50	=	180	nM
0.172	IC50	=	172	nM
0.02	IC50	=	20	nM
0.199	IC50	=	199	nM
0.075	IC50	=	75	nM
0.011	IC50	=	11	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL738708

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1982
Volume: 25
Issue: 10
First Page: 1133
Last Page: 1140
DOI: 10.1021/jm00352a007

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Protection	=	0	%
Protection	=	65	%
Protection	=	46	%
Protection	=	64	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL775217

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1989
Volume: 32
Issue: 12
First Page: 2573
Last Page: 2582
DOI: 10.1021/jm00132a012

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ED	=	40	mg kg-1
ED	=	10	mg kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M2

External ID: CHEMBL744142

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1989
Volume: 32
Issue: 10
First Page: 2375
Last Page: 2381
DOI: 10.1021/jm00130a025

Target ChEMBL ID: CHEMBL1907609
ChEMBL Target Name: Muscarinic acetylcholine receptor
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: H - Homologous protein target assigned
Confidence: Multiple homologous protein targets may be assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
61	IC50	=	61000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL775219

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1989
Volume: 32
Issue: 12
First Page: 2573
Last Page: 2582
DOI: 10.1021/jm00132a012

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ED	=	30	mg kg-1
ED	=	5	mg kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M2

External ID: CHEMBL744002

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1989
Volume: 32
Issue: 12
First Page: 2573
Last Page: 2582
DOI: 10.1021/jm00132a012

Target ChEMBL ID: CHEMBL1907609
ChEMBL Target Name: Muscarinic acetylcholine receptor
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
1	IC50	>	1000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL779450

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1989
Volume: 32
Issue: 12
First Page: 2573
Last Page: 2582
DOI: 10.1021/jm00132a012

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Activity	=	20

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M2

External ID: CHEMBL746568

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 1982
Volume: 25
Issue: 10
First Page: 1133
Last Page: 1140
DOI: 10.1021/jm00352a007

Target ChEMBL ID: CHEMBL1907609
ChEMBL Target Name: Muscarinic acetylcholine receptor
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.026	IC50	=	26	nM
0.074	IC50	=	74	nM
0.574	IC50	=	574	nM
0.064	IC50	=	64	nM
0.116	IC50	=	116	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL773648

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1980
Volume: 23
Issue: 8
First Page: 878
Last Page: 884
DOI: 10.1021/jm00182a013

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Activity	=	1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：D(2) dopamine receptor

External ID: CHEMBL672047

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1989
Volume: 32
Issue: 12
First Page: 2573
Last Page: 2582
DOI: 10.1021/jm00132a012

Target ChEMBL ID: CHEMBL339
ChEMBL Target Name: Dopamine D2 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.34	IC50	=	340	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL739104

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1980
Volume: 23
Issue: 8
First Page: 878
Last Page: 884
DOI: 10.1021/jm00182a013

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
LD50	=	150	mg.kg-1
LD50	>	100	mg.kg-1
LD50	=	400	mg.kg-1
LD50	=	400	mg.kg-1
LD50	>	200	mg.kg-1
LD50	>	400	mg.kg-1
LD50	=	200	mg.kg-1
LD50	>	200	mg.kg-1
LD50	>	200	mg.kg-1
LD50	>	400	mg.kg-1
LD50	=	150	mg.kg-1
LD50	>	400	mg.kg-1
LD50	>	400	mg.kg-1
LD50	=	200	mg.kg-1
LD50	>	400	mg.kg-1
LD50	=	200	mg.kg-1
LD50	>	800	mg.kg-1
LD50	>	400	mg.kg-1
LD50	>	200	mg.kg-1
LD50	>	400	mg.kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL736898

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1980
Volume: 23
Issue: 8
First Page: 878
Last Page: 884
DOI: 10.1021/jm00182a013

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
EDmin	=	50	mg kg-1
EDmin	=	3	mg kg-1
EDmin	=	25	mg kg-1
EDmin	=	6.25	mg kg-1
EDmin	=	25	mg kg-1
EDmin	=	100	mg kg-1
EDmin	=	3	mg kg-1
EDmin	=	25	mg kg-1
EDmin	=	6.25	mg kg-1
EDmin	>	400	mg kg-1
EDmin	=	25	mg kg-1
EDmin	>	400	mg kg-1
EDmin	=	50	mg kg-1
EDmin	=	25	mg kg-1
EDmin	=	12.5	mg kg-1
EDmin	=	12.5	mg kg-1
EDmin	=	100	mg kg-1
EDmin	>	400	mg kg-1
EDmin	=	12.5	mg kg-1
EDmin	=	200	mg kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL785497

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1989
Volume: 32
Issue: 10
First Page: 2375
Last Page: 2381
DOI: 10.1021/jm00130a025

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
EDmin	=	10	mg kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL736053

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1989
Volume: 32
Issue: 10
First Page: 2375
Last Page: 2381
DOI: 10.1021/jm00130a025

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
EDmin	=	100	mg kg-1
EDmin	=	6.25	mg kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL734446

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1989
Volume: 32
Issue: 12
First Page: 2573
Last Page: 2582
DOI: 10.1021/jm00132a012

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
EDmin	=	100	mg kg-1
EDmin	=	6.25	mg kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL736055

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1989
Volume: 32
Issue: 10
First Page: 2375
Last Page: 2381
DOI: 10.1021/jm00130a025

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
EDmin	=	50	mg kg-1
EDmin	=	1.6	mg kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL737862

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1989
Volume: 32
Issue: 12
First Page: 2573
Last Page: 2582
DOI: 10.1021/jm00132a012

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
EDmin	=	1.6	mg kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL743057

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1982
Volume: 25
Issue: 10
First Page: 1133
Last Page: 1140
DOI: 10.1021/jm00352a007

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Protection	=	67	%
Protection	=	46	%
Protection	=	75	%
Protection	=	33	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL878832

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1989
Volume: 32
Issue: 10
First Page: 2375
Last Page: 2381
DOI: 10.1021/jm00130a025

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
EDmin	=	30	mg kg-1
EDmin	=	5	mg kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：D(2) dopamine receptor

External ID: CHEMBL667093

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1989
Volume: 32
Issue: 10
First Page: 2375
Last Page: 2381
DOI: 10.1021/jm00130a025

Target ChEMBL ID: CHEMBL3998
ChEMBL Target Name: Dopamine D2 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10	IC50	>	10000	nM

61325-80-2 靶点实验数据