HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1641183

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2010
Volume: 45
Issue: 12
First Page: 5635
Last Page: 5645
DOI: 10.1016/j.ejmech.2010.09.016

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	2	%
Activity	=	4	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1641184

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2010
Volume: 45
Issue: 12
First Page: 5635
Last Page: 5645
DOI: 10.1016/j.ejmech.2010.09.016

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	6	%
Activity	=	3	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mitochondrial amidoxime-reducing component 1

External ID: CHEMBL4614164

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 12
First Page: 6538
Last Page: 6546
DOI: 10.1021/acs.jmedchem.9b01483

Target ChEMBL ID: CHEMBL3706559
ChEMBL Target Name: Mitochondrial amidoxime-reducing component 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Activity	=	471.5	nmol/mg.min
Activity	=	9.5	nmol/mg.min
Activity				Bld
Activity	=	499.8	nmol/mg.min
Activity	=	354.7	nmol/mg.min
Activity	=	7.2	nmol/mg.min
Activity				Bld
Activity	=	209.9	nmol/mg.min
Activity				Bld

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1641174

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2010
Volume: 45
Issue: 12
First Page: 5635
Last Page: 5645
DOI: 10.1016/j.ejmech.2010.09.016

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	77	%
Activity	=	8	%
Activity	=	35	%
Activity	=	15	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1641175

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2010
Volume: 45
Issue: 12
First Page: 5635
Last Page: 5645
DOI: 10.1016/j.ejmech.2010.09.016

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	84	%
Activity	=	19	%
Activity	=	57	%
Activity	=	9	%
Activity	=	7	%
Activity	=	21	%
Activity	=	7	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Nitric oxide synthase, inducible

External ID: CHEMBL748041

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2002
Volume: 45
Issue: 4
First Page: 944
Last Page: 954
DOI: 10.1021/jm011006h

Target ChEMBL ID: CHEMBL3464
ChEMBL Target Name: Nitric oxide synthase, inducible
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
NOHA	=	13	%
NOHA	<	0.2	%
NOHA	<	0.2	%
NOHA	<	0.2	%
NOHA	<	0.2	%
NOHA	<	0.2	%
NOHA	<	0.2	%
NOHA	<	0.2	%
NOHA	=	20	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1641177

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2010
Volume: 45
Issue: 12
First Page: 5635
Last Page: 5645
DOI: 10.1016/j.ejmech.2010.09.016

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	91	%
Activity	=	30	%
Activity	=	57	%
Activity	=	18	%
Activity	=	7	%
Activity	=	26	%
Activity	=	15	%
Activity	=	16	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL783918

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 1995
Volume: 5
Issue: 5
First Page: 423
Last Page: 426
DOI: 10.1016/0960-894X(95)00048-X

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0051	Formation of NO2-	=	5.1	nM
0.0046	Formation of NO2-	=	4.6	nM
0.0026	Formation of NO2-	=	2.6	nM
0.079	Formation of NO2-	=	79	nM
0.062	Formation of NO2-	=	62	nM
0.0032	Formation of NO2-	=	3.2	nM
0.002	Formation of NO2-	=	2	nM
0.0286	Formation of NO2-	=	28.6	nM
0.011	Formation of NO2-	=	11	nM
0.0068	Formation of NO2-	=	6.8	nM
0.0025	Formation of NO2-	=	2.5	nM
0.0037	Formation of NO2-	=	3.7	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mitochondrial amidoxime-reducing component 1

External ID: CHEMBL4614174

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 12
First Page: 6538
Last Page: 6546
DOI: 10.1021/acs.jmedchem.9b01483

Target ChEMBL ID: CHEMBL3706559
ChEMBL Target Name: Mitochondrial amidoxime-reducing component 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Activity	=	3.1	nmol/mg.min
Activity				Bld
Activity	=	549.6	nmol/mg.min
Activity	=	354.8	nmol/mg.min
Activity				Bld
Activity	=	239.3	nmol/mg.min

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL783919

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 1995
Volume: 5
Issue: 5
First Page: 423
Last Page: 426
DOI: 10.1016/0960-894X(95)00048-X

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1.0E-4	Formation of NO2-	<	0.1	nM
1.0E-4	Formation of NO2-	<	0.1	nM
7.0E-4	Formation of NO2-	=	0.7	nM
0.0011	Formation of NO2-	=	1.1	nM
9.0E-4	Formation of NO2-	=	0.9	nM
1.0E-4	Formation of NO2-	<	0.1	nM
1.0E-4	Formation of NO2-	<	0.1	nM
1.0E-4	Formation of NO2-	<	0.1	nM
1.0E-4	Formation of NO2-	<	0.1	nM
6.0E-4	Formation of NO2-	=	0.6	nM
2.0E-4	Formation of NO2-	=	0.2	nM
2.0E-4	Formation of NO2-	=	0.2	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mitochondrial amidoxime reducing component 2

External ID: CHEMBL4614179

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 12
First Page: 6538
Last Page: 6546
DOI: 10.1021/acs.jmedchem.9b01483

Target ChEMBL ID: CHEMBL4523423
ChEMBL Target Name: Mitochondrial amidoxime reducing component 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Activity				Bld
Activity				Bld
Activity	=	373.9	nmol/mg.min
Activity	=	184.2	nmol/mg.min
Activity				Bld
Activity				Bld

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mitochondrial amidoxime-reducing component 1

External ID: CHEMBL1014432

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2008
Volume: 51
Issue: 24
First Page: 8173
Last Page: 8177
DOI: 10.1021/jm8010417

Target ChEMBL ID: CHEMBL3706559
ChEMBL Target Name: Mitochondrial amidoxime-reducing component 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	1.3	nmol/min

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mitochondrial amidoxime-reducing component 1

External ID: CHEMBL1014430

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2008
Volume: 51
Issue: 24
First Page: 8173
Last Page: 8177
DOI: 10.1021/jm8010417

Target ChEMBL ID: CHEMBL3706559
ChEMBL Target Name: Mitochondrial amidoxime-reducing component 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	0.2	nmol/min

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Hepacivirus hominis

External ID: CHEMBL2439404

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2013
Volume: 23
Issue: 21
First Page: 5936
Last Page: 5940
DOI: 10.1016/j.bmcl.2013.08.081

Target ChEMBL ID: CHEMBL379
ChEMBL Target Name: Hepatitis C virus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
3	EC50	=	3000	nM
8	EC50	=	8000	nM
2	EC50	=	2000	nM
70	EC50	=	70000	nM
3	EC50	=	3000	nM
12	EC50	=	12000	nM
300	EC50	>	300000	nM	Outside typical range
20	EC50	=	20000	nM
300	EC50	>	300000	nM	Outside typical range
10	EC50	=	10000	nM
35	EC50	=	35000	nM
300	EC50	>	300000	nM	Outside typical range
10	EC50	=	10000	nM
85	EC50	=	85000	nM
3	EC50	=	3000	nM
3	EC50	=	3000	nM
15	EC50	=	15000	nM
300	EC50	>	300000	nM	Outside typical range
12	EC50	=	12000	nM
0.8	EC50	=	800	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mitochondrial amidoxime-reducing component 1

External ID: CHEMBL1014431

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2008
Volume: 51
Issue: 24
First Page: 8173
Last Page: 8177
DOI: 10.1021/jm8010417

Target ChEMBL ID: CHEMBL3706559
ChEMBL Target Name: Mitochondrial amidoxime-reducing component 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	0.23	nmol/min

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mitochondrial amidoxime reducing component 2

External ID: CHEMBL4614169

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 12
First Page: 6538
Last Page: 6546
DOI: 10.1021/acs.jmedchem.9b01483

Target ChEMBL ID: CHEMBL4523423
ChEMBL Target Name: Mitochondrial amidoxime reducing component 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Activity	=	34.4	nmol/mg.min
Activity				Bld
Activity				Bld
Activity	=	394.3	nmol/mg.min
Activity	=	142.1	nmol/mg.min
Activity	=	27.8	nmol/mg.min
Activity				Bld
Activity				Bld
Activity				Bld

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Huh-7

External ID: CHEMBL2439403

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 21
First Page: 5936
Last Page: 5940
DOI: 10.1016/j.bmcl.2013.08.081

Target ChEMBL ID: CHEMBL614039
ChEMBL Target Name: Huh-7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
70	CC50	=	70000	nM
110	CC50	=	110000	nM
25	CC50	=	25000	nM
570	CC50	=	570000	nM
55	CC50	=	55000	nM
180	CC50	=	180000	nM
800	CC50	>	800000	nM
340	CC50	=	340000	nM
800	CC50	>	800000	nM
120	CC50	=	120000	nM
800	CC50	>	800000	nM
800	CC50	>	800000	nM
800	CC50	=	800000	nM
650	CC50	=	650000	nM
270	CC50	=	270000	nM
350	CC50	=	350000	nM
900	CC50	=	900000	nM
800	CC50	>	800000	nM
310	CC50	=	310000	nM
140	CC50	=	140000	nM

613-92-3 靶点实验数据