HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Acetylcholinesterase

External ID: CHEMBL644838

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 1992
Volume: 2
Issue: 8
First Page: 861
Last Page: 864
DOI: 10.1016/S0960-894X(00)80545-4

Target ChEMBL ID: CHEMBL220
ChEMBL Target Name: Acetylcholinesterase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.164	IC50	=	164	nM
0.743	IC50	=	743	nM
0.0018	IC50	=	1.8	nM
0.0315	IC50	=	31.5	nM
0.0094	IC50	=	9.4	nM
0.0689	IC50	=	68.9	nM
0.0422	IC50	=	42.2	nM
1.1	IC50	=	1100	nM
0.0045	IC50	=	4.5	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carboxylic ester hydrolase

External ID: CHEMBL654883

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 1992
Volume: 2
Issue: 8
First Page: 861
Last Page: 864
DOI: 10.1016/S0960-894X(00)80545-4

Target ChEMBL ID: CHEMBL5077
ChEMBL Target Name: Butyrylcholinesterase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0533	IC50	=	53.3	nM
7.0E-4	IC50	=	0.7	nM
0.00793	IC50	=	7.93	nM
0.0013	IC50	=	1.3	nM
0.0127	IC50	=	12.7	nM
0.045	IC50	=	45	nM
0.0153	IC50	=	15.3	nM
0.017	IC50	=	17	nM
0.0217	IC50	=	21.7	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：J774.1

External ID: CHEMBL4057138

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 16
First Page: 4526
Last Page: 4531
DOI: 10.1016/j.bmc.2017.06.051

Target ChEMBL ID: CHEMBL4296442
ChEMBL Target Name: J774.1
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
43.2	IC50	=	43200	nM
41	IC50	=	41000	nM
44.6	IC50	=	44600	nM
1.9	IC50	=	1900	nM
2.8	IC50	=	2800	nM
42.6	IC50	=	42600	nM
44.9	IC50	=	44900	nM
43	IC50	=	43000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4057139

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 16
First Page: 4526
Last Page: 4531
DOI: 10.1016/j.bmc.2017.06.051

Standard Type	Standard Relation	Standard Value
Ratio IC50	=	7283
Ratio IC50	>	6.8
Ratio IC50	=	11.9
Ratio IC50	=	3.6
Ratio IC50	=	3.3
Ratio IC50	=	0.35
Ratio IC50	=	12.9
Ratio IC50	=	2.8

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Acetylcholinesterase

External ID: CHEMBL644101

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2000
Volume: 43
Issue: 10
First Page: 2007
Last Page: 2018
DOI: 10.1021/jm990971t

Target ChEMBL ID: CHEMBL220
ChEMBL Target Name: Acetylcholinesterase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
4.8	IC50	=	4800	nM
0.46	IC50	=	460	nM
0.028	IC50	=	28	nM
0.47	IC50	=	470	nM
0.087	IC50	=	87	nM
0.39	IC50	=	390	nM
0.066	IC50	=	66	nM
0.1	IC50	=	100	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Acetylcholinesterase

External ID: CHEMBL1119333

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur. J. Med. Chem.
Year: 2010
Volume: 45
Issue: 3
First Page: 1167
Last Page: 1172
DOI: 10.1016/j.ejmech.2009.12.038

Target ChEMBL ID: CHEMBL220
ChEMBL Target Name: Acetylcholinesterase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
0.104	IC50	=	104	nM
0.12	IC50	=	120	nM
15	IC50	=	15000	nM
0.17	IC50	=	170	nM
0.56	IC50	=	560	nM
0.46	IC50	=	460	nM
0.028	IC50	=	28	nM
0.47	IC50	=	470	nM
0.087	IC50	=	87	nM
0.39	IC50	=	390	nM
0.1	IC50	=	100	nM
0.0099	IC50	=	9.9	nM
0.0016	IC50	=	1.6	nM
0.064	IC50	=	64	nM
27	IC50	=	27000	nM
166.1	IC50	=	166100	nM	Outside typical range
0.0014	IC50	=	1.4	nM
0.0274	IC50	=	27.4	nM
8.2E-4	IC50	=	0.82	nM
34	IC50	=	34000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_1116_1

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	PubChem Standard Value	IC50	Target Accession(s)	Ligand	Target
IC50	8.1	8100	P22303	BDBM8984	Acetylcholinesterase
IC50	0.1	100	P22303	BDBM8985	Acetylcholinesterase
IC50	0.55	550	P22303	BDBM8986	Acetylcholinesterase
IC50	0.028	28	P22303	BDBM8989	Acetylcholinesterase
IC50	0.087	87	P22303	BDBM8992	Acetylcholinesterase
IC50	5.2	5200	P22303	BDBM8994	Acetylcholinesterase
IC50	3.7	3700	P22303	BDBM8995	Acetylcholinesterase
IC50	0.75	750	P22303	BDBM8996	Acetylcholinesterase
IC50	0.46	460	P22303	BDBM9004	Acetylcholinesterase

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Acetylcholinesterase

External ID: CHEMBL644109

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 1991
Volume: 1
Issue: 8
First Page: 411
Last Page: 414
DOI: 10.1016/S0960-894X(00)80267-X

Target ChEMBL ID: CHEMBL220
ChEMBL Target Name: Acetylcholinesterase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
2.6	IC50	=	2600	nM
0.313	IC50	=	313	nM
0.606	IC50	=	606	nM
0.429	IC50	=	429	nM
1.12	IC50	=	1120	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Acetylcholinesterase

External ID: CHEMBL829154

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2004
Volume: 47
Issue: 18
First Page: 4471
Last Page: 4482
DOI: 10.1021/jm049877p

Target ChEMBL ID: CHEMBL220
ChEMBL Target Name: Acetylcholinesterase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.02818	IC50	=	28.18	nM
8.12831	IC50	=	8128.31	nM
0.46774	IC50	=	467.74	nM
0.0871	IC50	=	87.1	nM
0.1	IC50	=	100	nM
0.01	IC50	=	10	nM
3.01995	IC50	=	3019.95	nM
0.07943	IC50	=	79.43	nM
10	IC50	=	10000	nM
0.50119	IC50	=	501.19	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Acetylcholinesterase

External ID: CHEMBL642726

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 1992
Volume: 2
Issue: 8
First Page: 861
Last Page: 864
DOI: 10.1016/S0960-894X(00)80545-4

Target ChEMBL ID: CHEMBL4078
ChEMBL Target Name: Acetylcholinesterase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.05983	IC50	=	59.83	nM
0.04	IC50	=	40	nM
0.00287	IC50	=	2.87	nM
0.01167	IC50	=	11.67	nM
0.00443	IC50	=	4.43	nM
0.036	IC50	=	36	nM
0.00652	IC50	=	6.52	nM
0.0777	IC50	=	77.7	nM
0.00233	IC50	=	2.33	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Acetylcholinesterase

External ID: CHEMBL829159

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2004
Volume: 47
Issue: 18
First Page: 4471
Last Page: 4482
DOI: 10.1021/jm049877p

Target ChEMBL ID: CHEMBL220
ChEMBL Target Name: Acetylcholinesterase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.03162	IC50	=	31.62	nM
0.009333	IC50	=	9.333	nM
0.06918	IC50	=	69.18	nM
0.04266	IC50	=	42.66	nM
1.09648	IC50	=	1096.48	nM
0.004467	IC50	=	4.467	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Acetylcholinesterase

External ID: CHEMBL638445

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2000
Volume: 43
Issue: 10
First Page: 2007
Last Page: 2018
DOI: 10.1021/jm990971t

Target ChEMBL ID: CHEMBL220
ChEMBL Target Name: Acetylcholinesterase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1.20226	IC50	=	1202.26	nM
0.02818	IC50	=	28.18	nM
3.89045	IC50	=	3890.45	nM
5.12861	IC50	=	5128.61	nM
67.6083	IC50	=	67608.3	nM
4.2658	IC50	=	4265.8	nM
0.38905	IC50	=	389.05	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Trypanosoma brucei brucei

External ID: CHEMBL4057136

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 16
First Page: 4526
Last Page: 4531
DOI: 10.1016/j.bmc.2017.06.051

Target ChEMBL ID: CHEMBL612851
ChEMBL Target Name: Trypanosoma brucei brucei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
17.1	IC50	=	17100	nM
15.1	IC50	=	15100	nM
0.66	IC50	=	660	nM
0.71	IC50	=	710	nM
5.6	IC50	=	5600	nM
18.1	IC50	=	18100	nM
3.5	IC50	=	3500	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL3815691

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2016
Volume: 24
Issue: 16
First Page: 3636
Last Page: 3642
DOI: 10.1016/j.bmc.2016.06.003

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
4.02	IC50	=	4020	nM
2.04	IC50	=	2040	nM
3.23	IC50	=	3230	nM
0.11	IC50	=	110	nM
0.02	IC50	=	20	nM
0.49	IC50	=	490	nM
0.21	IC50	=	210	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Trypanosoma brucei brucei

External ID: CHEMBL4057137

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 16
First Page: 4526
Last Page: 4531
DOI: 10.1016/j.bmc.2017.06.051

Target ChEMBL ID: CHEMBL612851
ChEMBL Target Name: Trypanosoma brucei brucei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
12	IC50	=	12000	nM
12.6	IC50	=	12600	nM
8.6	IC50	=	8600	nM
0.4	IC50	=	400	nM
0.64	IC50	=	640	nM
3.3	IC50	=	3300	nM
15.8	IC50	=	15800	nM
2.6	IC50	=	2600	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3815692

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2016
Volume: 24
Issue: 16
First Page: 3636
Last Page: 3642
DOI: 10.1016/j.bmc.2016.06.003

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
43.2	IC50	=	43200	nM
44.3	IC50	=	44300	nM
44.6	IC50	=	44600	nM
1.9	IC50	=	1900	nM
1.8	IC50	=	1800	nM
42.6	IC50	=	42600	nM
8.4	IC50	=	8400	nM

6115-67-9 靶点实验数据