HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3811632

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 8
First Page: 3920
Last Page: 3934
DOI: 10.1021/acs.jmedchem.6b00134

Standard Type	Standard Relation	Standard Value
Ratio IC50	=	375
Ratio IC50	=	3.5
Ratio IC50	>	25
Ratio IC50	=	45
Ratio IC50	=	5
Ratio IC50	>	10
Ratio IC50	>	10

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Prostaglandin G/H synthase 2

External ID: CHEMBL3811631

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 8
First Page: 3920
Last Page: 3934
DOI: 10.1021/acs.jmedchem.6b00134

Target ChEMBL ID: CHEMBL230
ChEMBL Target Name: Cyclooxygenase-2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10	IC50	=	10000	nM
0.08	IC50	=	80	nM
0.05	IC50	=	50	nM
56	IC50	=	56000	nM
55	IC50	=	55000	nM
2	IC50	=	2000	nM
2	IC50	=	2000	nM
0.1	IC50	=	100	nM
3	IC50	=	3000	nM
22	IC50	=	22000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Prostaglandin G/H synthase 1

External ID: CHEMBL3811630

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 8
First Page: 3920
Last Page: 3934
DOI: 10.1021/acs.jmedchem.6b00134

Target ChEMBL ID: CHEMBL2949
ChEMBL Target Name: Cyclooxygenase-1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10	IC50	>	10000	nM
10	IC50	>	10000	nM
0.3	IC50	=	300	nM
10	IC50	>	10000	nM
10	IC50	>	10000	nM
10	IC50	=	10000	nM
10	IC50	>	10000	nM
8	IC50	=	8000	nM
10	IC50	>	10000	nM
10	IC50	>	10000	nM

60254-83-3 靶点实验数据