HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2A

External ID: CHEMBL2343277

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2013
Volume: 21
Issue: 4
First Page: 856
Last Page: 868
DOI: 10.1016/j.bmc.2012.12.016

Target ChEMBL ID: CHEMBL224
ChEMBL Target Name: Serotonin 2a (5-HT2a) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
	Ki				Not Determined
	Ki				Not Determined
	Ki				Not Determined
	Ki				Not Determined
	Ki				Not Determined
	Ki				Not Determined
	Ki				Not Determined
	Ki				Not Determined
	Ki				Not Determined
0.48	Ki	=	480	nM
	Ki				Not Determined
	Ki				Not Determined
	Ki				Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2A

External ID: CHEMBL2343281

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2013
Volume: 21
Issue: 4
First Page: 856
Last Page: 868
DOI: 10.1016/j.bmc.2012.12.016

Target ChEMBL ID: CHEMBL224
ChEMBL Target Name: Serotonin 2a (5-HT2a) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Inhibition				Not Determined
Inhibition	=	100	%
Inhibition	=	45.6	%
Inhibition	=	46.6	%
Inhibition	=	68.8	%
Inhibition				Not Determined
Inhibition	=	20.9	%
Inhibition	=	40.6	%
Inhibition	=	40.4	%
Inhibition	=	29.7	%
Inhibition	=	49.1	%
Inhibition	=	10.9	%
Inhibition	=	40.5	%
Inhibition	=	38	%
Inhibition	=	59.1	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：D(1A) dopamine receptor

External ID: CHEMBL2343280

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2013
Volume: 21
Issue: 4
First Page: 856
Last Page: 868
DOI: 10.1016/j.bmc.2012.12.016

Target ChEMBL ID: CHEMBL2056
ChEMBL Target Name: Dopamine D1 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
0.231	Ki	=	231	nM
0.0034	Ki	=	3.4	nM
0.05	Ki	=	50	nM
0.443	Ki	=	443	nM
0.022	Ki	=	22	nM
0.0025	Ki	=	2.5	nM
0.0173	Ki	=	17.3	nM
	Ki				Not Determined
0.06	Ki	=	60	nM
5	Ki	>	5000	nM
0.0045	Ki	=	4.5	nM
0.0063	Ki	=	6.3	nM
	Ki				Not Determined
0.53	Ki	=	530	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：D(2) dopamine receptor

External ID: CHEMBL2343279

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2013
Volume: 21
Issue: 4
First Page: 856
Last Page: 868
DOI: 10.1016/j.bmc.2012.12.016

Target ChEMBL ID: CHEMBL217
ChEMBL Target Name: Dopamine D2 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
5	Ki	>	5000	nM
0.011	Ki	=	11	nM
0.305	Ki	=	305	nM
	Ki				Not Determined
0.214	Ki	=	214	nM
	Ki				Not Determined
0.147	Ki	=	147	nM
	Ki				Not Determined
5	Ki	>	5000	nM
	Ki				Not Determined
0.091	Ki	=	91	nM
0.145	Ki	=	145	nM
	Ki				Not Determined
5	Ki	>	5000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 1A

External ID: CHEMBL2343278

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2013
Volume: 21
Issue: 4
First Page: 856
Last Page: 868
DOI: 10.1016/j.bmc.2012.12.016

Target ChEMBL ID: CHEMBL214
ChEMBL Target Name: Serotonin 1a (5-HT1a) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
5	Ki	>	5000	nM
5	Ki	>	5000	nM
0.149	Ki	=	149	nM
	Ki				Not Determined
	Ki				Not Determined
	Ki				Not Determined
5	Ki	>	5000	nM
	Ki				Not Determined
5	Ki	>	5000	nM
	Ki				Not Determined
	Ki				Not Determined
0.908	Ki	=	908	nM
	Ki				Not Determined
	Ki				Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：D(1A) dopamine receptor

External ID: CHEMBL2343284

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2013
Volume: 21
Issue: 4
First Page: 856
Last Page: 868
DOI: 10.1016/j.bmc.2012.12.016

Target ChEMBL ID: CHEMBL2056
ChEMBL Target Name: Dopamine D1 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Inhibition				Not Determined
Inhibition				Not Determined
Inhibition	=	99.8	%
Inhibition	=	98.3	%
Inhibition	=	98.8	%
Inhibition	=	100	%
Inhibition	=	99.1	%
Inhibition	=	99.5	%
Inhibition	=	88.8	%
Inhibition	=	39.8	%
Inhibition	=	98.7	%
Inhibition	=	78.9	%
Inhibition	=	99.2	%
Inhibition	=	84.1	%
Inhibition	=	95.2	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：D(2) dopamine receptor

External ID: CHEMBL2343283

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2013
Volume: 21
Issue: 4
First Page: 856
Last Page: 868
DOI: 10.1016/j.bmc.2012.12.016

Target ChEMBL ID: CHEMBL217
ChEMBL Target Name: Dopamine D2 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Inhibition				Not Determined
Inhibition	=	100	%
Inhibition	=	97.5	%
Inhibition	=	88.7	%
Inhibition	=	88.8	%
Inhibition				Not Determined
Inhibition	=	93.4	%
Inhibition	=	90.5	%
Inhibition	=	71.5	%
Inhibition	=	20.5	%
Inhibition	=	78	%
Inhibition	=	20.4	%
Inhibition	=	90.9	%
Inhibition	=	63.2	%
Inhibition	=	79.8	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 1A

External ID: CHEMBL2343282

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2013
Volume: 21
Issue: 4
First Page: 856
Last Page: 868
DOI: 10.1016/j.bmc.2012.12.016

Target ChEMBL ID: CHEMBL214
ChEMBL Target Name: Serotonin 1a (5-HT1a) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Inhibition	=	100	%
Inhibition				Not Determined
Inhibition	=	89.3	%
Inhibition	=	84.4	%
Inhibition	=	97.4	%
Inhibition				Not Determined
Inhibition	=	14.2	%
Inhibition	=	64.2	%
Inhibition	=	55.4	%
Inhibition	=	30.4	%
Inhibition	=	82.8	%
Inhibition	=	25.5	%
Inhibition	=	71.1	%
Inhibition	=	50.5	%
Inhibition	=	60.5	%

6018-40-2 靶点实验数据