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601-54-7 靶点实验数据

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Mus musculus
External ID: CHEMBL844089
Protocol: N/A
Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1998
Volume: 8
Issue: 16
First Page: 2133
Last Page: 2138
DOI: 10.1016/s0960-894x(98)00362-x

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard Value
Feed efficiency=0.06
Feed efficiency=0.03
Feed efficiency=0.07
Feed efficiency=0.08
Feed efficiency=0.09
Feed efficiency=0.09
Feed efficiency=0.09
Feed efficiency=0.09
Feed efficiency=0.08
Feed efficiency=0.08
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:24565 靶标:N/A
External ID: ERK5 transcriptional activity-HTS
Protocol: Stable cells plated on a 384-well plate (2500 cells/well) were treated with test compounds at the concentration of 5 muM for 18 hrs. The level of luciferase activity was assayed using a
Luciferase kit (Promega corporation, Madison, WI) and a series of positive and negative control compounds were used as references.
Comment:
Luciferase activity (AU)
104
108
64
28
100
152
176
52
124
44
60
60
32
96
60
144
28
64
84
44
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Mus musculus
External ID: CHEMBL716249
Protocol: N/A
Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1998
Volume: 8
Issue: 16
First Page: 2133
Last Page: 2138
DOI: 10.1016/s0960-894x(98)00362-x

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard ValueStandard Units
Abdominal fat=0.48g
Abdominal fat=0.9g
Abdominal fat=1g
Abdominal fat=1.25g
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Solute carrier organic anion transporter family member 1B3
External ID: CHEMBL3039491
Protocol: N/A
Comment: Journal: Mol Pharmacol
Year: 2013
Volume: 83
Issue: 6
First Page: 1257
Last Page: 1267
DOI: 10.1124/mol.112.084152

Target ChEMBL ID: CHEMBL1743121
ChEMBL Target Name: Solute carrier organic anion transporter family member 1B3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned
Standard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
Inhibition=89.51%
Inhibition=81.71%
Inhibition=65.47%
Inhibition=50.32%
Inhibition=112.43%
Inhibition=99.94%
Inhibition=101.75%
Inhibition=98.72%
Inhibition=104.08%
Inhibition=114.2%
Inhibition=97.5%
Inhibition=120.61%
Inhibition=45.56%
Inhibition=105.72%
Inhibition=107.28%
Inhibition=93.09%
Inhibition=84.51%
Inhibition=155.79%Outside typical range
Inhibition=97.26%
Inhibition=72.91%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Mus musculus
External ID: CHEMBL713890
Protocol: N/A
Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1998
Volume: 8
Issue: 16
First Page: 2133
Last Page: 2138
DOI: 10.1016/s0960-894x(98)00362-x

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard ValueStandard Units
Body weight gain=0.35g day-1
Body weight gain=-0.1g day-1
Body weight gain=0.32g day-1
Body weight gain=0.4g day-1
Body weight gain=0.5g day-1
Body weight gain=0.52g day-1
Body weight gain=0.49g day-1
Body weight gain=0.58g day-1
Body weight gain=0.52g day-1
Body weight gain=0.56g day-1
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Solute carrier organic anion transporter family member 1B1
External ID: CHEMBL3039488
Protocol: N/A
Comment: Journal: Mol Pharmacol
Year: 2013
Volume: 83
Issue: 6
First Page: 1257
Last Page: 1267
DOI: 10.1124/mol.112.084152

Target ChEMBL ID: CHEMBL1697668
ChEMBL Target Name: Solute carrier organic anion transporter family member 1B1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned
Standard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
Inhibition=65.85%
Inhibition=63.37%
Inhibition=75.25%
Inhibition=97.38%
Inhibition=105.26%
Inhibition=97.94%
Inhibition=105.32%
Inhibition=99.4%
Inhibition=101.01%
Inhibition=86.27%
Inhibition=80.06%
Inhibition=89.01%
Inhibition=120.91%
Inhibition=102.46%
Inhibition=101.26%
Inhibition=90.74%
Inhibition=113.76%
Inhibition=82.92%
Inhibition=126.2%
Inhibition=116.63%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Mus musculus
External ID: CHEMBL620245
Protocol: N/A
Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1998
Volume: 8
Issue: 16
First Page: 2133
Last Page: 2138
DOI: 10.1016/s0960-894x(98)00362-x

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard ValueStandard Units
Serum cholesterol=115.8mg dl-1
Serum cholesterol=122.1mg dl-1
Serum cholesterol=112.7mg dl-1
Serum cholesterol=164.6mg dl-1
Serum cholesterol=161.3mg dl-1
Serum cholesterol=165.8mg dl-1
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Mus musculus
External ID: CHEMBL620246
Protocol: N/A
Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1998
Volume: 8
Issue: 16
First Page: 2133
Last Page: 2138
DOI: 10.1016/s0960-894x(98)00362-x

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard ValueStandard Units
Serum metabolite=22mg dl-1
Serum metabolite=0mg dl-1
Serum metabolite=22mg dl-1
Serum metabolite=0mg dl-1
Serum metabolite=22mg dl-1
Serum metabolite=0mg dl-1
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Mus musculus
External ID: CHEMBL620247
Protocol: N/A
Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1998
Volume: 8
Issue: 16
First Page: 2133
Last Page: 2138
DOI: 10.1016/s0960-894x(98)00362-x

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard ValueStandard Units
Serum triglyceride=218.3mg dl-1
Serum triglyceride=87.5mg dl-1
Serum triglyceride=172.6mg dl-1
Serum triglyceride=188.3mg dl-1
Serum triglyceride=291.2mg dl-1
Serum triglyceride=253.6mg dl-1
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:NON-PROTEIN TARGET
External ID: CHEMBL3602466
Protocol: N/A
Comment: Journal: J. Med. Chem.
Year: 2015
Volume: 58
Issue: 16
First Page: 6704
Last Page: 6709
DOI: 10.1021/acs.jmedchem.5b00755

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeActivity Comment
ActivityNot Active
ActivityNot Active
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Mus musculus
External ID: CHEMBL720247
Protocol: N/A
Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1998
Volume: 8
Issue: 16
First Page: 2133
Last Page: 2138
DOI: 10.1016/s0960-894x(98)00362-x

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard ValueStandard Units
Feed consumption=5.43g day-1
Feed consumption=3.62g day-1
Feed consumption=4.71g day-1
Feed consumption=4.94g day-1
Feed consumption=5.39g day-1
Feed consumption=5.83g day-1
Feed consumption=5.43g day-1
Feed consumption=6.48g day-1
Feed consumption=6.58g day-1
Feed consumption=6.95g day-1
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL660747
Protocol: N/A
Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1998
Volume: 8
Issue: 19
First Page: 2663
Last Page: 2668
DOI: 10.1016/s0960-894x(98)00478-8
Standard TypeStandard RelationStandard ValueStandard Units
k cat=0.2s-1
k cat=4.2s-1
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL660748
Protocol: N/A
Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1998
Volume: 8
Issue: 19
First Page: 2663
Last Page: 2668
DOI: 10.1016/s0960-894x(98)00478-8
Standard TypeStandard RelationStandard ValueStandard Units
k cat=64s-1
k cat=44s-1