HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：NCGC 靶标：

External ID: SNCA-p-activity-luciferase

Protocol: PROTOCOL TABLE
SEQUENCE No. (e.g., 1, 2, 3, etc.); PARAMETER (e.g., Cells, Incubation, Reagent, etc.); VALUE; DESCRIPTION

1; Cells; 4 uL; Dispense 1500 HEK-293-SNCA-luc cells/well into Greiner 1536-well white / solid bottom tissue culture treated plate. The plate was covered with metal lids with gas-exchange holes.
2; Incubate; 24 hours; Incubate at 37C, 5% CO2, 95% RH.
3; Compounds; 23 nL; Compounds and controls were transferred via a Kalypsys Pin Tool (Wako USA) equipped with a 1536-slotted pin array. The plate was covered with metal lids with gas-exchange holes.
4; Incubate; 24 hours; Incubate at 37C, 5% CO2, 95% RH.
5; Dispense; 1 uL; Dispense Gly-Phe-7-amino-4-trifluoromethylcoumarin (GF-AFC, prepared at 125 uM in PBS) was added. The plate was covered with metal lids with gas-exchange holes.
6; Incubate; 30 min; Incubate at 37C, 5% CO2.
7; Detector; Fluorescence; Measure fluorescence with ViewLux microplate reader (PerkinElmer) equipped with 405/10 excitation and 540/25 emission filters.
8; Dispense; 3 uL; Dispense ONE-Glo (PerkinElmer) lucifase detection reagent was added to each well. Plates were covered with metal lids with gas-exchange holes.
9; Incubate; 15 min; Incubate at room temperature.
10; Detector; Luminescence; Measure luminescence with ViewLux microplate reader (PerkinElmer) equipped with clear filters.

NOTES (numbers refer to sequence above)
1; HEK-293-SNCA-luc were cultured and suspended in phenol-red free DMEM (4.5 g/L glucose, 25 mM HEPES, cat #21063 (Thermo)).
3; Compounds were added to the assay plate in an 11-point intra plate dose response, 1:3 titration in DMSO with a final concentration range of xxx - yyy uM. Vehicle-only plates, with DMSO being pin-transferred to every well, were inserted at the beginning of screening runs to confirm expected assay performance. Activity was normalized to wells containing medium only (-100% activity, full inhibition) and SNCA-luc cells treated with DMSO vehicle control (0% activity), contained on the same plate as test samples.
10; Signals were analyzed, and dose-response curves were fit using the Hill equation. Compounds in curve classes -1.1, -1.2, -2.1, -2.2 in the SNCA-luc assay were considered active. Compounds were eliminated from further consideration if also active (curve class -1.1, -1.2, -1.3, -1.4, -2.1, -2.2, -2.3, -2.4) in the GF-AFC cytotoxicity assay.

Comment: Disclaimer:
Although all reasonable efforts have been made to ensure the accuracy and reliability of the data, caution should be exercised when interpreting the results as artifacts are possible from nonspecific effects such as assay signal interference. The curve fitting and activity calls presented here are based on the NCATS analysis methods.

Compound Ranking:
1. Compounds are first classified as having full titration curves, partial modulation, partial curve (weaker actives), single point activity (at highest concentration only), or inactive. For this assay, apparent inhibitors are ranked higher than compounds that showed apparent activation.
2. For all inactive compounds, with a ratio activity curve class of 4, PUBCHEM_ACTIVITY_SCORE is 0. For all active compounds, a score range was given for each curve class type given above. Active compounds have PUBCHEM_ACTIVITY_SCORE between 40 and 100. For a ratio activity curve class = -1.1, score = 80+abs((log_ac50+4.5)*inf_activity/20). For ratio.curve_class == -1.2 && abs(ratio.max_response) > 6*10, score = 60+abs((log_ac50+4.5)*inf_activity/20). For ratio.curve_class == -2.1 || ( ratio.curve_class==-2.2 && abs(ratio.max_response) > 6*10), score = 40+abs((log_ac50+4.5)*inf_activity/20). For ratio.curve_class == -1.2 || ratio.curve_class == -2.2, score = 20+abs((log_ac50+4.5)*inf_activity/20). Inconclusive compounds, with a donor curve class other than 4, have PUBCHEM_ACTIVITY_SCORE of 10. Inconclusive compounds have PUBCHEM_ACTIVITY_SCORE between 1 and 39.

Phenotype	Potency	Efficacy	Curve_Description	Fit_LogAC50	Fit_HillSlope	Fit_R2	Fit_InfiniteActivity	Fit_ZeroActivity	Fit_CurveClass	Excluded_Points	Max_Response	Activity at 0.079 uM	Activity at 1.068 uM	Activity at 11.39 uM	Activity at 57.25 uM	Compound QC
Inactive				-6.75	4.9549	0.9727	0.0901	17.5	4	0 0 0 1	8.9408	15.9527	-1.5916	1.4969	8.9408	QC'd by Sytravon
Inactive				-5.3	4.095	0.9996	5.5	-7.7823	4	0 0 0 1	-11.1081	-7.5736	-7.7353	5.034	-11.1081	QC'd by Sytravon
Inactive				-5.15	4.9549	0.907	-15.9207	9.5	4	0 0 0 1	17.8725	5.2874	13.9021	-13.6839	17.8725	QC'd by Sytravon
Activator	35.4813	46.4095	Single point of activity	-4.45	2.5884	1	45.9404	-0.4691	3	1 0 0 0	35.593	40.1678	-0.3909	1.933	35.593	QC'd by Sytravon
Activator	39.8107	72.2646	Single point of activity	-4.4	4.9549	0.9515	68.1912	-4.0733	3	0 0 0 0	58.0117	5.8738	-9.2278	-8.5224	58.0117	QC'd by Sytravon
Activator	14.1254	45.3319	Partial curve; partial efficacy; poor fit	-4.85	2.4064	0.9982	40.7728	-4.5591	2.4	1 0 0 0	40.0933	-24.9557	-3.8845	11.5254	40.0933	QC'd by Sytravon
Inactive				-5.75	4.9549	0.9291	-20.6086	33.1545	4	1 0 0 0	-12.8464	45.4569	28.2161	-28.42	-12.8464	QC'd by Sytravon
Inactive				-4.35	4.9549	0.855	-24.2184	-0.5	4	0 0 0 0	-18.932	-3.6477	-2.409	4.988	-18.932	QC'd by Sytravon
Inactive				-4.7	3.6272	0.8625	15	-8.5523	4	0 0 0 0	14.477	-2.951	-13.7936	-5.9646	14.477	QC'd by Sytravon
Inactive				-6.7	4.9549	0.6637	3	-16.864	4	0 0 0 0	8.8169	-15.72	6.3794	-6.3599	8.8169	QC'd by Sytravon
Inactive				-4.75	2.4064	0.9999	21.5	-2.4101	4	1 0 0 0	20.2184	33.3778	-2.4251	3.5771	20.2184	QC'd by Sytravon
Inactive				-4.4	4.9549	0.8117	2.5	-8.345	4	0 0 0 0	1.096	-8.966	-5.5054	-11.1209	1.096	QC'd by Sytravon
Activator	39.8107	38.7945	Single point of activity	-4.4	4.9549	0.6241	41.7557	2.9612	3	0 0 0 0	36.2039	21.355	-6.3904	-4.5325	36.2039	QC'd by Sytravon
Inactive				-6.05	4.095	0.9994	-6.0518	20	4	0 0 0 1	20.5156	19.7377	1.4122	-6.2932	20.5156	QC'd by Sytravon
Inactive				-5.2	4.095	1	10.5	-10.1683	4	1 0 0 1	-15.9884	36.1362	-10.1402	8.7939	-15.9884	QC'd by Sytravon
Inactive				-6.5	1.3905	0.9999	-24.241	0.2745	4	0 0 0 1	-5.5981	-4.3546	-20.7587	-23.9509	-5.5981	QC'd by Sytravon
Inactive				-6.8	4.9549	0.711	-2.4459	21	4	0 0 0 0	-3.3453	17.3219	-9.9549	5.5495	-3.3453	QC'd by Sytravon
Activator	39.8107	47.809	Partial curve; partial efficacy; poor fit	-4.4	4.9549	0.5212	50.2399	2.4309	2.4	0 0 0 0	43.4722	30.2363	-10.9855	-11.5143	43.4722	QC'd by Sytravon
Activator	22.3872	75.5081	Partial curve; high efficacy; poor fit	-4.65	1.9673	0.9829	96.5324	21.0243	2.3	0 0 0 0	86.4985	26.0932	16.3365	36.2613	86.4985	QC'd by Sytravon
Inactive				-6.8	4.9549	0.7429	-1	-13.0738	4	0 0 0 0	1.8063	-11.3115	0.8702	-5.1757	1.8063	QC'd by Sytravon

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：824 靶标：

External ID: CYP273

Protocol: Tox21 Assay Protocol Summary:

Two ul of enzyme-substrate mix was dispensed into medium binding white/solid 1536-well plates (Greiner Bio-One North America Inc., Monroe, NC) using a BioRaptr Flying Reagent Dispenser (FRD, Beckman Coulter, Brea, CA). Compounds dissolved in DMSO and positive control (furafyllline) were transferred to the assay plates at 23 nl using a Pintool station (Wako, San Diego, CA). The assay plates were incubated at room temperature for 10 min. Then 2 ul of NADPH regeneration solution was added to each well of the assay plates using an FRD and incubated at room temperature for 1 h. The reaction was stopped by adding 4 ul of detection reagent using an FRD and after 20 min incubation at room temperature the luminescence signal was measured using a ViewLux plate reader (Perkin Elmer, Shelton, CT). Data were expressed as relative luminescence units.

Comment: Disclaimer:

Although all reasonable efforts have been made to ensure the accuracy and reliability of the data, caution should be exercised when interpreting the results as artifacts are possible from nonspecific effects such as assay signal interference. The curve fitting and activity calls presented here are based on the NCATS analysis methods. Alternative analysis methods and interpretations of the data are available at EPA (http://actor.epa.gov) and NTP (http://tools.niehs.nih.gov/cebs3/ui/).

Compound Ranking:

1. Compounds are first classified as having full titration curves, partial modulation, partial curve (weaker actives), single point activity (at highest concentration only), or inactive. See data field "Curve Description". For this assay, apparent inhibitors are ranked higher than compounds that showed apparent activation.
2. For all inactive compounds, PUBCHEM_ACTIVITY_SCORE is 0. For all active compounds, a score range was given for each curve class type given above. Active compounds have PUBCHEM_ACTIVITY_SCORE between 40 and 100. Inconclusive compounds have PUBCHEM_ACTIVITY_SCORE between 1 and 39. Fit_LogAC50 was used for determining relative score and was scaled to each curve class' score range.

Phenotype-Replicate_1	Potency-Replicate_1	Efficacy-Replicate_1	Activity_Score-Replicate_1	Curve_Description-Replicate_1	Fit_LogAC50-Replicate_1	Fit_HillSlope-Replicate_1	Fit_R2-Replicate_1	Fit_InfiniteActivity-Replicate_1	Fit_ZeroActivity-Replicate_1	Fit_CurveClass-Replicate_1	Excluded_Points-Replicate_1	Max_Response-Replicate_1	Activity at 0.0007781017 uM-Replicate_1	Activity at 0.00212 uM-Replicate_1	Activity at 0.00657 uM-Replicate_1	Activity at 0.017 uM-Replicate_1	Activity at 0.038 uM-Replicate_1	Activity at 0.085 uM-Replicate_1	Activity at 0.191 uM-Replicate_1	Activity at 0.435 uM-Replicate_1	Activity at 1.330 uM-Replicate_1	Activity at 4.074 uM-Replicate_1	Activity at 10.46 uM-Replicate_1	Activity at 23.64 uM-Replicate_1	Activity at 52.95 uM-Replicate_1	Activity at 115.2 uM-Replicate_1	Compound QC-Replicate_1	Phenotype-Replicate_2	Potency-Replicate_2	Efficacy-Replicate_2	Activity_Score-Replicate_2	Curve_Description-Replicate_2	Fit_LogAC50-Replicate_2	Fit_HillSlope-Replicate_2	Fit_R2-Replicate_2
Inactive			0					0	0	4		-3.5643		-2.3504	-2.9312	-2.3657	-2.8224	-2.6018	0.0394	2.8539	-0.9099	-0.8614	-3.0049	-2.5808	-0.7	-3.5643	QC'd by SIGMA	Inactive			0
Inactive			0					0	0	4		-4.9449		-1.1401	-4.8828	1.7278	1.7167	-2.1117	-5.6964	0.3933	0.8939	0.1314	-2.7335	3.195	-4.9521	-4.9449	QC'd by SIGMA	Inactive			0
Inactive			0					0	0	4		2.7107		-2.1884	1.3985	1.4582	0.7693	-2.4787	1.52	2.8986	0.9702	-0.0253	2.1293	2.7766	1.539	2.7107	QC'd by Enamine	Inactive			0
Inactive			0					0	0	4		-2.1522		-2.3143	-3.894	-2.3698	3.0635	-2.9724	-0.698	1.807	-0.3874	-2.2387	0.0851	-4.1965	3.0171	-2.1522	QC'd by SIGMA	Inactive			0
Inactive			0		-4.3489	2.2526	0.8543	-15.2749	-1.5	4	0 0 0 0 0 0 0 0 0 0 0 0 0 0 0	-14.3957		-1.8486	-1.8251	-1.3415	-0.2999	-5.8043	-1.4625	0.152	0.0394	-2.6869	-2.4228	-2.2664	-9.6519	-14.3957	QC'd by SIGMA	Inactive			0		-4.0989	2.1876	0.881
Inactive			0		-4.3989	1.3443	0.8661	-18.2112	-1	4	0 0 0 0 0 0 0 0 0 0 0 0 0 0 0	-16.0093		-2.3466	0.8145	0.3878	-0.5249	-2.2045	-0.0596	-0.3675	-2.1137	-2.5302	-0.6582	-8.8446	-8.7305	-16.0093	QC'd by Acros	Inactive			0		-4.1989	1.6266	0.9372
Inactive			0		-4.3713	1.331	0.7782	-33.4439	-3.503	4	0 0 0 0 0 0 0 0 0 0 0 0 0 0 0	-29.5366	-4.0189	-0.7745	-2.4487	-0.7353	-13.4714	-1.9963	-2.0808	-1.5803	-2.9931	-5.0804	-13.0346	-7.2628	-16.8143	-29.5366	QC'd by LightBiologicals	Inactive			0		-4.3713	1.2221	0.9463
Inactive			0		-4.1489	1.6266	0.9461	-28.1716	-1	4	0 0 0 0 0 0 0 0 0 0 0 0 0 0 0	-20.143		-1.7608	-0.2388	0.2248	0.5264	-2.4986	-0.1313	-2.2365	-0.2423	-3.4362	-3.0971	-3.2181	-11.2156	-20.143	QC'd by Enamine	Inhibitor	79.6407	31.4916	10	Partial curve; partial efficacy; poor fit	-4.0989	2.5884	0.988
Inhibitor	79.6407	37.8784	10	Partial curve; partial efficacy; poor fit	-4.0989	2.3332	0.6037	-41.3784	-3.5	-2.4	0 0 0 0 0 0 0 0 0 0 0 0 0 0 0	-31.1486		0.0477	-0.2424	-0.1109	-17.1482	-2.6043	0.0987	1.3021	-8.8121	-0.6811	-2.6079	-6.0005	-11.8578	-31.1486	QC'd by LightBiologicals	Inhibitor	70.9799	33.8113	10	Partial curve; partial efficacy; poor fit	-4.1489	1.4787	0.9532
Inactive			0		-4.1489	1.331	0.6595	-35.6335	-1	4	0 0 0 0 0 0 0 0 0 0 0 0 0 0 0	-26.3612		1.8269	-1.2651	2.0528	-1.3342	-1.1508	-1.3078	-0.329	-8.1235	0.9213	-0.3901	-8.3475	-13.4823	-26.3612	QC'd by LightBiologicals	Inhibitor	63.2609	40.7162	21	Partial curve; partial efficacy	-4.1989	1.5579	0.9889
Inhibitor	31.7055	100.2192	40	Partial curve; high efficacy	-4.4989	1.4163	0.9793	-102.2947	-2.0755	-2.1	0 0 0 0 0 0 0 0 0 0 0 0 0 0 0	-88.7975		1.5993	1.9578	-0.4182	-5.9156	-12.3257	-6.8125	0.6301	-0.9357	-7.8675	-21.9718	-39.1747	-68.2733	-88.7975	QC'd by SIGMA	Inhibitor	28.2576	108.4027	40	Partial curve; high efficacy	-4.5489	1.2475	0.9984
Inactive			0		-4.4489	1.5386	0.9285	-23.7863	1	4	0 0 0 0 0 0 0 0 0 0 0 0 0 0 0	-21.4885		2.5819	2.144	-0.9228	1.5778	0.3813	-0.7273	-0.0178	0.4803	2.4385	-0.728	-9.9293	-11.8247	-21.4885	QC'd by SIGMA	Inactive			0		-4.3989	1.6259	0.9598
Inhibitor	9.3337	39.8967	21	Complete curve; partial efficacy	-5.0299	2.0437	0.9899	-39.8967	0	-1.2	0 0 0 0 0 0 0 0 0 0 0 0 0 0 0	-36.3129	-0.2423	-0.4463	-0.2999	0.6478	0.3636	1.006	-0.4987	1.2825	-1.1546	-7.8589	-17.895	-35.8398	-36.3129		QC'd by LightBiologicals	Inhibitor	11.7504	56.3884	21	Partial curve; partial efficacy	-4.9299	1.111	0.9845
Inhibitor	31.7055	101.4573	40	Partial curve; high efficacy	-4.4989	1.111	0.9982	-102.7597	-1.3024	-2.1	0 0 0 0 0 0 0 0 0 0 0 0 0 0 0	-82.349		-1.7206	-3.1014	-1.0307	-0.462	-0.0614	-0.5481	-3.1286	-4.6801	-13.1432	-23.5612	-42.1146	-67.192	-82.349	QC'd by SIGMA	Inhibitor	25.1846	89.5091	40	Partial curve; high efficacy	-4.5989	1.3723	0.9943
Inactive			0		-4.3989	1.3723	0.9408	-30.7143	-1.5	4	0 0 0 0 0 0 0 0 0 0 0 0 0 0 0	-27.2619		-3.9038	-4.2597	0.9522	0.2767	-0.086	-3.7725	-0.0863	-0.3476	-4.4856	-5.6587	-11.4378	-17.5999	-27.2619	QC'd by Enamine	Inactive			0		-4.3989	1.3723	0.9104
Inhibitor	0.02	91.5374	95	Complete curve; high efficacy	-7.6989	1.21	0.9985	-95.5053	-3.9679	-1.1	0 0 0 0 0 0 0 0 0 0 0 0 0 0 0	-96.9758		-10.1145	-26.2532	-42.3865	-67.4835	-79.9456	-90.8539	-91.593	-94.2489	-95.4721	-96.0956	-96.1267	-97.0582	-96.9758	QC'd by SIGMA	Inhibitor	0.1416	94.8402	91	Complete curve; high efficacy	-6.8489	1.21	0.9987
Inhibitor	70.9799	57.4014	21	Partial curve; partial efficacy	-4.1489	1.4641	0.9678	-60.4859	-3.0846	-2.2	0 0 0 0 0 0 0 0 0 0 0 0 0 0 0	-45.8227		-1.5241	-1.1304	-2.119	-3.4583	-2.7138	-4.9163	-1.3699	-5.0741	-7.7268	-8.2608	-10.3758	-24.1789	-45.8227	QC'd by TCI	Inhibitor	63.2609	59.3706	21	Partial curve; partial efficacy	-4.1989	1.8265	0.9826
Inhibitor	31.7055	88.4583	40	Partial curve; high efficacy	-4.4989	1.2475	0.9907	-90.0614	-1.6031	-2.1	0 0 0 0 0 0 0 0 0 0 0 0 0 0 0	-73.0646		-2.1792	-0.7242	-0.9217	-2.0267	-1.1711	-1.4022	-1.5555	-4.0648	-12.1704	-19.1709	-32.2561	-64.0802	-73.0646	QC'd by SIGMA	Inhibitor	31.7055	86.8385	40	Partial curve; high efficacy	-4.4989	1.111	0.9934
Inhibitor	7.098	99.9448	83	Complete curve; high efficacy	-5.1489	1.3443	0.9949	-102.6257	-2.681	-1.1	0 0 0 0 0 0 0 0 0 0 0 0 0 0 0	-98.8687		-2.2636	-1.9377	-0.2674	-0.3864	-3.2139	-8.5636	-4.0834	-14.5383	-36.543	-60.2337	-91.3595	-96.848	-98.8687	QC'd by TCI	Inhibitor	5.6381	99.0727	84	Complete curve; high efficacy	-5.2489	1.6266	0.998
Inhibitor	14.1623	99.522	42	Partial curve; high efficacy	-4.8489	0.7	0.9894	-100.6417	-1.1197	-2.1	0 0 0 0 0 0 0 0 0 0 0 0 0 0 0	-88.2822		-1.4919	-2.9847	-0.2649	-1.6478	-3.8502	-2.8959	-7.6423	-18.6375	-36.1235	-44.1844	-53.91	-71.7844	-88.2822	QC'd by SIGMA	Inhibitor	17.8293	95.7742	81	Complete curve; high efficacy	-4.7489	1.21	0.9995

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：NCGC 靶标：

External ID: 12hLO-f-round2

Protocol: PROTOCOL TABLE
SEQUENCE No. (e.g., 1, 2, 3, etc.); PARAMETER (e.g., Cells, Incubation, Reagent, etc.); VALUE; DESCRIPTION
1; Enzyme; 3 uL; 150 nM 12hLO enzyme solution dispensed in 1536-well Greiner black, clear bottom plates.
2; Compound; 23 nL; compounds and controls were added.
3; Incubate; 15 min; room temperature.
4; Substrate; 1 uL; 40 uM arachidonic acid (final concentration).
5; Incubate; 30 min; room temperature.
6; Reagent; 4 uL; Fe-XO solution was added to each well.
7; Incubation; 30 min; room temperature
8; Detector; absorbance; Read 1 at 405 nm absorbance using ViewLux (PerkinElmer) CCD imager.
9; Detector; absorbance; Read 2 at 573 nm absorbance using ViewLux (PerkinElmer) CCD imager.
NOTES (numbers refer to sequence above)
1; 150 nM 12hLO (final concentration) in buffer solution (25 mM Hepes, 0.01% Triton X-100, pH 7.0) was dispensed in columns 1, 2, 5-48. Column 1 is neutral (100% activity). Buffer only was dispensed in columns 3 and 4 as no enzyme negative controls. The plates were covered with metal lids with gas-exchange holes.
2; Compounds were pin transferred via a Kalypsys Pin Tool (Wako USA) in column 5 - 48. Control compound was transferred in column 2, titration of nordihydroguaiaretic acid (NDGA, Sigma-Aldrich, N5023) with top concentration of 20 mM in DMSO then 1:3 dilution in duplicate. Dilution factor of 23 nL into 4 uL final assay volume.
3; Covered assay plates were incubated for 15 min at room temperature.
4; Substrate was added to start the reaction; 40 uM arachidonic acid (Sigma-Aldrich, St. Louis, MO) was dispensed throughout the plate.
6; Chromogenic detection reagent solution (divalent iron/xylenol orange, Fe-XO) was added to each well: 200 uM xylenol orange, 300 uM ferrous ammonium sulfate prepared freshly in 50 mM sulfuric acid.
8, 9; Two absorbance readouts were obtained at 405 nm and at 573 nm using a ViewLux high-throughput CCD plate imager (PerkinElmer). The 573 to 405 (Read 2 / Read 1) absorbance ratio was used to compute reaction progress.

Comment: Disclaimer:
Although all reasonable efforts have been made to ensure the accuracy and reliability of the data, caution should be exercised when interpreting the results as artifacts are possible from nonspecific effects such as assay signal interference. The curve fitting and activity calls presented here are based on the NCATS analysis methods.

Compound Ranking:
1. Compounds are first classified as having full titration curves, partial modulation, partial curve (weaker actives), single point activity (at highest concentration only), or inactive. For this assay, apparent inhibitors are ranked higher than compounds that showed apparent activation.
2. For all inactive compounds, with a ratio activity curve class of 4, PUBCHEM_ACTIVITY_SCORE is 0. For all active compounds, a score range was given for each curve class type given above. Active compounds have PUBCHEM_ACTIVITY_SCORE between 40 and 100. For a ratio activity curve class = -1.1, score = 80+abs((log_ac50+4.5)*inf_activity/20). For ratio.curve_class == -1.2 && abs(ratio.max_response) > 6*10, score = 60+abs((log_ac50+4.5)*inf_activity/20). For ratio.curve_class == -2.1 || ( ratio.curve_class==-2.2 && abs(ratio.max_response) > 6*10), score = 40+abs((log_ac50+4.5)*inf_activity/20). For ratio.curve_class == -1.2 || ratio.curve_class == -2.2, score = 20+abs((log_ac50+4.5)*inf_activity/20). Inconclusive compounds, with a donor curve class other than 4, have PUBCHEM_ACTIVITY_SCORE of 10. Inconclusive compounds have PUBCHEM_ACTIVITY_SCORE between 1 and 39.

Phenotype	Potency	Efficacy	Activity_Score	Curve_Description	Fit_LogAC50	Fit_HillSlope	Fit_R2	Fit_InfiniteActivity	Fit_ZeroActivity	Fit_CurveClass	Excluded_Points	Max_Response	Activity at 0.0009699086 uM	Activity at 0.00203 uM	Activity at 0.00306 uM	Activity at 0.00610 uM	Activity at 0.00936 uM	Activity at 0.020 uM	Activity at 0.050 uM	Activity at 0.066 uM	Activity at 0.143 uM	Activity at 0.255 uM	Activity at 0.473 uM	Activity at 0.794 uM	Activity at 1.616 uM	Activity at 3.555 uM	Activity at 6.210 uM	Activity at 12.66 uM	Activity at 19.16 uM	Activity at 35.99 uM	Activity at 64.46 uM	Activity at 124.6 uM	Compound QC
Inhibitor	1.9314	106.592	86	Complete curve; high efficacy	-5.7141	2.2481	0.9918	-95.2276	11.3644	-1.1	0 0 0 0 0 0 0 0 0 0 0	-96.1895	3.0709		15.2647		7.6705	14.0043		8.0751		17.454		3.0001	-49.7114		-84.7302		-95.31		-96.1895		QC'd by NCGCChem
Inhibitor	6.1078	106.8252	83	Complete curve; high efficacy	-5.2141	1.4163	0.986	-85.461	21.3642	-1.1	0 0 0 0 0 0 0 0 0 0 0	-84.2092	20.1938		14.4806		23.4363	18.0529		21.7873		31.273		12.5934	2.8282		-32.3297		-65.7574		-84.2092		QC'd by NCGCChem
Inhibitor	15.8489	91.4763	81	Complete curve; high efficacy	-4.8	2.7202	0.9841	-98.9177	-7.4414	-1.1	0 0 0 0 0 0 0 0 0 0 0	-92.1021								-9.0788	-9.2047	-9.8858	-6.9308	-5.0138	-12.6976	-0.6647	-19.8236	-44.0558		-89.1961	-92.1021		QC'd by Analyticon
Inhibitor	5.0119	76.538	63	Complete curve; partial efficacy	-5.3	1.3723	0.9948	-81.1129	-4.5748	-1.2	0 0 0 0 0 0 0 0 0 0 0	-77.4193								-1.6663	-8.0529	-4.2491	-7.7256	-13.1641	-20.3102	-29.9673	-52.8586	-67.0299		-75.9994	-77.4193		QC'd by Analyticon
Inhibitor	6.2249	67.2176	63	Complete curve; partial efficacy	-5.2059	1	0.942	-77.3742	-10.1566	-1.2	0 0 0 0 0 0 0 0 0 0 0	-72.2581		-12.9831		-5.8462		-18.337	-16.7485		-11.3163		-7.9828		-12.1002	-40.6272		-63.6699		-64.4969		-72.2581	QC'd by ChemRoutes
Inhibitor	9.6802	110.1622	42	Partial curve; high efficacy	-5.0141	1.6604	0.9887	-90.8321	19.3301	-2.1	0 0 0 0 0 0 0 0 0 0 0	-84.6426	21.31		18.3857		10.4425	18.696		18.3198		22.7467		21.519	15.2621		-22.851		-62.2581		-84.6426		QC'd by Enamine
Inhibitor	21.6712	104.3593	41	Partial curve; high efficacy	-4.6641	1.5579	0.9529	-83.4596	20.8997	-2.1	0 0 0 0 0 0 0 0 0 0 0	-69.5496	18.6659		23.6825		21.8591	21.2888		24.7766		26.4485		24.111	1.1207		8.872		-22.5267		-69.5496		QC'd by NCGCChem
Inhibitor	61.5389	63.1209	21	Partial curve; partial efficacy	-4.2108	1	0.9237	-71.8651	-8.7442	-2.2	0 0 0 0 0 0 0 0 0 0 0	-54.4432		-18.5921		-9.1263		-5.7816		-2.9999	-3.9852		-11.1061		-10.9872		-12.9659		-23.0007	-33.5733		-54.4432	QC'd by ChemRoutes
Inhibitor	69.0478	38.2384	21	Partial curve; partial efficacy	-4.1608	1	0.8756	-45.2266	-6.9882	-2.2	0 0 0 0 0 0 0 0 0 0 0	-35.8942		-11.7589		-5.303		-8.9112		-4.1569	-5.0635		-7.3568		-5.4239		-14.383		-13.6471	-17.5503		-35.8942	QC'd by ChemRoutes
Inhibitor	3.9811	41.4412	21	Complete curve; partial efficacy	-5.4	0.5	0.8845	-30.9412	10.5	-1.2	0 0 0 0 0 0 0 0 0 0 0	-22.451								7.3805	1.2216	8.9658	-5.359	-7.5643	-3.0362	-7.2913	-11.2256	-16.8761		-21.3891	-22.451		QC'd by Chemdiv
Inhibitor	8.9125	72.1565	21	Partial curve; partial efficacy	-5.05	0.4	0.888	-51.0669	21.0895	-2.2	0 0 0 0 0 0 0 0 0 0 0	-38.1435								14.8042	12.4793	9.1585	-0.4614	-4.0272	-7.172	-7.4528	-6.2212	-11.9084		-22.761	-38.1435		QC'd by Chemdiv
Inhibitor	24.3155	68.3997	20	Partial curve; partial efficacy	-4.6141	2.3332	0.9198	-53.268	15.1318	-2.2	0 0 0 0 0 0 0 0 0 0 0	-53.9297	7.4839		18.4643		19.2492	14.5431		12.0779		22.3879		18.9801	13.5438		3.5117		-2.6741		-53.9297		QC'd by NCGCChem
Inhibitor	49.4462	50.1594	20	Partial curve; partial efficacy	-4.3059	1	0.8388	-36.8687	13.2907	-2.2	0 0 0 0 0 0 0 0 0 0 0	-26.6445		15.4207		15.6609		7.7999	15.18		22.3088		11.1409		4.6683	5.9713		2.2831		-1.2217		-26.6445	QC'd by ChemRoutes
Inhibitor	21.6712	81.8964	10	Partial curve; partial efficacy; poor fit	-4.6641	2.4064	0.9781	-69.8552	12.0413	-2.4	0 0 1 0 0 0 0 0 0 0 0	-64.9481	6.3692		15.2577		-38.9756	11.6437		11.8129		15.8251		9.2902	15.8777		2.2113		-20.2084		-64.9481		QC'd by NCGCChem
Inhibitor			10	Single point of activity				0	0	-3		-32.901		-18.1987		-14.0529		-14.167	-10.5998		-2.5897		-12.5459		-13.7461	-20.8757		-6.457		-19.942		-32.901	QC'd by ChemRoutes
Inhibitor			10	Single point of activity				0	0	-3		-35.8003		-8.845		-20.8688		-5.804	-9.398		1.2088		-19.4574		-2.5178	-11.7221		-18.1149		-26.6328		-35.8003	QC'd by ChemRoutes
Inhibitor	77.4729	47.357	10	Partial curve; partial efficacy; poor fit	-4.1108	1	0.7046	-39.4602	7.8968	-2.4	0 0 0 0 0 0 0 0 0 0 0	-32.8835		7.6652		14.4129		5.139		2.2509	-2.2368		6.8679		9.4092		7.2816		16.0847	-10.7248		-32.8835	QC'd by ChemRoutes
Inhibitor	113.6194	70.3623	10	Partial curve; partial efficacy; poor fit	-3.9445	1	0.7164	-76.5743	-6.212	-2.4	0 0 0 0 0 0 0 0 0 0 0	-63.8119			-18.1927		-12.7975	3.3085		-2.9533		-9.3005		0.4204	-14.3528		-12.5891		-1.8745		-19.6513	-63.8119	QC'd by ChemRoutes
Inhibitor	137.7685	47.7128	10	Single point of activity	-3.8608	1	0.4749	-44.6562	3.0565	-3	0 0 0 0 0 0 0 0 0 0 0	-33.1411		-1.2821		-2.0375		2.0548		-4.5034	-0.3688		-5.2324		15.7288		2.6069		12.7967	1.1953		-33.1411	QC'd by ChemRoutes
Inhibitor	12.4203	25.4212	10	Partial curve; partial efficacy; poor fit	-4.9059	1	0.7994	-28.4212	-3	-2.4	0 0 0 0 0 0 0 0 0 0 0	-30.351		-4.1561		-2.5178		-9.4349	1.4257		-1.5072		1.7076		-11.4956	-10.9066		-16.6914		-16.5994		-30.351	QC'd by ChemRoutes

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Escherichia coli

External ID: CHEMBL1661371

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2009
Volume: 53
Issue: 4
First Page: 1652
Last Page: 1656
DOI: 10.1128/aac.00822-08

Target ChEMBL ID: CHEMBL354
ChEMBL Target Name: Escherichia coli
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
MIC	Not Determined
MIC	Not Determined
MIC	Not Determined
MIC	Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Escherichia coli

External ID: CHEMBL1661372

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2009
Volume: 53
Issue: 4
First Page: 1652
Last Page: 1656
DOI: 10.1128/aac.00822-08

Target ChEMBL ID: CHEMBL354
ChEMBL Target Name: Escherichia coli
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
MIC	Not Determined
MIC	Not Determined
MIC	Not Determined
MIC	Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Escherichia coli

External ID: CHEMBL1661373

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2009
Volume: 53
Issue: 4
First Page: 1652
Last Page: 1656
DOI: 10.1128/aac.00822-08

Target ChEMBL ID: CHEMBL354
ChEMBL Target Name: Escherichia coli
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
MIC	Not Determined
MIC	Not Determined
MIC	Not Determined
MIC	Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Escherichia coli

External ID: CHEMBL1661374

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2009
Volume: 53
Issue: 4
First Page: 1652
Last Page: 1656
DOI: 10.1128/aac.00822-08

Target ChEMBL ID: CHEMBL354
ChEMBL Target Name: Escherichia coli
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
MIC	Not Determined
MIC	Not Determined
MIC	Not Determined
MIC	Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Escherichia coli

External ID: CHEMBL1661375

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2009
Volume: 53
Issue: 4
First Page: 1652
Last Page: 1656
DOI: 10.1128/aac.00822-08

Target ChEMBL ID: CHEMBL354
ChEMBL Target Name: Escherichia coli
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
MIC	Not Determined
MIC	Not Determined
MIC	Not Determined
MIC	Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Klebsiella aerogenes

External ID: CHEMBL1661367

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2009
Volume: 53
Issue: 4
First Page: 1652
Last Page: 1656
DOI: 10.1128/aac.00822-08

Target ChEMBL ID: CHEMBL612508
ChEMBL Target Name: Klebsiella aerogenes
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
MIC	Not Determined
MIC	Not Determined
MIC	Not Determined
MIC	Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Klebsiella aerogenes

External ID: CHEMBL1661368

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2009
Volume: 53
Issue: 4
First Page: 1652
Last Page: 1656
DOI: 10.1128/aac.00822-08

Target ChEMBL ID: CHEMBL612508
ChEMBL Target Name: Klebsiella aerogenes
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
MIC	Not Determined
MIC	Not Determined
MIC	Not Determined
MIC	Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Escherichia coli

External ID: CHEMBL1661369

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2009
Volume: 53
Issue: 4
First Page: 1652
Last Page: 1656
DOI: 10.1128/aac.00822-08

Target ChEMBL ID: CHEMBL354
ChEMBL Target Name: Escherichia coli
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
MIC	Not Determined
MIC	Not Determined
MIC	Not Determined
MIC	Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Escherichia coli

External ID: CHEMBL1661370

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2009
Volume: 53
Issue: 4
First Page: 1652
Last Page: 1656
DOI: 10.1128/aac.00822-08

Target ChEMBL ID: CHEMBL354
ChEMBL Target Name: Escherichia coli
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
MIC	Not Determined
MIC	Not Determined
MIC	Not Determined
MIC	Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycoplasmoides pneumoniae

External ID: CHEMBL1660014

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2009
Volume: 53
Issue: 12
First Page: 5317
Last Page: 5318
DOI: 10.1128/aac.00746-09

Target ChEMBL ID: CHEMBL612627
ChEMBL Target Name: Mycoplasmoides pneumoniae
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	0.5	ug.mL-1
MIC50	=	4	ug.mL-1
MIC90	=	4	ug.mL-1
MIC	=	0.016	ug.mL-1
MIC50	=	0.125	ug.mL-1
MIC90	=	0.125	ug.mL-1
MIC	=	0.06	ug.mL-1
MIC50	=	0.06	ug.mL-1
MIC90	=	0.12	ug.mL-1
MIC	=	0.004	ug.mL-1
MIC50	=	0.032	ug.mL-1
MIC90	=	0.125	ug.mL-1
MIC	=	0.001	ug.mL-1
MIC50	=	0.001	ug.mL-1
MIC90	=	0.016	ug.mL-1
MIC	=	0.016	ug.mL-1
MIC50	=	0.25	ug.mL-1
MIC90	=	0.25	ug.mL-1
MIC	=	0.25	ug.mL-1
MIC50	=	1	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Metamycoplasma hominis

External ID: CHEMBL1660015

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2009
Volume: 53
Issue: 12
First Page: 5317
Last Page: 5318
DOI: 10.1128/aac.00746-09

Target ChEMBL ID: CHEMBL615053
ChEMBL Target Name: Metamycoplasma hominis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	0.25	ug.mL-1
MIC50	=	1	ug.mL-1
MIC90	=	1	ug.mL-1
MIC	=	0.016	ug.mL-1
MIC50	=	0.125	ug.mL-1
MIC90	=	0.125	ug.mL-1
MIC	=	0.063	ug.mL-1
MIC50	=	0.06	ug.mL-1
MIC90	=	0.06	ug.mL-1
MIC	=	0.008	ug.mL-1
MIC50	=	2	ug.mL-1
MIC90	=	2	ug.mL-1
MIC	=	0.5	ug.mL-1
MIC50	=	8	ug.mL-1
MIC90	=	8	ug.mL-1
MIC	=	0.008	ug.mL-1
MIC50	=	0.032	ug.mL-1
MIC90	=	0.032	ug.mL-1
MIC	=	0.1	ug.mL-1
MIC50	=	0.25	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL912651

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2007
Volume: 51
Issue: 1
First Page: 307
Last Page: 316
DOI: 10.1128/aac.00808-06

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bacillus subtilis

External ID: CHEMBL892121

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2007
Volume: 42
Issue: 10
First Page: 1293
Last Page: 1299
DOI: 10.1016/j.ejmech.2007.01.022

Target ChEMBL ID: CHEMBL359
ChEMBL Target Name: Bacillus subtilis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	1.56	ug.mL-1
MIC	=	1.56	ug.mL-1
MIC	=	1.56	ug.mL-1
MIC	=	1.56	ug.mL-1
MIC	=	50	ug.mL-1
MIC	=	50	ug.mL-1
MIC	=	25	ug.mL-1
MIC	=	50	ug.mL-1
MIC	=	25	ug.mL-1
MIC	=	50	ug.mL-1
MIC	=	50	ug.mL-1
MIC	=	50	ug.mL-1
MIC	=	25	ug.mL-1
MIC	=	25	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL912652

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2007
Volume: 51
Issue: 1
First Page: 307
Last Page: 316
DOI: 10.1128/aac.00808-06

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	10	%
Activity	=	10	%
Activity	=	10	%
Activity	=	10	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Escherichia coli

External ID: CHEMBL892122

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2007
Volume: 42
Issue: 10
First Page: 1293
Last Page: 1299
DOI: 10.1016/j.ejmech.2007.01.022

Target ChEMBL ID: CHEMBL354
ChEMBL Target Name: Escherichia coli
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	3.13	ug.mL-1
MIC	=	3.12	ug.mL-1
MIC	=	12.5	ug.mL-1
MIC	=	3.12	ug.mL-1
MIC	=	100	ug.mL-1
MIC	=	50	ug.mL-1
MIC	=	100	ug.mL-1
MIC	=	50	ug.mL-1
MIC	=	25	ug.mL-1
MIC	=	50	ug.mL-1
MIC	=	25	ug.mL-1
MIC	=	50	ug.mL-1
MIC	=	25	ug.mL-1
MIC	=	50	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL912653

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2007
Volume: 51
Issue: 1
First Page: 307
Last Page: 316
DOI: 10.1128/aac.00808-06

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Pseudomonas aeruginosa

External ID: CHEMBL892123

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2007
Volume: 42
Issue: 10
First Page: 1293
Last Page: 1299
DOI: 10.1016/j.ejmech.2007.01.022

Target ChEMBL ID: CHEMBL348
ChEMBL Target Name: Pseudomonas aeruginosa
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	0.78	ug.mL-1
MIC	>	200	ug.mL-1
MIC	>	200	ug.mL-1
MIC	=	50	ug.mL-1
MIC	=	100	ug.mL-1
MIC	=	50	ug.mL-1
MIC	=	25	ug.mL-1
MIC	=	25	ug.mL-1
MIC	=	50	ug.mL-1
MIC	=	50	ug.mL-1
MIC	=	25	ug.mL-1
MIC	=	50	ug.mL-1
MIC	=	50	ug.mL-1
MIC	=	25	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL1660032

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2009
Volume: 53
Issue: 11
First Page: 4938
Last Page: 4939
DOI: 10.1128/aac.00724-09

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC50	=	0.004	ug.mL-1
MIC90	=	0.008	ug.mL-1
MIC	=	0.001	ug.mL-1
MIC50	=	0.032	ug.mL-1
MIC90	=	0.064	ug.mL-1
MIC	=	3.1E-5	ug.mL-1	Outside typical range
MIC50	=	2.5E-4	ug.mL-1	Outside typical range
MIC90	=	2.5E-4	ug.mL-1	Outside typical range
MIC	=	1.6E-5	ug.mL-1	Outside typical range
MIC50	=	6.3E-5	ug.mL-1	Outside typical range
MIC90	=	1.25E-4	ug.mL-1	Outside typical range
MIC	=	2.0E-7	ug.mL-1	Outside typical range
MIC50	=	1.0E-6	ug.mL-1	Outside typical range
MIC90	=	2.0E-6	ug.mL-1	Outside typical range
MIC	=	8.0E-6	ug.mL-1	Outside typical range
MIC50	=	6.3E-5	ug.mL-1	Outside typical range
MIC90	=	1.25E-4	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC50	=	1.25E-4	ug.mL-1	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL912647

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Antimicrob. Agents Chemother.
Year: 2007
Volume: 51
Issue: 1
First Page: 307
Last Page: 316
DOI: 10.1128/aac.00808-06

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
1023.3	MIC90	=	1023300	nM
1.1	IC50	=	1100	nM
15.8	MIC90	=	15800	nM
15.1	IC50	=	15100	nM
64.9	MIC90	=	64900	nM
575.4	IC50	=	575400	nM	Outside typical range
3090.3	MIC90	=	3090300	nM
0.15	IC50	=	150	nM
0.73	MIC90	=	730	nM
1548.8	IC50	=	1548800	nM	Outside typical range
6918.3	MIC90	=	6918300	nM
107.1	IC50	=	107100	nM	Outside typical range
346.1	MIC90	=	346100	nM
17782.8	IC50	=	17782800	nM	Outside typical range
58884.4	MIC90	=	58884400	nM	Outside typical range
524.8	IC50	=	524800	nM	Outside typical range
871	MIC90	=	871000	nM
134.9	IC50	=	134900	nM	Outside typical range
562.3	MIC90	=	562300	nM
7.2	IC50	=	7200	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL1660033

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2009
Volume: 53
Issue: 11
First Page: 4938
Last Page: 4939
DOI: 10.1128/aac.00724-09

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
MIC	=	0.001	ug.mL-1
MIC50	=	0.002	ug.mL-1
MIC90	=	0.008	ug.mL-1
MIC	>=	0.004	ug.mL-1
MIC50	>=	0.008	ug.mL-1
MIC90	>=	0.008	ug.mL-1
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC50	=	5.0E-4	ug.mL-1
MIC90	=	5.0E-4	ug.mL-1
MIC	=	3.1E-5	ug.mL-1	Outside typical range
MIC50	=	6.3E-5	ug.mL-1	Outside typical range
MIC90	=	1.25E-4	ug.mL-1	Outside typical range
MIC	=	2.0E-6	ug.mL-1	Outside typical range
MIC50	=	4.0E-6	ug.mL-1	Outside typical range
MIC90	=	8.0E-6	ug.mL-1	Outside typical range
MIC	=	1.6E-5	ug.mL-1	Outside typical range
MIC50	=	6.3E-5	ug.mL-1	Outside typical range
MIC90	=	1.25E-4	ug.mL-1	Outside typical range
MIC	=	1.25E-4	ug.mL-1	Outside typical range
MIC50	=	2.5E-4	ug.mL-1	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL912648

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Antimicrob. Agents Chemother.
Year: 2007
Volume: 51
Issue: 1
First Page: 307
Last Page: 316
DOI: 10.1128/aac.00808-06

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
190.5	MIC90	=	190500	nM
1.2	IC50	=	1200	nM
10.2	MIC90	=	10200	nM
16.9	IC50	=	16900	nM
52.3	MIC90	=	52300	nM
676.1	IC50	=	676100	nM	Outside typical range
1948.8	MIC90	=	1948800	nM
0.1	IC50	=	100	nM
0.48	MIC90	=	480	nM
1479.1	IC50	=	1479100	nM	Outside typical range
5754.4	MIC90	=	5754400	nM
97.7	IC50	=	97700	nM
346	MIC90	=	346000	nM
17378	IC50	=	17378000	nM	Outside typical range
51286.1	MIC90	=	51286100	nM	Outside typical range
457.1	IC50	=	457100	nM	Outside typical range
691.8	MIC90	=	691800	nM
2.19	IC50	=	2190	nM
26.9	MIC90	=	26900	nM
5.6	IC50	=	5600	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL1660034

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2009
Volume: 53
Issue: 11
First Page: 4938
Last Page: 4939
DOI: 10.1128/aac.00724-09

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
MIC	=	0.004	ug.mL-1
MIC	=	0.032	ug.mL-1
MIC	=	1.25E-4	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	1.0E-6	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	2.0E-6	ug.mL-1	Outside typical range
MIC	=	3.1E-5	ug.mL-1	Outside typical range
MIC	=	0.001	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL1660035

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2009
Volume: 53
Issue: 11
First Page: 4938
Last Page: 4939
DOI: 10.1128/aac.00724-09

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
MIC	=	0.004	ug.mL-1
MIC	=	0.032	ug.mL-1
MIC	=	1.25E-4	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	1.0E-6	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	2.0E-6	ug.mL-1	Outside typical range
MIC	=	3.1E-5	ug.mL-1	Outside typical range
MIC	=	0.001	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL912650

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2007
Volume: 51
Issue: 1
First Page: 307
Last Page: 316
DOI: 10.1128/aac.00808-06

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Staphylococcus aureus

External ID: CHEMBL892120

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2007
Volume: 42
Issue: 10
First Page: 1293
Last Page: 1299
DOI: 10.1016/j.ejmech.2007.01.022

Target ChEMBL ID: CHEMBL352
ChEMBL Target Name: Staphylococcus aureus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	3.12	ug.mL-1
MIC	=	1.56	ug.mL-1
MIC	=	1.56	ug.mL-1
MIC	=	1.56	ug.mL-1
MIC	=	200	ug.mL-1
MIC	=	50	ug.mL-1
MIC	=	50	ug.mL-1
MIC	=	50	ug.mL-1
MIC	=	25	ug.mL-1
MIC	=	50	ug.mL-1
MIC	=	100	ug.mL-1
MIC	=	50	ug.mL-1
MIC	=	50	ug.mL-1
MIC	=	50	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Staphylococcus aureus

External ID: CHEMBL1261266

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2010
Volume: 54
Issue: 6
First Page: 2704
Last Page: 2706
DOI: 10.1128/aac.00301-10

Target ChEMBL ID: CHEMBL352
ChEMBL Target Name: Staphylococcus aureus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC50	>	4	ug.mL-1
MIC90	>	4	ug.mL-1
MIC50	=	1	ug.mL-1
MIC90	=	2	ug.mL-1
MIC50	=	1	ug.mL-1
MIC90	=	1	ug.mL-1
MIC50	<=	1	ug.mL-1
MIC90	>	8	ug.mL-1
MIC50	<=	0.25	ug.mL-1
MIC90	>	2	ug.mL-1
MIC50	=	0.12	ug.mL-1
MIC90	=	0.25	ug.mL-1
MIC50	>	4	ug.mL-1
MIC90	>	4	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Staphylococcus aureus

External ID: CHEMBL1261274

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2010
Volume: 54
Issue: 6
First Page: 2704
Last Page: 2706
DOI: 10.1128/aac.00301-10

Target ChEMBL ID: CHEMBL352
ChEMBL Target Name: Staphylococcus aureus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Activity	=	25.2	%
Activity				Not Active
Activity	=	0	%
Activity	=	5	%
Activity	=	4.9	%
Activity				Not Active
Activity	=	6.8	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL1660044

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2009
Volume: 53
Issue: 11
First Page: 4938
Last Page: 4939
DOI: 10.1128/aac.00724-09

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	0.001	ug.mL-1
MIC	=	3.1E-5	ug.mL-1	Outside typical range
MIC	=	1.6E-5	ug.mL-1	Outside typical range
MIC	=	2.0E-7	ug.mL-1	Outside typical range
MIC	=	8.0E-6	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	5.0E-7	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	1.25E-4	ug.mL-1	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Staphylococcus aureus

External ID: CHEMBL1261273

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2010
Volume: 54
Issue: 6
First Page: 2704
Last Page: 2706
DOI: 10.1128/aac.00301-10

Target ChEMBL ID: CHEMBL352
ChEMBL Target Name: Staphylococcus aureus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	74.3	%
Activity	=	100	%
Activity	=	100	%
Activity	=	94.6	%
Activity	=	95	%
Activity	=	100	%
Activity	=	92.9	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL1660045

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2009
Volume: 53
Issue: 11
First Page: 4938
Last Page: 4939
DOI: 10.1128/aac.00724-09

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	0.001	ug.mL-1
MIC	=	3.1E-5	ug.mL-1	Outside typical range
MIC	=	1.6E-5	ug.mL-1	Outside typical range
MIC	=	2.0E-7	ug.mL-1	Outside typical range
MIC	=	8.0E-6	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	5.0E-7	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	1.25E-4	ug.mL-1	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Staphylococcus aureus

External ID: CHEMBL1261272

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2010
Volume: 54
Issue: 6
First Page: 2704
Last Page: 2706
DOI: 10.1128/aac.00301-10

Target ChEMBL ID: CHEMBL352
ChEMBL Target Name: Staphylococcus aureus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC50	<=	0.25	ug.mL-1
MIC90	>	4	ug.mL-1
MIC50	=	2	ug.mL-1
MIC90	=	2	ug.mL-1
MIC50	=	1	ug.mL-1
MIC90	=	1	ug.mL-1
MIC50	<=	1	ug.mL-1
MIC90	<=	1	ug.mL-1
MIC50	<=	0.25	ug.mL-1
MIC90	<=	0.25	ug.mL-1
MIC50	=	0.12	ug.mL-1
MIC90	=	0.25	ug.mL-1
MIC50	<=	0.5	ug.mL-1
MIC90	<=	0.5	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL1660046

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2009
Volume: 53
Issue: 11
First Page: 4938
Last Page: 4939
DOI: 10.1128/aac.00724-09

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	0.001	ug.mL-1
MIC	=	3.1E-5	ug.mL-1	Outside typical range
MIC	=	1.6E-5	ug.mL-1	Outside typical range
MIC	=	2.0E-7	ug.mL-1	Outside typical range
MIC	=	8.0E-6	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	5.0E-7	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	1.25E-4	ug.mL-1	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Klebsiella pneumoniae

External ID: CHEMBL3095208

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2013
Volume: 21
Issue: 23
First Page: 7499
Last Page: 7506
DOI: 10.1016/j.bmc.2013.09.041

Target ChEMBL ID: CHEMBL350
ChEMBL Target Name: Klebsiella pneumoniae
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	2	ug.mL-1
MIC	=	0.12	ug.mL-1
MIC	=	0.12	ug.mL-1
MIC	=	256	ug.mL-1
MIC	=	2	ug.mL-1
MIC	=	64	ug.mL-1
MIC	=	128	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL1660047

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2009
Volume: 53
Issue: 11
First Page: 4938
Last Page: 4939
DOI: 10.1128/aac.00724-09

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	0.001	ug.mL-1
MIC	=	3.1E-5	ug.mL-1	Outside typical range
MIC	=	1.6E-5	ug.mL-1	Outside typical range
MIC	=	2.0E-7	ug.mL-1	Outside typical range
MIC	=	8.0E-6	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	5.0E-7	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	1.25E-4	ug.mL-1	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Staphylococcus aureus

External ID: CHEMBL1261270

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2010
Volume: 54
Issue: 6
First Page: 2704
Last Page: 2706
DOI: 10.1128/aac.00301-10

Target ChEMBL ID: CHEMBL352
ChEMBL Target Name: Staphylococcus aureus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Activity	=	85.6	%
Activity	<	0.1	%
Activity	=	0.1	%
Activity	=	19.9	%
Activity	=	45.3	%
Activity				Not Active
Activity	=	77.9	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL1660048

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2009
Volume: 53
Issue: 11
First Page: 4938
Last Page: 4939
DOI: 10.1128/aac.00724-09

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	0.001	ug.mL-1
MIC	=	3.1E-5	ug.mL-1	Outside typical range
MIC	=	1.6E-5	ug.mL-1	Outside typical range
MIC	=	2.0E-7	ug.mL-1	Outside typical range
MIC	=	8.0E-6	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	5.0E-7	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	1.25E-4	ug.mL-1	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Stenotrophomonas maltophilia

External ID: CHEMBL3095210

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2013
Volume: 21
Issue: 23
First Page: 7499
Last Page: 7506
DOI: 10.1016/j.bmc.2013.09.041

Target ChEMBL ID: CHEMBL612366
ChEMBL Target Name: Stenotrophomonas maltophilia
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	0.25	ug.mL-1
MIC	=	128	ug.mL-1
MIC	=	0.12	ug.mL-1
MIC	=	128	ug.mL-1
MIC	=	8	ug.mL-1
MIC	=	32	ug.mL-1
MIC	=	128	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Staphylococcus aureus

External ID: CHEMBL1261269

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2010
Volume: 54
Issue: 6
First Page: 2704
Last Page: 2706
DOI: 10.1128/aac.00301-10

Target ChEMBL ID: CHEMBL352
ChEMBL Target Name: Staphylococcus aureus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	14.2	%
Activity	>	99.9	%
Activity	=	99.9	%
Activity	=	80.1	%
Activity	=	54.3	%
Activity	=	100	%
Activity	=	21.6	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL1660173

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2009
Volume: 53
Issue: 11
First Page: 4938
Last Page: 4939
DOI: 10.1128/aac.00724-09

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	0.001	ug.mL-1
MIC	=	3.1E-5	ug.mL-1	Outside typical range
MIC	=	1.6E-5	ug.mL-1	Outside typical range
MIC	=	2.0E-7	ug.mL-1	Outside typical range
MIC	=	8.0E-6	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	5.0E-7	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	1.25E-4	ug.mL-1	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL912047

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2007
Volume: 51
Issue: 1
First Page: 307
Last Page: 316
DOI: 10.1128/aac.00808-06

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Activity	=	0.1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Staphylococcus aureus

External ID: CHEMBL1261268

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2010
Volume: 54
Issue: 6
First Page: 2704
Last Page: 2706
DOI: 10.1128/aac.00301-10

Target ChEMBL ID: CHEMBL352
ChEMBL Target Name: Staphylococcus aureus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Activity	=	85.6	%
Activity				Not Active
Activity	=	0	%
Activity	=	19.1	%
Activity	=	45	%
Activity				Not Active
Activity	=	77.9	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL1660174

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2009
Volume: 53
Issue: 11
First Page: 4938
Last Page: 4939
DOI: 10.1128/aac.00724-09

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	0.001	ug.mL-1
MIC	=	3.1E-5	ug.mL-1	Outside typical range
MIC	=	1.6E-5	ug.mL-1	Outside typical range
MIC	=	2.0E-7	ug.mL-1	Outside typical range
MIC	=	8.0E-6	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	5.0E-7	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	1.25E-4	ug.mL-1	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Staphylococcus aureus

External ID: CHEMBL1261267

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2010
Volume: 54
Issue: 6
First Page: 2704
Last Page: 2706
DOI: 10.1128/aac.00301-10

Target ChEMBL ID: CHEMBL352
ChEMBL Target Name: Staphylococcus aureus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	13.9	%
Activity	>	99.9	%
Activity	=	99.9	%
Activity	=	80.7	%
Activity	=	54.7	%
Activity	=	100	%
Activity	=	21.6	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL1660175

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2009
Volume: 53
Issue: 11
First Page: 4938
Last Page: 4939
DOI: 10.1128/aac.00724-09

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	0.001	ug.mL-1
MIC	=	3.1E-5	ug.mL-1	Outside typical range
MIC	=	1.6E-5	ug.mL-1	Outside typical range
MIC	=	2.0E-7	ug.mL-1	Outside typical range
MIC	=	8.0E-6	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	5.0E-7	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	1.25E-4	ug.mL-1	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL1660036

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2009
Volume: 53
Issue: 11
First Page: 4938
Last Page: 4939
DOI: 10.1128/aac.00724-09

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
MIC	=	0.004	ug.mL-1
MIC	=	0.032	ug.mL-1
MIC	=	1.25E-4	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	1.0E-6	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	2.0E-6	ug.mL-1	Outside typical range
MIC	=	3.1E-5	ug.mL-1	Outside typical range
MIC	=	0.001	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL1660037

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2009
Volume: 53
Issue: 11
First Page: 4938
Last Page: 4939
DOI: 10.1128/aac.00724-09

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
MIC	=	0.004	ug.mL-1
MIC	=	0.032	ug.mL-1
MIC	=	1.25E-4	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	1.0E-6	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	2.0E-6	ug.mL-1	Outside typical range
MIC	=	3.1E-5	ug.mL-1	Outside typical range
MIC	=	0.001	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL1660038

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2009
Volume: 53
Issue: 11
First Page: 4938
Last Page: 4939
DOI: 10.1128/aac.00724-09

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
MIC	=	0.004	ug.mL-1
MIC	=	0.032	ug.mL-1
MIC	=	1.25E-4	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	1.0E-6	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	6.3E-5	ug.mL-1	Outside typical range
MIC	=	2.0E-6	ug.mL-1	Outside typical range
MIC	=	3.1E-5	ug.mL-1	Outside typical range
MIC	=	0.001	ug.mL-1

60-54-8 靶点实验数据