HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Ecdysone receptor

External ID: CHEMBL1051107

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2009
Volume: 17
Issue: 16
First Page: 5868
Last Page: 5873
DOI: 10.1016/j.bmc.2009.07.011

Target ChEMBL ID: CHEMBL5676
ChEMBL Target Name: Ecdysone receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
0.0912	IC50	=	91.2	nM
38.9045	IC50	=	38904.51	nM
245.471	IC50	>	245470.89	nM	Outside typical range
14.4544	IC50	=	14454.4	nM
2.5704	IC50	=	2570.4	nM
0.05888	IC50	=	58.88	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oxysterol-binding protein 1

External ID: CHEMBL5320826

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2023
Volume: 66
Issue: 6
First Page: 3866
Last Page: 3875
DOI: 10.1021/acs.jmedchem.2c01025

Target ChEMBL ID: CHEMBL4523203
ChEMBL Target Name: Oxysterol-binding protein 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.12	Ki	=	120	nM
0.068	Ki	=	68	nM
0.13	Ki	=	130	nM
100	Ki	>	100000	nM
50	Ki	>	50000	nM
30	Ki	>	30000	nM
10	Ki	>	10000	nM
100	Ki	>	100000	nM
0.078	Ki	=	78	nM
10	Ki	>	10000	nM
0.12	Ki	=	120	nM
20	Ki	>	20000	nM
50	Ki	>	50000	nM
100	Ki	>	100000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oxysterol-binding protein 2

External ID: CHEMBL5320827

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2023
Volume: 66
Issue: 6
First Page: 3866
Last Page: 3875
DOI: 10.1021/acs.jmedchem.2c01025

Target ChEMBL ID: CHEMBL5465343
ChEMBL Target Name: Oxysterol-binding protein 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.32	Ki	=	320	nM
50	Ki	>	50000	nM
30	Ki	>	30000	nM
15	Ki	>	15000	nM
3	Ki	>	3000	nM
0.092	Ki	=	92	nM
20	Ki	>	20000	nM
0.87	Ki	>	870	nM
30	Ki	>	30000	nM
50	Ki	>	50000	nM
100	Ki	>	100000	nM

596-94-1 靶点实验数据