HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Transient receptor potential cation channel subfamily A member 1

External ID: CHEMBL3596060

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2015
Volume: 78
Issue: 8
First Page: 1937
Last Page: 1941
DOI: 10.1021/acs.jnatprod.5b00272

Target ChEMBL ID: CHEMBL6007
ChEMBL Target Name: Transient receptor potential cation channel subfamily A member 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Transient receptor potential cation channel subfamily A member 1

External ID: CHEMBL3595872

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2015
Volume: 78
Issue: 8
First Page: 1937
Last Page: 1941
DOI: 10.1021/acs.jnatprod.5b00272

Target ChEMBL ID: CHEMBL6007
ChEMBL Target Name: Transient receptor potential cation channel subfamily A member 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Transient receptor potential cation channel subfamily A member 1

External ID: CHEMBL3596064

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2015
Volume: 78
Issue: 8
First Page: 1937
Last Page: 1941
DOI: 10.1021/acs.jnatprod.5b00272

Target ChEMBL ID: CHEMBL6007
ChEMBL Target Name: Transient receptor potential cation channel subfamily A member 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.58	EC50	=	580	nM
0.53	EC50	=	530	nM
0.42	EC50	=	420	nM
0.45	EC50	=	450	nM
0.68	EC50	=	680	nM
0.69	EC50	=	690	nM
0.36	EC50	=	360	nM
0.54	EC50	=	540	nM
1.04	EC50	=	1040	nM
1.05	EC50	=	1050	nM
20	EC50	=	20000	nM
0.5	EC50	=	500	nM
0.61	EC50	=	610	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Transient receptor potential cation channel subfamily A member 1

External ID: CHEMBL3596065

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2015
Volume: 78
Issue: 8
First Page: 1937
Last Page: 1941
DOI: 10.1021/acs.jnatprod.5b00272

Target ChEMBL ID: CHEMBL6007
ChEMBL Target Name: Transient receptor potential cation channel subfamily A member 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
max activation	=	95	%
max activation	=	94	%
max activation	=	97	%
max activation	=	92	%
max activation	=	82	%
max activation	=	97	%
max activation	=	94	%
max activation	=	88	%
max activation	=	89	%
max activation	=	95	%
max activation	=	90	%
max activation	=	93	%
max activation	=	90	%
max activation	=	96	%
max activation	=	92	%
max activation	=	90	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3596062

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2015
Volume: 78
Issue: 8
First Page: 1937
Last Page: 1941
DOI: 10.1021/acs.jnatprod.5b00272

Standard Type	Activity Comment
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Transient receptor potential cation channel subfamily V member 1

External ID: CHEMBL3596066

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2015
Volume: 78
Issue: 8
First Page: 1937
Last Page: 1941
DOI: 10.1021/acs.jnatprod.5b00272

Target ChEMBL ID: CHEMBL4794
ChEMBL Target Name: Vanilloid receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
	EC50				Not Active
100	EC50	=	100000	nM
	EC50				Not Active
	EC50				Not Active
100	EC50	=	100000	nM
	EC50				Not Active
	EC50				Not Active
	EC50				Not Active
	EC50				Not Active
	EC50				Not Active
170	EC50	=	170000	nM		Outside typical range
	EC50				Not Active
	EC50				Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Transient receptor potential cation channel subfamily V member 1

External ID: CHEMBL3596067

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2015
Volume: 78
Issue: 8
First Page: 1937
Last Page: 1941
DOI: 10.1021/acs.jnatprod.5b00272

Target ChEMBL ID: CHEMBL4794
ChEMBL Target Name: Vanilloid receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
max activation	=	49	%
max activation	=	43	%
max activation	=	25	%
max activation				Not Active
max activation	=	50	%
max activation				Not Active
max activation				Not Active
max activation	=	62	%
max activation				Not Active
max activation				Not Active
max activation				Not Active
max activation				Not Active
max activation				Not Active
max activation	=	63	%
max activation				Not Active
max activation				Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Transient receptor potential cation channel subfamily M member 8

External ID: CHEMBL3596071

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2015
Volume: 78
Issue: 8
First Page: 1937
Last Page: 1941
DOI: 10.1021/acs.jnatprod.5b00272

Target ChEMBL ID: CHEMBL3108632
ChEMBL Target Name: Transient receptor potential cation channel subfamily M member 8
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

591-82-2 靶点实验数据