HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Hepacivirus hominis

External ID: CHEMBL1100136

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2010
Volume: 20
Issue: 5
First Page: 1598
Last Page: 1600
DOI: 10.1016/j.bmcl.2010.01.084

Target ChEMBL ID: CHEMBL379
ChEMBL Target Name: Hepatitis C virus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	5	%
Inhibition	=	9.4	%
Inhibition	=	17.2	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Hepacivirus hominis

External ID: CHEMBL1100135

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2010
Volume: 20
Issue: 5
First Page: 1598
Last Page: 1600
DOI: 10.1016/j.bmcl.2010.01.084

Target ChEMBL ID: CHEMBL379
ChEMBL Target Name: Hepatitis C virus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	22.8	%
Inhibition	=	14.8	%
Inhibition	=	21.2	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Hepacivirus hominis

External ID: CHEMBL1099731

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2010
Volume: 20
Issue: 5
First Page: 1598
Last Page: 1600
DOI: 10.1016/j.bmcl.2010.01.084

Target ChEMBL ID: CHEMBL379
ChEMBL Target Name: Hepatitis C virus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	40.7	%
Inhibition	=	30.9	%
Inhibition	=	35.7	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Hepacivirus hominis

External ID: CHEMBL1099730

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2010
Volume: 20
Issue: 5
First Page: 1598
Last Page: 1600
DOI: 10.1016/j.bmcl.2010.01.084

Target ChEMBL ID: CHEMBL379
ChEMBL Target Name: Hepatitis C virus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	4.2	%
Inhibition	=	14.6	%
Inhibition	=	18.4	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Hepacivirus hominis

External ID: CHEMBL1099729

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2010
Volume: 20
Issue: 5
First Page: 1598
Last Page: 1600
DOI: 10.1016/j.bmcl.2010.01.084

Target ChEMBL ID: CHEMBL379
ChEMBL Target Name: Hepatitis C virus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	28.9	%
Inhibition	=	58.8	%
Inhibition	=	51.3	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Hepacivirus hominis

External ID: CHEMBL1099728

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2010
Volume: 20
Issue: 5
First Page: 1598
Last Page: 1600
DOI: 10.1016/j.bmcl.2010.01.084

Target ChEMBL ID: CHEMBL379
ChEMBL Target Name: Hepatitis C virus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	72.3	%
Inhibition	=	81.1	%
Inhibition	=	92.8	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL941398

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 1992
Volume: 55
Issue: 8
First Page: 1033
Last Page: 1043
DOI: 10.1021/np50086a002

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ED50	=	3.57	ug ml-1
ED50	=	5.5	ug ml-1
ED50	=	3.05	ug ml-1
ED50	>	10	ug ml-1
ED50	=	0.66	ug ml-1
ED50	=	3.45	ug ml-1
ED50	>	10	ug ml-1
ED50	=	0.55	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	=	0.43	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	=	5.01	ug ml-1
ED50	<	0.01	ug ml-1
ED50	=	2.74	ug ml-1
ED50	=	0.35	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：A549

External ID: CHEMBL941400

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 1992
Volume: 55
Issue: 8
First Page: 1033
Last Page: 1043
DOI: 10.1021/np50086a002

Target ChEMBL ID: CHEMBL392
ChEMBL Target Name: A549
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：KB

External ID: CHEMBL941399

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 1992
Volume: 55
Issue: 8
First Page: 1033
Last Page: 1043
DOI: 10.1021/np50086a002

Target ChEMBL ID: CHEMBL398
ChEMBL Target Name: KB
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Beta-secretase 1

External ID: CHEMBL3293240

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 13
First Page: 2945
Last Page: 2948
DOI: 10.1016/j.bmcl.2014.04.060

Target ChEMBL ID: CHEMBL4822
ChEMBL Target Name: Beta-secretase 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
0.41	IC50	=	410	nM
3.1	IC50	=	3100	nM
6.84	Ki	=	6840	nM
	Inhibition				Dose-dependent effect
62.21	IC50	=	62210	nM
	Inhibition				Dose-dependent effect
3000	IC50	>	3000000	nM		Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：TE-671

External ID: CHEMBL941402

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 1992
Volume: 55
Issue: 8
First Page: 1033
Last Page: 1043
DOI: 10.1021/np50086a002

Target ChEMBL ID: CHEMBL615012
ChEMBL Target Name: TE-671
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HCT-8

External ID: CHEMBL941401

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 1992
Volume: 55
Issue: 8
First Page: 1033
Last Page: 1043
DOI: 10.1021/np50086a002

Target ChEMBL ID: CHEMBL613510
ChEMBL Target Name: HCT-8
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1
ED50	>	10	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Squalene monooxygenase

External ID: CHEMBL947712

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2001
Volume: 64
Issue: 8
First Page: 1010
Last Page: 1014
DOI: 10.1021/np010100y

Target ChEMBL ID: CHEMBL4241
ChEMBL Target Name: Squalene monooxygenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
73	IC50	=	73000	nM
13.3	IC50	=	13300	nM
16.4	IC50	=	16400	nM
0.47	IC50	=	470	nM
4	IC50	=	4000	nM
4.2	IC50	=	4200	nM
3.2	IC50	=	3200	nM
20	IC50	=	20000	nM
40	IC50	=	40000	nM
0.59	IC50	=	590	nM
7.9	IC50	=	7900	nM
0.83	IC50	=	830	nM
8	IC50	=	8000	nM
30	IC50	=	30000	nM
32	IC50	=	32000	nM
12	IC50	=	12000	nM
10	IC50	=	10000	nM

58970-75-5 靶点实验数据