HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_2050_1

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	PubChem Standard Value	Ki	Target Accession(s)	Ligand	Target
Ki	7.5	7500	P15121	BDBM16415	Aldo-keto reductase family 1 member B1 [W220Y,C299A]
Ki	1.5	1500	P15121	BDBM16417	Aldo-keto reductase family 1 member B1
Ki	96	96000	P15121	BDBM16419	Aldo-keto reductase family 1 member B1
Ki	360	360000	P15121	BDBM16419	Aldo-keto reductase family 1 member B1 [W220Y,C299A]
Ki	303	303000	P15121	BDBM16419	Aldo-keto reductase family 1 member B1 [C299A]
Ki	621	621000	P15121	BDBM16420	Aldo-keto reductase family 1 member B1
Ki	361	361000	P15121	BDBM16421	Aldo-keto reductase family 1 member B1
Ki	13	13000	P15121	BDBM16422	Aldo-keto reductase family 1 member B1
Ki	100	100000	P15121	BDBM16422	Aldo-keto reductase family 1 member B1 [W220Y,C299A]
Ki	80	80000	P15121	BDBM16423	Aldo-keto reductase family 1 member B1
Ki	62	62000	P15121	BDBM16423	Aldo-keto reductase family 1 member B1 [W220Y,C299A]
Ki	38	38000	P15121	BDBM16424	Aldo-keto reductase family 1 member B1
Ki	42	42000	P15121	BDBM16424	Aldo-keto reductase family 1 member B1 [W220Y,C299A]
Ki	38	38000	P15121	BDBM16425	Aldo-keto reductase family 1 member B1
Ki	11	11000	P15121	BDBM16425	Aldo-keto reductase family 1 member B1 [W220Y,C299A]
Ki	3.5	3500	P15121	BDBM16426	Aldo-keto reductase family 1 member B1
Ki	32	32000	P15121	BDBM16426	Aldo-keto reductase family 1 member B1 [W220Y,C299A]
Ki	18.1	18100	P15121	BDBM16426	Aldo-keto reductase family 1 member B1 [C299A]
Ki	34.2	34200	P15121	BDBM16427	Aldo-keto reductase family 1 member B1
Ki	170	170000	P15121	BDBM16427	Aldo-keto reductase family 1 member B1 [W220Y,C299A]

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tyrosine-protein phosphatase non-receptor type 1

External ID: CHEMBL770117

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2001
Volume: 11
Issue: 14
First Page: 1935
Last Page: 1938
DOI: 10.1016/s0960-894x(01)00325-0

Target ChEMBL ID: CHEMBL335
ChEMBL Target Name: Protein-tyrosine phosphatase 1B
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
4900	IC50	=	4900000	nM	Outside typical range
640	IC50	=	640000	nM	Outside typical range
5700	IC50	=	5700000	nM	Outside typical range
3500	IC50	=	3500000	nM	Outside typical range
3300	IC50	=	3300000	nM	Outside typical range
5500	IC50	=	5500000	nM	Outside typical range
150	IC50	=	150000	nM	Outside typical range
390	IC50	=	390000	nM	Outside typical range
950	IC50	=	950000	nM	Outside typical range
1500	IC50	=	1500000	nM	Outside typical range
2700	IC50	=	2700000	nM	Outside typical range
2300	IC50	=	2300000	nM	Outside typical range
1700	IC50	=	1700000	nM	Outside typical range
2700	IC50	=	2700000	nM	Outside typical range
790	IC50	=	790000	nM	Outside typical range

581-96-4 靶点实验数据