HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：G-protein coupled receptor 35

External ID: CHEMBL3391253

Protocol: N/A

Comment: Journal: MedChemComm
Year: 2012
Volume: 3
Issue: 10
First Page: 1270
Last Page: 1274
DOI: 10.1039/C2MD20210G

Target ChEMBL ID: CHEMBL1293267
ChEMBL Target Name: G-protein coupled receptor 35
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Efficacy	=	28	%
Efficacy	=	6	%
Efficacy	=	37	%
Efficacy	=	15	%
Efficacy	=	25	%
Efficacy	=	13	%
Efficacy	=	21	%
Efficacy	=	13	%
Efficacy	=	91	%
Efficacy	=	83	%
Efficacy	=	34	%
Efficacy				Not Active
Efficacy	>	6	%
Efficacy	=	26	%
Efficacy	=	32	%
Efficacy	=	72	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：G-protein coupled receptor 35

External ID: CHEMBL3391240

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: MedChemComm
Year: 2012
Volume: 3
Issue: 10
First Page: 1270
Last Page: 1274
DOI: 10.1039/C2MD20210G

Target ChEMBL ID: CHEMBL1293267
ChEMBL Target Name: G-protein coupled receptor 35
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
	Activity				Dose-dependent effect
5.66	EC50	=	5660	nM
	Activity				Dose-dependent effect
6.91	EC50	=	6910	nM
	Activity				Dose-dependent effect
	Activity				Dose-dependent effect
52.6	EC50	=	52600	nM
7.44	EC50	=	7440	nM
	Activity				Dose-dependent effect
0.82	EC50	=	820	nM
	Activity				Dose-dependent effect
	Activity				Dose-dependent effect
22	EC50	=	22000	nM
8.66	EC50	=	8660	nM
	Activity				Dose-dependent effect
0.19	EC50	=	190	nM
	Activity				Dose-dependent effect
5.27	EC50	=	5270	nM
	Activity				Dose-dependent effect
	Activity				Dose-dependent effect

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：G-protein coupled receptor 35

External ID: CHEMBL3391245

Protocol: N/A

Comment: Journal: MedChemComm
Year: 2012
Volume: 3
Issue: 10
First Page: 1270
Last Page: 1274
DOI: 10.1039/C2MD20210G

Target ChEMBL ID: CHEMBL1293267
ChEMBL Target Name: G-protein coupled receptor 35
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：G-protein coupled receptor 35

External ID: CHEMBL3391252

Protocol: N/A

Comment: Journal: MedChemComm
Year: 2012
Volume: 3
Issue: 10
First Page: 1270
Last Page: 1274
DOI: 10.1039/C2MD20210G

Target ChEMBL ID: CHEMBL1293267
ChEMBL Target Name: G-protein coupled receptor 35
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Efficacy	=	249	pM
Efficacy	=	254	pM
Efficacy	=	283	pM
Efficacy	=	229	pM
Efficacy	=	269	pM
Efficacy	=	400	pM
Efficacy	=	207	pM
Efficacy	=	232	pM
Efficacy	=	257	pM
Efficacy	=	212	pM
Efficacy	=	235	pM
Efficacy	=	288	pM
Efficacy	=	192	pM
Efficacy	=	178	pM
Efficacy	=	217	pM
Efficacy	=	195	pM
Efficacy	=	195	pM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：G-protein coupled receptor 35

External ID: CHEMBL3391251

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: MedChemComm
Year: 2012
Volume: 3
Issue: 10
First Page: 1270
Last Page: 1274
DOI: 10.1039/C2MD20210G

Target ChEMBL ID: CHEMBL1293267
ChEMBL Target Name: G-protein coupled receptor 35
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
81.1	EC50	=	81100	nM
331	EC50	=	331000	nM	Outside typical range
49.2	EC50	=	49200	nM
17.1	EC50	=	17100	nM
123	EC50	=	123000	nM	Outside typical range
54.4	EC50	=	54400	nM
5.37	EC50	=	5370	nM
36.4	EC50	=	36400	nM
76	EC50	=	76000	nM
500	EC50	>	500000	nM	Outside typical range
41.7	EC50	=	41700	nM
24.2	EC50	=	24200	nM
2.12	EC50	=	2120	nM
29.2	EC50	=	29200	nM

577-71-9 靶点实验数据