HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Sodium-dependent dopamine transporter

External ID: CHEMBL3377149

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 19
First Page: 4754
Last Page: 4758
DOI: 10.1016/j.bmcl.2014.07.062

Target ChEMBL ID: CHEMBL338
ChEMBL Target Name: Dopamine transporter
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0786	EC50	=	78.6	nM
0.037	EC50	=	37	nM
10	EC50	>	10000	nM
0.113	EC50	=	113	nM
10	EC50	>	10000	nM
0.321	EC50	=	321	nM
0.106	EC50	=	106	nM
3.38	EC50	=	3380	nM
0.0126	EC50	=	12.6	nM
0.478	EC50	=	478	nM
0.232	EC50	=	232	nM
0.0543	EC50	=	54.3	nM
10	EC50	>	10000	nM
2.118	EC50	=	2118	nM
0.654	EC50	=	654	nM
0.0576	EC50	=	57.6	nM
0.15	EC50	=	150	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Transporter

External ID: CHEMBL3377151

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 19
First Page: 4754
Last Page: 4758
DOI: 10.1016/j.bmcl.2014.07.062

Target ChEMBL ID: CHEMBL304
ChEMBL Target Name: Norepinephrine transporter
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.112	EC50	=	112	nM
0.078	EC50	=	78	nM
10	EC50	>	10000	nM
0.465	EC50	=	465	nM
10	EC50	>	10000	nM
0.733	EC50	=	733	nM
1.575	EC50	=	1575	nM
10	EC50	>	10000	nM
0.0111	EC50	=	11.1	nM
10	EC50	>	10000	nM
0.64	EC50	=	640	nM
3.434	EC50	=	3434	nM
10	EC50	>	10000	nM
5.6	EC50	=	5600	nM
3.67	EC50	=	3670	nM
0.592	EC50	=	592	nM
10	EC50	>	10000	nM
5.334	EC50	=	5334	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Sodium-dependent serotonin transporter

External ID: CHEMBL3377150

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 19
First Page: 4754
Last Page: 4758
DOI: 10.1016/j.bmcl.2014.07.062

Target ChEMBL ID: CHEMBL313
ChEMBL Target Name: Serotonin transporter
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0217	EC50	=	21.7	nM
0.014	EC50	=	14	nM
0.139	EC50	=	139	nM
0.0538	EC50	=	53.8	nM
0.0224	EC50	=	22.4	nM
0.108	EC50	=	108	nM
0.0237	EC50	=	23.7	nM
0.0034	EC50	=	3.4	nM
0.075	EC50	=	75	nM
0.0232	EC50	=	23.2	nM
0.0162	EC50	=	16.2	nM
0.0186	EC50	=	18.6	nM
0.00803	EC50	=	8.03	nM
0.0446	EC50	=	44.6	nM
0.0549	EC50	=	54.9	nM
0.0347	EC50	=	34.7	nM
0.0332	EC50	=	33.2	nM
0.0366	EC50	=	36.6	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2A

External ID: CHEMBL3377153

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 19
First Page: 4754
Last Page: 4758
DOI: 10.1016/j.bmcl.2014.07.062

Target ChEMBL ID: CHEMBL224
ChEMBL Target Name: Serotonin 2a (5-HT2a) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Emax	=	104	%
Emax	=	119	%
Emax	=	110	%
Emax	=	103	%
Emax	=	107	%
Emax	=	100	%
Emax	=	108	%
Emax	=	96	%
Emax	=	108	%
Emax	=	101	%
Emax				Not Determined
Emax	=	108	%
Emax	=	109	%
Emax	=	99	%
Emax	=	99	%
Emax	=	110	%
Emax	=	102	%
Emax	=	107	%
Emax				Not Active
Emax	=	61	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2A

External ID: CHEMBL3377152

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 19
First Page: 4754
Last Page: 4758
DOI: 10.1016/j.bmcl.2014.07.062

Target ChEMBL ID: CHEMBL224
ChEMBL Target Name: Serotonin 2a (5-HT2a) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
0.0231	EC50	=	23.1	nM
0.00847	EC50	=	8.47	nM
0.006	EC50	=	6	nM
2.443	EC50	=	2443	nM
0.00902	EC50	=	9.02	nM
0.0507	EC50	=	50.7	nM
0.00456	EC50	=	4.56	nM
0.0447	EC50	=	44.7	nM
	EC50				Not Determined
0.00514	EC50	=	5.14	nM
10	EC50	>	10000	nM
0.00627	EC50	=	6.27	nM
0.0383	EC50	=	38.3	nM
0.0188	EC50	=	18.8	nM
0.496	EC50	=	496	nM
	EC50				Not Active
1.25	EC50	=	1250	nM
0.249	EC50	=	249	nM
0.246	EC50	=	246	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Strictosidine synthase

External ID: CHEMBL866892

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2006
Volume: 16
Issue: 9
First Page: 2475
Last Page: 2478
DOI: 10.1016/j.bmcl.2006.01.098

Target ChEMBL ID: CHEMBL4369
ChEMBL Target Name: Strictosidine synthase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
42	Km	=	42000	nM
8.9	Km	=	8900	nM
13	Km	=	13000	nM
7.7	Km	=	7700	nM
80	Km	=	80000	nM
198	Km	=	198000	nM

575-85-9 靶点实验数据