HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Coptotermes formosanus

External ID: CHEMBL3054387

Protocol: N/A

Comment: Journal: J Agric Food Chem
Year: 2008
Volume: 56
Issue: 11
First Page: 4021
Last Page: 4026
DOI: 10.1021/jf800331r

Target ChEMBL ID: CHEMBL613952
ChEMBL Target Name: Coptotermes formosanus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	0.3	mg
Activity	=	0.1	mg
Activity	=	0.1	mg

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tyrosine-protein phosphatase non-receptor type 1

External ID: CHEMBL980220

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2006
Volume: 69
Issue: 11
First Page: 1629
Last Page: 1632
DOI: 10.1021/np060284m

Target ChEMBL ID: CHEMBL335
ChEMBL Target Name: Protein-tyrosine phosphatase 1B
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HCT-8

External ID: CHEMBL980219

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2006
Volume: 69
Issue: 11
First Page: 1629
Last Page: 1632
DOI: 10.1021/np060284m

Target ChEMBL ID: CHEMBL613510
ChEMBL Target Name: HCT-8
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1.49	IC50	=	1490	nM
1.54	IC50	=	1540	nM
	IC50	>	10	ug.mL-1
	IC50	>	10	ug.mL-1
0.78	IC50	=	780	nM
	IC50	>	10	ug.mL-1
	IC50	>	10	ug.mL-1
	IC50	>	10	ug.mL-1
	IC50	>	10	ug.mL-1
	IC50	>	10	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Coptotermes formosanus

External ID: CHEMBL3053127

Protocol: N/A

Comment: Journal: J Agric Food Chem
Year: 2008
Volume: 56
Issue: 11
First Page: 4021
Last Page: 4026
DOI: 10.1021/jf800331r

Target ChEMBL ID: CHEMBL613952
ChEMBL Target Name: Coptotermes formosanus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
mortality	=	5	%
mortality	=	31.7	%
mortality	=	45	%
mortality	=	36.7	%
mortality	=	20	%
mortality	=	100	%
mortality	=	46.7	%
mortality	=	38.3	%
mortality	=	15	%
mortality	=	81.7	%
mortality	=	3.3	%
mortality	=	8.3	%
mortality	=	100	%
mortality	=	10	%
mortality	=	100	%
mortality	=	25	%
mortality	=	100	%
mortality	=	90	%
mortality	=	93.3	%
mortality	=	15	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Coptotermes formosanus

External ID: CHEMBL3053128

Protocol: N/A

Comment: Journal: J Agric Food Chem
Year: 2008
Volume: 56
Issue: 11
First Page: 4021
Last Page: 4026
DOI: 10.1021/jf800331r

Target ChEMBL ID: CHEMBL613952
ChEMBL Target Name: Coptotermes formosanus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
mortality	=	1.7	%
mortality	=	21.7	%
mortality	=	45	%
mortality	=	18.3	%
mortality	=	11.7	%
mortality	=	75	%
mortality	=	18.3	%
mortality	=	0	%
mortality	=	11.7	%
mortality	=	76.7	%
mortality	=	3.3	%
mortality	=	6.7	%
mortality	=	100	%
mortality	=	10	%
mortality	=	100	%
mortality	=	15	%
mortality	=	100	%
mortality	=	81.7	%
mortality	=	56.7	%
mortality	=	15	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Prothrombin

External ID: CHEMBL976587

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2006
Volume: 69
Issue: 11
First Page: 1629
Last Page: 1632
DOI: 10.1021/np060284m

Target ChEMBL ID: CHEMBL204
ChEMBL Target Name: Thrombin
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Coptotermes formosanus

External ID: CHEMBL3053129

Protocol: N/A

Comment: Journal: J Agric Food Chem
Year: 2008
Volume: 56
Issue: 11
First Page: 4021
Last Page: 4026
DOI: 10.1021/jf800331r

Target ChEMBL ID: CHEMBL613952
ChEMBL Target Name: Coptotermes formosanus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
mortality	=	0	%
mortality	=	13.3	%
mortality	=	31.7	%
mortality	=	0	%
mortality	=	1.7	%
mortality	=	13.3	%
mortality	=	3.3	%
mortality	=	0	%
mortality	=	1.7	%
mortality	=	5	%
mortality	=	0	%
mortality	=	3.3	%
mortality	=	87.5	%
mortality	=	0	%
mortality	=	70	%
mortality	=	0	%
mortality	=	100	%
mortality	=	75	%
mortality	=	18.3	%
mortality	=	15	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Polyunsaturated fatty acid 5-lipoxygenase

External ID: CHEMBL3420629

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur. J. Med. Chem.
Year: 2015
Volume: 94
First Page: 132
Last Page: 139
DOI: 10.1016/j.ejmech.2015.02.042

Target ChEMBL ID: CHEMBL215
ChEMBL Target Name: Arachidonate 5-lipoxygenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
2.5	IC50	=	2500	nM
4.3	IC50	=	4300	nM
0.6	IC50	=	600	nM
0.27	IC50	=	270	nM
10	IC50	>	10000	nM
2	IC50	=	2000	nM
10	IC50	>	10000	nM
3.4	IC50	=	3400	nM
10	IC50	>	10000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5121983

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Nat Prod
Year: 2022
Volume: 85
Issue: 4.0
First Page: 776
Last Page: 786
DOI: 10.1021/acs.jnatprod.1c00765

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
1.6	IC50	=	1600	nM
2	IC50	=	2000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Polyunsaturated fatty acid 5-lipoxygenase

External ID: CHEMBL3420628

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur. J. Med. Chem.
Year: 2015
Volume: 94
First Page: 132
Last Page: 139
DOI: 10.1016/j.ejmech.2015.02.042

Target ChEMBL ID: CHEMBL215
ChEMBL Target Name: Arachidonate 5-lipoxygenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.22	IC50	=	220	nM
0.23	IC50	=	230	nM
1.8	IC50	=	1800	nM
0.42	IC50	=	420	nM
4	IC50	=	4000	nM
0.18	IC50	=	180	nM
1.8	IC50	=	1800	nM
3.3	IC50	=	3300	nM
1.6	IC50	=	1600	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Polyunsaturated fatty acid 5-lipoxygenase

External ID: CHEMBL3420867

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur. J. Med. Chem.
Year: 2015
Volume: 94
First Page: 132
Last Page: 139
DOI: 10.1016/j.ejmech.2015.02.042

Target ChEMBL ID: CHEMBL215
ChEMBL Target Name: Arachidonate 5-lipoxygenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
4.7	IC50	=	4700	nM
10	IC50	>	10000	nM
1.7	IC50	=	1700	nM
0.49	IC50	=	490	nM
10	IC50	>	10000	nM
7.1	IC50	=	7100	nM
10	IC50	>	10000	nM
7.9	IC50	=	7900	nM
3.5	IC50	=	3500	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Polyunsaturated fatty acid lipoxygenase ALOX12

External ID: CHEMBL3420874

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2015
Volume: 94
First Page: 132
Last Page: 139
DOI: 10.1016/j.ejmech.2015.02.042

Target ChEMBL ID: CHEMBL3687
ChEMBL Target Name: Arachidonate 12-lipoxygenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Activity				Not Determined
Activity	=	0.91	%
Activity	=	74.9	%
Activity	=	84.3	%
Activity	=	138.4	%
Activity	=	73.2	%
Activity	=	160.8	%
Activity	=	90.6	%
Activity	=	137.5	%
Activity	=	58.8	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Macrophage-expressed gene 1 protein

External ID: CHEMBL3420871

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur. J. Med. Chem.
Year: 2015
Volume: 94
First Page: 132
Last Page: 139
DOI: 10.1016/j.ejmech.2015.02.042

Target ChEMBL ID: CHEMBL3414409
ChEMBL Target Name: Macrophage-expressed gene 1 protein
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.8	IC50	=	800	nM
0.9	IC50	=	900	nM
2.1	IC50	=	2100	nM
10	IC50	>	10000	nM
10	IC50	>	10000	nM
10	IC50	>	10000	nM
1	IC50	=	1000	nM
10	IC50	>	10000	nM
10	IC50	>	10000	nM
10	IC50	>	10000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Polyunsaturated fatty acid lipoxygenase ALOX15

External ID: CHEMBL3420872

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2015
Volume: 94
First Page: 132
Last Page: 139
DOI: 10.1016/j.ejmech.2015.02.042

Target ChEMBL ID: CHEMBL2903
ChEMBL Target Name: Arachidonate 15-lipoxygenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Activity				Not Determined
Activity	=	5.2	%
Activity	=	91.5	%
Activity	=	123.6	%
Activity	=	131.2	%
Activity	=	88.1	%
Activity	=	93.4	%
Activity	=	65.1	%
Activity	=	118.9	%
Activity	=	84.1	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL3074453

Protocol: N/A

Comment: Journal: Med Chem Res
Year: 2013
Volume: 22
Issue: 11
First Page: 5141
Last Page: 5152
DOI: 10.1007/s00044-013-0485-8

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	0.8	ug.mL-1
MIC	=	2.5	ug.mL-1
MIC	=	15	ug.mL-1
MIC	=	35	ug.mL-1
MIC	=	15	ug.mL-1
MIC	=	7.5	ug.mL-1
MIC	=	60	ug.mL-1
MIC	=	50	ug.mL-1
MIC	=	45	ug.mL-1
MIC	=	7.5	ug.mL-1
MIC	=	10	ug.mL-1
MIC	=	85	ug.mL-1
MIC	=	3.3	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：A2780

External ID: CHEMBL980216

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2006
Volume: 69
Issue: 11
First Page: 1629
Last Page: 1632
DOI: 10.1021/np060284m

Target ChEMBL ID: CHEMBL614004
ChEMBL Target Name: A2780
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1.79	IC50	=	1790	nM
1.57	IC50	=	1570	nM
	IC50	>	10	ug.mL-1
	IC50	>	10	ug.mL-1
1.06	IC50	=	1060	nM
	IC50	>	10	ug.mL-1
	IC50	>	10	ug.mL-1
	IC50	>	10	ug.mL-1
	IC50	>	10	ug.mL-1
	IC50	>	10	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL3074452

Protocol: N/A

Comment: Journal: Med Chem Res
Year: 2013
Volume: 22
Issue: 11
First Page: 5141
Last Page: 5152
DOI: 10.1007/s00044-013-0485-8

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	2.7	ug.mL-1
MIC	=	15	ug.mL-1
MIC	=	50	ug.mL-1
MIC	=	65	ug.mL-1
MIC	=	32.9	ug.mL-1
MIC	=	30	ug.mL-1
MIC	=	70	ug.mL-1
MIC	=	55	ug.mL-1
MIC	=	106	ug.mL-1
MIC	=	60	ug.mL-1
MIC	=	20	ug.mL-1
MIC	=	115	ug.mL-1
MIC	=	2.5	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：A549

External ID: CHEMBL980215

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2006
Volume: 69
Issue: 11
First Page: 1629
Last Page: 1632
DOI: 10.1021/np060284m

Target ChEMBL ID: CHEMBL392
ChEMBL Target Name: A549
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1.47	IC50	=	1470	nM
1.42	IC50	=	1420	nM
	IC50	>	10	ug.mL-1
	IC50	>	10	ug.mL-1
0.46	IC50	=	460	nM
	IC50	>	10	ug.mL-1
	IC50	>	10	ug.mL-1
	IC50	>	10	ug.mL-1
	IC50	>	10	ug.mL-1
	IC50	>	10	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：BGC-823

External ID: CHEMBL980218

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2006
Volume: 69
Issue: 11
First Page: 1629
Last Page: 1632
DOI: 10.1021/np060284m

Target ChEMBL ID: CHEMBL614526
ChEMBL Target Name: BGC-823
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1.69	IC50	=	1690	nM
1.79	IC50	=	1790	nM
	IC50	>	10	ug.mL-1
	IC50	>	10	ug.mL-1
1.43	IC50	=	1430	nM
	IC50	>	10	ug.mL-1
	IC50	>	10	ug.mL-1
	IC50	>	10	ug.mL-1
	IC50	>	10	ug.mL-1
	IC50	>	10	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bel-7402

External ID: CHEMBL980217

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2006
Volume: 69
Issue: 11
First Page: 1629
Last Page: 1632
DOI: 10.1021/np060284m

Target ChEMBL ID: CHEMBL614279
ChEMBL Target Name: Bel-7402
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1.66	IC50	=	1660	nM
1.91	IC50	=	1910	nM
	IC50	>	10	ug.mL-1
	IC50	>	10	ug.mL-1
1.07	IC50	=	1070	nM
	IC50	>	10	ug.mL-1
	IC50	>	10	ug.mL-1
	IC50	>	10	ug.mL-1
	IC50	>	10	ug.mL-1
	IC50	>	10	ug.mL-1

573-40-0 靶点实验数据