HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HepG2-CD81

External ID: CHEMBL4483864

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Science
Year: 2018
Volume: 362
Issue: 6419
DOI: 10.1126/science.aat9446

Target ChEMBL ID: CHEMBL4543887
ChEMBL Target Name: HepG2-CD81
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: Winzeler Lab Plasmodium Screening

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
3.48	HEPG2TOX ASSAY - CC90	=	3.48	uM
1.05	HEPG2TOX ASSAY - CC50	=	1.05	uM
1.05	HEPG2TOX ASSAY - CC90	=	1.05	uM
6.54	HEPG2TOX ASSAY - CC50	=	6.54	uM
4.75	HEPG2TOX ASSAY - CC90	=	4.75	uM
1.63	HEPG2TOX ASSAY - CC50	=	1.63	uM
1.63	HEPG2TOX ASSAY - CC90	=	1.63	uM
7.48	HEPG2TOX ASSAY - CC50	=	7.48	uM
3.26	HEPG2TOX ASSAY - CC90	=	3.26	uM
0.0189	HEPG2TOX ASSAY - CC50	=	0.0189	uM
6.77	HEPG2TOX ASSAY - CC90	=	6.77	uM
7.54	HEPG2TOX ASSAY - CC50	=	7.54	uM
12.4	HEPG2TOX ASSAY - CC90	>	12.4	uM
6.3	HEPG2TOX ASSAY - CC50	=	6.3	uM
6.3	HEPG2TOX ASSAY - CC90	=	6.3	uM
9.05	HEPG2TOX ASSAY - CC50	=	9.05	uM
14.9	HEPG2TOX ASSAY - CC90	>	14.9	uM
12.7	HEPG2TOX ASSAY - CC50	>	12.7	uM
12.7	HEPG2TOX ASSAY - CC90	>	12.7	uM
8.37	HEPG2TOX ASSAY - CC50	>	8.37	uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium berghei

External ID: CHEMBL4483863

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Science
Year: 2018
Volume: 362
Issue: 6419
DOI: 10.1126/science.aat9446

Target ChEMBL ID: CHEMBL612653
ChEMBL Target Name: Plasmodium berghei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: Winzeler Lab Plasmodium Screening

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
9.56	LUCIFERASE EXPRESSION CONTROL - IC90	>	9.56	uM
1.17	LUCIFERASE INFECTION ASSAY - IC50	=	1.17	uM
1.41	LUCIFERASE INFECTION ASSAY - IC90	=	1.41	uM
10	LUCIFERASE EXPRESSION CONTROL - IC50	>	10	uM
9.72	LUCIFERASE EXPRESSION CONTROL - IC90	>	9.72	uM
9.01	LUCIFERASE INFECTION ASSAY - IC50	>	9.01	uM
9.01	LUCIFERASE INFECTION ASSAY - IC90	>	9.01	uM
9.01	LUCIFERASE EXPRESSION CONTROL - IC50	>	9.01	uM
9.01	LUCIFERASE EXPRESSION CONTROL - IC90	>	9.01	uM
8.99	LUCIFERASE INFECTION ASSAY - IC50	=	8.99	uM
10	LUCIFERASE INFECTION ASSAY - IC90	>	10	uM
10	LUCIFERASE EXPRESSION CONTROL - IC50	>	10	uM
9.81	LUCIFERASE EXPRESSION CONTROL - IC90	>	9.81	uM
3.23	LUCIFERASE INFECTION ASSAY - IC50	=	3.23	uM
6.33	LUCIFERASE INFECTION ASSAY - IC90	>	6.33	uM
6.33	LUCIFERASE EXPRESSION CONTROL - IC50	>	6.33	uM
8.74	LUCIFERASE EXPRESSION CONTROL - IC90	>	8.74	uM
10	LUCIFERASE INFECTION ASSAY - IC50	>	10	uM
10	LUCIFERASE INFECTION ASSAY - IC90	>	10	uM
10	LUCIFERASE EXPRESSION CONTROL - IC50	>	10	uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3301364

Protocol: N/A

Comment: Data Source: AstraZeneca DMPK/physicochemical

PubChem Standard Value	Standard Type	Standard Value	Standard Units
0.2	Solubility	200	nM
0.1	Solubility	100	nM
79.4	Solubility	79400	nM
741.3	Solubility	741300	nM
1445.4	Solubility	1445400	nM
151.4	Solubility	151400	nM
245.5	Solubility	245500	nM
239.9	Solubility	239900	nM
1445.4	Solubility	1445400	nM
1445.4	Solubility	1445400	nM
50.1	Solubility	50100	nM
154.9	Solubility	154900	nM
144.5	Solubility	144500	nM
10.5	Solubility	10500	nM
426.6	Solubility	426600	nM
407.4	Solubility	407400	nM
457.1	Solubility	457100	nM
9.1	Solubility	9100	nM
2.1	Solubility	2100	nM
158.5	Solubility	158500	nM

573-34-2 靶点实验数据