HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MCF7

External ID: CHEMBL4417014

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Nat Prod
Year: 2019
Volume: 82
Issue: 11
First Page: 3065
Last Page: 3073
DOI: 10.1021/acs.jnatprod.9b00659

Target ChEMBL ID: CHEMBL387
ChEMBL Target Name: MCF7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10	IC50	>	10000	nM
10	IC50	>	10000	nM
5.5	IC50	=	5500	nM
10	IC50	>	10000	nM
5.2	IC50	=	5200	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MCF7

External ID: CHEMBL4141913

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Nat Prod
Year: 2018
Volume: 81
Issue: 3
First Page: 465
Last Page: 474
DOI: 10.1021/acs.jnatprod.7b00578

Target ChEMBL ID: CHEMBL387
ChEMBL Target Name: MCF7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
7.7	IC50	=	7700	nM
10	IC50	>	10000	nM
	Activity				Dose-dependent effect

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Erythrocyte

External ID: CHEMBL4141914

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Nat Prod
Year: 2018
Volume: 81
Issue: 3
First Page: 465
Last Page: 474
DOI: 10.1021/acs.jnatprod.7b00578

Target ChEMBL ID: CHEMBL4296518
ChEMBL Target Name: Erythrocyte
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
500	HD50	>	500	uM
73.1	HD50	=	73.1	uM
500	HD50	>	500	uM
290	HD50	=	290	uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HT-29

External ID: CHEMBL4341159

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2019
Volume: 168
First Page: 436
Last Page: 446
DOI: 10.1016/j.ejmech.2019.02.057

Target ChEMBL ID: CHEMBL384
ChEMBL Target Name: HT-29
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
30	EC50	>	30000	nM
30	EC50	>	30000	nM
19	EC50	=	19000	nM
6.1	EC50	=	6100	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：A2780

External ID: CHEMBL4341158

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2019
Volume: 168
First Page: 436
Last Page: 446
DOI: 10.1016/j.ejmech.2019.02.057

Target ChEMBL ID: CHEMBL614004
ChEMBL Target Name: A2780
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
30	EC50	>	30000	nM
30	EC50	>	30000	nM
11.9	EC50	=	11900	nM
9.7	EC50	=	9700	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：FaDu

External ID: CHEMBL4341157

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2019
Volume: 168
First Page: 436
Last Page: 446
DOI: 10.1016/j.ejmech.2019.02.057

Target ChEMBL ID: CHEMBL612250
ChEMBL Target Name: FaDu
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
30	EC50	>	30000	nM
30	EC50	>	30000	nM
15.4	EC50	=	15400	nM
30	EC50	>	30000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：A549

External ID: CHEMBL4417010

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Nat Prod
Year: 2019
Volume: 82
Issue: 11
First Page: 3065
Last Page: 3073
DOI: 10.1021/acs.jnatprod.9b00659

Target ChEMBL ID: CHEMBL392
ChEMBL Target Name: A549
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
6.2	IC50	=	6200	nM
6.2	IC50	=	6200	nM
4.7	IC50	=	4700	nM
5.3	IC50	=	5300	nM
4.8	IC50	=	4800	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MDA-MB-231

External ID: CHEMBL4417011

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Nat Prod
Year: 2019
Volume: 82
Issue: 11
First Page: 3065
Last Page: 3073
DOI: 10.1021/acs.jnatprod.9b00659

Target ChEMBL ID: CHEMBL400
ChEMBL Target Name: MDA-MB-231
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
9.4	IC50	=	9400	nM
10	IC50	>	10000	nM
5.5	IC50	=	5500	nM
7.3	IC50	=	7300	nM
5.4	IC50	=	5400	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：KB

External ID: CHEMBL4417012

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Nat Prod
Year: 2019
Volume: 82
Issue: 11
First Page: 3065
Last Page: 3073
DOI: 10.1021/acs.jnatprod.9b00659

Target ChEMBL ID: CHEMBL398
ChEMBL Target Name: KB
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
6.6	IC50	=	6600	nM
7.4	IC50	=	7400	nM
5	IC50	=	5000	nM
7	IC50	=	7000	nM
5.3	IC50	=	5300	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4417013

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Nat Prod
Year: 2019
Volume: 82
Issue: 11
First Page: 3065
Last Page: 3073
DOI: 10.1021/acs.jnatprod.9b00659

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10	IC50	>	10000	nM
8.5	IC50	=	8500	nM
6.4	IC50	=	6400	nM
40	IC50	>	40000	nM
5.1	IC50	=	5100	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NIH3T3

External ID: CHEMBL4341162

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2019
Volume: 168
First Page: 436
Last Page: 446
DOI: 10.1016/j.ejmech.2019.02.057

Target ChEMBL ID: CHEMBL614822
ChEMBL Target Name: NIH3T3
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
30	EC50	>	30000	nM
30	EC50	>	30000	nM
9.6	EC50	=	9600	nM
7	EC50	=	7000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：SW-1736

External ID: CHEMBL4341161

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2019
Volume: 168
First Page: 436
Last Page: 446
DOI: 10.1016/j.ejmech.2019.02.057

Target ChEMBL ID: CHEMBL614773
ChEMBL Target Name: SW-1736
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
30	EC50	>	30000	nM
30	EC50	>	30000	nM
17.7	EC50	=	17700	nM
12.2	EC50	=	12200	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MCF7

External ID: CHEMBL4341160

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2019
Volume: 168
First Page: 436
Last Page: 446
DOI: 10.1016/j.ejmech.2019.02.057

Target ChEMBL ID: CHEMBL387
ChEMBL Target Name: MCF7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
	EC50				Not Determined
	EC50				Not Determined
9.8	EC50	=	9800	nM
30	EC50	>	30000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4141911

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Nat Prod
Year: 2018
Volume: 81
Issue: 3
First Page: 465
Last Page: 474
DOI: 10.1021/acs.jnatprod.7b00578

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
4.9	IC50	=	4900	nM
10	IC50	>	10000	nM
	Activity				Dose-dependent effect

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：KB

External ID: CHEMBL4141909

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Nat Prod
Year: 2018
Volume: 81
Issue: 3
First Page: 465
Last Page: 474
DOI: 10.1021/acs.jnatprod.7b00578

Target ChEMBL ID: CHEMBL398
ChEMBL Target Name: KB
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
4.2	IC50	=	4200	nM
10	IC50	>	10000	nM
	Activity				Dose-dependent effect

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4341172

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2019
Volume: 168
First Page: 436
Last Page: 446
DOI: 10.1016/j.ejmech.2019.02.057

Standard Type	Standard Relation	Standard Value
Ratio EC50	=	0.9
Ratio EC50	=	0.5

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MDA-MB-231

External ID: CHEMBL4141907

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Nat Prod
Year: 2018
Volume: 81
Issue: 3
First Page: 465
Last Page: 474
DOI: 10.1021/acs.jnatprod.7b00578

Target ChEMBL ID: CHEMBL400
ChEMBL Target Name: MDA-MB-231
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
5.5	IC50	=	5500	nM
10	IC50	>	10000	nM
	Activity				Dose-dependent effect

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4341171

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2019
Volume: 168
First Page: 436
Last Page: 446
DOI: 10.1016/j.ejmech.2019.02.057

Standard Type	Standard Relation	Standard Value
Ratio EC50	=	1.3
Ratio EC50	=	0.9

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4341170

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2019
Volume: 168
First Page: 436
Last Page: 446
DOI: 10.1016/j.ejmech.2019.02.057

Standard Type	Standard Relation	Standard Value
Ratio EC50	=	0.9
Ratio EC50	=	0.5

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：A549

External ID: CHEMBL4141905

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Nat Prod
Year: 2018
Volume: 81
Issue: 3
First Page: 465
Last Page: 474
DOI: 10.1021/acs.jnatprod.7b00578

Target ChEMBL ID: CHEMBL392
ChEMBL Target Name: A549
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
4.6	IC50	=	4600	nM
10	IC50	>	10000	nM
	Activity				Dose-dependent effect

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4341169

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2019
Volume: 168
First Page: 436
Last Page: 446
DOI: 10.1016/j.ejmech.2019.02.057

Standard Type	Standard Relation	Standard Value
Ratio EC50	=	1.2
Ratio EC50	=	0.8

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4341168

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2019
Volume: 168
First Page: 436
Last Page: 446
DOI: 10.1016/j.ejmech.2019.02.057

Standard Type	Standard Relation	Standard Value
Ratio EC50	=	1.2
Ratio EC50	=	0.6

5672-32-2 靶点实验数据