HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NCI-H460

External ID: CHEMBL1176781

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 14
First Page: 5172
Last Page: 5182
DOI: 10.1016/j.bmc.2010.05.062

Target ChEMBL ID: CHEMBL396
ChEMBL Target Name: NCI-H460
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
RatioGI50	=	33
RatioGI50	=	2.92
RatioGI50	=	4.66

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MCF7

External ID: CHEMBL1176780

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 14
First Page: 5172
Last Page: 5182
DOI: 10.1016/j.bmc.2010.05.062

Target ChEMBL ID: CHEMBL387
ChEMBL Target Name: MCF7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
RatioGI50	=	1.74
RatioGI50	=	2.5
RatioGI50	=	2.06

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Detroit 551

External ID: CHEMBL1176779

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 14
First Page: 5172
Last Page: 5182
DOI: 10.1016/j.bmc.2010.05.062

Target ChEMBL ID: CHEMBL614284
ChEMBL Target Name: Detroit 551
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1.77	GI50	=	1770	nM
100	GI50	>	100000	nM
100	GI50	>	100000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：SF-268

External ID: CHEMBL1176778

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 14
First Page: 5172
Last Page: 5182
DOI: 10.1016/j.bmc.2010.05.062

Target ChEMBL ID: CHEMBL613977
ChEMBL Target Name: SF-268
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.6	GI50	=	600	nM
16.54	GI50	=	16540	nM
7.9	GI50	=	7900	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NCI-H460

External ID: CHEMBL1176777

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 14
First Page: 5172
Last Page: 5182
DOI: 10.1016/j.bmc.2010.05.062

Target ChEMBL ID: CHEMBL396
ChEMBL Target Name: NCI-H460
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.38	GI50	=	380	nM
6.76	GI50	=	6760	nM
7.46	GI50	=	7460	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MCF7

External ID: CHEMBL1176776

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 14
First Page: 5172
Last Page: 5182
DOI: 10.1016/j.bmc.2010.05.062

Target ChEMBL ID: CHEMBL387
ChEMBL Target Name: MCF7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.86	GI50	=	860	nM
10.15	GI50	=	10150	nM
13.32	GI50	=	13320	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Raji

External ID: CHEMBL1018461

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1989
Volume: 52
Issue: 5
First Page: 987
Last Page: 995
DOI: 10.1021/np50065a012

Target ChEMBL ID: CHEMBL614628
ChEMBL Target Name: Raji
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	=	70	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：SF-268

External ID: CHEMBL1176775

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 14
First Page: 5172
Last Page: 5182
DOI: 10.1016/j.bmc.2010.05.062

Target ChEMBL ID: CHEMBL613977
ChEMBL Target Name: SF-268
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	25	%
Activity	=	16	%
Activity	=	16	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NCI-H460

External ID: CHEMBL1176774

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 14
First Page: 5172
Last Page: 5182
DOI: 10.1016/j.bmc.2010.05.062

Target ChEMBL ID: CHEMBL396
ChEMBL Target Name: NCI-H460
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	1	%
Activity	=	2	%
Activity	=	15	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：K562

External ID: CHEMBL1176788

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 14
First Page: 5172
Last Page: 5182
DOI: 10.1016/j.bmc.2010.05.062

Target ChEMBL ID: CHEMBL385
ChEMBL Target Name: K562
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	8.24	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：K562

External ID: CHEMBL1176787

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 14
First Page: 5172
Last Page: 5182
DOI: 10.1016/j.bmc.2010.05.062

Target ChEMBL ID: CHEMBL385
ChEMBL Target Name: K562
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	43.2	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL720678

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1997
Volume: 7
Issue: 15
First Page: 2043
Last Page: 2048
DOI: 10.1016/S0960-894X(97)00354-5

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Lysis	=	33	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：K562

External ID: CHEMBL1176786

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 14
First Page: 5172
Last Page: 5182
DOI: 10.1016/j.bmc.2010.05.062

Target ChEMBL ID: CHEMBL385
ChEMBL Target Name: K562
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	29.4	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：K562

External ID: CHEMBL1176785

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 14
First Page: 5172
Last Page: 5182
DOI: 10.1016/j.bmc.2010.05.062

Target ChEMBL ID: CHEMBL385
ChEMBL Target Name: K562
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	27.4	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：K562

External ID: CHEMBL1176784

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 14
First Page: 5172
Last Page: 5182
DOI: 10.1016/j.bmc.2010.05.062

Target ChEMBL ID: CHEMBL385
ChEMBL Target Name: K562
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
RatioGI50	=	16.5
RatioGI50	=	22.82
RatioGI50	=	239

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：K562

External ID: CHEMBL1176783

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 14
First Page: 5172
Last Page: 5182
DOI: 10.1016/j.bmc.2010.05.062

Target ChEMBL ID: CHEMBL385
ChEMBL Target Name: K562
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0074	GI50	=	7.4	nM
0.6	GI50	=	600	nM
8.59	GI50	=	8590	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：SF-268

External ID: CHEMBL1176782

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 14
First Page: 5172
Last Page: 5182
DOI: 10.1016/j.bmc.2010.05.062

Target ChEMBL ID: CHEMBL613977
ChEMBL Target Name: SF-268
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
RatioGI50	=	5.21
RatioGI50	=	2.62
RatioGI50	=	2.95

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NQO1 protein

External ID: CHEMBL2175345

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2012
Volume: 55
Issue: 16
First Page: 7273
Last Page: 7284
DOI: 10.1021/jm3009597

Target ChEMBL ID: CHEMBL2169730
ChEMBL Target Name: NQO1 protein
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	1	umol/L/min
Activity	=	1.4	umol/L/min
Activity	=	0.4	umol/L/min

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HaCaT

External ID: CHEMBL2175346

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2012
Volume: 55
Issue: 16
First Page: 7273
Last Page: 7284
DOI: 10.1021/jm3009597

Target ChEMBL ID: CHEMBL614392
ChEMBL Target Name: HaCaT
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Flu intensity	=	44
Flu intensity	=	20.5
Flu intensity	=	13

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HaCaT

External ID: CHEMBL2175343

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2012
Volume: 55
Issue: 16
First Page: 7273
Last Page: 7284
DOI: 10.1021/jm3009597

Target ChEMBL ID: CHEMBL614392
ChEMBL Target Name: HaCaT
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Flu intensity	=	457.2
Flu intensity	=	741.4
Flu intensity	=	601.1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HaCaT

External ID: CHEMBL2175344

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2012
Volume: 55
Issue: 16
First Page: 7273
Last Page: 7284
DOI: 10.1021/jm3009597

Target ChEMBL ID: CHEMBL614392
ChEMBL Target Name: HaCaT
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Flu intensity	=	431.9
Flu intensity	=	725.5
Flu intensity	=	452.5

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HaCaT

External ID: CHEMBL2175349

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2012
Volume: 55
Issue: 16
First Page: 7273
Last Page: 7284
DOI: 10.1021/jm3009597

Target ChEMBL ID: CHEMBL614392
ChEMBL Target Name: HaCaT
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
7.54	IC50	=	7540	nM
0.5	IC50	=	500	nM
12.18	IC50	=	12180	nM
2.76	IC50	=	2760	nM
30	IC50	>	30000	nM
2.34	IC50	=	2340	nM
0.89	IC50	=	890	nM
0.92	IC50	=	920	nM
0.24	IC50	=	240	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NADPH--cytochrome P450 reductase

External ID: CHEMBL2175347

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2012
Volume: 55
Issue: 16
First Page: 7273
Last Page: 7284
DOI: 10.1021/jm3009597

Target ChEMBL ID: CHEMBL2169731
ChEMBL Target Name: NADPH--cytochrome P450 reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	2.1	umol/L/min
Activity	=	3	umol/L/min
Activity	=	2.2	umol/L/min

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HaCaT

External ID: CHEMBL2175348

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2012
Volume: 55
Issue: 16
First Page: 7273
Last Page: 7284
DOI: 10.1021/jm3009597

Target ChEMBL ID: CHEMBL614392
ChEMBL Target Name: HaCaT
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Activity	=	268	mU/ml
Activity				Not Determined
Activity	=	239	mU/ml
Activity	=	255	mU/ml
Activity				Not Determined
Activity				Not Determined
Activity	=	186	mU/ml
Activity				Not Determined
Activity				Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MCF7

External ID: CHEMBL1176773

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 14
First Page: 5172
Last Page: 5182
DOI: 10.1016/j.bmc.2010.05.062

Target ChEMBL ID: CHEMBL387
ChEMBL Target Name: MCF7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	33	%
Activity	=	1	%
Activity	=	30	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Raji

External ID: CHEMBL1018458

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1989
Volume: 52
Issue: 5
First Page: 987
Last Page: 995
DOI: 10.1021/np50065a012

Target ChEMBL ID: CHEMBL614628
ChEMBL Target Name: Raji
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	0	%
Activity	=	20	%
Activity	=	70	%
Activity	=	0	%
Activity	=	40	%
Activity	>	80	%
Activity	=	40	%
Activity	>	80	%
Activity	=	60	%
Activity	>	80	%
Activity	=	70	%
Activity	>	80	%
Activity	=	20	%
Activity	=	70	%
Activity	=	0	%
Activity	=	0	%
Activity	=	0	%
Activity	=	70	%
Activity	>	80	%
Activity	=	70	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Saccharomyces cerevisiae

External ID: CHEMBL979668

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1999
Volume: 62
Issue: 7
First Page: 963
Last Page: 968
DOI: 10.1021/np9900019

Target ChEMBL ID: CHEMBL361
ChEMBL Target Name: Saccharomyces cerevisiae
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
IC12				Not Determined
IC12	=	17	ug ml-1
IC12	=	44	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1018457

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 1989
Volume: 52
Issue: 5
First Page: 987
Last Page: 995
DOI: 10.1021/np50065a012

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	31.5	%
Inhibition	=	68.9	%
Inhibition	=	100	%
Inhibition	=	89.4	%
Inhibition	=	100	%
Inhibition	=	100	%
Inhibition	=	100	%
Inhibition	=	89.2	%
Inhibition	=	100	%
Inhibition	=	94.2	%
Inhibition	=	100	%
Inhibition	=	100	%
Inhibition	=	100	%
Inhibition	=	100	%
Inhibition	=	32.7	%
Inhibition	=	59.4	%
Inhibition	=	81.4	%
Inhibition	=	100	%
Inhibition	=	100	%
Inhibition	=	100	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Raji

External ID: CHEMBL1018460

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1989
Volume: 52
Issue: 5
First Page: 987
Last Page: 995
DOI: 10.1021/np50065a012

Target ChEMBL ID: CHEMBL614628
ChEMBL Target Name: Raji
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	50	%
Activity	=	50	%
Activity	>	80	%
Activity	=	70	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	=	50	%
Activity	>	80	%
Activity	=	70	%
Activity	=	10	%
Activity	=	70	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL979670

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 1999
Volume: 62
Issue: 7
First Page: 963
Last Page: 968
DOI: 10.1021/np9900019

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
5	IC50	=	5000	nM
2	IC50	=	2000	nM
20	IC50	>	20000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Raji

External ID: CHEMBL1018459

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1989
Volume: 52
Issue: 5
First Page: 987
Last Page: 995
DOI: 10.1021/np50065a012

Target ChEMBL ID: CHEMBL614628
ChEMBL Target Name: Raji
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	10	%
Activity	=	40	%
Activity	>	80	%
Activity	=	0	%
Activity	=	60	%
Activity	>	80	%
Activity	=	60	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	=	50	%
Activity	>	80	%
Activity	=	0	%
Activity	=	10	%
Activity	=	0	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Saccharomyces cerevisiae

External ID: CHEMBL979669

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1999
Volume: 62
Issue: 7
First Page: 963
Last Page: 968
DOI: 10.1021/np9900019

Target ChEMBL ID: CHEMBL361
ChEMBL Target Name: Saccharomyces cerevisiae
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
IC12	=	14	ug ml-1
IC12	=	83	ug ml-1
IC12	=	160	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1015774

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 1989
Volume: 52
Issue: 5
First Page: 987
Last Page: 995
DOI: 10.1021/np50065a012

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	0	%
Inhibition	=	0	%
Inhibition	=	89.5	%
Inhibition	=	0	%
Inhibition	=	0	%
Inhibition	=	18.2	%
Inhibition	=	0	%
Inhibition	=	0	%
Inhibition	=	71.4	%
Inhibition	=	23.8	%
Inhibition	=	27.1	%
Inhibition	=	28.5	%
Inhibition	=	0	%
Inhibition	=	34.6	%
Inhibition	=	0	%
Inhibition	=	0	%
Inhibition	=	0	%
Inhibition	=	40.6	%
Inhibition	=	45.8	%
Inhibition	=	55.5	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1018456

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 1989
Volume: 52
Issue: 5
First Page: 987
Last Page: 995
DOI: 10.1021/np50065a012

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	15.8	%
Inhibition	=	0	%
Inhibition	=	100	%
Inhibition	=	65.7	%
Inhibition	=	88.4	%
Inhibition	=	91.1	%
Inhibition	=	97.8	%
Inhibition	=	61.5	%
Inhibition	=	100	%
Inhibition	=	71.2	%
Inhibition	=	92.3	%
Inhibition	=	89.9	%
Inhibition	=	37.5	%
Inhibition	=	100	%
Inhibition	=	0	%
Inhibition	=	0	%
Inhibition	=	52.8	%
Inhibition	=	77.5	%
Inhibition	=	92.5	%
Inhibition	=	100	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1015775

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 1989
Volume: 52
Issue: 5
First Page: 987
Last Page: 995
DOI: 10.1021/np50065a012

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	0	%
Inhibition	=	0	%
Inhibition	=	100	%
Inhibition	=	0	%
Inhibition	=	0	%
Inhibition	=	54.2	%
Inhibition	=	13.1	%
Inhibition	=	60.5	%
Inhibition	=	92.4	%
Inhibition	=	61.9	%
Inhibition	=	70.1	%
Inhibition	=	78.6	%
Inhibition	=	0	%
Inhibition	=	54.3	%
Inhibition	=	0	%
Inhibition	=	0	%
Inhibition	=	0	%
Inhibition	=	48.7	%
Inhibition	=	89.2	%
Inhibition	=	94.1	%

5656-82-6 靶点实验数据