HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Leishmania infantum

External ID: CHEMBL3299756

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2014
Volume: 57
Issue: 12
First Page: 5157
Last Page: 5168
DOI: 10.1021/jm4019492

Target ChEMBL ID: CHEMBL612848
ChEMBL Target Name: Leishmania infantum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
EC50	<	60	ug.mL-1	Outside typical range
EC50	<	60	ug.mL-1	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Leishmania donovani

External ID: CHEMBL3299755

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2014
Volume: 57
Issue: 12
First Page: 5157
Last Page: 5168
DOI: 10.1021/jm4019492

Target ChEMBL ID: CHEMBL367
ChEMBL Target Name: Leishmania donovani
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
EC50	<	60	ug.mL-1	Outside typical range
EC50	<	60	ug.mL-1	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3299758

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2014
Volume: 57
Issue: 12
First Page: 5157
Last Page: 5168
DOI: 10.1021/jm4019492

Standard Type	Standard Text Value	Standard Units
Stability	Unstable	%
Stability	Unstable	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3299757

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2014
Volume: 57
Issue: 12
First Page: 5157
Last Page: 5168
DOI: 10.1021/jm4019492

Standard Type	Activity Comment
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MCF7

External ID: CHEMBL1167767

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 12
First Page: 4530
Last Page: 4534
DOI: 10.1016/j.bmc.2010.04.062

Target ChEMBL ID: CHEMBL387
ChEMBL Target Name: MCF7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	0	%
Inhibition	=	13	%
Inhibition	=	22	%
Inhibition	=	14	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Trypanosoma cruzi

External ID: CHEMBL1167766

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 12
First Page: 4530
Last Page: 4534
DOI: 10.1016/j.bmc.2010.04.062

Target ChEMBL ID: CHEMBL368
ChEMBL Target Name: Trypanosoma cruzi
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
IC50	=	2.62	ug.mL-1
IC50	>	100	ug.mL-1	Outside typical range
IC50	>	100	ug.mL-1	Outside typical range
IC50	=	48.35	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Leishmania donovani

External ID: CHEMBL1167765

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 12
First Page: 4530
Last Page: 4534
DOI: 10.1016/j.bmc.2010.04.062

Target ChEMBL ID: CHEMBL367
ChEMBL Target Name: Leishmania donovani
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
IC50	=	65.07	ug.mL-1	Outside typical range
IC50	>	100	ug.mL-1	Outside typical range
IC50	>	100	ug.mL-1	Outside typical range
IC50	=	29.9	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Leishmania amazonensis

External ID: CHEMBL1167764

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 12
First Page: 4530
Last Page: 4534
DOI: 10.1016/j.bmc.2010.04.062

Target ChEMBL ID: CHEMBL612877
ChEMBL Target Name: Leishmania amazonensis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
IC50	=	27.3	ug.mL-1
IC50	=	0.83	ug.mL-1
IC50	>	100	ug.mL-1	Outside typical range
IC50	=	9.04	ug.mL-1

56252-05-2 靶点实验数据