HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Thoracic aorta

External ID: CHEMBL4021828

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2017
Volume: 27
Issue: 12
First Page: 2812
Last Page: 2817
DOI: 10.1016/j.bmcl.2017.04.076

Target ChEMBL ID: CHEMBL2367449
ChEMBL Target Name: Thoracic aorta
ChEMBL Target Type: TISSUE - Target is a healthy or diseased tissue
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1068155

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 6
First Page: 2337
Last Page: 2345
DOI: 10.1016/j.bmc.2010.01.046

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	11.9	%
Inhibition	<	8.8	%
Inhibition	<	8.8	%
Inhibition	<	8.8	%
Inhibition	<	8.8	%
Inhibition	<	8.8	%
Inhibition	<	8.8	%
Inhibition	<	8.8	%
Inhibition	<	8.8	%
Inhibition	=	17.6	%
Inhibition	<	8.8	%
Inhibition	<	8.8	%
Inhibition	<	8.8	%
Inhibition	<	8.8	%
Inhibition	=	16.3	%
Inhibition	=	23.4	%
Inhibition	<	8.8	%
Inhibition	<	8.8	%
Inhibition	<	8.8	%
Inhibition	<	8.8	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Thoracic aorta

External ID: CHEMBL4021826

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2017
Volume: 27
Issue: 12
First Page: 2812
Last Page: 2817
DOI: 10.1016/j.bmcl.2017.04.076

Target ChEMBL ID: CHEMBL2367449
ChEMBL Target Name: Thoracic aorta
ChEMBL Target Type: TISSUE - Target is a healthy or diseased tissue
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Fructose-1,6-bisphosphatase 1

External ID: CHEMBL4629675

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2020
Volume: 83
Issue: 5
First Page: 1541
Last Page: 1552
DOI: 10.1021/acs.jnatprod.0c00014

Target ChEMBL ID: CHEMBL3975
ChEMBL Target Name: Fructose-1,6-bisphosphatase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	<	20	%
Inhibition	<	20	%
Inhibition	<	20	%
Inhibition	<	20	%
Inhibition	<	20	%
Inhibition	<	20	%
Inhibition	<	20	%
Inhibition	<	20	%
Inhibition	<	20	%
Inhibition	<	20	%
Inhibition	<	20	%
Inhibition	=	22	%
Inhibition	=	46	%
Inhibition	<	20	%
Inhibition	<	20	%
Inhibition	=	37	%
Inhibition	<	20	%
Inhibition	<	20	%
Inhibition	<	20	%
Inhibition	<	20	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Thoracic aorta

External ID: CHEMBL4021824

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2017
Volume: 27
Issue: 12
First Page: 2812
Last Page: 2817
DOI: 10.1016/j.bmcl.2017.04.076

Target ChEMBL ID: CHEMBL2367449
ChEMBL Target Name: Thoracic aorta
ChEMBL Target Type: TISSUE - Target is a healthy or diseased tissue
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1068151

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 6
First Page: 2337
Last Page: 2345
DOI: 10.1016/j.bmc.2010.01.046

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
25	IC50	=	25000	nM
14	IC50	=	14000	nM
17	IC50	=	17000	nM
174	IC50	=	174000	nM	Outside typical range
15	IC50	=	15000	nM
16	IC50	=	16000	nM
25	IC50	=	25000	nM
21	IC50	=	21000	nM
29	IC50	=	29000	nM
30	IC50	=	30000	nM
6.1	IC50	=	6100	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Thoracic aorta

External ID: CHEMBL4021825

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2017
Volume: 27
Issue: 12
First Page: 2812
Last Page: 2817
DOI: 10.1016/j.bmcl.2017.04.076

Target ChEMBL ID: CHEMBL2367449
ChEMBL Target Name: Thoracic aorta
ChEMBL Target Type: TISSUE - Target is a healthy or diseased tissue
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4021822

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2017
Volume: 27
Issue: 12
First Page: 2812
Last Page: 2817
DOI: 10.1016/j.bmcl.2017.04.076

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Not Active
Activity	Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1068149

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 6
First Page: 2337
Last Page: 2345
DOI: 10.1016/j.bmc.2010.01.046

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	13.9	%
Inhibition	=	9.8	%
Inhibition	=	14.4	%
Inhibition	=	-1.1	%
Inhibition	=	7.1	%
Inhibition	=	6.5	%
Inhibition	=	6	%
Inhibition	=	3.5	%
Inhibition	=	3.5	%
Inhibition	=	-0.6	%
Inhibition	=	6.2	%
Inhibition	=	4.1	%
Inhibition	=	16.8	%
Inhibition	=	8.5	%
Inhibition	=	4.5	%
Inhibition	=	10.3	%
Inhibition	=	-2.8	%
Inhibition	=	-1.6	%
Inhibition	=	8.8	%
Inhibition	=	16.5	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4021823

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2017
Volume: 27
Issue: 12
First Page: 2812
Last Page: 2817
DOI: 10.1016/j.bmcl.2017.04.076

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1048098

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2009
Volume: 19
Issue: 17
First Page: 4912
Last Page: 4915
DOI: 10.1016/j.bmcl.2009.07.098

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
	Inhibition			%	Dose-dependent effect
15.97	IC50	=	15970	nM
	Inhibition			%	Dose-dependent effect
4.6	IC50	=	4600	nM
	Inhibition			%	Dose-dependent effect
1.53	IC50	=	1530	nM
	Inhibition			%	Dose-dependent effect
10.74	IC50	=	10740	nM
	Inhibition			%	Dose-dependent effect
0.38	IC50	=	380	nM
	Inhibition			%	Dose-dependent effect
29.01	IC50	=	29010	nM
	Inhibition			%	Dose-dependent effect
8.14	IC50	=	8140	nM
	Inhibition			%	Dose-dependent effect
1.13	IC50	=	1130	nM
	Inhibition			%	Dose-dependent effect

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Solute carrier organic anion transporter family member 2B1

External ID: CHEMBL5260630

Protocol: N/A

Comment: Journal: RSC Med Chem
Year: 2023
Volume: 14
Issue: 5
First Page: 890
Last Page: 898
DOI: 10.1039/d3md00078h

Target ChEMBL ID: CHEMBL1743124
ChEMBL Target Name: Solute carrier organic anion transporter family member 2B1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	40	%
Inhibition	=	40	%
Inhibition	<	20	%
Inhibition	=	40	%
Inhibition	=	20	%
Inhibition	=	40	%
Inhibition	=	20	%
Inhibition	=	40	%
Inhibition	<	20	%
Inhibition	=	40	%
Inhibition	<	20	%
Inhibition	<	20	%
Inhibition	<	20	%
Inhibition	>=	80	%
Inhibition	=	20	%
Inhibition	=	20	%
Inhibition	<	20	%
Inhibition	=	40	%
Inhibition	<	20	%
Inhibition	<	20	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1048099

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2009
Volume: 19
Issue: 17
First Page: 4912
Last Page: 4915
DOI: 10.1016/j.bmcl.2009.07.098

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
	Ki				Not Determined
2.01	Ki	=	2010	nM
7.16	Ki	=	7160	nM
0.19	Ki	=	190	nM
10.82	Ki	=	10820	nM
7.2	Ki	=	7200	nM
1.96	Ki	=	1960	nM
	Ki				Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Solute carrier organic anion transporter family member 2B1

External ID: CHEMBL5260629

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: RSC Med Chem
Year: 2023
Volume: 14
Issue: 5
First Page: 890
Last Page: 898
DOI: 10.1039/d3md00078h

Target ChEMBL ID: CHEMBL1743124
ChEMBL Target Name: Solute carrier organic anion transporter family member 2B1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
5.24807	IC50	=	5248.07	nM
7.3	IC50	=	7300	nM
7.24436	IC50	=	7244.36	nM
21	IC50	=	21000	nM
20.893	IC50	=	20892.96	nM
28.7	IC50	=	28700	nM
28.8403	IC50	=	28840.32	nM
29	IC50	=	29000	nM
28.8403	IC50	=	28840.32	nM
6.7	IC50	=	6700	nM
6.76083	IC50	=	6760.83	nM
40.9	IC50	=	40900	nM
40.738	IC50	=	40738.03	nM
3.9	IC50	=	3900	nM
3.89045	IC50	=	3890.45	nM
47.2	IC50	=	47200	nM
46.7735	IC50	=	46773.51	nM
79.6	IC50	=	79600	nM
79.4328	IC50	=	79432.82	nM
0.35	IC50	=	350	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Thoracic aorta

External ID: CHEMBL4021834

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2017
Volume: 27
Issue: 12
First Page: 2812
Last Page: 2817
DOI: 10.1016/j.bmcl.2017.04.076

Target ChEMBL ID: CHEMBL2367449
ChEMBL Target Name: Thoracic aorta
ChEMBL Target Type: TISSUE - Target is a healthy or diseased tissue
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Solute carrier organic anion transporter family member 2B1

External ID: CHEMBL5260631

Protocol: N/A

Comment: Journal: RSC Med Chem
Year: 2023
Volume: 14
Issue: 5
First Page: 890
Last Page: 898
DOI: 10.1039/d3md00078h

Target ChEMBL ID: CHEMBL1743124
ChEMBL Target Name: Solute carrier organic anion transporter family member 2B1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	>	40	%
Inhibition	>	40	%
Inhibition	>	40	%
Inhibition	>	40	%
Inhibition	>	40	%
Inhibition	>	40	%
Inhibition	>	40	%
Inhibition	>	40	%
Inhibition	>	40	%
Inhibition	>	40	%
Inhibition	>	40	%
Inhibition	>	40	%
Inhibition	>	40	%
Inhibition	>	40	%
Inhibition	>	40	%
Inhibition	>	40	%
Inhibition	>	40	%
Inhibition	>	40	%
Inhibition	>	40	%
Inhibition	>	40	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Polyphenol oxidase 2

External ID: CHEMBL1068161

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 6
First Page: 2337
Last Page: 2345
DOI: 10.1016/j.bmc.2010.01.046

Target ChEMBL ID: CHEMBL3318
ChEMBL Target Name: Tyrosinase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	<	10.4	%
Inhibition	<	10.4	%
Inhibition	=	23	%
Inhibition	<	10.4	%
Inhibition	=	78.2	%
Inhibition	=	38.4	%
Inhibition	=	17.6	%
Inhibition	=	27.8	%
Inhibition	=	18.6	%
Inhibition	<	10.4	%
Inhibition	<	10.4	%
Inhibition	<	10.4	%
Inhibition	<	10.4	%
Inhibition	=	29.1	%
Inhibition	=	42.7	%
Inhibition	=	27.6	%
Inhibition	=	45.5	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Thoracic aorta

External ID: CHEMBL4021835

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2017
Volume: 27
Issue: 12
First Page: 2812
Last Page: 2817
DOI: 10.1016/j.bmcl.2017.04.076

Target ChEMBL ID: CHEMBL2367449
ChEMBL Target Name: Thoracic aorta
ChEMBL Target Type: TISSUE - Target is a healthy or diseased tissue
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：RAW264.7

External ID: CHEMBL4021832

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2017
Volume: 27
Issue: 12
First Page: 2812
Last Page: 2817
DOI: 10.1016/j.bmcl.2017.04.076

Target ChEMBL ID: CHEMBL612557
ChEMBL Target Name: RAW264.7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Units	Activity Comment
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Thoracic aorta

External ID: CHEMBL4021830

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2017
Volume: 27
Issue: 12
First Page: 2812
Last Page: 2817
DOI: 10.1016/j.bmcl.2017.04.076

Target ChEMBL ID: CHEMBL2367449
ChEMBL Target Name: Thoracic aorta
ChEMBL Target Type: TISSUE - Target is a healthy or diseased tissue
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HEK293

External ID: CHEMBL971518

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2009
Volume: 19
Issue: 8
First Page: 2116
Last Page: 2120
DOI: 10.1016/j.bmcl.2009.03.017

Target ChEMBL ID: CHEMBL614818
ChEMBL Target Name: HEK293
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
FC	=	1.2
FC	=	2.1
FC	=	2.3
FC	=	1.1
FC	=	0.4
FC	=	1.4
FC	=	4.2
FC	=	2.1
FC	=	1.9
FC	=	3.6
FC	=	1.3
FC	=	1.3
FC	=	1
FC	=	1.2
FC	=	4.3
FC	=	1.6
FC	=	0.4
FC	=	2.4
FC	=	1.3
FC	=	1.6

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_7962_1

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	PubChem Standard Value	IC50	Target Accession(s)	Ligand	Target
IC50	0.0183	18.3	P08238	BDBM20807	Heat shock protein HSP 90-beta
IC50	50	50000	P08238	BDBM50234650	Heat shock protein HSP 90-beta
IC50	50	50000	P08238	BDBM50303915	Heat shock protein HSP 90-beta
IC50	0.2	200	P08238	BDBM50325671	Heat shock protein HSP 90-beta
IC50	0.462	462	P08238	BDBM81729	Heat shock protein HSP 90-beta
IC50	0.06	60	P08238	BDBM50347493	Heat shock protein HSP 90-beta
IC50	4.3	4300	P08238	BDBM76094	Heat shock protein HSP 90-beta
IC50	41.9	41900	P08238	BDBM225711	Heat shock protein HSP 90-beta
IC50	0.154	154	P08238	BDBM225712	Heat shock protein HSP 90-beta
IC50	6.14	6140	P08238	BDBM225769	Heat shock protein HSP 90-beta
IC50	6.14	6140	P08238	BDBM225769	Heat shock protein HSP 90-beta
IC50	9.64	9640	P08238	BDBM225769	Heat shock protein HSP 90-beta
IC50	9.64	9640	P08238	BDBM225769	Heat shock protein HSP 90-beta
IC50	6.14	6140	P08238	BDBM225769	Heat shock protein HSP 90-beta
IC50	6.14	6140	P08238	BDBM225769	Heat shock protein HSP 90-beta
IC50	5	5000	P08238	BDBM225777	Heat shock protein HSP 90-beta
IC50	6.71	6710	P08238	BDBM225778	Heat shock protein HSP 90-beta
IC50	0.0961	96.1	P08238	BDBM225782	Heat shock protein HSP 90-beta
IC50	50	50000	P08238	BDBM225831	Heat shock protein HSP 90-beta
IC50	50	50000	P08238	BDBM225836	Heat shock protein HSP 90-beta

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 1

External ID: CHEMBL3631188

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2015
Volume: 23
Issue: 22
First Page: 7219
Last Page: 7225
DOI: 10.1016/j.bmc.2015.10.018

Target ChEMBL ID: CHEMBL261
ChEMBL Target Name: Carbonic anhydrase I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10	Ki	>	10000	nM
10	Ki	>	10000	nM
10	Ki	>	10000	nM
10	Ki	>	10000	nM
10	Ki	>	10000	nM
10	Ki	>	10000	nM
10	Ki	>	10000	nM
10	Ki	>	10000	nM
10	Ki	>	10000	nM
10	Ki	>	10000	nM
10	Ki	>	10000	nM
10	Ki	>	10000	nM
10	Ki	>	10000	nM
10	Ki	>	10000	nM
10	Ki	>	10000	nM
10	Ki	>	10000	nM
10	Ki	>	10000	nM
10	Ki	>	10000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Polyphenol oxidase 2

External ID: CHEMBL1069536

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 6
First Page: 2337
Last Page: 2345
DOI: 10.1016/j.bmc.2010.01.046

Target ChEMBL ID: CHEMBL3318
ChEMBL Target Name: Tyrosinase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Units	Activity Comment
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4021821

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2017
Volume: 27
Issue: 12
First Page: 2812
Last Page: 2817
DOI: 10.1016/j.bmcl.2017.04.076

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Xanthine dehydrogenase/oxidase

External ID: CHEMBL1015630

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1988
Volume: 51
Issue: 2
First Page: 345
Last Page: 348
DOI: 10.1021/np50056a030

Target ChEMBL ID: CHEMBL3649
ChEMBL Target Name: Xanthine dehydrogenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	0	%
Inhibition	=	0	%
Inhibition	=	85.5	%
Inhibition	=	47.8	%
Inhibition	=	66.9	%
Inhibition	=	17.8	%
Inhibition	=	50.2	%
Inhibition	=	15.4	%
Inhibition	=	0	%
Inhibition	=	67.3	%
Inhibition	=	100	%
Inhibition	=	0.5	%
Inhibition	=	32.1	%
Inhibition	=	47.7	%
Inhibition	=	0	%
Inhibition	=	98.5	%
Inhibition	=	95	%
Inhibition	=	49	%
Inhibition	=	82.9	%
Inhibition	=	22	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 12

External ID: CHEMBL3631192

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2015
Volume: 23
Issue: 22
First Page: 7219
Last Page: 7225
DOI: 10.1016/j.bmc.2015.10.018

Target ChEMBL ID: CHEMBL3242
ChEMBL Target Name: Carbonic anhydrase XII
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0311	Ki	=	31.1	nM
0.0325	Ki	=	32.5	nM
0.0347	Ki	=	34.7	nM
0.1459	Ki	=	145.9	nM
0.0603	Ki	=	60.3	nM
0.0418	Ki	=	41.8	nM
0.0525	Ki	=	52.5	nM
0.0549	Ki	=	54.9	nM
0.0049	Ki	=	4.9	nM
0.1343	Ki	=	134.3	nM
0.0521	Ki	=	52.1	nM
0.4541	Ki	=	454.1	nM
0.515	Ki	=	515	nM
0.0398	Ki	=	39.8	nM
0.0048	Ki	=	4.8	nM
0.4536	Ki	=	453.6	nM
0.0435	Ki	=	43.5	nM
0.4089	Ki	=	408.9	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 7

External ID: CHEMBL3631191

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2015
Volume: 23
Issue: 22
First Page: 7219
Last Page: 7225
DOI: 10.1016/j.bmc.2015.10.018

Target ChEMBL ID: CHEMBL2326
ChEMBL Target Name: Carbonic anhydrase VII
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0043	Ki	=	4.3	nM
0.4931	Ki	=	493.1	nM
0.17141	Ki	=	171.41	nM
0.025	Ki	=	25	nM
0.0047	Ki	=	4.7	nM
0.0245	Ki	=	24.5	nM
0.3715	Ki	=	371.5	nM
0.0044	Ki	=	4.4	nM
0.4237	Ki	=	423.7	nM
0.0046	Ki	=	4.6	nM
0.0038	Ki	=	3.8	nM
0.0033	Ki	=	3.3	nM
0.4526	Ki	=	452.6	nM
0.0714	Ki	=	71.4	nM
0.2683	Ki	=	268.3	nM
0.0355	Ki	=	35.5	nM
0.0039	Ki	=	3.9	nM
0.0047	Ki	=	4.7	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 4

External ID: CHEMBL3631190

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2015
Volume: 23
Issue: 22
First Page: 7219
Last Page: 7225
DOI: 10.1016/j.bmc.2015.10.018

Target ChEMBL ID: CHEMBL3729
ChEMBL Target Name: Carbonic anhydrase IV
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0728	Ki	=	72.8	nM
9.0982	Ki	=	9098.2	nM
0.53775	Ki	=	537.75	nM
10	Ki	>	10000	nM
0.5683	Ki	=	568.3	nM
7.0785	Ki	=	7078.5	nM
0.2129	Ki	=	212.9	nM
5.5912	Ki	=	5591.2	nM
5.4687	Ki	=	5468.7	nM
0.0757	Ki	=	75.7	nM
0.1021	Ki	=	102.1	nM
10	Ki	>	10000	nM
0.0666	Ki	=	66.6	nM
0.1012	Ki	=	101.2	nM
0.0656	Ki	=	65.6	nM
0.0673	Ki	=	67.3	nM
0.3442	Ki	=	344.2	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL3631189

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2015
Volume: 23
Issue: 22
First Page: 7219
Last Page: 7225
DOI: 10.1016/j.bmc.2015.10.018

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10	Ki	>	10000	nM
10	Ki	>	10000	nM
10	Ki	>	10000	nM
9.5257	Ki	=	9525.7	nM
3.6916	Ki	=	3691.6	nM
10	Ki	>	10000	nM
10	Ki	>	10000	nM
10	Ki	>	10000	nM
0.168	Ki	=	168	nM
10	Ki	>	10000	nM
6.2112	Ki	=	6211.2	nM
10	Ki	>	10000	nM
10	Ki	>	10000	nM
9.5944	Ki	=	9594.4	nM
10	Ki	>	10000	nM
10	Ki	>	10000	nM
6.3677	Ki	=	6367.7	nM
8.7902	Ki	=	8790.2	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HT-22

External ID: CHEMBL3124066

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2014
Volume: 77
Issue: 3
First Page: 446
Last Page: 454
DOI: 10.1021/np400518k

Target ChEMBL ID: CHEMBL614316
ChEMBL Target Name: HT-22
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HT-22

External ID: CHEMBL3124067

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2014
Volume: 77
Issue: 3
First Page: 446
Last Page: 454
DOI: 10.1021/np400518k

Target ChEMBL ID: CHEMBL614316
ChEMBL Target Name: HT-22
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HT-22

External ID: CHEMBL3124068

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2014
Volume: 77
Issue: 3
First Page: 446
Last Page: 454
DOI: 10.1021/np400518k

Target ChEMBL ID: CHEMBL614316
ChEMBL Target Name: HT-22
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Dose-dependent effect
Activity	Dose-dependent effect

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HT-22

External ID: CHEMBL3124069

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2014
Volume: 77
Issue: 3
First Page: 446
Last Page: 454
DOI: 10.1021/np400518k

Target ChEMBL ID: CHEMBL614316
ChEMBL Target Name: HT-22
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Dose-dependent effect
Activity	Dose-dependent effect
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HT-22

External ID: CHEMBL3124070

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2014
Volume: 77
Issue: 3
First Page: 446
Last Page: 454
DOI: 10.1021/np400518k

Target ChEMBL ID: CHEMBL614316
ChEMBL Target Name: HT-22
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active
Activity	Active
Activity	Not Active
Activity	Active
Activity	Active
Activity	Active
Activity	Not Active
Activity	Not Active
Activity	Active
Activity	Not Active
Activity	Not Active
Activity	Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Helicobacter pylori

External ID: CHEMBL983106

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2003
Volume: 66
Issue: 5
First Page: 699
Last Page: 702
DOI: 10.1021/np020472m

Target ChEMBL ID: CHEMBL612600
ChEMBL Target Name: Helicobacter pylori
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Activity				Not Active
MIC	=	50	ug.mL-1
MIC	=	50	ug.mL-1
MIC	=	25	ug.mL-1
MIC	=	6.25	ug.mL-1
MIC	=	6.25	ug.mL-1
MIC	=	50	ug.mL-1
MIC	=	12.5	ug.mL-1
Activity				Not Active
MIC	=	25	ug.mL-1
MIC	=	50	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL1042169

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2008
Volume: 71
Issue: 11
First Page: 1919
Last Page: 1922
DOI: 10.1021/np800333r

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
IC50				Not Determined
IC50	=	0.02	ug.mL-1
IC50	=	1.1	ug.mL-1
IC50	=	15.8	ug.mL-1
IC50	>	26.3	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Vero

External ID: CHEMBL1042170

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 11
First Page: 1919
Last Page: 1922
DOI: 10.1021/np800333r

Target ChEMBL ID: CHEMBL391
ChEMBL Target Name: Vero
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
IC50	=	110	ug.mL-1		Outside typical range
IC50				Not Determined
IC50	=	48.5	ug.mL-1
IC50	=	170.3	ug.mL-1		Outside typical range
IC50	=	107	ug.mL-1		Outside typical range
IC50	=	805	ug.mL-1		Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Proteus mirabilis

External ID: CHEMBL983108

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2003
Volume: 66
Issue: 5
First Page: 699
Last Page: 702
DOI: 10.1021/np020472m

Target ChEMBL ID: CHEMBL614444
ChEMBL Target Name: Proteus mirabilis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
MIC	=	400	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL1042167

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 11
First Page: 1919
Last Page: 1922
DOI: 10.1021/np800333r

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
IC50	=	2.4	ug.mL-1
IC50				Not Determined
IC50	=	0.14	ug.mL-1
IC50				Not Determined
IC50	=	9.4	ug.mL-1
IC50	>	26.3	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL1042168

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 11
First Page: 1919
Last Page: 1922
DOI: 10.1021/np800333r

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
IC50				Not Determined
IC50	=	0.06	ug.mL-1
IC50				Not Determined
IC50	=	9.1	ug.mL-1
IC50	>	26.3	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：L929

External ID: CHEMBL1006812

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 1997
Volume: 60
Issue: 8
First Page: 775
Last Page: 778
DOI: 10.1021/np960581z

Target ChEMBL ID: CHEMBL612267
ChEMBL Target Name: L929
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
240	EC50	=	240000	nM	Outside typical range
115	EC50	=	115000	nM	Outside typical range
25	EC50	=	25000	nM
250	EC50	>	250000	nM	Outside typical range
140	EC50	=	140000	nM	Outside typical range
59	EC50	=	59000	nM
50	EC50	=	50000	nM
250	EC50	>	250000	nM	Outside typical range
350	EC50	=	350000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL1042166

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 11
First Page: 1919
Last Page: 1922
DOI: 10.1021/np800333r

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
IC50				Not Determined
IC50				Not Determined
IC50	=	0.03	ug.mL-1
IC50				Not Determined
IC50	>	30	ug.mL-1
IC50	>	26.3	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：L929

External ID: CHEMBL1006810

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 1997
Volume: 60
Issue: 8
First Page: 775
Last Page: 778
DOI: 10.1021/np960581z

Target ChEMBL ID: CHEMBL612267
ChEMBL Target Name: L929
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
4	EC50	=	4000	nM
200	EC50	=	200000	nM		Outside typical range
120	EC50	=	120000	nM		Outside typical range
	Activity				Dose-dependent effect
20	EC50	=	20000	nM
	Activity				Dose-dependent effect
250	EC50	>	250000	nM		Outside typical range
129	EC50	=	129000	nM		Outside typical range
	Activity				Dose-dependent effect
55	EC50	=	55000	nM
	Activity				Dose-dependent effect
40	EC50	=	40000	nM
	Activity				Dose-dependent effect
250	EC50	=	250000	nM		Outside typical range
	Activity				Dose-dependent effect
300	EC50	=	300000	nM		Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：U-937

External ID: CHEMBL885742

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 3
First Page: 1539
Last Page: 1546
DOI: 10.1016/j.bmc.2006.09.024

Target ChEMBL ID: CHEMBL612794
ChEMBL Target Name: U-937
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
100	IC50	>	100000	nM
100	IC50	>	100000	nM
28	IC50	=	28000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
44	IC50	=	44000	nM
100	IC50	>	100000	nM
16	IC50	=	16000	nM
23	IC50	=	23000	nM
0.07	IC50	=	70	nM
48	IC50	=	48000	nM
100	IC50	>	100000	nM
85	IC50	=	85000	nM
72	IC50	=	72000	nM
25	IC50	=	25000	nM
100	IC50	>	100000	nM
35	IC50	=	35000	nM
32	IC50	=	32000	nM
20	IC50	=	20000	nM
100	IC50	>	100000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：U-937

External ID: CHEMBL885743

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 3
First Page: 1539
Last Page: 1546
DOI: 10.1016/j.bmc.2006.09.024

Target ChEMBL ID: CHEMBL612794
ChEMBL Target Name: U-937
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
100	IC50	>	100000	nM
100	IC50	>	100000	nM
20	IC50	=	20000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
45	IC50	=	45000	nM
100	IC50	>	100000	nM
5.8	IC50	=	5800	nM
7.3	IC50	=	7300	nM
0.09	IC50	=	90	nM
43	IC50	=	43000	nM
100	IC50	>	100000	nM
74	IC50	=	74000	nM
48	IC50	=	48000	nM
21	IC50	=	21000	nM
100	IC50	>	100000	nM
32	IC50	=	32000	nM
28	IC50	=	28000	nM
13	IC50	=	13000	nM
100	IC50	>	100000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Pseudomonas aeruginosa

External ID: CHEMBL983109

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2003
Volume: 66
Issue: 5
First Page: 699
Last Page: 702
DOI: 10.1021/np020472m

Target ChEMBL ID: CHEMBL348
ChEMBL Target Name: Pseudomonas aeruginosa
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：U-937

External ID: CHEMBL885741

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 3
First Page: 1539
Last Page: 1546
DOI: 10.1016/j.bmc.2006.09.024

Target ChEMBL ID: CHEMBL612794
ChEMBL Target Name: U-937
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
100	IC50	>	100000	nM
100	IC50	>	100000	nM
36	IC50	=	36000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
50	IC50	=	50000	nM
100	IC50	>	100000	nM
42	IC50	=	42000	nM
30	IC50	=	30000	nM
3.6	IC50	=	3600	nM
49	IC50	=	49000	nM
73	IC50	=	73000	nM
68	IC50	=	68000	nM
100	IC50	>	100000	nM
46	IC50	=	46000	nM
100	IC50	>	100000	nM
28	IC50	=	28000	nM
35	IC50	=	35000	nM
26	IC50	=	26000	nM
100	IC50	>	100000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Peritoneal macrophage

External ID: CHEMBL3874799

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 2
First Page: 779
Last Page: 788
DOI: 10.1016/j.bmc.2016.11.055

Target ChEMBL ID: CHEMBL5314330
ChEMBL Target Name: Peritoneal macrophage
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
29	IC50	=	29000	nM
20	IC50	=	20000	nM
14	IC50	=	14000	nM
26	IC50	=	26000	nM
99	IC50	=	99000	nM
8.9	IC50	=	8900	nM
25	IC50	=	25000	nM
85	IC50	=	85000	nM
84	IC50	=	84000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：KB

External ID: CHEMBL1026751

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Nat Prod
Year: 2004
Volume: 67
Issue: 3
First Page: 343
Last Page: 347
DOI: 10.1021/np0304417

Target ChEMBL ID: CHEMBL398
ChEMBL Target Name: KB
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
	ED50	>	1	10'3nM
	ED50	>	1	10'3nM
0.142	ED50	=	142	nM
0.147	ED50	=	147	nM
0.204	ED50	=	204	nM
0.168	ED50	=	168	nM
	ED50	>	1	10'3nM

Standard Type	Standard Relation	Standard Value
FC	=	1.2
FC	=	2.1
FC	=	2.3
FC	=	1.1
FC	=	0.4
FC	=	1.4
FC	=	4.2
FC	=	2.1
FC	=	1.9
FC	=	3.6
FC	=	1.3
FC	=	1.3
FC	=	1
FC	=	1.2
FC	=	4.3
FC	=	1.6
FC	=	0.4
FC	=	2.4
FC	=	1.3
FC	=	1.6

Standard Type	Standard Relation	Standard Value
FC	=	1.2
FC	=	2.1
FC	=	2.3
FC	=	1.1
FC	=	0.4
FC	=	1.4
FC	=	4.2
FC	=	2.1
FC	=	1.9
FC	=	3.6
FC	=	1.3
FC	=	1.3
FC	=	1
FC	=	1.2
FC	=	4.3
FC	=	1.6
FC	=	0.4
FC	=	2.4
FC	=	1.3
FC	=	1.6

552-58-9 靶点实验数据

Standard Type	Standard Relation	Standard Value
FC	=	1.2
FC	=	2.1
FC	=	2.3
FC	=	1.1
FC	=	0.4
FC	=	1.4
FC	=	4.2
FC	=	2.1
FC	=	1.9
FC	=	3.6
FC	=	1.3
FC	=	1.3
FC	=	1
FC	=	1.2
FC	=	4.3
FC	=	1.6
FC	=	0.4
FC	=	2.4
FC	=	1.3
FC	=	1.6