HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：T47D

External ID: CHEMBL1104030

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2009
Volume: 72
Issue: 12
First Page: 2163
Last Page: 2168
DOI: 10.1021/np900676y

Target ChEMBL ID: CHEMBL614361
ChEMBL Target Name: T47D
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
0.3	Activity	=	0.3	uM
5.1	Activity	=	5.1	uM
0.03	Activity	=	0.03	uM
0.3	Activity	=	0.3	uM
5.7	Activity	=	5.7	uM
7.6	Activity	=	7.6	uM
2.1	Activity	=	2.1	uM
6.4	Activity	=	6.4	uM
0.64	Activity	=	0.64	uM
100	Activity	>	100	uM
0.02	Activity	=	0.02	uM
	Activity				Not Active
100	Activity	>	100	uM
100	Activity	>	100	uM
0.2	Activity	=	0.2	uM
0.01	Activity	=	0.01	uM
100	Activity	>	100	uM
100	Activity	>	100	uM
0.6	Activity	=	0.6	uM
0.01	Activity	=	0.01	uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：11908 靶标：N/A

External ID: RMI-FANCM-MM2

Protocol: FP HTS. Screening took place at the University of Wisconsin Small Molecule Screening and Synthesis Facility. A master mix of RMI core complex and F-MM2 (30 microL per well) was plated in black 384 shallow well plates (ThermoFisher, Waltham, MA), using a BioTek "MicroFlo Select" reagent dispenser. Compounds were added using a Beckman FX liquid handler; 0.33 microL of 10 mM stock was added for a final compound concentration of 33 microM. MM2 and cMM2 were each added to 4 wells of master mix per plate to a final concentration of 10 muM to serve as controls. Following compound addition, plates were covered, centrifuged briefly, and incubated for 20 minutes at room temperature. FP measurements were taking using a Tecan "Safire 2" microplate reader. Instrument settings were as follows: top read, EX 470, EM 525/20, G-factor 0.89947. A suitable gain was calculated from the first plate of each day. Z' scores for were calculated for each plate; plates with Z' scores <0.5 were rerun prior to analysis.

Comment:

Concentration uM	Data readout
33	55
33	63
33	65
33	63
33	61
33	62
33	61
33	58
33	71
33	61
33	64
33	83
33	158
33	84
33	104
33	60
33	62
33	59
33	58
33	59

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：20881 靶标：interleukin-1 receptor-like 1 isoform [homo sapiens]

External ID: ST2_IL33_Inhibitors_Primary_Screening_77700

Protocol: High-throughput screening was performed at Indiana University screening facility (Indiana University, Indianapolis, IN).

In summary, a mixture of ST2 and IL-33 was prepared by adding 0.30 microL of 14.1 microM recombinant human ST2-Fc Chimera and 0.30 microL of 55.25 biotinylated recombinant human IL-33 to 1.4 mL of assay buffer. In the HTS, each well of a 384-well Proxi-plate was first blocked by 100 microL of assay buffer for 1 h at room temperature. After removing the blocking buffer, 20 microL of ST2/IL-33 mixture was pipetted into each well and incubated at room temperature for 1 h followed by addition of compounds at 17 microM (0.8 microL) to each well and incubated at room temperature for 1 h. Ten microliters of 60 microg/mL anti-6xHis-conjugated AlphaLISA acceptor beads were added to each well and incubated at room temperature for 1 h before addition of 10 microL of 60 microg/mL of streptavidin-labeled AlphaLISA donor beads for incubation at room temperature for 30 min. Incubation of acceptor and receptor beads was conducted in darkness. The well with 3 nM ST2 alone was used as a negative control, whereas the ST2/IL-33 mixture with a human ST2 antibody added at 0.45 ng/microL was used as the positive control. Plates were read using the Envision Plate Reader. The buffer used in the assay contains 14.37 mL PBS, 30 microL Tween 20, and 600 microL of 5% bovine serum albumin in PBS.

Comment: PubChem active indicates >= 30% inhibition of ST2/IL-33 at 17 uM of the compound. Inconclusive: >=10% and < 30% inhibition.

% Inhibition
98
97
97
97
97
97
96
96
96
96
95
95
94
94
93
92
92
89
88
85

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：T47D

External ID: CHEMBL1104037

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2009
Volume: 72
Issue: 12
First Page: 2163
Last Page: 2168
DOI: 10.1021/np900676y

Target ChEMBL ID: CHEMBL614361
ChEMBL Target Name: T47D
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
0.01	Activity	=	0.01	uM
100	Activity	>	100	uM
0.01	Activity	=	0.01	uM
2.2	Activity	=	2.2	uM
100	Activity	>	100	uM
100	Activity	>	100	uM
100	Activity	>	100	uM
100	Activity	>	100	uM
5.9	Activity	=	5.9	uM
5.8	Activity	=	5.8	uM
100	Activity	>	100	uM
	Activity				Not Active
8.4	Activity	=	8.4	uM
100	Activity	>	100	uM
2	Activity	=	2	uM
100	Activity	>	100	uM
100	Activity	>	100	uM
100	Activity	>	100	uM
100	Activity	>	100	uM
6.2	Activity	=	6.2	uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：T47D

External ID: CHEMBL1104036

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2009
Volume: 72
Issue: 12
First Page: 2163
Last Page: 2168
DOI: 10.1021/np900676y

Target ChEMBL ID: CHEMBL614361
ChEMBL Target Name: T47D
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
0.01	Activity	=	0.01	uM
100	Activity	>	100	uM
0.01	Activity	=	0.01	uM
1.4	Activity	=	1.4	uM
0.3	Activity	=	0.3	uM
100	Activity	>	100	uM
0.6	Activity	=	0.6	uM
100	Activity	>	100	uM
0.01	Activity	=	0.01	uM
1.2	Activity	=	1.2	uM
100	Activity	>	100	uM
	Activity				Not Active
5.6	Activity	=	5.6	uM
100	Activity	>	100	uM
0.2	Activity	=	0.2	uM
5.3	Activity	=	5.3	uM
100	Activity	>	100	uM
100	Activity	>	100	uM
2.6	Activity	=	2.6	uM
1.8	Activity	=	1.8	uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL1175692

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 13
First Page: 3872
Last Page: 3875
DOI: 10.1016/j.bmcl.2010.05.038

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Units	Activity Comment
Inhibition	%	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MCF7

External ID: CHEMBL977510

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2005
Volume: 68
Issue: 3
First Page: 361
Last Page: 364
DOI: 10.1021/np040175c

Target ChEMBL ID: CHEMBL387
ChEMBL Target Name: MCF7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
0.02	Activity	=	0.02	uM
50.3	Activity	=	50.3	uM
	Activity				Not Determined
	Activity				Not Determined
	Activity				Not Determined
	Activity				Not Determined
	Activity				Not Determined
	Activity				Not Determined
0.8	Activity	=	0.8	uM
0.7	Activity	=	0.7	uM
5.6	Activity	=	5.6	uM
26.1	Activity	=	26.1	uM
77.3	Activity	=	77.3	uM
	Activity				Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MCF7

External ID: CHEMBL1104035

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2009
Volume: 72
Issue: 12
First Page: 2163
Last Page: 2168
DOI: 10.1021/np900676y

Target ChEMBL ID: CHEMBL387
ChEMBL Target Name: MCF7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
100	Activity	>	100	uM
100	Activity	>	100	uM
0.01	Activity	=	0.01	uM
100	Activity	>	100	uM
100	Activity	>	100	uM
100	Activity	>	100	uM
100	Activity	>	100	uM
100	Activity	>	100	uM
0.01	Activity	=	0.01	uM
2.2	Activity	=	2.2	uM
100	Activity	>	100	uM
	Activity				Not Active
100	Activity	>	100	uM
100	Activity	>	100	uM
100	Activity	>	100	uM
0.6	Activity	=	0.6	uM
100	Activity	>	100	uM
3.4	Activity	=	3.4	uM
1.6	Activity	=	1.6	uM
100	Activity	>	100	uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MCF7

External ID: CHEMBL1104034

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2009
Volume: 72
Issue: 12
First Page: 2163
Last Page: 2168
DOI: 10.1021/np900676y

Target ChEMBL ID: CHEMBL387
ChEMBL Target Name: MCF7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
100	Activity	>	100	uM
100	Activity	>	100	uM
0.01	Activity	=	0.01	uM
100	Activity	>	100	uM
100	Activity	>	100	uM
100	Activity	>	100	uM
100	Activity	>	100	uM
100	Activity	>	100	uM
0.01	Activity	=	0.01	uM
1.1	Activity	=	1.1	uM
100	Activity	>	100	uM
	Activity				Not Active
100	Activity	>	100	uM
100	Activity	>	100	uM
100	Activity	>	100	uM
0.01	Activity	=	0.01	uM
5.9	Activity	=	5.9	uM
1.2	Activity	=	1.2	uM
0.7	Activity	=	0.7	uM
100	Activity	>	100	uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MCF7

External ID: CHEMBL1104033

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2009
Volume: 72
Issue: 12
First Page: 2163
Last Page: 2168
DOI: 10.1021/np900676y

Target ChEMBL ID: CHEMBL387
ChEMBL Target Name: MCF7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
0.3	Activity	=	0.3	uM
100	Activity	>	100	uM
100	Activity	>	100	uM
0.5	Activity	=	0.5	uM
100	Activity	>	100	uM
17	Activity	=	17	uM
2.1	Activity	=	2.1	uM
4.5	Activity	=	4.5	uM
0.1	Activity	=	0.1	uM
4.7	Activity	=	4.7	uM
100	Activity	>	100	uM
	Activity				Not Active
100	Activity	>	100	uM
100	Activity	>	100	uM
4.5	Activity	=	4.5	uM
1.8	Activity	=	1.8	uM
4.7	Activity	=	4.7	uM
100	Activity	>	100	uM
2.1	Activity	=	2.1	uM
0.3	Activity	=	0.3	uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：T47D

External ID: CHEMBL1104032

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2009
Volume: 72
Issue: 12
First Page: 2163
Last Page: 2168
DOI: 10.1021/np900676y

Target ChEMBL ID: CHEMBL614361
ChEMBL Target Name: T47D
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
0.5	Activity	=	0.5	uM
100	Activity	>	100	uM
100	Activity	>	100	uM
6.9	Activity	=	6.9	uM
100	Activity	>	100	uM
100	Activity	>	100	uM
8.9	Activity	=	8.9	uM
100	Activity	>	100	uM
100	Activity	>	100	uM
100	Activity	>	100	uM
0.2	Activity	=	0.2	uM
	Activity				Not Active
100	Activity	>	100	uM
100	Activity	>	100	uM
8.6	Activity	=	8.6	uM
100	Activity	>	100	uM
100	Activity	>	100	uM
100	Activity	>	100	uM
11.6	Activity	=	11.6	uM
1.7	Activity	=	1.7	uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MCF7

External ID: CHEMBL1104031

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2009
Volume: 72
Issue: 12
First Page: 2163
Last Page: 2168
DOI: 10.1021/np900676y

Target ChEMBL ID: CHEMBL387
ChEMBL Target Name: MCF7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
3.8	Activity	=	3.8	uM
100	Activity	>	100	uM
100	Activity	>	100	uM
2.7	Activity	=	2.7	uM
100	Activity	>	100	uM
100	Activity	>	100	uM
9.4	Activity	=	9.4	uM
50.4	Activity	=	50.4	uM
0.65	Activity	=	0.65	uM
100	Activity	>	100	uM
100	Activity	>	100	uM
	Activity				Not Active
100	Activity	>	100	uM
100	Activity	>	100	uM
93.3	Activity	=	93.3	uM
4.2	Activity	=	4.2	uM
100	Activity	>	100	uM
100	Activity	>	100	uM
4	Activity	=	4	uM
5.2	Activity	=	5.2	uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：T47D

External ID: CHEMBL977512

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2005
Volume: 68
Issue: 3
First Page: 361
Last Page: 364
DOI: 10.1021/np040175c

Target ChEMBL ID: CHEMBL614361
ChEMBL Target Name: T47D
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
0.2	Activity	=	0.2	uM
	Activity				Not Determined
	Activity				Not Determined
	Activity				Not Determined
	Activity				Not Determined
	Activity				Not Determined
	Activity				Not Determined
	Activity				Not Determined
0.09	Activity	=	0.09	uM
4.9	Activity	=	4.9	uM
	Activity				Not Determined
	Activity				Not Determined
	Activity				Not Determined
	Activity				Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Polyphenol oxidase 4

External ID: CHEMBL5586196

Protocol: N/A

Comment: Journal: RSC Med Chem
Year: 2024
Volume: 15
Issue: 7
First Page: 2226
Last Page: 2253
DOI: 10.1039/d4md00224e

Target ChEMBL ID: CHEMBL6066154
ChEMBL Target Name: Mushroom tyrosinase
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
	IC50	=	2.62	ug.mL-1
30	IC50	=	30000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MCF7

External ID: CHEMBL977511

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2005
Volume: 68
Issue: 3
First Page: 361
Last Page: 364
DOI: 10.1021/np040175c

Target ChEMBL ID: CHEMBL387
ChEMBL Target Name: MCF7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
0.08	Activity	=	0.08	uM
	Activity				Not Determined
	Activity				Not Determined
	Activity				Not Determined
	Activity				Not Determined
	Activity				Not Determined
	Activity				Not Determined
	Activity				Not Determined
12.8	Activity	=	12.8	uM
6.8	Activity	=	6.8	uM
12.7	Activity	=	12.7	uM
	Activity				Not Determined
	Activity				Not Determined
	Activity				Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：T47D

External ID: CHEMBL977513

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2005
Volume: 68
Issue: 3
First Page: 361
Last Page: 364
DOI: 10.1021/np040175c

Target ChEMBL ID: CHEMBL614361
ChEMBL Target Name: T47D
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
	Activity				Not Determined
	Activity				Not Determined
	Activity				Not Determined
	Activity				Not Determined
	Activity				Not Determined
	Activity				Not Determined
	Activity				Not Determined
	Activity				Not Determined
37.1	Activity	=	37.1	uM
	Activity				Not Determined
	Activity				Not Determined
	Activity				Not Determined
	Activity				Not Determined
	Activity				Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5586199

Protocol: N/A

Comment: Journal: RSC Med Chem
Year: 2024
Volume: 15
Issue: 7
First Page: 2226
Last Page: 2253
DOI: 10.1039/d4md00224e

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
IC50	=	46.34	ug.mL-1
IC50	=	5.65	ug.mL-1
IC50	=	69.36	ug.mL-1	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5586200

Protocol: N/A

Comment: Journal: RSC Med Chem
Year: 2024
Volume: 15
Issue: 7
First Page: 2226
Last Page: 2253
DOI: 10.1039/d4md00224e

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
IC50	=	45.6	ug.mL-1
IC50	=	44.62	ug.mL-1
IC50	=	135.31	ug.mL-1	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Xanthine dehydrogenase/oxidase

External ID: CHEMBL1015630

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1988
Volume: 51
Issue: 2
First Page: 345
Last Page: 348
DOI: 10.1021/np50056a030

Target ChEMBL ID: CHEMBL3649
ChEMBL Target Name: Xanthine dehydrogenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	0	%
Inhibition	=	0	%
Inhibition	=	85.5	%
Inhibition	=	47.8	%
Inhibition	=	66.9	%
Inhibition	=	17.8	%
Inhibition	=	50.2	%
Inhibition	=	15.4	%
Inhibition	=	0	%
Inhibition	=	67.3	%
Inhibition	=	100	%
Inhibition	=	0.5	%
Inhibition	=	32.1	%
Inhibition	=	47.7	%
Inhibition	=	0	%
Inhibition	=	98.5	%
Inhibition	=	95	%
Inhibition	=	49	%
Inhibition	=	82.9	%
Inhibition	=	22	%

Concentration uM	Data readout
33	55
33	63
33	65
33	63
33	61
33	62
33	61
33	58
33	71
33	61
33	64
33	83
33	158
33	84
33	104
33	60
33	62
33	59
33	58
33	59

Concentration uM	Data readout
33	55
33	63
33	65
33	63
33	61
33	62
33	61
33	58
33	71
33	61
33	64
33	83
33	158
33	84
33	104
33	60
33	62
33	59
33	58
33	59

548-77-6 靶点实验数据

Concentration uM	Data readout
33	55
33	63
33	65
33	63
33	61
33	62
33	61
33	58
33	71
33	61
33	64
33	83
33	158
33	84
33	104
33	60
33	62
33	59
33	58
33	59