HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1121086

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 9
First Page: 3147
Last Page: 3158
DOI: 10.1016/j.bmc.2010.03.038

Standard Type	Standard Relation	Standard Value
Ratio IC50	=	1.09
Ratio IC50	=	0.19
Ratio IC50	=	1.67
Ratio IC50	=	0.33
Ratio IC50	=	1.18
Ratio IC50	=	0.2
Ratio IC50	=	1.34
Ratio IC50	=	0.97
Ratio IC50	=	1.33
Ratio IC50	=	1
Ratio IC50	=	1
Ratio IC50	=	0.24
Ratio IC50	=	0.66

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Voltage-dependent L-type calcium channel subunit alpha-1C

External ID: CHEMBL1121085

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 9
First Page: 3147
Last Page: 3158
DOI: 10.1016/j.bmc.2010.03.038

Target ChEMBL ID: CHEMBL2830
ChEMBL Target Name: Voltage-gated L-type calcium channel alpha-1C subunit
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.21	IC50	=	210	nM
0.46	IC50	=	460	nM
0.049	IC50	=	49	nM
0.016	IC50	=	16	nM
0.023	IC50	=	23	nM
0.031	IC50	=	31	nM
0.025	IC50	=	25	nM
0.031	IC50	=	31	nM
0.008	IC50	=	8	nM
0.006	IC50	=	6	nM
2.217	IC50	=	2217	nM
0.05	IC50	=	50	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Voltage-dependent L-type calcium channel subunit alpha-1D

External ID: CHEMBL1121084

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 9
First Page: 3147
Last Page: 3158
DOI: 10.1016/j.bmc.2010.03.038

Target ChEMBL ID: CHEMBL4132
ChEMBL Target Name: Voltage-gated L-type calcium channel alpha-1D subunit
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.17	IC50	=	170	nM
0.615	IC50	=	615	nM
0.13	IC50	=	130	nM
0.082	IC50	=	82	nM
0.047	IC50	=	47	nM
0.035	IC50	=	35	nM
0.015	IC50	=	15	nM
0.023	IC50	=	23	nM
0.039	IC50	=	39	nM
0.011	IC50	=	11	nM
2.315	IC50	=	2315	nM
0.137	IC50	=	137	nM

54527-89-8 靶点实验数据