HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit theta

External ID: CHEMBL3370250

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur. J. Med. Chem.
Year: 2014
Volume: 84
First Page: 404
Last Page: 416
DOI: 10.1016/j.ejmech.2014.07.039

Target ChEMBL ID: CHEMBL2093872
ChEMBL Target Name: GABA-A receptor; anion channel
ChEMBL Target Type: PROTEIN COMPLEX GROUP - Target is a poorly defined protein complex, where subunit composition is unclear (e.g., GABA-A receptor)
Relationship Type: H - Homologous protein target assigned
Confidence: Multiple homologous protein targets may be assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.51	Ki	=	510	nM
100	Ki	>	100000	nM
0.05495	Ki	=	54.95	nM
0.055	Ki	=	55	nM
100	Ki	>	100000	nM
4.0738	Ki	=	4073.8	nM
4.4	Ki	=	4400	nM
89.1251	Ki	=	89125.09	nM
90	Ki	=	90000	nM
19.0546	Ki	=	19054.61	nM
19	Ki	=	19000	nM
72.4436	Ki	=	72443.6	nM
73	Ki	=	73000	nM
100	Ki	>	100000	nM
100	Ki	>	100000	nM
1.34896	Ki	=	1348.96	nM
1.4	Ki	=	1400	nM
2.0893	Ki	=	2089.3	nM
2.1	Ki	=	2100	nM
7.07946	Ki	=	7079.46	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit rho-1

External ID: CHEMBL3370253

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur. J. Med. Chem.
Year: 2014
Volume: 84
First Page: 404
Last Page: 416
DOI: 10.1016/j.ejmech.2014.07.039

Target ChEMBL ID: CHEMBL3561
ChEMBL Target Name: GABA receptor rho-1 subunit
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
0.69183	EC50	=	691.83	nM
	EC50				Active
39	EC50	=	39000	nM
38.9045	EC50	=	38904.51	nM
	EC50				Not Determined
1000	EC50	>	1000000	nM		Outside typical range
1000	EC50	>	1000000	nM		Outside typical range
1000	EC50	>	1000000	nM		Outside typical range
1000	EC50	>	1000000	nM		Outside typical range
1000	EC50	>	1000000	nM		Outside typical range
1000	EC50	>	1000000	nM		Outside typical range
	EC50				Not Determined
2.3	EC50	=	2300	nM
1.23027	EC50	=	1230.27	nM
1.58489	EC50	=	1584.89	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit beta-2

External ID: CHEMBL3370251

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur. J. Med. Chem.
Year: 2014
Volume: 84
First Page: 404
Last Page: 416
DOI: 10.1016/j.ejmech.2014.07.039

Target ChEMBL ID: CHEMBL2095172
ChEMBL Target Name: GABA-A receptor; alpha-1/beta-2/gamma-2
ChEMBL Target Type: PROTEIN COMPLEX - Target is a defined protein complex, consisting of multiple subunits
Relationship Type: D - Direct protein target assigned
Confidence: Direct protein complex subunits assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
0.53703	EC50	=	537.03	nM
	EC50				Active
11	EC50	=	11000	nM
11.2202	EC50	=	11220.18	nM
	EC50				Not Determined
316.228	EC50	>	316227.77	nM		Outside typical range
	EC50				Active
1000	EC50	>	1000000	nM		Outside typical range
1000	EC50	>	1000000	nM		Outside typical range
1000	EC50	>	1000000	nM		Outside typical range
1000	EC50	>	1000000	nM		Outside typical range
1000	EC50	>	1000000	nM		Outside typical range
1000	EC50	>	1000000	nM		Outside typical range
1000	EC50	>	1000000	nM		Outside typical range
	EC50				Not Determined
2.6	EC50	=	2600	nM
2.63027	EC50	=	2630.27	nM
1000	EC50	>	1000000	nM		Outside typical range
	EC50				Active
14.1254	EC50	=	14125.38	nM

543740-89-2 靶点实验数据