HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Staphylococcus aureus

External ID: CHEMBL4296184

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL352
ChEMBL Target Name: Staphylococcus aureus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: CO-ADD Antimicrobial Screening

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
10	MIC	>	10000	nM	Median N= 2; Maxinhib 24.4 Pct
20	MIC	>	20000	nM	Median N= 2; Maxinhib -0.9 Pct
5	MIC	=	5000	nM	Median N= 2
	Inhibition	=	7.42	%	Average; N=2
0.0781	MIC	<=	78.1	nM	Median N= 2
	Inhibition	=	5.44	%	Average; N=2
	Inhibition	=	-0.36	%	Average; N=2
	Inhibition	=	-1.51	%	Average; N=2
	Inhibition	=	9.71	%	Average; N=2
20	MIC	>	20000	nM	Median N= 2; Maxinhib 6.2 Pct
10	MIC	>	10000	nM	Median N= 2; Maxinhib 14.7 Pct
	Inhibition	=	13.34	%	Average; N=2
	Inhibition	=	5.78	%	Average; N=2
	Inhibition	=	15.7	%	Average; N=2
20	MIC	>	20000	nM	Median N= 2; Maxinhib 11.5 Pct
5	MIC	=	5000	nM	Median N= 2
5	MIC	=	5000	nM	Median N= 2
	Inhibition	=	9.69	%	Average; N=2
2.5	MIC	=	2500	nM	Median N= 2; Range 5 - 2.5 Um
	Inhibition	=	12.6	%	Average; N=2

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Klebsiella pneumoniae

External ID: CHEMBL4296186

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL350
ChEMBL Target Name: Klebsiella pneumoniae
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: CO-ADD Antimicrobial Screening

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
Inhibition	=	0.93	%	Average; N=2
Inhibition	=	16.87	%	Average; N=4
Inhibition	=	14.36	%	Average; N=4
Inhibition	=	8.63	%	Average; N=2
Inhibition	=	22.77	%	Average; N=2
MIC	>	32	ug.mL-1	Median N= 2; Maxinhib 12.7 Pct
Inhibition	=	-22.42	%	Average; N=2	Outside typical range
Inhibition	=	0.23	%	Average; N=4
MIC	>	32	ug.mL-1	Median N= 2; Maxinhib 20.1 Pct
Inhibition	=	10.23	%	Average; N=4
Inhibition	=	3.15	%	Average; N=4
Inhibition	=	7.81	%	Average; N=4
Inhibition	=	-10.52	%	Average; N=4	Outside typical range
MIC	>	32	ug.mL-1	Median N= 2; Maxinhib 19.8 Pct
Inhibition	=	7.19	%	Average; N=4
Inhibition	=	6.16	%	Average; N=2
Inhibition	=	11.98	%	Average; N=4
Inhibition	=	3.45	%	Average; N=2
Inhibition	=	3.96	%	Average; N=2
Inhibition	=	4.88	%	Average; N=2

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Escherichia coli

External ID: CHEMBL4296185

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL354
ChEMBL Target Name: Escherichia coli
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: CO-ADD Antimicrobial Screening

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
10	MIC	>	10000	nM	Median N= 2; Maxinhib 62.6 Pct
20	MIC	>	20000	nM	Median N= 2; Maxinhib 7.3 Pct
0.625	MIC	=	625	nM	Median N= 2
	Inhibition	=	3.55	%	Average; N=2
10	MIC	=	10000	nM	Median N= 2
	Inhibition	=	-0.79	%	Average; N=2
	Inhibition	=	-2.76	%	Average; N=2
	Inhibition	=	6.59	%	Average; N=2
	Inhibition	=	3.05	%	Average; N=2
20	MIC	>	20000	nM	Median N= 2; Maxinhib 8.1 Pct
10	MIC	>	10000	nM	Median N= 2; Maxinhib 17.5 Pct
	Inhibition	=	-6.11	%	Average; N=2
	Inhibition	=	3.59	%	Average; N=2
	Inhibition	=	-1.89	%	Average; N=2
20	MIC	>	20000	nM	Median N= 2; Maxinhib 7.5 Pct
1.25	MIC	=	1250	nM	Median N= 2; Range 2.5 - 1.25 Um
2.5	MIC	=	2500	nM	Median N= 2
	Inhibition	=	2.4	%	Average; N=2
5	MIC	=	5000	nM	Median N= 2; Range 10 - 5 Um
	Inhibition	=	-4.2	%	Average; N=2

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Escherichia coli

External ID: CHEMBL3077461

Protocol: N/A

Comment: Journal: Med Chem Res
Year: 2013
Volume: 22
Issue: 3
First Page: 1090
Last Page: 1101
DOI: 10.1007/s00044-012-0084-0

Target ChEMBL ID: CHEMBL354
ChEMBL Target Name: Escherichia coli
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
IZ	=	18.7	mm
IZ	=	13.6	mm
IZ	=	13.4	mm
IZ	=	12.8	mm
IZ	=	13.3	mm
IZ	=	12.6	mm

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bacillus subtilis

External ID: CHEMBL3077462

Protocol: N/A

Comment: Journal: Med Chem Res
Year: 2013
Volume: 22
Issue: 3
First Page: 1090
Last Page: 1101
DOI: 10.1007/s00044-012-0084-0

Target ChEMBL ID: CHEMBL359
ChEMBL Target Name: Bacillus subtilis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
IZ	=	19	mm
IZ	=	13	mm
IZ	=	13.3	mm
IZ	=	13.6	mm
IZ	=	13.3	mm
IZ	=	13.3	mm

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Staphylococcus aureus

External ID: CHEMBL3077463

Protocol: N/A

Comment: Journal: Med Chem Res
Year: 2013
Volume: 22
Issue: 3
First Page: 1090
Last Page: 1101
DOI: 10.1007/s00044-012-0084-0

Target ChEMBL ID: CHEMBL352
ChEMBL Target Name: Staphylococcus aureus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
IZ	=	17.3	mm
IZ	=	13.3	mm
IZ	=	13.3	mm
IZ	=	13	mm
IZ	=	13.6	mm
IZ	=	13.1	mm

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Staphylococcus epidermidis

External ID: CHEMBL3077464

Protocol: N/A

Comment: Journal: Med Chem Res
Year: 2013
Volume: 22
Issue: 3
First Page: 1090
Last Page: 1101
DOI: 10.1007/s00044-012-0084-0

Target ChEMBL ID: CHEMBL353
ChEMBL Target Name: Staphylococcus epidermidis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
IZ	=	16.6	mm
IZ	=	13.3	mm
IZ	=	13.3	mm
IZ	=	13.6	mm
IZ	=	13.6	mm
IZ	=	12.7	mm

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：G-361

External ID: CHEMBL3077477

Protocol: N/A

Comment: Journal: Med Chem Res
Year: 2013
Volume: 22
Issue: 3
First Page: 1090
Last Page: 1101
DOI: 10.1007/s00044-012-0084-0

Target ChEMBL ID: CHEMBL614036
ChEMBL Target Name: G-361
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	-24	%
Activity	=	100	%
Activity	=	100	%
Activity	=	100	%
Activity	=	100	%
Activity	=	100	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Acinetobacter baumannii

External ID: CHEMBL4296188

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL614425
ChEMBL Target Name: Acinetobacter baumannii
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: CO-ADD Antimicrobial Screening

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
10	MIC	>	10000	nM	Median N= 2; Maxinhib 10.4 Pct
20	MIC	>	20000	nM	Median N= 2; Maxinhib 10.3 Pct
5	MIC	=	5000	nM	Median N= 2
	Inhibition	=	22.02	%	Average; N=2
10	MIC	>	10000	nM	Median N= 2; Maxinhib 7.2 Pct
	Inhibition	=	0.29	%	Average; N=2
	Inhibition	=	13.44	%	Average; N=2
	Inhibition	=	15.75	%	Average; N=2
	Inhibition	=	30.31	%	Average; N=2
20	MIC	>	20000	nM	Median N= 2; Maxinhib 19.9 Pct
10	MIC	>	10000	nM	Median N= 2; Maxinhib 13.5 Pct
	Inhibition	=	12.68	%	Average; N=2
	Inhibition	=	8.04	%	Average; N=2
	Inhibition	=	21.28	%	Average; N=2
20	MIC	>	20000	nM	Median N= 2; Maxinhib 17.6 Pct
10	MIC	>	10000	nM	Median N= 2; Maxinhib 10.9 Pct
20	MIC	>	20000	nM	Median N= 2; Maxinhib 24.8 Pct
	Inhibition	=	19.94	%	Average; N=2
10	MIC	>	10000	nM	Median N= 2; Maxinhib 15.2 Pct
	Inhibition	=	19.7	%	Average; N=2

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：G-361

External ID: CHEMBL3077478

Protocol: N/A

Comment: Journal: Med Chem Res
Year: 2013
Volume: 22
Issue: 3
First Page: 1090
Last Page: 1101
DOI: 10.1007/s00044-012-0084-0

Target ChEMBL ID: CHEMBL614036
ChEMBL Target Name: G-361
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	-62.5	%
Activity	=	90.8	%
Activity	=	100	%
Activity	=	100	%
Activity	=	97.5	%
Activity	=	100	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Pseudomonas aeruginosa

External ID: CHEMBL4296187

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL348
ChEMBL Target Name: Pseudomonas aeruginosa
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: CO-ADD Antimicrobial Screening

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
Inhibition	=	10.84	%	Average; N=1
Inhibition	=	14.55	%	Average; N=1
Inhibition	=	-13.46	%	Average; N=1	Outside typical range
Inhibition	=	21.47	%	Average; N=2
Inhibition	=	32.07	%	Average; N=1
Inhibition	=	2.27	%	Average; N=1
Inhibition	=	-21.74	%	Average; N=1	Outside typical range
Inhibition	=	9.41	%	Average; N=1
Inhibition	=	19.34	%	Average; N=1
Inhibition	=	-25.08	%	Average; N=1	Outside typical range
Inhibition	=	9.21	%	Average; N=4
Inhibition	=	15.98	%	Average; N=4
Inhibition	=	8.03	%	Average; N=1
Inhibition	=	-1.26	%	Average; N=1
Inhibition	=	6.81	%	Average; N=1
Inhibition	=	-8.48	%	Average; N=1
Inhibition	=	25.25	%	Average; N=1
Inhibition	=	44.67	%	Average; N=1
Inhibition	=	1.69	%	Average; N=1
Inhibition	=	2.93	%	Average; N=1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：G-361

External ID: CHEMBL3077479

Protocol: N/A

Comment: Journal: Med Chem Res
Year: 2013
Volume: 22
Issue: 3
First Page: 1090
Last Page: 1101
DOI: 10.1007/s00044-012-0084-0

Target ChEMBL ID: CHEMBL614036
ChEMBL Target Name: G-361
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	-64.2	%
Activity	=	43.4	%
Activity	=	90.9	%
Activity	=	99.6	%
Activity	=	92.3	%
Activity	=	100	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cryptococcus neoformans

External ID: CHEMBL4296190

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL365
ChEMBL Target Name: Cryptococcus neoformans
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: CO-ADD Antimicrobial Screening

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
10	MIC	>	10000	nM	Median N= 2; Maxinhib 9.6 Pct
	Inhibition	=	-7.36	%	Average; N=2; Conc=25 Um ;
20	MIC	>	20000	nM	Median N= 2; Maxinhib 17.1 Pct
10	MIC	>	10000	nM	Median N= 2; Maxinhib 6.5 Pct
	Inhibition	=	-5.61	%	Average; N=2
10	MIC	>	10000	nM	Median N= 2; Maxinhib 7.2 Pct
	Inhibition	=	-0.18	%	Average; N=2
	Inhibition	=	-8.54	%	Average; N=2
	Inhibition	=	-5.03	%	Average; N=2
	Inhibition	=	-1.5	%	Average; N=2
20	MIC	>	20000	nM	Median N= 2; Maxinhib 8.8 Pct
0.1563	MIC	=	156.3	nM	Median N= 2
	Inhibition	=	-9.6	%	Average; N=2; Conc=25 Um ;
	Inhibition	=	-0.09	%	Average; N=2
	Inhibition	=	-3.07	%	Average; N=2
	Inhibition	=	-2.97	%	Average; N=2
20	MIC	>	20000	nM	Median N= 2; Maxinhib 9.3 Pct
	Inhibition	=	-12.66	%	Average; N=2; Conc=25 Um ;	Outside typical range
10	MIC	>	10000	nM	Median N= 2; Maxinhib 4.5 Pct
20	MIC	>	20000	nM	Median N= 2; Maxinhib 9.3 Pct

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：G-361

External ID: CHEMBL3077480

Protocol: N/A

Comment: Journal: Med Chem Res
Year: 2013
Volume: 22
Issue: 3
First Page: 1090
Last Page: 1101
DOI: 10.1007/s00044-012-0084-0

Target ChEMBL ID: CHEMBL614036
ChEMBL Target Name: G-361
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	-70.7	%
Activity	=	-4.5	%
Activity	=	-59.3	%
Activity	=	29.2	%
Activity	=	51.7	%
Activity	=	45.5	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Candida albicans

External ID: CHEMBL4296189

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL366
ChEMBL Target Name: Candida albicans
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: CO-ADD Antimicrobial Screening

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
10	MIC	>	10000	nM	Median N= 2; Maxinhib 3.0 Pct
	Inhibition	=	8.04	%	Average; N=2; Conc=25 Um ;
20	MIC	>	20000	nM	Median N= 2; Maxinhib 7.4 Pct
10	MIC	>	10000	nM	Median N= 2; Maxinhib 4.8 Pct
	Inhibition	=	3.92	%	Average; N=2
10	MIC	>	10000	nM	Median N= 2; Maxinhib 10.4 Pct
	Inhibition	=	-0.23	%	Average; N=2
	Inhibition	=	0.3	%	Average; N=2
	Inhibition	=	-0.48	%	Average; N=2
	Inhibition	=	2.62	%	Average; N=2
20	MIC	>	20000	nM	Median N= 2; Maxinhib 8.0 Pct
0.0781	MIC	<=	78.1	nM	Median N= 2
	Inhibition	=	-3.39	%	Average; N=2; Conc=25 Um ;
	Inhibition	=	5.22	%	Average; N=2
	Inhibition	=	3.37	%	Average; N=2
	Inhibition	=	4.56	%	Average; N=2
20	MIC	>	20000	nM	Median N= 2; Maxinhib 3.4 Pct
	Inhibition	=	-0.73	%	Average; N=2; Conc=25 Um ;
10	MIC	>	10000	nM	Median N= 2; Maxinhib 7.9 Pct
20	MIC	>	20000	nM	Median N= 2; Maxinhib 1.4 Pct

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：G-361

External ID: CHEMBL3077481

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Med Chem Res
Year: 2013
Volume: 22
Issue: 3
First Page: 1090
Last Page: 1101
DOI: 10.1007/s00044-012-0084-0

Target ChEMBL ID: CHEMBL614036
ChEMBL Target Name: G-361
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
2.1	GI50	=	2100	nM
37	TGI	=	37000	nM
100	LC50	>	100000	nM
36	GI50	=	36000	nM
100	TGI	>	100000	nM
100	LC50	>	100000	nM
100	GI50	>	100000	nM
100	TGI	>	100000	nM
100	LC50	>	100000	nM
100	GI50	>	100000	nM
100	TGI	>	100000	nM
100	LC50	>	100000	nM
2.02	GI50	=	2020	nM
32	TGI	=	32000	nM
100	LC50	>	100000	nM
2.2	GI50	=	2200	nM
37	TGI	=	37000	nM
100	LC50	>	100000	nM

5401-50-3 靶点实验数据